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Recent Longevity News for the week ending 8/17/22

Sexual Dysfunction, Hair Loss Linked With - Medscape, 8/12/22 - "Hair loss, reduced sex drive, and erectile dysfunction have joined a list of better-known symptoms linked to long COVID in patients who were not hospitalized" - Note: One more thing for the anti-vaxxers, who only think about themselves, to think about.

B Vitamins Show Promise Against Advanced Fatty Liver Disease - Medscape, 8/11/22 - "In the preclinical models, supplementing the diet with vitamin B12 and folic acid increases hepatic Stx17 levels, restores its role in autophagy, and slows NASH progression and reverses liver inflammation and fibrosis ... The potential for using vitamin B12 and folate, which have high safety profiles and are designated as dietary supplements by the US Food and Drug Administration, as first-line therapies for the prevention and treatment of NASH could result in tremendous cost savings and reduce the health burden from NASH in both developed and developing countries ... Currently, the only treatment for patients with end-stage liver disease is to receive a transplant" - See vitamin B12 and folic acid combinations at Amazon.com.

Can Folic Acid Halt or Reverse Progression of Gastric Precancerous Conditions? - Medscape, 8/10/22 - "Folic acid supplementation can improve histopathologic aspects of gastric precancerous conditions (GPC), including gastric mucosal atrophy and intestinal metaplasia ... A meta-analysis of five studies showed a statistically significant positive treatment effect of folic acid supplementation on gastric mucosal atrophy (relative risk [RR]: 1.61; 95% CI: 1.07 – 2.41) ... A meta-analysis of two trials showed a statistically significant effect of folic acid on reversal of intestinal metaplasia (RR: 1.77; 95% CI: 1.32 – 2.37) ... Our study indicates that folic acid has a beneficial effect in the treatment of pathological changes of GPC when the dose was maintained at 20–30 mg/d and the duration of treatment was maintained at 3–6 months" - See folic acid products at Amazon.com.

Heart Failure Medication: Moving From Evidence Generation to Implementation - Medscape, 8/11/22 - "Treating patients with heart failure (HF) and reduced ejection fraction (HFrEF) with renin–angiotensin–aldosterone system (RAAS) inhibitors, beta-blockers, and sodium–glucose co-transporter-2 (SGLT2) inhibitors at guideline-recommended dosages (GRD) improves quality of life and increases longevity ... mineralocorticoid receptor antagonists (MRAs) ... Sequences starting with an SGLT2 inhibitor, MRA, or both were associated with the most significant reduction in CV death, HF hospitalization, and all-cause death. Notably, up to half of the reduction in events was primarily attributed to shortening the time to reach target dose. This might partially explain why sequences starting with medications with fewer up-titration steps (i.e. SGLT2 inhibitors or MRAs) were associate"

• Mineralocorticoid Receptor Antagonists for Treatment of Hypertension and Heart Failure - Methodist Debakey Cardiovasc J. 2015 Oct-Dec; 11(4) - "Spironolactone and eplerenone are both mineralocorticoid-receptor antagonists. These compounds block both the epithelial and nonepithelial actions of aldosterone, with the latter assuming increasing clinical relevance"
• Renin Angiotensin Aldosterone System Inhibitors in Hypertension: Is There Evidence for Benefit Independent of Blood Pressure Reduction? - Prog Cardiovasc Dis 2016 Nov-Dec - "The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in the pathogenesis of hypertension (HTN). Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are first line anti-HTN drug classes that are potent, effective and largely safe"

Regular Fasting Linked to Less Severe COVID: Study - WebMD, 8/10/22 - "Intermittent fasting has already shown to lower inflammation and improve cardiovascular health ... But among those who tested positive for the virus, fewer patients were hospitalized for COVID or died during the study follow-up if they had fasted regularly (11%) than if they had not fasted regularly (29%) ... Fasting reduces inflammation, and after 12 to 14 hours of fasting, the body switches from using glucose in the blood to using ketones, including linoleic acid"

PFAS 'Forever Chemicals' Are Linked With Liver Cancer - WebMD, 8/10/22 - "The strongest link was between PFOS and liver cancer. People with PFOS levels in the top 10% were 4.5 times more likely to develop liver cancer than those with the lowest levels"

New Study Shows Which is Better? NMN Alone Or NMN With Resveratrol - Review By Modern Healthspan, YouTube - Claims that taking NMN with resveratrol or ginseng increases absorption.

How Testosterone is Transforming Aging – Epic Results - Dr Brad Stanfield, YouTube

I was telling my wife about a poem my grandfather Johnston used to tell. It goes like this:

“There is the story of Norma Ray,
Who died defending her right of way.
She was right, dead right as she road alone,
But she was just as dead as if she’d been wrong.”

It’s the same for the anti-vax people. If they contract covid and pass it to someone with underlying conditions such as Collin Powell, who then dies from it, it doesn’t matter whether that person died from the ignorance of an anti-vaxxer or a gun, the person is just as dead. That's why I get so mad at them.

Abstracts from this week:

Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption - Nutrients 2022 Jul 30 - "Our work indicates that A. muciniphila ameliorates the disruption of the intestinal mucosal barrier under high fructose and restraint stress. These results provided a rationale for the development of probiotic colonization for the prevention or treatment of intestinal diseases" - See Akkermansia muciniphila at Amazon.com.

Supplementation with NAD + and Its Precursors to Prevent Cognitive Decline across Disease Contexts - Nutrients 2022 Aug 7 - "The preservation of cognitive ability by increasing nicotinamide adenine dinucleotide (NAD+) levels through supplementation with NAD+ precursors has been identified as a promising treatment strategy for a number of conditions; principally, age-related cognitive decline (including Alzheimer's disease and vascular dementia), but also diabetes, stroke, and traumatic brain injury. Candidate factors have included NAD+ itself, its reduced form NADH, nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and niacin (or nicotinic acid). This review summarises the research findings for each source of cognitive impairment for which NAD+ precursor supplementation has been investigated as a therapy. The findings are mostly positive but have been made primarily in animal models, with some reports of null or adverse effect" - See NMN at Amazon.com.

Artemisia argyi exhibits anti-aging effects through decreasing the senescence in aging stem cells - Aging (Albany NY) 2022 Aug 9 - "Aging is accompanied by functional loss of many cellular pathways, creating an increased risk of many age-related complications (ARC). Aging causes stem cell exhaustion with a concomitant increase in cellular dysfunction. Recently, interest in senotherapeutics has been growing rapidly to promote healthy aging and as an intervention for ARCs. This research focused on screening the senomorphic properties of Artemisia argyi, as an emerging strategy for longevity, and prevention or treatment of ARCs. In this study, we aimed to find the clinical efficacy of daily consumption of Artemisia argyi water extract (AAW) on aging ... In vitro study showed the protective effect of AAW in telomere shortening and helps in maintaining a balance in the expression of anti-aging protein Klotho and TERT. AAW effectively reduced mitochondrial superoxide and also provided a protective shield against senescence markers like over-expression of p21 and formation of double strand breaks, which is known to cause premature aging. Moreover, animal studies indicated that AAW promoted the expression of Klotho in naturally aging rats. In addition, AAW successfully restored the decline cardiac function and improved the grip strength and memory of aging rat. These findings showed that therapeutic targeting of senescent stem cells by AAW restored stem cell homeostasis and improves overall health" - See Artemisia argyi at Amazon.com.

Ascorbic acid induces salivary gland function through TET2/acetylcholine receptor signaling in aging SAMP1/Klotho (-/-) mice - Aging (Albany NY) 2022 Aug 11 - "Aging affects salivary gland function and alters saliva production and excretion. This study aimed to investigate whether ascorbic acid can be used to treat salivary gland dysfunction in an extensive aging mouse model of SAMP1/Klotho-/- mice ... In SAMP1/Klotho -/- mice, daily supplementation with ascorbic acid (100 mg/kg for 18 days) significantly increased saliva secretion compared with the control ... These results suggest that ascorbic acid could overcome the lack caused by dysfunction of ascorbic acid biosynthesis and induce the recovery of salivary gland function" - See vitamin C products at Amazon.com.

Chlorogenic Acid Prevents Hyperuricemia Nephropathy via Regulating TMAO-Related Gut Microbes and Inhibiting the PI3K/AKT/mTOR Pathway - J Agric Food Chem 2022 Aug 11 - "Hyperuricemia is an independent hazard factor of renal injury and can induce renal fibrosis, promoting the development of chronic kidney disease (CKD). This study aimed to explore the probability of chlorogenic acid (CGA) as a potential substance for preventing hyperuricemia nephropathy (HN) ... CGA delayed kidney fibrosis in HN rats as evidenced by regulating the cascade response of the microbiota-TMAO-PI3K/AKT/mTOR signaling pathway. In summary, CGA can be an excellent candidate for HN prevention" - See chlorogenic acid at Amazon.com.

The association between dairy products consumption and prostate cancer risk: A systematic review and meta-analysis - Br J Nutr. 2022 Aug 10 - "We performed subgroup analyses stratified by dairy type, prostate cancer type, follow-up years, treatment era, collection times, adjustment for confounders, and geographic location. In the subgroup analysis stratified by prostate cancer type, the pooled RRs were 0.98 (95% CI: 0.94-1.03) in the advanced group, 1.10 (95% CI: 0.98-1.24) in the non-advanced group and 0.92 (95% CI: 0.84-1.00) in the fatal group. In dose-response analysis, a positive association for the risk of prostate cancer was observed for total dairy products 400 g/d (RR: 1.02; 95% CI: 1.00, 1.03), total milk 200 g/d (RR: 1.02; 95% CI: 1.01, 1.03), cheese 40 g/d (RR: 1.01; 95% CI: 1.00, 1.03), and butter 50 g/d (RR: 1.03; 95% CI: 1.01, 1.05). A decreased risk was observed for the intake of whole milk 100 g/d (RR: 0.97; 95% CI: 0.96, 0.99)"

The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial - J Diet Suppl 2022 Aug 10 - "Oral supplementation of hesperidin and diosmin was associated with improvement in metabolic syndrome and diabetic neuropathy and the combination of both was superior in efficacy" - See hesperidin and diosmin at Amazon.com.

Trehalose improves palmitic acid-induced apoptosis of osteoblasts by regulating SIRT3-medicated autophagy via the AMPK/mTOR/ULK1 pathway - FASEB J 2022 Sep - "Accumulation of lipid substances decreased the activity of osteoblasts. Trehalose is a typical stress metabolite to form a protective membrane on cell surface which has been demonstrated to regulate lipid metabolism. This activity of Trehalose indicates the potential effect of osteoporosis treatment ... Trehalose could inhibit the bone mass loss with HFD. Our study revealed the effect and mechanism of Trehalose in the treatment of osteoporosis" - See trehalose at Amazon.com.

Berberine inhibits glioma cell migration and invasion by suppressing TGF-β1/COL11A1 pathway - Biochem Biophys Res Commun 2022 Jul 31 - "Glioma is a clinically heterogeneous disease with a poor prognosis. Berberine (BBR), as a multi-target anti-tumor alkaloid, has the ability to penetrate the blood-brain barrier and shows cytotoxicity to glioma cells. In previous studies, we demonstrated that berberine inhibits glioma cell proliferation by inhibiting mutant p53 protein and promoting mitochondrial damage. In addition, berberine has been shown to reduce collagen accumulation in pulmonary fibrosis, diabetic nephropathy and arthritis. However, its effect on collagen in cancer needs to be further elucidated ... Collectively, berberine that targets COL11A1 to inhibit glioma migration and invasion, may serve as a promising candidate for the development of anti-glioma drugs in the future" - See berberine at Amazon.com.

Curcumol Inhibits the Development of Prostate Cancer by miR-125a/STAT3 Axis - Evid Based Complement Alternat Med 2022 Jul 30 - "This study aimed to learn the antineoplastic activity of curcumol (Cur) on prostate cancer (PCa) and elucidate its potential molecular mechanism ... Cur inhibited the development of PCa by miR-125a/STAT3 axis. This may provide a potential agent for treating PCa" - See curcumin at Amazon.com.

• Curcumol - NIH - "Curcumol is a natural product found in Curcuma aromatica, Curcuma wenyujin, and Cunninghamella blakesleeana with data available"

Effects of medium chain triglycerides on lipid metabolism in high-fat diet induced obese rats - Food Funct 2022 Aug 9 - "A high fat diet was fed to Sprague-Dawley rats to induce obesity, and then caprylic triglyceride (CYT), capric triglyceride (CT) and lauric triglyceride (LT) were synthesized and used to treat the obese rats for 12 weeks. The obesity phenotype and molecular changes related to lipid metabolism were determined. The results showed that all the three MCTs reduced the body weight (BW) and fat coefficient in obese rats, and the levels of plasma and liver lipids were also improved. Among the MCT groups, the LT group showed the lowest BW with the lowest food intake" - See medium-chain triglycerides at Amazon.com.

Neat Tech Stuff / "How To's":

That's me. You remove the pellets and kill the flies with only the CO2. At Amazon: https://amzn.to/3SzKIl0

This is what I have. I bought it about 10 years ago when there weren't as many options: https://amzn.to/3QBQ2Tm

Health Focus (Cruciferous Vegetables):