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Recent Longevity News for the week ending 9/28/22

Elijah McClain died from ketamine injection, amended autopsy report says - Hill, 9/23/22 - "Elijah McClain, a 23-year-old Black man who died in police custody in 2019, died from a ketamine injection that was too large for his size, according to an amended autopsy report released on Friday" - Note: I threw this in because many are jumping on the ketamine bandwagon for depression and many don't realize the risks.

Yes, AirPods can double as hearing aids. Here’s how - Washington Post, 9/23/22 - "Ear buds can provide some amplification, but they're going to be limited in terms of how much amplification they provide and how customized they can get ... So-called hearables, or ear buds with hearing enhancement, can work great for people with mild hearing loss or trouble in noisy environments ... Apple, Beats, Bose and Panasonic are the brands her patients have had the best luck with for wireless ear buds with amplification or noise cancellation"

Eat More Dairy, Less Red Meat to Prevent Type 2 Diabetes - Medscape, 9/20/22 - "Significant increases in the risk of developing type 2 diabetes were found for consumption of 100 g/day of total meat (RR, 1.20; 20% increase) and red meat (1.22, 22% increase) and with 50 g/day of processed meats (1.30, 30% increase). A borderline increased risk was also seen for 50 g/day of white meat (1.04, 4% increase) ... The opposite was found for dairy foods. Inverse associations for type 2 diabetes development were found for an intake of 200 g/day of total dairy (0.95, 5% reduction), low-fat dairy (0.96, 4% reduction), milk (0.90, 10% reduction), and for 100 g/day of yogurt (0.94, 6% reduction) ... Neutral (nonsignificant) effects were found for 200 g/day of full-fat dairy (0.98) and for 30 g/day of cheese (0.97). Fish consumption also had a neutral association with type 2 diabetes risk (1.04 for 100 g/day) as did one egg per day (1.07), but evidence quality was low ... processed meats also contain nitrates, nitrites, and sodium that can contribute to pancreatic cell damage and vascular dysfunction, thus affecting insulin sensitivity"

Wholegrains May Improve Survival in People With Type 2 Diabetes - Medscape, 9/20/22 - "Decreased mortality from any cause was found for a higher intake of fish (SRR per serving/week: 0.95, over six studies); whole grain (SRR per 20 g/day: 0.84; two studies); fiber (SRR per 5 g/day: 0.86; three studies), and omega-3 polyunsaturated fatty acids (SRR per 0.1 g/day: 0.87; two studies) ... A low certainty of evidence was found for an inverse association between all-cause mortality and vegetable consumption (SRR per 100 g/day: 0.88; two studies) and plant protein intake (SRR per 10 g/day: 0.91; three studies) ... Eggs were associated with an increased risk of all-cause mortality (SRR per 10 g/day: 1.05; seven studies), as was dietary cholesterol (SRR per 300 mg/day: 1.19; two studies)"

Abstracts from this week:

Association of omega-3 and omega-6 fatty acid intake with leukocyte telomere length in US males - Am J Clin Nutr 2022 Sep 20 - "Omega-3 (n-3) and omega-6 (n-6) fatty acids may contribute to oxidative stress and inflammation, which are related to telomere shortening. Evidence supporting an association between intake of n-3 or n-6 fatty acids and leukocyte telomere length (LTL) in males has been limited ... We found that consumption of docosahexaenoic acid (DHA) was positively associated with LTL. In the multivariable-adjusted model, compared to individuals who had the lowest intake of DHA (i.e., first quartile group), the percentage differences [95% confidence intervals (CIs)] of LTL were -3.7 (-13.7, 7.5), 7.0 (-4.3, 19.7), and 8.2 (-3.5, 21.3) for individuals in the second, third, and fourth quartiles of consumption, respectively (P for trend = 0.0498). We did not find significant associations between total n-3 or total n-6 fatty acid intakes and LTL. Additionally, we found that males who consumed canned tuna had longer LTL than those who did not; in the multivariable-adjusted model, the percentage difference (95% CI) of LTL was 10.5 (1.3, 20.4) (P value = 0.02)" - See docosahexaenoic acid at Amazon.com.

Rutin prevents seizures in kainic acid-treated rats: evidence of glutamate levels, inflammation and neuronal loss modulation - Food Funct 2022 Sep 23 - "Rutin, a naturally derived flavonoid molecule with known neuroprotective properties, has been demonstrated to have anticonvulsive potential, but the mechanism of this effect is still unclear ... Taken together, the results indicate that the preventive treatment of rats with rutin attenuated KA-induced seizures and neuronal loss by decreasing glutamatergic hyperactivity and suppressing the IL-1R1/TLR4-related neuroinflammatory cascade" - See rutin at Amazon.com.

Dietary astaxanthin-rich extract ameliorates atherosclerosis/retinopathy and restructures gut microbiome in apolipoprotein E-deficient mice fed on a high-fat diet - Food Funct 2022 Sep 22 - "Atherosclerosis (AS) is the leading cause of ischemic disease. However, the anti-AS effects of astaxanthin and its potential mechanisms remain unclear. This study is aimed to investigate the function of astaxanthin-rich extract (ASTE) on AS and gut microbiota as well as the difference from atorvastatin (ATO) in apolipoprotein E-deficient (ApoE-/-) mice ... Our results suggested that ASTE could prevent AS in both macrovascular and/or microvascular as well as used as novel prebiotics by supporting the bile acid excretion and growth of Akkermansia" - See astaxanthin at Amazon.com.

Association between Serum Spermidine and TyG Index: Results from a Cross-Sectional Study - Nutrients 2022 Sep 17 - "After multivariable adjustment, including demographic characteristics, behavioral factors associated with heath, and a history of taking medicine, SPD was inversely associated with the TyG index (β = -0.036; SE: 0.009; p < 0.001). Furthermore, each increase of 1 lnSPD significantly decreased the risk of IR with an odds ratio (ORs) (95% confidence intervals (CIs)) of 0.89 (0.83-0.96). Relative to the first quintile, the multivariate-adjusted ORs (95% CIs) for the third and fourth quartile group were 0.80 (0.65, 0.99) and 0.71 (0.57, 0.88), respectively" - See spermidine at Amazon.com.

• Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease - NIH - "Triglyceride glucose (TyG) index is a novel marker, which has been demonstrated to have a high sensitivity and specificity in identifying metabolic syndrome (14). Previous studies have shown that TyG index is associated with carotid atherosclerosis, coronary artery calcification and high risk of CVD"

Leucine Supplementation in Middle-Aged Male Mice Improved Aging-Induced Vascular Remodeling and Dysfunction via Activating the Sirt1-Foxo1 Axis - Nutrients 2022 Sep 17 - "Vascular aging is associated with metabolic remodeling, and most studies focused on fatty acid and glucose metabolism. Based on our metabolomic data, leucine was significantly reduced in the aortas of aged mice. Whether leucine supplementation can reverse aging-induced vascular remodeling remains unknown ... Compared with the 21-month-old mice without leucine, leucine supplementation from 15 months significantly improved vascular relaxation, maintained the contractile phenotype of VSMCs, and repressed vascular inflammation and ROS levels. These benefits were not observed in the mice supplemented with leucine starting from 18 months, which was likely due to the reduction in leucine transporters Slc3a2 or Slc7a5 at 18 months. Furthermore, we found benefits from leucine via activating the Sirt1-induced Foxo1 deacetylation. Our findings indicated that leucine supplementation in middle-aged mice improved aging-induced vascular remodeling and dysfunction" - See leucine products at Amazon.com.

Natural polyphenols: a potential prevention and treatment strategy for metabolic syndrome - Food Funct 2022 Sep 22 - "Metabolic syndrome (MS) is the term for a combination of hypertension, dyslipidemia, insulin resistance, and central obesity as factors leading to cardiovascular and metabolic disease. Epidemiological investigation has shown that polyphenol intake is negatively correlated with the incidence of MS. Natural polyphenols are widely found in cocoa beans, tea, vegetables, fruits, and some Chinese herbal medicines; they are a class of plant compounds containing a variety of phenolic structural units, which are potent antioxidants and anti-inflammatory agents in plants. Polyphenols are composed of flavonoids (such as flavanols, anthocyanidins, anthocyanins, isoflavones, etc.) and non-flavonoids (such as phenolic acids, stilbenes, and lignans). Modern pharmacological studies have proved that polyphenols can reduce blood pressure, improve lipid metabolism, lower blood glucose, and reduce body weight, thereby preventing and improving MS" - See polyphenols at Amazon.com.

Association of Prostate-Specific Antigen Levels with Prostate Cancer Risk in a Multiethnic Population: Stability over Time and Comparison with Polygenic Risk Score - Cancer Epidemiol Biomarkers Prev 2022 Sep 20 - "We found PSA to be an informative marker of PCa risk at least a decade before diagnosis across multiethnic populations. This association was diminished with increasing time, greater for low grade tumors, and comparable to a PRS when measured 10+ years before diagnosis"

Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway - J Cachexia Sarcopenia Muscle 2022 Sep 20 - "GRd ameliorates aging- and cancer-induced muscle wasting. Our findings suggest that GRd may be a novel therapeutic agent or adjuvant for reversing muscle wasting" - See ginseng at Amazon.com.

One-year longitudinal association between changes in dietary choline or betaine intake association with cardiometabolic variables in the PREDIMED-Plus trial - Am J Clin Nutr 2022 Sep 16 - "The greatest one-year increase in dietary choline or betaine intake (Q4) was associated with improved serum glucose (-3.39 and -2.72 mg/dL for choline or betaine, respectively) and glycated hemoglobin levels (-0.10% for Q4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were: reduced body weight (-2.93 and -2.78 Kg, respectively), BMI (-1.05 and -0.99 Kg/m2, respectively), waist circumference (-3.37 and -3.26 cm, respectively), total cholesterol (-4.74 and -4.52 mg/dL, respectively) and LDL cholesterol (-4.30 and -4.16 mg/dL, respectively). Urine creatinine was reduced in Q4 of one-year increase in choline or betaine intake (-5.42 and -5.74 mg/dL, respectively)" - See citicholine at Amazon.com and betaine anhydrous (TMG) at Amazon.com.

An insight into the neuroprotective effects and molecular targets of pomegranate ( Punica granatum) against Alzheimer's disease - Nutr Neurosci 2022 Sep 20 - "In spite of the lack of studies on humans, there are compelling evidence indicating that pomegranate can reduce various risk factors involved in the causation of AD and thus can be used as a persistent nutraceutical to slow ageing and for providing neuroprotection for the treatment of AD" - See pomegranate extract at Amazon.com.

Protective effects of curcumin on ischemia/reperfusion injury - Phytother Res 2022 Sep 19 - "Ischemia/reperfusion (I/R) injury is a term used to describe phenomena connected to the dysfunction of various tissue damage due to reperfusion after ischemic injury. While I/R may result in systemic inflammatory response syndrome or multiple organ dysfunction syndrome, there is still a long way to improve therapeutic outcomes. A number of cellular metabolic and ultrastructural alterations occur by prolonged ischemia. Ischemia increases the expression of proinflammatory gene products and bioactive substances within the endothelium, such as cytokines, leukocytes, and adhesion molecules, even as suppressing the expression of other "protective" gene products and substances, such as thrombomodulin and constitutive nitric oxide synthase (e.g., prostacyclin, nitric oxide [NO]). Curcumin is the primary phenolic pigment derived from turmeric, the powdered rhizome of Curcuma longa. Numerous studies have shown that curcumin has strong antiinflammatory and antioxidant characteristics. It also prevents lipid peroxidation and scavenges free radicals like superoxide anion, singlet oxygen, NO, and hydroxyl" - See curcumin at Amazon.com.

Preventive Effects of l-Glutamine on High-Fat Diet-Induced Metabolic Disorders Linking with Regulation of Intestinal Barrier Integrity, Hepatic Lipid Metabolism, and Gut Microbiota in Rats - J Agric Food Chem 2022 Sep 19 - "The results demonstrated that Gln administration reduced body weight, improved serum lipids, and decreased glucose tolerance in HFD-fed rats. Meanwhile, Gln administration alleviated liver injury, reduced the hepatic inflammatory response by inhibiting NLRP3 inflammasome activation, and decreased hepatic lipid accumulation by promoting VLDL secretion and fatty acid β-oxidation, as well as reduced bile acid synthesis by activating hepatic and ileal FXR in HFD-fed rats. Moreover, Gln administration restored HFD-induced intestinal barrier dysfunction, promoted intestinal fat absorption, suppressed intestinal inflammation, and also reshaped the gut microbiota composition in HFD-fed rats by downregulating the abundance of potential pathogens Escherichia-Shigella and upregulating the abundance of beneficial bacteria such as Akkermansia. To conclude, the present results showed that Gln may be a potential option for preventing HFD-induced metabolic disorders via the gut-liver axis" - See l-glutamine at Amazon.com.

The role of protein intake in the relationship between egg consumption and body composition in young adults. A mediation analysis - Clin Nutr 2022 Sep 6 - "The association between egg consumption and body composition is mediated by protein intake. This finding is important from a public health perspective, suggesting that higher egg consumption (≥5 eggs/week) may lead to a healthier body composition, especially due to higher protein intake" - Note: I eat a couple scrambled eggs per day. Love my Hexclad frying pan. I spay it with avocado oil.

A huge Chevrolet pickup slammed into my Tesla while I was in the car wash. I couldn't figure out what happened until I got home and looked at the video. With the license number from the video, my insurance company was able to go after the perpetrator. I consider it a hit and run. The damage was $1756. If it weren't for the cameras on the Tesla, I would have been out of luck. I'm an environmental person. I hate SUVs and huge pickups as it is.

Health Focus (Olive Leaf):