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Green Coffee Bean Extract

Specific Recommendations:

• Green coffee bean extract at Amazon.com
• Coffee fruit extract at Amazon.com

News & Research:

• Chemical in coffee may help prevent obesity-related disease - Science Daily, 11/14/14 - "chlorogenic acid, or CGA, significantly reduced insulin resistance and accumulation of fat in the livers of mice who were fed a high-fat diet ... which is found in great abundance in coffee, but also in other fruits and vegetables like apples, pears, tomatoes and blueberries ... CGA was not only effective in preventing weight gain, but it also helped maintain normal blood sugar levels and healthy liver composition ... CGA is a powerful antioxidant that reduces inflammation" - See chlorogenic acid at Amazon.com.
• Green Coffee Bean Extract: Helpful or All Hype? - U.S. News, 8/1/13
• Could Coffee Bean Extract Help Control Blood Sugar? - WebMD, 4/9/13 - "Vinson's study analyzed 30 men and women of normal weight who did not have diabetes. They took supplements containing between 100 milligrams (mg) and 400 mg of the green coffee extract in a capsule with water, followed by glucose tolerance tests at several points afterward ... All doses of the extract appeared to lower participants' blood sugar levels, Vinson said, but a dose of 400 mg was associated with a 24 percent drop 30 minutes after taking the extract and a 31 percent drop 120 minutes later ... Vinson said he believes the sugar-lowering effects of green coffee extract are due to its concentration of chlorogenic acids -- antioxidants found in apples, cherries, plums and other fruits and vegetables. High temperatures used to roast coffee beans typically break down chlorogenic acids, he said, so coffee beverages contain less of them than extracts found in supplements" - [Science Daily]

Abstracts:

• The effect of green coffee and/or endurance exercise on sperm function in pre-diabetic mice - Andrologia 2022 Aug 24 - "This study aimed to investigate the effect of green coffee (GC), chlorogenic acid (CA) as an active ingredient of GC and exercise, alone or in a combination with exercise, on spermatogenesis and sperm function in pre-diabetic mice ... Although lipid peroxidation, intracellular ROS production, and persistent histones in sperm were high in pre-diabetic mice, exercise only can improve sperm motility. GC alone only improved sperm motility in pre-diabetic mice while CA alone, even did not have this beneficial effect. However, GC along with exercise, did not improve motility but reduce DNA damage, while CA with exercise, significantly improved motility compared to pre-diabetic stage and to the level comparable to control. Therefore, based on this result in individuals with high DNA damage, GC supplementation and exercise could be useful approach while in asthenozoospermia, CA supplementation and exercise should be considered as an alternative approach" - See green coffee bean extract at Amazon.com.
• Acute Effects of Combined Bacopa, American Ginseng and Whole Coffee Fruit on Working Memory and Cerebral Haemodynamic Response of the Prefrontal Cortex: A Double-Blind, Placebo-Controlled Study - Nutr Neurosci 2019 Nov 18;1-12 - "This study assessed whether a multi-ingredient herbal supplement containing Bacopa monniera (BM), Panax quinquefolius ginseng (PQ) and whole coffee fruit extract (WCFE) could enhance cognitive performance and cerebral-cortical activation during tasks of working memory and attention ... 40 healthy adults between 18-60 years (M = 34.46 SD = 12.95) completed tasks of working memory and attention at baseline and 45 min post active or placebo supplement consumption ... prefrontal cortex (PFC) ... Working memory task performance on the N-back task was significantly improved following active supplement consumption compared to placebo in terms of accuracy (p < .01) and response time (p < .05). Improved performance was associated with a reduction of PFC activation (p < .001) related to effortful mental demand, reflecting increased neural efficiency concomitant with improved cognitive performance" - [Nutra USA] - See Bacopa monnieri at Amazon.com and iHerb, ginseng at Amazon.com and iHerb, coffee fruit extract at Amazon.com and iHerb.
• The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose-response meta-analysis of randomized controlled trials - Phytother Res. 2020 Mar 11 - "The results of present study support the use of GCE for the enhancement of blood glucose, while subgroup analysis highlighted significant improvements in insulin levels when GCE is supplemented in doses ≥400 mg/day."
• Green coffee ameliorates components of diet-induced metabolic syndrome in rats - j func foods Jun 2019 - "Metabolic syndrome, especially obesity, increases the risk of type 2 diabetes and cardiovascular disease. We hypothesised that green coffee will attenuate metabolic, cardiovascular and liver parameters in high-carbohydrate high-fat diet-fed rats. Male Wistar rats (8–9 weeks old) were divided into 6 groups and fed for 16 weeks with either corn starch diet (C), C with either 5% green or decaffeinated green coffee in food for the last 8 weeks, high-carbohydrate high-fat diet (H) or H with either 5% green or decaffeinated green coffee in food for the last 8 weeks. Green coffee contained chlorogenic acids, trigonelline, caffeine and diterpenoids; decaffeinated green coffee contained these compounds but no caffeine. Green coffee attenuated body weight, systolic blood pressure, inflammation in the heart and liver and diastolic stiffness without improving glucose sensitivity or plasma lipids. We suggest that chlorogenic acids, trigonelline and diterpenoids in green coffee attenuate diet-induced abnormalities in heart and liver." - [Nutra USA]
• Chlorogenic acid-enriched green coffee bean extract affects arterial stiffness assessed by the cardio-ankle vascular index in healthy men: a pilot study - Int J Food Sci Nutr. 2019 Mar 25:1-7 - "chlorogenic acid-enriched green coffee bean extract (cGCE) ... cardio-ankle vascular index (CAVI) ... Endothelium-dependent flow-mediated dilation (FMD) and sympathetic nervous activity (SNA) ... The CAVI change was significantly greater in the cGCE group than in the placebo group. In addition, FMD increased and SNA decreased in the cGCE group. These findings suggest that 2-week ingestion of cGCE may improve arterial stiffness as assessed by the CAVI" - See chlorogenic acid at Amazon.com.
• Green Coffee Extract Improves Cardiometabolic Parameters and Modulates Gut Microbiota in High-Fat-Diet-Fed ApoE-/- Mice - Nutrients. 2019 Feb 27;11(3) - "Chlorogenic acids (CGA) are the most abundant phenolic compounds in green coffee beans and in the human diet and have been suggested to mitigate several cardiometabolic risk factors ... Although GCE did not reduce atherosclerotic lesion progression or plasma lipid levels, it induced important favorable changes. Specifically, improved metabolic parameters, including fasting glucose, insulin resistance, serum leptin, urinary catecholamines, and liver triglycerides, were observed. These changes were accompanied by reduced weight gain, decreased adiposity, lower inflammatory infiltrate in adipose tissue, and protection against liver damage. Interestingly, GCE also modulated hepatic IL-6 and total serum IgM and induced shifts in gut microbiota. Altogether, our results reveal the cooccurrence of these beneficial cardiometabolic effects in response to GCE in the same experimental model and suggest potential mediators and pathways involved"  - See green coffee bean extract at Amazon.com.
• Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system: a randomised, placebo-controlled, double-blinded cross-over trial - Br J Nutr. 2017 Apr 17:1-6 - "Chlorogenic acids (CGA) are the most abundant polyphenols in coffee. Continuous consumption of CGA reduces body fat and body weight ... A period of 5-d CGA consumption significantly increased fat oxidation during sleep, suggesting that beverages containing CGA may be beneficial to reduce body fat and prevent obesity. Consumption of CGA shortened sleep latency and did not adversely affect sleep quality" - [Nutra USA] - See green coffee bean extract at Amazon.com (usually standardized to 50% chlorogenic acids).
• Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials - Clin Nutr. 2016 Nov 30 - "polyphenol intake has been linked to improvements in human vascular function, although data on hydroxycinnamates, such as chlorogenic acid (CGA) have not yet been studied. We aimed to investigate the impact of coffee intake rich in chlorogenic acid on human vascular function and whether CGAs are involved in potential effects ... flow-mediated dilatation (FMD) ... FMD responses to coffee intake was closely paralleled by the appearance of CGA metabolites in plasma ... pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee (5-CQA; 450 mg and 900 mg) on FMD was also investigated ... Coffee intake acutely improves human vascular function, an effect, in part, mediated by 5-CQA and its physiological metabolites"
• Chlorogenic Acid Extends the Lifespan of Caenorhabditis elegans via Insulin/IGF-1 Signaling Pathway - J Gerontol A Biol Sci Med Sci. 2016 Jul 4 - "Coffee and tea, two of the most popular drinks around the world, share many in common from chemical components to beneficial effects on human health. One of their shared components, the polyphenols, most notably chlorogenic acid (CGA), was supposed to account for many of the beneficial effects on ameliorating diseases occurred accompanying people aging, such as the antioxidant effect and against diabetes and cardiovascular disease ... We found that CGA could extend the lifespan of C. elegans by up to 20.1%, delay the age-related decline of body movement, and improve stress resistance"
• Chlorogenic acid and caffeine in combination inhibit fat accumulation by regulating hepatic lipid metabolism-related enzymes in mice - Br J Nutr. 2014 Sep;112(6):1034-40 - "chlorogenic acid (CGA) ... forty mice were randomly assigned to four groups and fed diets containing no CGA or caffeine, CGA, caffeine, or CGA+caffeine for 24 weeks ... There was a decrease in the body weight and IPAT weight of mice fed the CGA+caffeine diet. There was a significant decrease in the serum and hepatic concentrations of total cholesterol, TAG and leptin of mice fed the CGA+caffeine diet ... These results indicate that CGA+caffeine suppresses fat accumulation and body weight gain by regulating the activities and mRNA and protein expression levels of hepatic lipid metabolism-related enzymes and that these effects are stronger than those exerted by CGA and caffeine individually" - See green coffee bean extract at Amazon.com.
• Cognitive and neuroprotective effects of chlorogenic acid - Nutr Neurosci. 2014 Aug 17 - "chlorogenic acid (CGA) ... A literature search was conducted using PubMed ... Recent research suggests that dietary consumption of CGA could produce a wide range of health benefits and physiological effects. There is also mounting evidence that the consumption of polyphenols, including CGA, in the diet could reduce the risk of developing neurodegenerative conditions"
  • Chlorogenic acid - Wikipedia - "Chlorogenic acid can be found in bamboo Phyllostachys edulis.[8] as well as in many other plants.[9] It is one of the major phenolic compounds identified in peach[10] and in prunes.[11] It also is one of the phenols found in green coffee bean extract"
• The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials - J Hum Hypertens. 2014 Jun 19 - "Meta-analysis revealed a statistically significant reduction in systolic blood pressure in favour of CGA (mean difference (MD): -4.31 mm Hg; 95% confidence interval (CI): -5.60 to -3.01; I2=65%; P<0.00001). Meta-analysis also showed a significant reduction in diastolic blood pressure favouring CGA (MD: -3.68 mm Hg; 95% CI: -3.91 to -3.45; I2=97%; P<0.00001)" - See artichoke extract at Amazon.com and chlorogenic acid at Amazon.com.
• Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice - Evid Based Complement Alternat Med. 2014;2014:718379 - "decaffeinated green coffee bean extract appeared to reverse HFD-induced fat accumulation and insulin resistance by downregulating the genes involved in adipogenesis and inflammation in visceral adipose tissue" - See green coffee bean extract at Amazon.com.