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Hops (Humulus lupulus)

Specific Recommendations:

• Hops supplements at Amazon.com

News & Research:

• Hops (Humulus lupulus L.) - M. D. Anderson Cancer Center
• Liver, colon cancer cells thwarted by compounds derived from hops - Science Daily, 4/2/19 - "xanthohumol, known as XN ... XN had been shown to inhibit proliferation of a variety of cancer cell lines, and in this study, we demonstrated XN's ability to halt cell growth and kill two liver cancer cell lines and two colon cancer cell lines" - See xanthohumol at Amazon.com.
• Hops compound may prevent prostate cancer - Science Daily, 12/9/09 - "xanthohumol blocks the action of estrogen by binding to its receptor, which may lead to prevention of breast cancer ... Since testosterone receptors act similarly to that of estrogen -- by binding, then stimulating hormone-dependent effects, such as gene expression and cell growth ... Xanthohumol prevented the receptor from translocating to the cell nucleus, thus inhibiting its potential to stimulate the secretion of PSA and other hormone-dependent effects"
• Beer ingredient may fight prostate cancer - USA Today, 6/12/06 - "the ingredient is present in such small amounts that a person would have to drink more than 17 beers to benefit ... the compound xanthohumol, found in hops, inhibits a specific protein in the cells along the surface of the prostate gland"
• Anti-cancer Compound In Beer Gaining Interest - Science Daily, 11/25/05
• Drinker's Delight: Beer May Fight Disease - ABC News, 11/11/05

Abstracts:

• Supplementation with Matured Hop Bitter Acids Improves Cognitive Performance and Mood State in Healthy Older Adults with Subjective Cognitive Decline - J Alzheimers Dis 2020 May 26 - "matured hop bitter acid (MHBA) ...  randomly assigned into placebo (n = 50) and MHBA (n = 50) groups, and received placebo or MHBA capsules daily for 12 weeks ... Symbol Digit Modalities Test (SDMT) score assessing divided attention at week 12 was significantly higher (p = 0.045) and β-endorphin at week 12 was significantly lower (p = 0.043) in the subjects receiving MHBA. Transthyretin in serum, a putative mild cognitive impairment marker, was significantly higher at week 12 in the MHBA group than in the placebo group (p = 0.048). Subgroup analysis classified by the subjective cognitive decline questionnaire revealed that in addition to improved SDMT scores, memory retrieval assessed using the standard verbal paired-associate learning tests and the Ray Verbal Learning Test at week 12 had significantly improved in the subgroup with perceived subjective cognitive decline and without requirement for medical assistance in the MHBA group compared with that in the placebo group ... This study suggested that MHBA intake improves cognitive function, attention, and mood state in older adults" - [Nutra USA] - See hops supplements at Amazon.com.
• Hops compounds help with metabolic syndrome while reducing microbiome diversity - Science Daily, 11/25/19 - "The study builds on earlier research at OSU that found xanthohumol, often abbreviated to XN, and two hydrogenated derivatives, DXN and TXN, can likely improve cognitive and other functions in people with the syndrome ... Results show that each of the hops compounds decreased the amount and diversity of microbes, reduced inflammation and changed bile acid metabolism -- there was a reduction in secondary bile acid production and an increase of conjugated bile acids, which are indicators of improved energy metabolism, glucose metabolism and cholesterol metabolism ... the hops compounds have previously been shown to have antimicrobial properties, "so they may be killing off certain bugs that aren't beneficial and preserving other ones that are.""