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Recent Longevity News for the week ending 3/22/23

Sometimes Hair Loss in Women Can Point to Bigger Health Issues - WebMD. 3/17/23 - "Research shows that women who experience hair loss can also have other medical conditions like diabetes, acne and breast cancer ... By recognizing the signs of hair loss and seeing your dermatologist as soon as possible, you may be able to limit the progression, hold on to the hair you have, and discover any other underlying medical conditions you may have"

High Caffeine Levels May Lower Body Fat, Type 2 Diabetes Risks - Medscape, 3/14/23 - "This publication supports existing studies suggesting a link between caffeine consumption and increased fat burn ... The big leap of faith that the authors have made is to assume that the weight loss brought about by increased caffeine consumption is sufficient to reduce the risk of developing type 2 diabetes"

Endurance Exercise Tied to More Coronary Atherosclerosis - Medscape, 3/10/23 - "We consistently see higher plaque burden in lifelong endurance athletes. This is regardless of the plaque type, whether it is calcified, mixed, noncalcified, in the proximal segment or causing more than 50% stenosis ... the worst thing you can do is nothing at all. As soon as you do a little bit of exercise ― just brisk walking or jogging up to 3 hours a week ― it seems that's where you get the most benefit. And after that, we tend to see an increase in coronary plaque burden"

Abstracts from this week:

C-reactive protein partially mediates the inverse association between coffee consumption and risk of type 2 diabetes: The UK Biobank and the Rotterdam study cohorts - Clin Nutr 2023 Mar 7 - "Lower subclinical inflammation may partially mediate the beneficial association between coffee consumption and lower T2D risk. Consumers of ground coffee and non-smokers may benefit the most"

Association between antidiabetic drugs and the incidence of atrial fibrillation in patients with type 2 diabetes: a nationwide cohort study in South Korea - Diabetes Res Clin Pract 2023 Mar 16 - "The combination therapy of MET and TZD is the most effective antidiabetic drug for preventing AF in patients with type 2 diabetes." - See metformin at ReliableRX.

The effect of statins on bone turnover biomarkers: a systematic review and meta-analysis of randomized controlled trials - Endocr J 2023 Mar 15 - "The results showed that statins increased the osteocalcin (OC) ... Statins increase bone formation biomarker OC and decrease bone resorption biomarker NTX and CTX levels"

• Osteocalcin—A Versatile Bone-Derived Hormone - Front Endocrinol (Lausanne). 2018; 9: 794 - "osteocalcin is secreted solely by osteoblasts but only has minor effects on bone mineralization and density. Instead, it has been reported to control several physiological processes in an endocrine manner, such as glucose homeostasis and exercise capacity, brain development, cognition, and male fertility"

Effects of Highly Bioavailable Curcumin Supplementation on Common Cold Symptoms and Immune and Inflammatory Functions in Healthy Japanese Subjects: A Randomized Controlled Study - J Diet Suppl 2023 Mar 16 - "This study aimed to investigate the effects of 12-week consumption of highly bioavailable curcumin (150 mg/day of Theracurmin Super [TS-P1] or Theracurmin [CR-033P]) on common cold symptoms, immune function, and inflammatory markers ... The cumulative number of days for which common cold symptoms persisted was significantly lower in the TS-P1 and CR-033P groups than that in the placebo group. No adverse effects were observed. Consumption of highly bioavailable curcumin, TS-P1 or CR-033P (150 mg/day), for 12 weeks reduced the number of days for which common cold symptoms persisted in healthy Japanese adults" - See curcumin at Amazon.com.

Effect of Ginkgo biloba extract on pharmacology and pharmacokinetics of atorvastatin in rats with hyperlipidaemia - Food Funct 2023 Mar 14 - "The results showed that statins combined with GBE could significantly improve the blood lipid parameters, reduce the liver fat content, and reduce the size of adipocytes in abdominal fat. The effect was superior to statin therapy alone. In addition, the combination has shown additional liver protection against possible pathological liver injury or statin-induced liver injury. A lipidomic study showed that GBE could regulate the abnormal lipid metabolism of the liver in hyperlipemia. When statins are combined with GBE, this callback effect introduced by GBE on endogenous metabolism has important implications for resistance to disease progression and statin resistance. Finally, in the presence of GBE, there was a significant increase in plasma statin exposure. These results all confirmed that GBE has incremental benefits as a dietary supplement of statin therapy for dyslipidaemia" - See Ginkgo biloba at Amazon.com.

Caffeine can alleviate non-alcoholic fatty liver disease by augmenting LDLR expression via targeting EGFR - Food Funct 2023 Mar 14 - "Increasing low-density lipoprotein receptor (LDLR) protein levels represents a key strategy for the prevention and treatment. Berberine can reportedly alleviate non-alcoholic fatty liver disease (NAFLD) by increasing the LDLR expression in an ERK1/2 signaling-dependent manner of NAFLD. Studies have shown that caffeine can inhibit fat deposition in the livers of mice; however, caffeine has not been reported to alleviate NAFLD by augmenting the LDLR expression via targeting EGFR ... we found that caffeine could also activate EGFR-ERK1/2 signaling and promote the LDLR expression in ApoE KO mice. In summary, caffeine can enhance the LDLR expression by directly binding to EGFR and activating the EGFR-ERK1/2 signaling pathway. EGFR signaling may represent a novel target for the prevention and treatment of NAFLD." - See berberine at Amazon.com.

Health Focus (Oxytocin):