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Home > Health
Conditions > Huntington's Disease
Huntington's Disease
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Alternative News:
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Metformin to
treat Huntington disease: a pleiotropic drug against a
multi-system disorder - Mech Ageing Dev 2022 Mar 30 -
"Huntington disease (HD) is a neurodegenerative disorder
produced by an expansion of CAG repeats in the HTT gene. Patients of HD show
involuntary movements, cognitive decline and psychiatric impairment. People
carrying abnormally long expansions of CAGs (more than 35 CAG repeats) produce
mutant huntingtin (mHtt), which encodes tracks of polyglutamines (polyQs). These
polyQs make the protein prone to aggregate and cause it to acquire a toxic gain
of function. Principally affecting the frontal cortex and the striatum, mHtt
disrupts many cellular functions ... Several studies reported that metformin, a
widely-used anti-diabetic drug, is neuroprotective in models of HD ... Metformin
is a pleiotropic drug, modulating different targets such as AMPK, insulin
signalling and many others. These molecules regulate autophagy, chaperone
expression, and more, which in turn reduce mHtt toxicity. Moreover, metformin
alters gut microbiome and its metabolic processes" - See
metformin at ReliableRX.
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Neuroprotective effects of
rutin on ASH neurons in Caenorhabditis elegans model of Huntington's disease
- Nutr Neurosci 2021 Jul 26;1-14 - "Huntington's disease
(HD) is an autosomal dominant, progressive neurodegenerative disease. It occurs
due to a mutated huntingtin gene that contains an abnormal expansion of
cytosine-adenine-guanine repeats, leading to a variable-length N-terminal
polyglutamine (polyQ) chain. The mutation confers toxic functions to mutant
huntingtin protein, causing neurodegeneration. Rutin is a flavonoid found in
various plants, such as buckwheat, some teas, and apples ... we investigated the
effects of rutin in a Caenorhabditis elegans model of HD, focusing on ASH
neurons and antioxidant defense ... our data demonstrate that chronic rutin
treatment maintains the function of ASH neurons, and decreases the degeneration
of their sensory termination ... Our findings provide new evidence of rutin's
potential neuroprotective role in the C. elegans model and should inform
treatment strategies for neurodegenerative diseases and other diseases caused by
age-related protein aggregation" - See
rutin at Amazon.com and
rutin at iHerb.com.
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High-Dose Creatine
Promising in Prodromal Huntington's - Medscape, 3/14/14 -
"Creatine helps maintain intracellular energy levels and
so may prevent or impede the neurodegenerative process. Past studies have
reported that reduced energy stores play a role in neuronal loss ... The drug or
placebo came in packets, each with of 5 g of powder that could be added to foods
such as yogurt or apple juice. Participants could take the maximum tolerated
dose of the drug (30 g) daily. The creatine was pharmaceutical grade ...
Interestingly, more carriers (9 of 10) dropped out of the study during the
placebo-controlled phase, 7 of whom knew their genetic status (2 had been
assigned to placebo) ... That so many carriers dropped out of the study was
"completely counterintuitive," said Dr. Rosas. "You come in with this notion
that if you know what your risk ... the rate of cortical thinning in several
regions, including portions of precentral, superior and middle-temporal,
superior and middle frontal precuneus, posterior parietal and occipital was
significantly slower in the carriers taking creatine compared with the carriers
receiving placebo" - See
creatine at Amazon.com
 .
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Huntington disease prevention trial shows creatine safe, slows progression -
Science Daily, 2/8/14 - "Among the ways that the mutated
form of the huntingtin protein damages brain cells is by interfering with
cellular energy production, leading to a depletion of ATP, the molecule that
powers most biological processes. Known to help restore ATP and maintain
cellular energy, creatine is being investigated to treat a number of
neurological conditions -- including Parkinson disease, amyotrophic lateral
sclerosis and spinal cord injury. Studies in mouse models of HD showed that
creatine raises brain ATP levels and protects against neurodegeneration ... In
participants who carried the HD mutation, the MRI scans taken at the outset of
the trial had revealed significant atrophy in regions of the cerebral cortex and
basal ganglia known to be affected by the disease. Followup MRI scans at six
months showed a slower rate of atrophy in participants taking creatine compared
to those on placebo. At the end of the second phase, the rate of brain atrophy
had also slowed in presymptomatic participants that started taking creatine
after 6 months on placebo" - See
creatine at Amazon.com.
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Lithium
profoundly prevents brain damage associated with Parkinson's disease, mouse
study suggests - Science Daily, 6/24/11 - "lithium
has recently been suggested to be neuroprotective in relation to several
neurodegenerative conditions including Alzheimer's disease, Huntington's disease
and amyotrophic lateral sclerosis and has been touted for its anti-aging
properties in simple animals" - See lithium supplements at Amazon.com.
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Natural compound shows promise against Huntington's disease - Science
Daily, 11/15/10 - "Fisetin, a naturally occurring
compound found in strawberries and other fruits and vegetables, slows the
onset of motor problems and delays death in three models of Huntington's
disease ... tested fisetin's effects in a mouse model of HD. HD mice develop
motor defects early on and have much shorter life spans than normal control
animals. When Maher and her team fed them fisetin, the onset of the motor
defects was delayed, and their life span was extended by about 30 percent"
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New
study links DHA type of omega-3 to better nervous-system function -
Science Daily, 12/16/09 - "The omega-3 essential
fatty acids commonly found in fatty fish and algae help animals avoid
sensory overload ... The finding connects low omega-3s to the
information-processing problems found in people with schizophrenia; bipolar,
obsessive-compulsive, and attention-deficit hyperactivity disorders;
Huntington's disease; and other afflictions of the nervous system" -
See
Jarrow Max DHA at Amazon.com.
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Green tea chemical combined with another may hold promise for treatment of
brain disorders - Science Daily, 12/3/09 -
"Scientists at Boston Biomedical Research Institute (BBRI) and the
University of Pennsylvania have found that combining two chemicals, one of
which is the green tea component EGCG, can prevent and destroy a variety of
protein structures known as amyloids. Amyloids are the primary culprits in
fatal brain disorders such as Alzheimer's, Huntington's, and Parkinson's
diseases" - See
green tea extract at Amazon.com.
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Fish
Oil Protects Against Diseases Like Parkinson's - Science Daily, 4/19/09
- "Dr. Nicolas Bazan, Director of the Neuroscience
Center of Excellence, Boyd Professor, and Ernest C. and Yvette C. Villere
Chair of Retinal Degenerative Diseases Research at LSU Health Sciences
Center New Orleans, will present new research findings showing that an omega
three fatty acid in the diet protects brain cells by preventing the
misfolding of a protein resulting from a gene mutation in neurodegenerative
diseases like Parkinson's and Huntington's ... the omega three fatty acid,
docosahexaenoic acid (DHA), protects cells from this defect ... Dr. Bazan's
laboratory discovered earlier that neuroprotectin D1 (NPD1), a
naturally-occurring molecule in the human brain that is derived from DHA
also promotes brain cell survival" - See
Jarrow Max DHA at Amazon.com.
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Antioxidants Could Help Huntington’s Disease Sufferers, Study Suggests -
Science Daily, 10/10/08 - "strategies to strengthen
antioxidant defences could help to prevent the progression of Huntington’s
Disease ... oxidative stress and damage to certain macromolecules are
involved in the progression of Huntington’s Disease (HD)"
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Worried About Huntington's - Dr. Weil, 2/25/08
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Green tea extract may slow Huntington’s disease - Nutra USA, 9/8/06
- Essential Fatty
Acids May Slow or Reverse the Progression of Huntington’s Disease - New
Hope Natural Media, 7/3/02
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CoQ10 Shows Promise In Slowing Progression Of Huntington's Disease -
Intelihealth, 8/23/01
Other News:
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New
drugs target delay of Huntington’s symptoms - Science Daily, 5/29/11
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Transplanted Neurons Develop Disease-like Pathology In Huntington's Patients
- Science Daily, 7/23/09
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Risk
Of Transmission Of Huntington's Disease To Offspring Among Male Carriers
Estimated - Science Daily, 6/9/09
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Old
Gastrointestinal Drug Slows Aging, Researchers Say - Science Daily,
1/6/08 - "Recent animal studies have shown that
clioquinol – an 80-year old drug once used to treat diarrhea and other
gastrointestinal disorders – can reverse the progression of Alzheimer's,
Parkinson's and Huntington's diseases ... clioquinol acts directly on a
protein called CLK-1, often informally called "clock-1," and might slow down
the aging process ... Because clock-1 affects longevity in invertebrates and
mice, and because we're talking about three age-dependent neurodegenerative
diseases, we hypothesize that clioquinol affects them by slowing down the
rate of aging ... clioquinol was withdrawn from the market after being
blamed for a devastating outbreak of subacute myelo-optic neuropathy (SMON)
in Japan in the 1960s. However, because no rigorous scientific study was
conducted at the time, and because clioquinol was used safely by millions
before and after the Japanese outbreak, some researchers think its
connection to SMON has yet to be proven" - I Googled clioquinol and I
don't think it's available anywhere.
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Huntington's Disease Problem Start Early - Science Daily, 1/9/08
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Subtle Signs Can Help Predict Huntington's Disease Early - Doctor's
Guide, 5/15/07
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Prestwick Pharmaceuticals Receives FDA Approvable Letter for Xenazine
(Tetrabenazine) for Treatment of Chorea Associated with Huntington's Disease
- Doctor's Guide, 3/31/06
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Avicena Compound Receives Orphan Drug Designation for Huntington's Disease
- Doctor's Guide, 3/22/06
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Combination of PET, MR Imaging Shows White Matter Degeneration in
Huntington's Disease Patients - Doctor's Guide, 2/15/06
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Old
Drug Shows New Promise For Huntington's Disease - Science Daily, 9/12/05
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Tetrabenazine Appears to Significantly Improve Debilitating Movement
Disorder Associated with Huntington's Disease - Doctor's Guide, 10/4/04
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Huntington's Study Looks Promising - Intelihealth, 7/30/02
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Study Stirs Debate On Huntington's - Intelihealth, 8/22/01
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