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Home > Anti-aging Research > beta-hydroxybutyrate

Beta-hydroxybutyrate

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  • β-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer's disease pathology - J Neuroinflammation 2020 Sep 21 - "we find BHB levels are lower in red blood cells and brain parenchyma of AD patients when compared with non-AD controls. Furthermore, exogenous BHB administration reduced plaque formation, microgliosis, apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc) speck formation, and caspase-1 activation in the 5XFAD mouse model of AD. Taken together, our findings demonstrate that BHB reduces AD pathology by inhibiting NLRP3 inflammasome activation. Additionally, our data suggest dietary or pharmacological approaches to increase BHB levels as promising therapeutic strategies for AD" - See beta-Hydroxybutyrate at Amazon.com and iHerb.