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Anti-aging Research > Boswellia.
Boswellia (Boswellia serrata)
Specific Recommendations:
News & Research:
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On
The Cover: Eating Your Way To Prostate Cancer - Life Extension Magazine,
2/07 - "Boswellia extracts have been thoroughly studied
as natural remedies for inflammatory disorders. A patented extract from
boswellia called 5-LOXIN® has potent ability to inhibit the enzyme 5-LOX,
preventing the formation of protein-degrading enzymes, and protecting against
inflammation-induced events that can promote tumor angiogenesis" - See
5-LOXIN at Amazon.com
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Ease Gout Pain - Nutrition Science News, 7/99 -
"During acute gout attacks, herbal anti-inflammatories including boswellia
(Boswellia serrata), curcumin (Curcuma longa), devil's claw (Harpagophytum
procumbens) and yucca (Yucca spp.) can be tried instead of aspirin or
arthritis drugs"
Abstracts:
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Boswellia serrata Extract,
5-Loxin®, Prevents Joint Pain and Cartilage Degeneration in a Rat Model of
Osteoarthritis through Inhibition of Inflammatory Responses and Restoration of
Matrix Homeostasis - Evid Based Complement Alternat Med 2022 Oct 19 -
"Osteoarthritis (OA) is a chronic, progressive joint
disease associated with pain, functional impairment, and diminished quality of
life in affected individuals. At a societal level, it also has a high economic
burden. Boswellia serrata has been reported to have potent anti-inflammatory,
antiarthritic, and analgesic effects ... Results indicated that administration
of 5-Loxin® can relieve OA joint pain through inhibition of both inflammatory
processes and cartilage degeneration. In the group of rats treated with
5-Loxin®, the suppression of inflammatory enzymes such as cyclooxygenase (COX)-2
and 5-lipoxygenase (LOX) resulted in a significant reduction in the
prostaglandin (PG) E2 and leukotriene (LT) B4 levels. Moreover, 5-Loxin®
ameliorated the deterioration of the main components of the articular
extracellular matrix (ECM), such as glycosaminoglycans (GAGs) and aggrecan,
through the downregulation of matrix metalloproteinases (MMPs). These findings
suggest that 5-Loxin® may be a potential therapeutic agent for the treatment of
OA" - See 5-Loxin at Amazon.com.
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Efficacy and Safety of
Aflapin®, a Novel Boswellia Serrata Extract, in the Treatment of Osteoarthritis
of the Knee: A Short-Term 30-Day Randomized, Double-Blind, Placebo-Controlled
Clinical Study - J Am Nutr Assoc 2022 Feb 15 - "Aflapin®, also known as AprèsFlex® was developed as an enhanced bioavailable extract of Boswellia
serrata gum resin, standardized to 20% 3-O-acetyl-11-keto-β-boswellic acid ...
Sixty-seven subjects completed the study. Aflapin conferred significant
improvements in pain scores as early as five days of treatment. Post-trial, VAS,
LFI, WOMAC pain, WOMAC stiffness, WOMAC function, and total WOMAC scores
decreased in the Aflapin group by 45%, 40.9%, 44.4%, 66.3%, 44.4%, and 48%,
respectively. Aflapin supplementation also reduced circulating MMP-3, TNFα,
hsCRP, and C2C" - See Aflapin® at Amazon.com.
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Benefits of a Food
Supplement Containing Boswellia serrata and Bromelain for Improving the Quality
of Life in Patients with Osteoarthritis: A Pilot Study - J Altern Complement
Med. 2019 Nov 1 - "From this pilot study, it emerges
that the use of the gastroresistant formulation containing the combination of
Boswellia and bromelain supplements can represent a valuable nonpharmacological
tool for improving the QoL of patients suffering from different forms of OA"
- See Boswellia at Amazon.com and
bromelain at Amazon.com.
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Boswellia
serrata has Beneficial Anti-Inflammatory and Antioxidant Properties in a Model
of Experimental Colitis - Phytother Res. 2014 Mar 12 -
"Boswellia serrata plant ... The B. serrata extract has
protective anti-inflammatory and antioxidant effects that inhibit inflammatory
mediators in acute experimental colitis"
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Boswellic
acid inhibits growth and metastasis of human colorectal cancer in orthotopic
mouse model by downregulating inflammatory, proliferative, invasive, and
angiogenic biomarkers - Int J Cancer. 2011 Jun 23 -
"We found that the oral administration of AKBA (50-200 mg/kg) dose-dependently
inhibited the growth of CRC tumors in mice, resulting in decrease in tumor
volumes than those seen in vehicle-treated mice without significant decreases in
body weight. In addition, we observed that AKBA was highly effective in
suppressing ascites and distant metastasis to the liver, lungs, and spleen in
orthotopically-implanted tumors in nude mice. When examined for the mechanism,
we found that markers of tumor proliferation index Ki-67 and the microvessel
density CD31; were significantly downregulated by AKBA treatment. We also found
that AKBA significantly suppressed NF-κB activation in the tumor tissue and
expression of pro-inflammatory (COX2), tumor survival (bcl-2, bcl-xL, IAP-1,
survivin), proliferative (cyclin D1), invasive (ICAM-1, MMP-9) and angiogenic
(CXCR4 and VEGF) biomarkers. When examined for serum and tissue levels of AKBA,
a dose-dependent increase in the levels of the drug was detected, indicating its
bioavailability. Thus, our findings suggest that this boswellic acid analogue
can inhibit the growth and metastasis of human CRC in vivo through
downregulation of cancer-associated biomarkers"
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Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells
through the downregulation of CXCR4 chemokine receptor expression - Int J
Cancer. 2011 Feb 3 - "Ninety percent of cancer-mediated
deaths are due to metastasis of the tumor; however, the mechanisms controlling
metastasis remain poorly understood. Thus, no therapy targeting this process has
yet been approved. Chemokines and their receptors are mediators of chronic
inflammation and have been linked to the metastasis of numerous cancers. More
recently, the Cysteine X Cysteine (CXC) chemokine receptor 4 (CXCR4) has emerged
as a key mediator of tumor metastasis; therefore, identification of inhibitors
of this receptor has the potential to abrogate metastasis. In this report, we
demonstrate that acetyl-11-keto-β-boswellic acid (AKBA), a component of the
therapeutic plant Boswellia serrata, can downregulate CXCR4 expression in
pancreatic cancer cells. The reduction in CXCR4 induced by this terpenoid was
found to be cell-type specific, as its expression was also abrogated in
leukemia, myeloma and breast cancer cell lines. Neither proteasome inhibitors
nor lysosomal stabilization could prevent the AKBA-induced reduction in CXCR4
expression. This downregulation occurred at the transcriptional level.
Suppression of CXCR4 by AKBA was accompanied by the inhibition of pancreatic
cancer cell invasion, which is induced by CXCL12, the ligand for CXCR4. In
addition, abrogation of the expression of chemokine receptor by AKBA was found
in human pancreatic tissues from orthotopic animal model. AKBA also abolished
breast tumor cell invasion, and this effect correlated with the disappearance of
both the CXCR4 messenger RNA and CXCR4 protein. Overall, our results show that
AKBA is a novel inhibitor of CXCR4 expression and, thus, has the potential to
suppress the invasion and metastasis of cancer cells"
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Inhibition of microsomal prostaglandin E(2) synthase-1 as a molecular basis
for the anti-inflammatory actions of boswellic acids from frankincense -
Br J Pharmacol. 2010 Sep 14 - "BAs reversibly
suppressed the transformation of prostaglandin (PG)H(2) to PGE(2) mediated
by mPGES1 (IC(50) = 3-10 µM). Also in intact A549 cells, BAs selectively
inhibited PGE(2) generation and, in human whole blood, β-BA reduced
lipopolysaccharide-induced PGE(2) biosynthesis without affecting formation
of the COX-derived metabolites 6-keto PGF(1α) and thromboxane B(2) .
Intraperitoneal or oral administration of β-BA (1 mg kg(-1) ) suppressed rat
pleurisy, accompanied by impaired levels of PGE(2) ,.and β-BA (1 mg kg(-1) ,
given i.p.) also reduced mouse paw oedema, both induced by carrageenan.
Conclusions and implications: Suppression of PGE(2) formation by BAs via
interference with mPGES1 contributed to the anti-inflammatory effectiveness
of BAs and of frankincense, and may constitute a biochemical basis for their
anti-inflammatory properties"
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