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Home > Anti-aging Research > Antidepressants & Psychotropics > Naltrexone


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  • Low-Dose Naltrexone: An Inexpensive Medicine for Many Ills? - Medscape, 3/11/20 - "Raknes and Småbrekke examined data from the Norwegian Prescription Database and found that the number of naltrexone users increased from 14 in 2012 to more than 11,000 in 2013 ... Further analysis showed that 71% of the country's GPs had prescribed LDN, at a median daily dose of 3.7 mg, to 15,297 individuals (0.3% of the entire population), during 2013–2014 ... Among individuals with rheumatoid and seropositive arthritis who filled four or more LDN prescriptions, there was a significant 13% reduction in the total number of doses dispensed of all examined medicines and a significant 13% relative reduction in the number of users of disease-modifying antirheumatic drugs (DMARDs) ... In the psychiatry/neurology category, significant reductions were seen in use of antipsychotics between the highest and lowest LDN use (P = .007), and in the number of users of antiepileptics (P < .001), antipsychotics (P < .001), and antidepressants (P = .001)." - See naltrexone at ReliableRx.
  • Naltrexone Alters Responses to Social and Physical Warmth: Implications for Social Bonding - Medscape, 8/14/19 - "Socially warm experiences, when one feels connected to others, have been linked with physical warmth. Opioids, hypothesized to support social bonding with close others and, separately, physical warmth, may underlie both experiences. In order to test this hypothesis, 80 participants were randomly assigned to the opioid antagonist, naltrexone or placebo before neural and emotional responses to social and physical warmth were collected. Social and physical warmth led to similar increases in ventral striatum (VS) and middle-insula (MI) activity. Further, feelings of social connection were positively related to neural activity to social warmth. However, naltrexone (vs placebo) disrupted these effects by (i) reducing VS and MI activity to social and physical warmth, (ii) erasing the subjective experience–brain association to social warmth and (iii) disrupting the neural overlap between social and physical warmth"
  • Use of naltrexone reduces inflammation in Crohn's patients, study suggests - Science Daily, 5/19/11
  • Once-a-month Naltrexone Successfully Used To Treat Alcohol Dependence - Science Daily, 5/17/05
  • Naltrexone Reduces Cravings in Smokers Trying to Quit - Doctor's Guide, 9/24/03