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Home > Health
Conditions > Burns.
Brown Fat
Alternative News:
Other News:
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Study
of 50,000 people finds brown fat may protect against numerous chronic diseases
- Science Daily, 1/4/21 - "the researchers reviewed
130,000 PET scans from more than 52,000 patients, and found the presence of
brown fat in nearly 10 percent of individuals. (Cohen notes that this figure
is likely an underestimate because the patients had been instructed to avoid
cold exposure, exercise, and caffeine, all of which are thought to increase
brown fat activity) ... Several common and chronic diseases were less
prevalent among people with detectable brown fat. For example, only 4.6
percent had type 2 diabetes, compared with 9.5 percent of people who did not
have detectable brown fat. Similarly, 18.9 percent had abnormal cholesterol,
compared to 22.2 percent in those without brown fat ... Moreover, the study
revealed three more conditions for which people with brown fat have lower
risk: hypertension, congestive heart failure, and coronary artery disease --
links that had not been observed in previous studies."
Abstracts:
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Melatonin induces fat
browning by transdifferentiation of white adipocytes and de novo differentiation
of mesenchymal stem cells - Food Funct 2022 Mar 11 -
"The role of melatonin in obesity control is extensively accepted, but its
mechanism of action is still unclear. Previously we demonstrated that chronic
oral melatonin acts as a brown-fat inducer, driving subcutaneous white adipose
tissue (sWAT) into a brown-fat-like function (beige) in obese diabetic rats ...
Mesenchymal stem cells (MSCs) ... melatonin increases brown fat in obese
diabetic rats by both adipocyte transdifferentiation and de novo
differentiation. Furthermore, it promotes beige MSC adipogenesis in humans. This
may contribute to the control of body weight attributed to melatonin and its
metabolic benefits in human diabesity" - See
melatonin at Amazon.com.
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Rutin promotes white adipose
tissue "browning" and brown adipose tissue activation partially through the
calmodulin-dependent protein kinase kinase β/AMP-activated protein kinase
pathway - Endocr J 2021 Oct 29 - "Promoting white
adipose tissue (WAT) "browning" and brown adipose tissue (BAT) activation could
contribute to increasing energy expenditure ... Male C57BL/6 mice (n = 6) were
fed a high-fat diet (HFD) for 12 weeks with/out rutin. In HFD-fed mice, rutin
treatment significantly inhibited weight gain, improved the metabolic profile of
plasma samples, decreased the weights of epididymal WAT (eWAT), inguina WAT (iWAT),
and liver, and adipocyte size. Furthermore, rutin also increased the expression
of uncoupling protein 1 (Ucp-1) and other thermogenic markers in the WAT and
BAT. In 3T3-L1 cells, rutin effectively reduced the formation of lipid droplets,
stimulated the expression of thermogenic markers, and reduced the expression of
adipogenic genes. Additionally, rutin markedly upregulated the AMP-activated
protein kinase (AMPK) pathway, and these effects were diminished by treatment
with the AMPK inhibitor compound C (CC). Pretreatment with the calmodulin-dependent
protein kinase kinase β (CaMKKβ) inhibitor STO-609 blocked the induction of
thermogenic markers in 3T3-L1 cells by rutin. Our results indicated that rutin
increased energy consumption, induced WAT "browning" and BAT activation, and
thus was a promising target for the development of new therapeutic approaches to
improve adipose tissue energy metabolism" - See
rutin at Amazon.com and
rutin at iHerb.com.
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