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Home > Health Conditions > Huntington's Disease

Huntington's Disease

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  • Metformin to treat Huntington disease: a pleiotropic drug against a multi-system disorder - Mech Ageing Dev 2022 Mar 30 - "Huntington disease (HD) is a neurodegenerative disorder produced by an expansion of CAG repeats in the HTT gene. Patients of HD show involuntary movements, cognitive decline and psychiatric impairment. People carrying abnormally long expansions of CAGs (more than 35 CAG repeats) produce mutant huntingtin (mHtt), which encodes tracks of polyglutamines (polyQs). These polyQs make the protein prone to aggregate and cause it to acquire a toxic gain of function. Principally affecting the frontal cortex and the striatum, mHtt disrupts many cellular functions ... Several studies reported that metformin, a widely-used anti-diabetic drug, is neuroprotective in models of HD ... Metformin is a pleiotropic drug, modulating different targets such as AMPK, insulin signalling and many others. These molecules regulate autophagy, chaperone expression, and more, which in turn reduce mHtt toxicity. Moreover, metformin alters gut microbiome and its metabolic processes" - See metformin at ReliableRX.
  • Neuroprotective effects of rutin on ASH neurons in Caenorhabditis elegans model of Huntington's disease - Nutr Neurosci 2021 Jul 26;1-14 - "Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disease. It occurs due to a mutated huntingtin gene that contains an abnormal expansion of cytosine-adenine-guanine repeats, leading to a variable-length N-terminal polyglutamine (polyQ) chain. The mutation confers toxic functions to mutant huntingtin protein, causing neurodegeneration. Rutin is a flavonoid found in various plants, such as buckwheat, some teas, and apples ... we investigated the effects of rutin in a Caenorhabditis elegans model of HD, focusing on ASH neurons and antioxidant defense ... our data demonstrate that chronic rutin treatment maintains the function of ASH neurons, and decreases the degeneration of their sensory termination ... Our findings provide new evidence of rutin's potential neuroprotective role in the C. elegans model and should inform treatment strategies for neurodegenerative diseases and other diseases caused by age-related protein aggregation" - See rutin at Amazon.com and rutin at iHerb.com.
  • High-Dose Creatine Promising in Prodromal Huntington's - Medscape, 3/14/14 - "Creatine helps maintain intracellular energy levels and so may prevent or impede the neurodegenerative process. Past studies have reported that reduced energy stores play a role in neuronal loss ... The drug or placebo came in packets, each with of 5 g of powder that could be added to foods such as yogurt or apple juice. Participants could take the maximum tolerated dose of the drug (30 g) daily. The creatine was pharmaceutical grade ... Interestingly, more carriers (9 of 10) dropped out of the study during the placebo-controlled phase, 7 of whom knew their genetic status (2 had been assigned to placebo) ... That so many carriers dropped out of the study was "completely counterintuitive," said Dr. Rosas. "You come in with this notion that if you know what your risk ... the rate of cortical thinning in several regions, including portions of precentral, superior and middle-temporal, superior and middle frontal precuneus, posterior parietal and occipital was significantly slower in the carriers taking creatine compared with the carriers receiving placebo"  - See creatine at Amazon.com.
  • Huntington disease prevention trial shows creatine safe, slows progression - Science Daily, 2/8/14 - "Among the ways that the mutated form of the huntingtin protein damages brain cells is by interfering with cellular energy production, leading to a depletion of ATP, the molecule that powers most biological processes. Known to help restore ATP and maintain cellular energy, creatine is being investigated to treat a number of neurological conditions -- including Parkinson disease, amyotrophic lateral sclerosis and spinal cord injury. Studies in mouse models of HD showed that creatine raises brain ATP levels and protects against neurodegeneration ... In participants who carried the HD mutation, the MRI scans taken at the outset of the trial had revealed significant atrophy in regions of the cerebral cortex and basal ganglia known to be affected by the disease. Followup MRI scans at six months showed a slower rate of atrophy in participants taking creatine compared to those on placebo. At the end of the second phase, the rate of brain atrophy had also slowed in presymptomatic participants that started taking creatine after 6 months on placebo" - See creatine at Amazon.com.
  • Lithium profoundly prevents brain damage associated with Parkinson's disease, mouse study suggests - Science Daily, 6/24/11 - "lithium has recently been suggested to be neuroprotective in relation to several neurodegenerative conditions including Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis and has been touted for its anti-aging properties in simple animals" - See lithium supplements at Amazon.com.
  • Natural compound shows promise against Huntington's disease - Science Daily, 11/15/10 - "Fisetin, a naturally occurring compound found in strawberries and other fruits and vegetables, slows the onset of motor problems and delays death in three models of Huntington's disease ... tested fisetin's effects in a mouse model of HD. HD mice develop motor defects early on and have much shorter life spans than normal control animals. When Maher and her team fed them fisetin, the onset of the motor defects was delayed, and their life span was extended by about 30 percent"
  • New study links DHA type of omega-3 to better nervous-system function - Science Daily, 12/16/09 - "The omega-3 essential fatty acids commonly found in fatty fish and algae help animals avoid sensory overload ... The finding connects low omega-3s to the information-processing problems found in people with schizophrenia; bipolar, obsessive-compulsive, and attention-deficit hyperactivity disorders; Huntington's disease; and other afflictions of the nervous system" - See Jarrow Max DHA at Amazon.com.
  • Green tea chemical combined with another may hold promise for treatment of brain disorders - Science Daily, 12/3/09 - "Scientists at Boston Biomedical Research Institute (BBRI) and the University of Pennsylvania have found that combining two chemicals, one of which is the green tea component EGCG, can prevent and destroy a variety of protein structures known as amyloids. Amyloids are the primary culprits in fatal brain disorders such as Alzheimer's, Huntington's, and Parkinson's diseases" - See green tea extract at Amazon.com.
  • Fish Oil Protects Against Diseases Like Parkinson's - Science Daily, 4/19/09 - "Dr. Nicolas Bazan, Director of the Neuroscience Center of Excellence, Boyd Professor, and Ernest C. and Yvette C. Villere Chair of Retinal Degenerative Diseases Research at LSU Health Sciences Center New Orleans, will present new research findings showing that an omega three fatty acid in the diet protects brain cells by preventing the misfolding of a protein resulting from a gene mutation in neurodegenerative diseases like Parkinson's and Huntington's ... the omega three fatty acid, docosahexaenoic acid (DHA), protects cells from this defect ... Dr. Bazan's laboratory discovered earlier that neuroprotectin D1 (NPD1), a naturally-occurring molecule in the human brain that is derived from DHA also promotes brain cell survival" - See Jarrow Max DHA at Amazon.com.
  • Antioxidants Could Help Huntington’s Disease Sufferers, Study Suggests - Science Daily, 10/10/08 - "strategies to strengthen antioxidant defences could help to prevent the progression of Huntington’s Disease ... oxidative stress and damage to certain macromolecules are involved in the progression of Huntington’s Disease (HD)"
  • Worried About Huntington's - Dr. Weil, 2/25/08
  • Green tea extract may slow Huntington’s disease - Nutra USA, 9/8/06
  • Essential Fatty Acids May Slow or Reverse the Progression of Huntington’s Disease - New Hope Natural Media, 7/3/02
  • CoQ10 Shows Promise In Slowing Progression Of Huntington's Disease - Intelihealth, 8/23/01

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