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Addison's (adrenal insufficiency)

Alternative News:

• Grapefruit juice and liquorice increase cortisol availability in patients with Addison's disease - Eur J Endocrinol. 2011 Sep 6 - "Compared to the ordinary treatment, the median AUC for serum cortisol increased with liquorice (53783 vs. 50882, p<0.05) and GFJ (60661 vs. 50882, p<0.05). Cortisol levels in serum were also elevated 2.6h after tablet ingestion (liquorice 223 vs. 186 nmol/L, p<0.05; GFJ 337 vs. 186 nmol/L, p<0.01). Liquorice increased the median urinary cortisol/cortisone-ratio (0.43 vs 0.21, p<0.00001), whereas GFJ increased the (aTHF+THF)/THE-ratio (0.55 vs 0.43, p<0.05)" - Note:  From my readings, most have too much cortisol already.  I've read where licorice increases it.  Licorice and grapefruit juice sounds like an unlikely combination but people might want to be aware of it.
• How to Handle a Hormonal Disease? - Dr. Weil, 3/23/04

News & Research:

• Adrenal Function After Adrenalectomy for Subclinical Hypercortisolism and Cushing's Syndrome: A Systematic Review of the Literature - J Clin Endocrinol Metab. 2014 May 30:jc20141401 - "subclinical hypercortisolism (SH) ... Adrenal insufficiency occurs in about half of the patients with SH if defined only by the pathological dexamethasone test. However, prevalence of adrenal insufficiency and time to recovery are tightly related to the degree of hypercortisolism and diagnostic criteria to define SH, which might help to better define SH for future studies"
• Evaluation of Serum Test to Screen for Secondary Adrenal Insufficiency - Doctor's Guide, 5/27/05
• FDA Grants Orphan Drug Designation For Fidelin (DHEA), Treatment For Adrenal Insufficiency - Doctor's Guide, 8/29/03
• Inhaled Fluticasone Linked to Acute Adrenal Insufficiency - Doctor's Guide, 11/6/01