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Anti-aging Research > Gardasil
Gardasil® and Cervarix®
News & Research:
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Gardasil-9 Approved for
Prevention of Head and Neck Cancers - Medscape, 6/15/20 -
"The US Food and Drug Administration (FDA) has expanded
the indication for the Gardasil-9 (Merck) vaccine to include prevention of
oropharyngeal and other head and neck cancers caused by HPV types 16, 18, 31,
33, 45, 52, and 58" - Get it. Don't be like me with a nine-inch vertical
scare from the back of your ear to your collar bone and then from the middle of
that to your Adam's apple.
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'Compelling Evidence'
Shows HPV Vaccine Is Working - Medscape, 6/26/19 -
"It found that, at 5-8 years of vaccination, the prevalence of HPV 16 and 18 had
significantly decreased by 83% (relative risk [RR], 0.17) among girls aged 13-19
years, and by 66% (RR, 0.34) in the older cohort, aged 20-24 years ... The
prevalence of HPV 31, 33, and 45 also decreased significantly, by 54% (RR, 0.46)
among girls aged 13-19 years, showing evidence of vaccine cross-protection ...
Additionally, diagnoses of anogenital wart also decreased significantly in both
females and males, demonstrating evidence of herd effects from girls-only
vaccination programs. Among girls aged 15-19 years, it declined by 67% (RR,
0.33), by 54% (RR, 0.46) in women aged 20-24 years, and by 31% (RR, 0.69) among
women aged 25-29 years ... Among boys aged 15-19 years, the prevalence of
anogenital wart diagnoses decreased significantly, by 48% (RR, 0.52), and among
men aged 20-24 years by 32% (RR, 0.68)"
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HPV vaccine eliminates advanced skin cancer in 97-year-old - Medical
Express, 7/24/18 - "We were surprised that all of the
patient's tumors regressed," Nichols told HealthDay, "even those that were not
directly injected with the HPV vaccine. This has never been reported until now."
Many questions remain, of course. More testing is planned to reconfirm the
vaccine's effectiveness against squamous cell carcinomas, Nichols said. It's
unclear if it will prove similarly effective against other forms of skin cancer.
But Nichols believes that the HPV vaccine "could be considered for carefully
selected patients who have limited conventional treatment options."
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It is
projected that by 2020, HPV-related oropharyngeal cancer will become the most
common HPV-related cancer in the US, surpassing cervical cancer - Science
Daily, 4/13/15 - "HPV vaccination could save from $8
million to $28 million Canadian dollars over the boys' lifetimes. Factors that
could impact the cost savings of HPV vaccination in boys include, among others,
vaccine cost, vaccine effectiveness, costs of cancer treatment, and survival of
patients with HPV-related oropharyngeal cancers ... It is projected that by
2020, HPV-related oropharyngeal cancer will become the most common HPV-related
cancer in the US, surpassing cervical cancer"
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Partial HPV Vaccine Series May Help Prevent Genital Warts in Girls - WebMD,
2/11/14 - "the difference between three and two doses
was that with two doses there would be 59 more cases of genital warts per
100,000 women who were observed for one year"
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Cervical Cancer Vaccine May
Also Guard Against Oral Cancer - Medscape, 7/23/13 -
"The analysis is unique because it is the first demonstration of the efficacy of
the bivalent vaccine (Cervarix) to prevent HPV 16 and 18 infections in the oral
cavity ... These viruses are associated with an important and growing fraction
of cancer of the oropharynx and tonsils ... The vaccine was found to be
effective against oral HPV 16/18 infection in 93.3% of the women (95% confidence
interval, 63% - 100%). There were 15 prevalent HPV 16/18 infections in the
control group and only 1 in the HPV vaccine group"
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Vaccinating boys plays key role in HPV prevention - Science Daily, 7/22/13 -
"HPV has been linked to anal, penile and certain
types of throat cancers in men. Since the virus is also responsible for various
cancers in women, vaccinating boys aged 11 to 21 will play a crucial role in
reducing cancer rates across the sexes ... HPV is the single most common
sexually transmitted infection"
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HPV Vaccines Working Despite Limited Use - ABC News, 6/19/13 -
"The HPV infection rate among girls between the ages
of 14 and 19 dropped by 56 percent with the arrival of the vaccines Cervarix
and Gardasil ... The CDC urges boys to get vaccinated against HPV ... While
a single dose of the HPV vaccines was found to cut the risk of HPV infection
by 82 percent, clinical trials suggest the protection rises to 96 percent
with all three doses"
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CDC Panel: All Young Boys Should Get HPV Vaccine - ABC News, 10/25/11 -
"All males starting at age 11 should receive the HPV
vaccine Gardasil to protect themselves against sexually transmitted forms of
human papillomavirus, the cause of most cervical and anal cancers as well as
most mouth and throat cancers, a Centers for Disease Control and Prevention
advisory committee voted today" - Think water boarding which is used
to torture and get information. That's what it's like the first few weeks
after throat surgery. I've had both. Anyone want their kids going through
that?
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Cancer
spike in men tied to HPV from oral sex - MSNBC, 10/3/11 -
"Within the next decade, the study authors argue,
the incidence of such cancers — which are almost always contracted as a
result of oral sex — will surpass that of cervical cancer, and the majority
of those cases are going to be in men ... in many cases, health experts
believe that economics and health are aligned on this issue and that boys
and young men ought to be receiving the HPV vaccine right now"
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Fewer than three doses of cervical cancer vaccine effective, study suggests
- Science Daily, 9/9/11
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Explosive Rise in HPV Throat Cancer; Panel Mulls Vaccinating Boys -
WebMD, 6/23/11 - "oropharyngeal (OP) cancer ... If
current trends continue, OP cancer in men will pass cervical cancer in 2025
... And HPV is to blame. Only a few decades ago, the major risk factors for
throat cancer were smoking and alcohol. Not any more. In the five-year
period of 1984-1989, only 16% of OP cancers were linked to HPV. By
2000-2004, HPV was behind 75% of OP cancers ... What are the risk factors?
Not all are known, but HPV-related throat cancer risk goes up with increased
oral sex and kissing ... Husbands of women with cervical cancer have a
threefold higher risk of tonsil cancer. And people who have anal cancer have
a fourfold to sixfold higher risk of tonsil cancer ... These findings are
tipping the ACIP in favor of recommending routine HPV vaccination for boys"
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HPV
vaccine works for boys: Study shows first clear benefits - Science
Daily, 2/4/11 - "The vaccine for human
papillomavirus (HPV) can prevent 90 percent of genital warts in men when
offered before exposure to the four HPV strains covered by the vaccine ...
In addition to preventing warts, the vaccine also effectively prevented
HPV-persistent infection in 86 percent of the participants without previous
exposure ... while they find it likely that the prevention of HPV infection
and disease in men will have additional benefits, such as preventing anal,
genital and throat cancers, these benefits need to be directly demonstrated
through further clinical trials"
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HPV Vaccine: Not Just for Women? - US News and World Report, 11/10/10 -
"the federal Advisory Committee on Immunization
Practices is deliberating whether to issue a public recommendation that boys
and men be vaccinated with Gardasil, the only HPV vaccine approved for that
group, just as it's recommended for women" - Note: The author talks
about several cancers but leaves out head and neck which I believe is the
main reason for boys to get vaccinate with Gardasil. I was given a 25%
chance of survival six years ago from cancer of the tonsil that spread to
the lymph nodes. They believe it was caused by HPV. Somehow I made it
through that with just a 6 inch scar on my neck that's hardly noticeable but
I went through a lot of agony with that operation, lost about 15 pounds from
not being able to eat for a long time after the operation plus about 15
months with the doctors convinced it would return because I refused
radiation and chemo. I still need to be very careful with eating meat
because the muscle tissue they took from my tonsil area makes it difficult
to swallow. I mostly eat turkey meat balls for the protein portion of
meals. That may have been prevented by Gardasil.
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HPV
vaccine protects from cancer recurrence - Science Daily, 3/16/10 -
"The study shows that Gardasil reduces by
approximately 40 percent the chances that more cancer or pre-cancerous
changes will occur in the cervix, vagina and vulva up to 3.8 years after a
female has surgery for one of those conditions"
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Study Does Not Support
HPV Vaccine in Older Women - Medscape, 2/17/10
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CDC: Partial OK of Gardasil for Boys - WebMD, 10/21/09
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2 ALS Cases May Be Linked to Gardasil Vaccine - WebMD, 10/16/09
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FDA Panel OKs HPV Vaccine Gardasil for Boys - WebMD, 9/9/09 -
"An FDA advisory committee voted to recommend
approval of the vaccine Gardasil for males ages 9 to 26 to prevent genital
warts" - Note: If I were younger I would use that as an excuse to
use it off label as a precaution
against head and neck cancer.
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HPV Vaccine Gardasil for Boys? - WebMD, 9/8/09
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HPV Vaccine Likely to Prevent Many Cases of Penile Carcinoma - Medscape,
8/25/09 - "Nearly half of cancers of the penis are
associated with infection by high-risk human papillomavirus (HPV-16 and
HPV-18) ... Dr. de Sanjose and associates point out that HPV prophylactic
vaccine in men appears to be safe and immunogenic"
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Should Young Men Be Vaccinated With Gardasil®? - Medscape, 8/24/09 -
"Gardasil® safety and immunogenicity trials included 9-
to 15-year-old boys and demonstrated a robust immunologic response in this
population. If efficacy in males is demonstrated in clinical trials, it is
likely that vaccination may be recommended for prevention of anogenital
warts (and, indirectly, infection and anogenital neoplasia and warts in
partners); a subset of anal, penile, oral, and
head and neck cancers; and juvenile respiratory papillomatosis in their
children"
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HPV Infections Linked to Penile Cancer - WebMD, 8/24/09 -
"HPV-16 is
the leading HPV type liked to penile cancer; HPV-18 is the second most
common type ... The study's authors say about 7,000 cases of penile cancer
could be prevented each year if such infections could be wiped out. A
vaccine called Gardasil is available in the U.S. to protect girls and women
against certain HPV infections. It is not approved for men"
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