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Hyaluronic Acid

Specific Recommendations:

• Hyaluronic acid at Amazon.com

News & Research:

• Efficacy and Safety of a Hyaluronic Acid–Containing Cream in the Treatment of Chronic, Venous, or Mixed-Origin Leg Ulcers - Medscape, 2/4/22 - "Treatment of subjects with chronic leg ulcers of venous or mixed origin with HA cream is safe, well tolerated, and results in a higher rate of healing than a neutral comparator cream" - See hyaluronic acid cream at Amazon.com.
• Hyaluronic Acid and Platelet-Rich Plasma, a New Therapeutic Alternative for Scleroderma Patients - Medscape, 1/28/20 - "Systemic sclerosis is a systemic connective tissue disease characterized by endothelium damage, fibrosis, and subsequent atrophy of the skin ... Ten female patients aged between 18 and 70 were included in this study. Each patient was treated with three filler injections of hyaluronic acid and platelet-rich plasma at an interval of 15 to 20 days ... Our study demonstrates that filler injections of hyaluronic acid and platelet-rich plasma represent an efficient local therapeutic alternative for patients affected by scleroderma. The treatment has significantly improved patients' quality of living" - See hyaluronic acid at Amazon.com.
• Preclinical and Clinical Studies of Hyaluronic Acid in Wound Care - Medscape, 4/1/19 - "The presented literature supports the contention that hyaluronic acid is a critical component in the complex cascade of wound healing and most likely is responsible for the clinical wound improvement in the case series presented." - See hyaluronic acid at Amazon.com.
• Use of Hyaluronic Acid–based Biological Bilaminar Matrix in Wound Bed Preparation - Medscape, 4/4/18 - "This case series shows a strong trend for Hyalomatrix to play an important role in supporting wound healing in complex, surgical wounds" - See Hyalomatrix at Amazon.com.
• Hyaluronic Acid as a Treatment Option for Pressure Ulcers - Medscape, 2/10/14 - "One of the components of the extracellular matrix, hyaluronic acid is present in skin, cartilage, bone, and brain, among other tissues. It has proved valuable in neurosurgery and dermatology because hyaluronic acid and degradation products can modulate wound healing. [8] Numerous studies have demonstrated the usefulness of hyaluronic acid in skin lesions and cartilage defects, in glial cell culture, and in the regeneration/increase of sperm motility ... Physiologically, the key characteristic of this molecule is its high hydroscopicity, which serves to regulate tissue hydration and osmotic balance" - See hyaluronic acid at Amazon.com.
• Three Treatments Shown to Work Against Wrinkles - NYTimes.com, 8/18/08 - "A recent review in The Archives of Dermatology concludes that three anti-aging treatments are proven clinically effective: the topical application of retinol; carbon dioxide laser resurfacing; and injection of hyaluronic acid, a moisture-retaining acid that occurs naturally in the skin"

Abstracts:

• Skin dryness induced in the KK-Ay/TaJcl type 2 diabetes mouse model deteriorates following dapagliflozin administration - Biol Pharm Bull 2022 May 17 - "SGLT-2 inhibitors cause skin dryness ... Dapagliflozin treatment decreased collagen type I and hyaluronic acid levels in mice; additionally, it affected the TGF-β/hyaluronan synthase pathway, further reducing hyaluronic acid levels. The results indicate that the reduction in hyaluronic acid levels plays an important role in the occurrence of dry skin in diabetes" - See collagen supplements at Amazon.com and hyaluronic acid at Amazon.com.
• Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study - Curr Med Res Opin 2021 Jul 15 - "LBSA0103 is a recently developed high-molecular-weight, cross-linked, non-animal hyaluronic acid (HA) ... A single intra-articular injection of LBSA0103 in patients with OA of the knee joint was safe, and no significant safety concerns were observed. As such, LBSA0103 could be safely applied as an intra-articular injection for the management of knee OA" - See hyaluronic acid at Amazon.com.
• Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial - Altern Ther Health Med. 2019 Jun 13 - "The intervention consisted of twice daily oral administration of a supplement containing BioCell Collagen, a chicken sternal cartilage derived dietary ingredient composed of a naturally-occurring matrix of hydrolyzed collagen type-II (≥300 mg), chondroitin sulfate (≥100 mg), hyaluronic acid (≥50 mg) ... For the 113 participants completing the study, the dietary supplementation compared to a placebo: (1) significantly reduced facial lines and wrinkles (P = .019) and crow's feet lines and wrinkles (P = .05), (2) increased skin elasticity (P = .008) and cutaneous collagen content (P < .001) by 12%, (3) improved indicators associated with a more youthful skin appearance based on visual grading and wrinkle width (P = .046), and (4) decreased skin dryness and erythema. No difference existed between the supplement and the placebo for skin-surface water content or retention. The supplement was well tolerated, with no reported adverse reactions" - [Nutra USA] - See BioCell Collagen at Amazon.com, collagen UC-II at Amazon, hyaluronic acid at Amazon.com and chondroitin sulfate at Amazon.com.

• Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period - Clin Cosmet Investig Dermatol. 2017 Jul 18 - "Sixty Japanese male and female subjects aged 22-59 years who presented with crow's feet wrinkles were randomly assigned to the HA 2 k or HA 300 k at 120 mg/day or the placebo group. The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks ... During the study period, the HA groups showed better level of the whole sulcus volume ratio, wrinkle area ratio, and wrinkle volume ratio than the placebo group. After 8 weeks of ingestion, the HA 300 k group showed significantly diminished wrinkles compared with the placebo group. Skin luster and suppleness significantly improved after 12 weeks in all groups compared with the baseline" - [Nutra USA]