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Recent Longevity News for the week ending 9/21/22

Doctors want alcohol warning labels to flag cancer risks - Washington Post, 9/19/22 - "But those labels haven’t been updated since the late 1980s. Now, researchers say they don’t adequately advertise alcohol consumption’s biggest potential health consequence: cancer, including breast cancer ... Though even moderate consumption carries risk, excessive alcohol use is more dangerous. Guidelines suggest alcohol intake should be limited to two drinks or less a day for men and one or less a day for women, but data suggests the majority of adult drinkers imbibe more."

Is Acetaminophen Really Safer Than NSAIDs in Heart Disease? - Medscape, 9/15/22 - "The analysis found a significant correlation between the use of acetaminophen and elevated systolic blood pressure ... acetaminophen (3-4 g/day) vs placebo ... They found that patients receiving acetaminophen had significantly higher systolic blood pressure compared with those receiving placebo (standard mean difference [SMD] = 0.35"

Mental Disorders Up in Youth With Prenatal Cannabis Exposure - Medscape, 9/14/22 - "Among children who had been exposed to cannabis both before and after their mothers knew of their pregnancy, the mean Total Problems score on the CBCL was 31.47 ± 23.41, which was significantly greater than the 23.78 ± 19.66 among those whose mothers consumed cannabis prior to knowing of their pregnancy only (P < .001), and the 16.70 ± 15.55 for those who were not exposed to cannabis at all (P < .001). Similar relationships were found in the various subscales of the CBCL ... On the PQ-BC, among the children exposed to cannabis both before and after their mothers knew they were pregnant, the mean score was 3.14 ± 3.32 for psychotic-like experiences, compared with 2.95 ± 2.97 (P = .26) among those exposed to the drug only before their mothers learned of the pregnancy and 2.01 ± 2.54 (P = .03) for those not exposed at all. Significant findings were primarily driven by exposure following maternal knowledge of pregnancy"

Vitamins or Cocoa: Which Preserves Cognition? - Medscape, 9/14/22 - "Findings from a phase 3 study show daily multivitamin use, but not cocoa, is linked to a significantly slower rate of age-related cognitive decline"

Abstracts from this week:

The effects of astaxanthin supplementation on expression of microRNAs involved in cardiovascular diseases: a systematic review of current evidence - Int J Food Sci Nutr 2022 Sep 17 - "MicroRNAs (miRNAs) have biological roles in controlling oxidative stress. Astaxanthin (AST) may regulate circulating miRNAs in cardiovascular diseases (CVDs) ... The findings indicate that AST regulated different pathways of miRNAs implicated in various conditions. Therefore AST as a new therapeutic strategy could be essential in preventing and controlling CVDs" - See astaxanthin at Amazon.com.

Nobiletin mitigates NAFLD via lipophagy and inflammation - Food Funct 2022 Sep 16 - "Nonalcoholic fatty liver disease (NAFLD), an increasingly serious health issue around the world, is characterized as a lipid metabolic disorder without any satisfactory treatment. Nobiletin (NOB), a citrus flavonoid, is considered a promising candidate for NAFLD prevention although there is limited research towards its exact mechanism ... Our research not only illustrated NOB as a potential candidate for NAFLD prevention, but also provided new insight into the pathogenic mechanisms of NAFLD development" - See nobiletin at Amazon.com.

Lactobacillus plantarum HNU082 alleviates dextran sulfate sodium-induced ulcerative colitis in mice through regulating gut microbiome - Food Funct 2022 Sep 16 - "Probiotics have shown good efficacy in the prevention of ulcerative colitis (UC), but the specific mechanism remains unclear ... In conclusion, improving gut microbiota dysbiosis, protecting the intestinal mucosal barrier, regulating inflammatory and disease pathways, and affecting neutrophil infiltration are the potential mechanisms of probiotic Lp082 in alleviating UC. Our study enriches the mechanism and provides a new prospect for Lactobacillus plantarum HNU082 in the prevention of colitis, provides support for the development of probiotic-based microbial products as an alternative prevention strategy for UC, and provides guidance for the future probiotic prevention of human colitis" - See probiotic supplements at Amazon.com.

The effect of probiotics on postsurgical complications in patients with colorectal cancer: a systematic review and meta-analysis - Nutr Rev 2022 Sep 15 - "Clinical trials have investigated the effect of probiotics on postsurgical complications in colorectal cancer (CRC). However, so far, there are no systematic reviews evaluating the effect of probiotics and synbiotics on the clinical or infectious postsurgical complications of colorectal cancer ... Probiotics and synbiotics seem to be a promising strategy for the prevention of postoperative complications after CRC surgery" - See probiotic supplements at Amazon.com.

Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort - Eur J Clin Nutr. 2022 Sep 13 - "After multivariate adjustment, higher dietary folate intake was inversely associated with CVDs with hazard ratios of 0.99, 0.92, and 0.88 in groups 2-4 compared with group 1 (the lowest group); inversely associated with stroke with hazard ratios of 0.94, 0.90, and 0.86 groups 2-4 compared to group 1 (lowest group); inversely associated with MI with hazard ratios of 1.01, 0.90 and 0.86 groups 2-4 compared to group 1 (lowest group); inversely associated with CVD mortality with hazard ratios of 0.95, 0.80 and 0.74 Groups 2-4 compared to group 1 (lowest group). Each tablespoon/day higher intake of raw vegetable intake, pieces/day higher intake of fresh fruit intake bowls/week higher intake of cereal intake, and g/day higher intake of dietary fiber were associated with higher intakes of folate every 0.02,0.06,0.05, and 0.08 SD, respectively" - See folic acid products at Amazon.com.

Association between Folic Acid Supplementation and Hypertensive Disorder Complicating Pregnancy in Jiangsu Province: A Cross-Sectional Study - Evid Based Complement Alternat Med 2022 Sep 6 - "hypertensive disorder complicating pregnancy (HDCP) ... Maternal women with and without FA supplement intake were compared in this study. FA supplementation included 0.4 mg FA (0.4 FA), multivitamins with 0.4 mg FA (multivitamin (MV)+0.4 FA), and multivitamins with 0.8 mg FA (MV + 0.8 FA) ... MV supplement with 0.8 mg FA during early pregnancy may be effective in reducing HDCP and preeclampsia risk" - See folic acid products at Amazon.com.

Association between serum 25-hydroxy vitamin D concentrations and mortality among individuals with metabolic dysfunction-associated fatty liver disease: a prospective cohort study - Am J Clin Nutr 2022 Sep 15 - "Compared with participants with serum 25(OH)D concentrations ≤30.0 nmol/L, the multivariable-adjusted HR and 95% CI of all-cause mortality were 0.62 (0.43, 0.89) for participants with MAFLD having serum 25(OH)D >75.0 nmol/L (P-trend = 0.001), and 0.63 (0.42, 0.95) for participants with NAFLD having serum 25(OH)D >75.0 nmol/L (P-trend = 0.002). A nonlinearly inverse association was observed between serum 25(OH)D concentrations and all-cause mortality among participants with MAFLD (Poverall <0.001; Pnonlinear = 0.003) or NAFLD (Poverall <0.001; Pnonlinear = 0.009), with a threshold effect at around 50.0 nmol/L. The inverse association was stronger among participants with MAFLD aged <60 years (P-interaction = 0.001) ... This study suggested a nonlinearly inverse association between serum 25(OH)D concentrations and all-cause mortality among patients with MAFLD/NAFLD, with a threshold effect at around 50.0 nmol/L of serum 25(OH)D" - See Vitamin D at Amazon.com.

Heart Failure with Preserved Ejection Fraction and Obstructive Sleep Apnea: A Novel Paradigm for Additional Cardiovascular Benefit of SGLT2 Inhibitors in Subjects With or Without Type 2 Diabetes - Adv Ther 2022 Sep 16 - "we emphasized the promising role of SGLT2is in prevention, rehabilitation, and treatment of patients with OSA regardless of coexisting type 2 diabetes (T2DM). Indeed, SGLT2is enhance lipolysis and fatty acid beta-oxidation. These phenomena might prevent OSA by reducing the size of visceral and subcutaneous adipose tissue and, as proven in humans and animals with T2DM, counteract NAFLD onset and progression. The aforementioned mechanisms may represent an additional SGLT2i cardioprotective effect in terms of HFpEF prevention in patients with OSA, whose NAFLD prevalence is estimated to be over 50%" - See empagliflozin inhousepharmacy.vu.

Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells - JCI Insight 2022 Sep 15 - "Acute kidney injury (AKI) represents a common complication in critically ill patients that is associated with increased morbidity and mortality. In a murine AKI model induced by ischemia-reperfusion-injury (IRI), we show that glutamine significantly decreases kidney damage and improves kidney function ... Glutamine administration attenuated kidney damage in vivo during AKI and TEC viability in vitro under inflammatory or hypoxic conditions" - See L-glutamine at Amazon.com.

The Effect of Saffron (Crocus sativus L.) Supplementation on Renal Function: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials - Int J Clin Pract 2022 Aug 29 - "BUN reduction was significant in the saffron group compared to placebo" - See saffron supplements at Amazon.com.

DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode-of-actions in a Pentylenetetrazole-Induced Kindling Model in Mice - Mol Nutr Food Res 2022 Sep 13 - "The administration of EPA and DHA at a dose of 1% (w/w) significantly inhibited PTZ-induced seizures and depressive-like behavior, whereas EPA outcompetes DHA" - See omega-3 supplements at Amazon.com.

Omega-3 fatty acids enhance the beneficial effect of BCAA supplementation on muscle function following eccentric contractions - J Int Soc Sports Nutr 2022 Sep 8 - "maximal voluntary contraction (MVC) using dumbbells ... The MVC torque was significantly higher in the BCAA+FO group than in the PL group immediately after ECCs (p < 0.05) but not in the BCAA group. Both BCAA and BCAA+FO groups showed greater ROM and lower muscle soreness than the PL group (p < 0.05). CK was significantly lower in the BCAA group than in the PL group at 5 days after ECCs (p < 0.05) ... This study reveals that supplementation with BCAA and FO may favorably impact immediate recovery of peak torque production. Alternatively, in comparison to PL group, BCAA supplementation favorably reduces creatine kinase" - See omega-3 supplements at Amazon.com and BCAA products at Amazon.com.

Urolithin A Attenuates Helicobacter pylori-Induced Damage In Vivo - J Agric Food Chem 2022 Sep 15 - "Urolithin A (UA) is a metabolite produced in the gut following the consumption of ellagic acid (EA) rich foods. EA has shown anti-inflammatory, antioxidant, and anticancer properties. Because EA is poorly absorbed in the gastrointestinal tract, urolithins are considered to play a major role in bioactivity. Helicobacter pylori (H. pylori) infection is the most common chronic bacterial infection all over the world. It is potentially hazardous to humans because of its relationship to various gastrointestinal diseases. In this study, we investigated the effect of UA on inflammation by H. pylori. The results indicated that UA attenuated H. pylori-induced inflammation in vitro and in vivo. UA also reduced the secretion of H. pylori virulence factors and tissue injuries in mice. Furthermore, UA decreased the relative abundance of Helicobacteraceae in feces of H. pylori-infected mice. In summary, taking UA effectively inhibited the injury caused by H. pylori" - See urolithin a supplement at Amazon.com.

Piperine attenuates the inflammation, oxidative stress, and pyroptosis to facilitate recovery from spinal cord injury via autophagy enhancement - Phytother Res 2022 Sep 17 - "Spinal cord injury (SCI) is a serious injury that can lead to irreversible motor dysfunction. Due to its complicated pathogenic mechanism, there are no effective drug treatments. Piperine, a natural active alkaloid extracted from black pepper, has been reported to influence neurogenesis and exert a neuroprotective effect in traumatic brain injury ... Piperine enhanced functional recovery after SCI. Additionally, piperine reduced inflammation, oxidative stress, pyroptosis, and activated autophagy. However, the effects of piperine on functional recovery after SCI were reversed by autophagy inhibition. The study demonstrated that piperine facilitated functional recovery after SCI by inhibiting inflammatory, oxidative stress, and pyroptosis, mediated by the activation of autophagy" - See piperine extract at Amazon.com.

Piperine Enhances the Antimalarial Activity of Curcumin in Plasmodium berghei ANKA-Infected Mice: A Novel Approach for Malaria Prophylaxis - Evid Based Complement Alternat Med 2022 Sep 5 - "The delayed onset of clinical symptoms and prolonged survival rate were also significant (p < 0.05) in the combination of curcumin and piperine treated group. In addition, the low parasitic load in the liver and mild histopathological changes in the liver suggest that the combination of curcumin and piperine had synergistic or additive effects. These findings demonstrate the promising use of these combined compounds as a malarial prophylactic" - See piperine extract at Amazon.com and curcumin at Amazon.com.

Leucine intake and risk of impaired physical function and frailty in older adults - J Gerontol A Biol Sci Med Sci 2022 Sep 15 - "Leucine is suggested to play a central role in age-related physical decline, but the effect of dietary leucine intake on physical functioning is uncertain. We examined the prospective association between dietary leucine intake and impaired lower-extremity function (ILEF) and frailty in older adults ... Higher leucine intake was associated with reduced risk of ILEF and frailty. Dietary leucine, obtained from foods rich in high-quality protein, could be a key nutrient to prevent age-related physical function decline in older adults" - See leucine products at Amazon.com.

The effects of rutin flavonoid supplement on glycemic status, lipid profile, atherogenic index of plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and oxidative stress factors in patients with type 2 diabetes mellitus: A double-blind, placebo-controlled trial - Phytother Res 2022 Sep 13 - "randomized and supplemented with 500 mg rutin or placebo per day for 3-months ... The results showed a significant decrease in FBG, insulin, HbA1c, HOMO-IR, LDL-c, TG, VLDL, CHOL, LDL-c.HDL-c ratio, AIP, IL-6, and MDA and a significant increase in HDL-c, QUICKI index, BDNF, and TAC compared with the initial value (p for all <.05). In the adjusted model, the mean changes of FBG, insulin, HbA1c, HOMO-IR, LDL-c, CHOL, LDL.HDL ratio, AIP, MDA, and IL-6 were significantly lower and mean changes of QUICKI index, HDL-c, and TAC were significantly higher in the rutin group compared with the placebo group (adjusted p for all <.05). It seems that rutin may have beneficial effects on improving metabolic parameters, BDNF, and inflammatory and oxidative stress factors in T2DM patients" - See rutin at Amazon.com.

Linkage between a plant-based diet and age-related eye diseases: a systematic review and meta-analysis - Nutr Rev 2022 Sep 14 - "Meta-analysis indicated regular consumption of fish (odds ratio [OR], 0.70; 95%CI, 0.62-0.79) and skim milk, poultry, and non-meat animal products (OR, 0.70; 95%CI, 0.61-0.79) reduced the risk of age-related eye disease development among adults. Consumption of red meat (OR, 1.41; 95%CI, 1.07-1.86) may increase the risk of age-related eye disease development"

Antioxidant-rich foods, antioxidant supplements, and sarcopenia in old-young adults ≥55 years old: A systematic review and meta-analysis of observational studies and randomized controlled trials - Clin Nutr 2022 Aug 17 - "antioxidant-rich foods (A-RF) ... A-RF or antioxidant supplementation could be effective tools for sarcopenia, especially improving muscle strength and function. The best interventions according to the meta-analysis of the RCTs were supplementation of vitamin E in combination with vitamin D and protein, magnesium, tea catechins, and increasing fruit and vegetable consumption"

Cognitive Improvement Following Physical Exercise and Cognitive Training Intervention for Older Adults with MCI - J Gerontol A Biol Sci Med Sci 2022 Sep 13 - "Both aquatic- and land-based exercise with CT interventions resulted significant in improvement in learning and memory outcomes, though improvement in executive functioning, processing speed, language, and visuospatial abilities was limited to water-based and CT treatment group"

Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort - Eur J Clin Nutr. 2022 Sep 13 - "After multivariate adjustment, higher dietary folate intake was inversely associated with CVDs with hazard ratios of 0.99, 0.92, and 0.88 in groups 2-4 compared with group 1 (the lowest group); inversely associated with stroke with hazard ratios of 0.94, 0.90, and 0.86 groups 2-4 compared to group 1 (lowest group); inversely associated with MI with hazard ratios of 1.01, 0.90 and 0.86 groups 2-4 compared to group 1 (lowest group); inversely associated with CVD mortality with hazard ratios of 0.95, 0.80 and 0.74 Groups 2-4 compared to group 1 (lowest group). Each tablespoon/day higher intake of raw vegetable intake, pieces/day higher intake of fresh fruit intake bowls/week higher intake of cereal intake, and g/day higher intake of dietary fiber were associated with higher intakes of folate every 0.02,0.06,0.05, and 0.08 SD, respectively"

Neat Tech Stuff / "How To's":

My wife's son had his car stolen. If he had an AirTag in it, he would have been able to tell where it was. I bought one for both of our cars. My Tesla app tells where my Tesla is but I think they could reprogram the Tesla computer as a new owner. I also got an AirTag along with the holder for one of our two cats who is moving out with my wife's daughter who got married. I'm worried that the cat will try to find it's old home. That cat was a stray that showed up on my security camera. I bought a HavaHart trap and caught her. At first, she wanted out and wasn't taking 'no' for an answer so I named her 'Karen'. She succeeded a couple times but I found her via the AirTag. Now she doesn't want to escape. She got locked out accidently a couple times so now she stays close to the door when she goes out.

Health Focus (Breast Cancer):