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Recent Longevity News for the week ending 8/3/22

Low Calcium, Potassium Key Risk Factors for Kidney Stones - Medscape, 8/1/22 - "A higher calcium diet is associated with a higher urinary pH, and citrate confers an alkali load which helps protect against the formation of calcium oxalate stones. Foods that are high in potassium also contain more fluid, citrate, and phytate, which, again, have been reported to be protective against kidney stones" - See potassium citrate at Amazon.com.

Do ICDs Still 'Work' in Primary Prevention Given Today's Recommended HF Meds? - Medscape, 7/29/22 - "The cohort study of almost 5000 patients with HFrEF and such devices saw their all-cause mortality risk improve stepwise with each additional prescription they were given toward the full quadruple drug combo at the core of modern HFrEF guideline-directed medical therapy (GDMT). The four classes are SGLT2 inhibitors, beta blockers, mineralocorticoid receptor antagonists (MRA), and renin-angiotensin system (RAS) inhibitors."

Combination therapy using tafamidis and neurohormonal blockers for cardiac amyloidosis and a reduced ejection fraction: a case report - J Int Med Res 2022 Jul - "We report a 77-year-old man who was diagnosed with wild-type cardiac amyloidosis and systolic dysfunction with a left ventricular ejection fraction of 27%. Following 6-month medical therapy of tafamidis 80 mg and neurohormonal blockers (carvedilol 5.0 mg, enalapril 2.5 mg, and spironolactone 25 mg), the left ventricular ejection fraction improved to 55%. Tafamidis-incorporated neurohormonal blocker therapy might be a promising strategy to facilitate cardiac reverse remodeling in patients with cardiac amyloidosis and systolic dysfunction"

Metformin Linked With Less Dementia in People With Diabetes - Medscape, 7/28/22 - "In an observational study of more than 112,000 US residents aged 50 years or older with type 2 diabetes, new users of metformin had about a 20% lower rate of incident dementia compared to new users of sulfonylurea during 5 years of follow-up." - See metformin at ReliableRX.

Boosters Targeting Omicron May Be Available Earlier - Medscape, 7/27/22 - "But opening eligibility now could have several consequences, NPR reported. Allowing more people to get boosted with the original vaccine, for instance, could interfere with the plans to boost people with an updated vaccine in the fall — both from a public health messaging standpoint and the potential that a fourth shot could train the immune system to fight the original strain of the coronavirus, rather than the latest subvariants ... I think this will increase trust. We can't give a booster now and then again in 1.5 months or 2 months — that will decrease trust ... Giving two boosters close together could also backfire from an immunity perspective ... If you get a booster now with the original formulation of the vaccine, this may in fact be counter-productive. It may prevent the second booster dose given this fall from taking and from you developing an immune response to that booster"

Cocoa shown to reduce blood pressure and arterial stiffness in real-life study - Science Daily, 7/26/22 - "Doctors often fear that some blood pressure tablets can decrease the blood pressure too much on some days ... What we have found indicates that cocoa flavanols only decrease blood pressure if it is elevated. Working with participants' personal health technologies showed us how variable blood pressure and arterial stiffness can be from day to day and shows the role of personal health monitors in developing and implementing effective personalised care" - See dark Chocolate at Amazon.com.

Exposure to 'forever chemicals' costs US billions in health costs - Science Daily, 7/26/22 - "The new work revolves around per- and polyfluoroalkyl substances (PFAS), a group of over 4,700 humanmade chemicals that experts have detected for decades in the blood of millions of people. The chemicals are used, for example, in the production of water- and oil-resistant clothing, electronics, and nonstick cookware, and people are thought to ingest them as food comes into contact with packaging. The substances are believed to disrupt the function of hormones, signaling compounds that influence many bodily processes ... Among the findings, the investigation revealed that childhood obesity was the largest contributor to the overall economic toll of PFAS exposure, costing about $2.7 billion. Hypothyroidism in women, a condition in which the thyroid cannot release enough hormones into the bloodstream, was the next highest contributor at $1.26 billion ... The study investigators also expanded the scope of their economic estimates to include eight other conditions with preliminary links to PFAS exposure, including endometriosis, obesity in adults, and pneumonia in children. When such diseases were considered, the total costs reached as high as $63 billion"

Green tea extract promotes gut health, lowers blood sugar - Science Daily, 7/26/22 - "Forty participants -- 21 with metabolic syndrome and 19 healthy adults -- consumed gummy confections containing green tea extract rich in anti-inflammatory compounds called catechins for 28 days. The daily dose equaled five cups of green tea. In the randomized double-blind crossover trial, all participants spent another 28 days taking a placebo, with a month off of any supplement between the treatments ... fasting blood glucose levels for all participants were significantly lower after taking green tea extract compared to levels after taking the placebo. Decreased gut inflammation due to the green tea treatment in all participants was established through an analysis that showed a reduction in pro-inflammatory proteins in fecal samples. Using a technique to assess sugar ratios in urine samples, researchers also found that with green tea, participants' small intestine permeability favorably decreased" - See green tea extract at Amazon.com.

In rare feat, researchers decipher how one gut bacterium influences immunity - Science Daily, 7/27/22 - "Clardy, Xavier, and colleagues focused on Akkermansia muciniphila, a species that accounts for an impressive 3 percent of the gut microbiome. It gets its name from the intestinal mucus it breaks down ... Study after study had suggested that A. muciniphila plays a key role in maintaining healthy immune processes, seeming to protect against diseases such as type 2 diabetes and inflammatory bowel disease and make cancer cells more responsive to immune checkpoint therapies" - See Akkermansia muciniphila at Amazon.com.

Potent Cannabis Linked to More Worldwide Addiction - Medscape, 7/26/22 - "One of the highest-quality studies included in our publication found that use of high-potency cannabis, compared to low-potency cannabis, was linked to a four-fold increased risk of addiction"

High-strength cannabis linked to addiction and mental health problems - Science Daily, 7/25/22 - "people who use higher potency cannabis could be at increased risks of addiction as well as psychosis"

B6 a New Approach for Depression, Anxiety? - Medscape, 7/26/22 - "The study participants were randomly assigned to receive either vitamin B6 (100 mg pyroxidine hydrochloride), vitamin B12 (1000 mg methylcobalmin), or placebo tablets once daily for a month" - See vitamin B6 at Amazon.com.

Abstracts from this week:

Coenzyme Q10 levels associated to cognitive functioning and executive function in older adults - J Gerontol A Biol Sci Med Sci 2022 Jul 31 - "Brain deterioration with age is associated with inflammation and oxidative stress that result in structural and functional changes. Recent studies have indicated that coenzyme Q10 (CoQ10) is associated to neurological oxidative stress and cognitive impairment. Studies with older people have shown a relationship between neurodegenerative diseases and CoQ10 levels ... According to previous studies, physical activity and nutritional status are positively associated with cognitive functioning. However, the main finding of this study was that plasma CoQ10, controlling for other measures, was significantly associated to cognitive functioning and executive function. The current findings suggest that a decline in cognitive capacities may be related to reduced antioxidant defenses, as reflected by low CoQ10 levels in older adults" - See ubiquinol products at Amazon.com.

Cellular senescence: a key therapeutic target in aging and diseases - J Clin Invest 2022 Aug 1 - "Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives secondary senescence and disrupts tissue homeostasis, resulting in loss of tissue repair and regeneration. The use of transgenic mouse models in which SnCs can be genetically ablated has established a key role for SnCs in driving aging and age-related disease. Importantly, senotherapeutics have been developed to pharmacologically eliminate SnCs, termed senolytics, or suppress the SASP and other markers of senescence, termed senomorphics. Based on extensive preclinical studies as well as small clinical trials demonstrating the benefits of senotherapeutics, multiple clinical trials are under way"

Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study - Nutrients 2022 Feb 11 - "Deteriorating sleep quality and physical or mental fatigue in older adults leads to decreased quality of life and increased mortality rates. This study investigated the effects of the time-dependent intake of nicotinamide mononucleotide (NMN) on sleep quality, fatigue, and physical performance in older adults ... NMN (250 mg) or placebo was administered once a day for 12 weeks. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index. Fatigue was evaluated using the "Jikaku-sho shirabe" questionnaire. Grip strength, 5-times sit-to-stand (5-STS), timed up and go, and 5-m habitual walk were evaluated to assess the physical performance. Significant interactions were observed between 5-STS and drowsiness. 5-STS of all groups on post-intervention and drowsiness of the NMN_PM and Placebo_PM groups on mid- and post-intervention showed significant improvement compared with those in pre-intervention. The NMN_PM group demonstrated the largest effect size for 5-STS (d = 0.72) and drowsiness (d = 0.64). Overall, NMN intake in the afternoon effectively improved lower limb function and reduced drowsiness in older adults. These findings suggest the potential of NMN in preventing loss of physical performance and improving fatigue in older adults" - See NMN at Amazon.com.

Elevated Fasting Insulin Results in Snoring: A View Emerged from Causal Evaluation of Glycemic Traits and Snoring - Eur J Clin Invest 2022 Jul 31 - "Snorers are subjected to higher FBG, HbA1c, FINS and 2hGlu levels, and elevated FINS levels further provides robust causality on snoring, suggesting that behind common snoring may lie hyperinsulinemia or insulin resistance"

Trehalose Suppresses Lysosomal Anomalies in Supporting Cells of Oocytes and Maintains Female Fertility - Nutrients 2022 May 22 - "Our results suggest that autophagy maintains the healthy state of the supporting cells of human oocytes by suppressing the formation of lysosomes. Thus, our results provide insights into the therapeutic effects of trehalose on female fertility" - See trehalose at Amazon.com.

Quercetin improves high-fat diet-induced obesity by modulating gut microbiota and metabolites in C57BL/6J mice - Phytother Res 2022 Jul 29 - "High-fat diet-induced obesity is characterized by low-grade inflammation, which has been linked to gut microbiota dysbiosis. We hypothesized that quercetin supplementation would alter gut microbiota and reduce inflammation in obese mice ... Quercetin influenced the production of metabolites that were linked to alterations in obesity-related inflammation and oxidative stress, such as Glycerophospho-N-palmitoyl ethanolamine, sanguisorbic acid dilactone, O-Phospho-L-serine, and P-benzoquinone. Our results demonstrate that the anti-obesity effects of quercetin may be mediated through regulation in gut microbiota and metabolites" - See quercetin at Amazon.com.

Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator Blinded, Randomized Trial - Front Med (Lausanne) 2022 Jul - "The efficacy of topical minoxidil (MX) alone on female pattern hair loss (FPHL) is limited. Combination therapy based on topical MX is currently expected to provide better outcomes ... This study aimed to assess whether the combined therapies including MX plus oral spironolactone (SPT) and MX plus microneedling (MN) have advantages in efficacy and safety over topical MX alone on mild-to-moderate FPHL with normal hormone levels in the blood and regular menstrual cycle ... Topical MX combined with MN is a better choice than either MX plus oral SPT or MX alone for the treatment of mild-to-moderate FPHL patients" - See midoxinil at Amazon.com.

Coenzyme Q 10 alleviates testicular endocrine and spermatogenic dysfunction induced by high-fat diet in male Wistar rats: Role of adipokines, oxidative stress and MAPK/ERK/JNK pathway - Andrologia 2022 Jul 27 - "The current study investigated the possible protective effects of Coenzyme Q10 (Co Q10 ) on rat model of high-fat diet (HFD) induced testicular dysfunction ... In comparison to the untreated HFD group, the Co Q10 treated group revealed significantly increased serum testosterone, adiponectin levels, and decreased LH, FSH, and leptin levels. In addition, HFD resulted in significant increase in testicular oxidative stress (increased MDA, iNOS, NO, XO & decreased catalase, SOD, GSH) and inflammation (increased pJNK/JNK, pERK/ERK, and p-p38MAPK/MAPK), while Co Q10 was effective to ameliorate these changes. In addition, Co Q10 significantly increased sperm count, motility and viability that were markedly deteriorated by HFD. Regarding testicular ultrastructure, seminiferous tubular diameter and epithelium height were reduced in HFD group and Co Q10 significantly improved these testicular changes. Finally, a significant reduction in spermatogenic cell proliferation was detected by PCNA fluorescent expression and Co Q10 significantly reversed this change" - See ubiquinol products at Amazon.com.

  • Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction - Am J Cardiol 2022 May 26 - "Patients with heart failure with preserved ejection fraction (HFpEF) have few pharmacologic therapies, and it is not known if supplementing with ubiquinol and/or d-ribose could improve outcomes ... Group 1 received placebo ubiquinol capsules and d-ribose powder, Group 2 received ubiquinol capsules (600 mg/d) and placebo d-ribose powder, Group 3 received placebo ubiquinol capsules with d-ribose powder (15 g/d), and Group 4 received ubiquinol capsules and d-ribose powder ... Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score ... Treatment with ubiquinol and/or d-ribose significantly improved the KCCQ clinical summary score (17.30 to 25.82 points), vigor score (7.65 to 8.15 points), and EF (7.08% to 8.03%) and reduced B-type natriuretic peptides (-72.02 to -47.51) and lactate/adenosine triphosphate ratio (-4.32 to -3.35 × 10-4). There were no significant increases in the septal E/e' or the 6-minute walk test. In conclusion, ubiquinol and d-ribose reduced the symptoms of HFpEF and increased the EF. These findings support the use of these supplements in addition to standard therapeutic treatments for patients with HFpEF" - See ubiquinol products at Amazon.com and D-ribose at Amazon.com.

Metformin and testosterone replacement therapy inversely associated with hormone-associated cancers (prostate, colorectal and male breast cancers) among older White and Black men - Clin Endocrinol (Oxf) 2022 Jul 28 - "The independent and joint association of metformin and testosterone replacement therapy (TTh) with the incidence of prostate, colorectal, and male breast cancers remain poorly understood, including the investigation of the risk of these cancers combined (HRCs, hormone-associated cancers) among men of different racial and ethnic background ... We found independent and joint associations of metformin and TTh with incident prostate (ORjoint = 0.44, 95% CI: 0.36 - 0.54) and colorectal cancers (ORjoint = 0.47, 95% CI: 0.34 - 0.64), but not with male breast cancer. There were also inversed joint associations of metformin and TTh with HRCs (ORjoint = 0.45, 95% CI: 0.38 - 0.54)" - See metformin at ReliableRX.

Hepatoprotective effects of different mulberry leaf extracts against acute liver injury in rats by alleviating oxidative stress and inflammatory response - Food Funct 2022 Jul 27 - "This study investigated the hepatoprotective effects of various mulberry (Morus alba L.) leaf extracts (MLEs), including mulberry ethanol extract (MEE), aqueous extract (MAE) and a combination extract (MCE) against D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced acute liver injury in rats ... These results indicated that the active components from mulberry leaves protected rats against acute liver injury, attributed to a reduction in both oxidative stress and inflammatory response. The protective effect may be implicated in regulating the Nrf2, NLRP3 and MAPK signaling pathways" - See mulberry leaf extract at Amazon.com.

Polyphenols in Highland barley tea inhibit the production of Advanced glycosylation end-products and alleviate the skeletal muscle damage - Mol Nutr Food Res 2022 Jul 27 - "Highland barley tea is a kind of caffeine-free cereal tea. Previous studies have shown that it was rich in polyphenol flavonoids. Here, the effect of Highland barley tea polyphenols (HBP) on the production of advanced glycosylation end-products and alleviate the skeletal muscle damage is systematically investigated ... These data indicate that the relationship between the biological activity and HBP properties is relevant since Highland barley could be a potential functional food to prevent AGEs-mediated skeletal muscle damage"

Vitamin D: an essential adjuvant therapeutic agent in breast cancer - J Int Med Res 2022 Jul - "Low serum levels of vitamin D have been reported as a risk factor for breast cancer. This narrative review provides an update on the impact of vitamin D on hormone receptors, notably estrogen receptor subunits, and gives insights on possible therapeutic interventions to overcome breast cancer. In addition, evidence that supports the beneficial use of vitamin D as adjuvant treatment of breast cancer is summarized. Vitamin D deficiency is significantly widespread in patients with triple-negative tumors. Several studies have observed a possible modulatory effect of vitamin D or its analogues on the expression of different hormone receptors in breast cancer and increased sensitivity to tamoxifen. Vitamin D possesses anti-inflammatory and immunomodulatory effects in patients with breast cancer, and the mechanism of action of vitamin D in patients with breast cancer is discussed" - See vitamin D at Amazon.com.

Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial - Nutrients 2022 Jul 26 - "Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19 ... A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo. The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (4 days vs. 8 days; p = 0.003). At Day 7, a significantly lower percentage of patients were still hospitalized in the vitamin D group compared to the placebo group (19% vs. 54%; p = 0.0161), and none of the patients treated with vitamin D were hospitalized after 21 days compared to 14% of the patients treated with placebo. Vitamin D significantly reduced the duration of supplemental oxygen among the patients who needed it (4 days vs. 7 days in the placebo group; p = 0.012) and significantly improved the clinical recovery of the patients, as assessed by the WHO scale" - See vitamin D at Amazon.com.

Low Vitamin D Status Relates to the Poor Response of Peripheral Pulse Wave Velocity Following Acute Maximal Exercise in Healthy Young Men - Nutrients 2022 Jul 26 - "Vitamin D deficiency may increase the risk of incident cardiovascular events after acute exhaustive exercise, even in healthy and active adults" - See vitamin D at Amazon.com.

Association of dietary intake of n-3 polyunsaturated fatty acids with breast cancer risk in pre- and postmenopausal Chinese women - Menopause 2022 Jul 26 - "Higher intake of marine n-3 PUFAs and total n-3 PUFAs was associated with lower risk of breast cancer, with adjusted OR quartile 4 v.1 (95% confidence intervals) of 0.68 (0.55-0.84) and 0.56 (0.42-0.75), respectively. Dietary a-linolenic acid, eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid were also inversely associated with breast cancer risk, with adjusted ORs (95% confidence intervals) of 0.51 (0.38-0.70), 0.68 (0.55-0.84), 0.68 (0.55-0.85), and 0.76 (0.61-0.94), respectively. In stratified analyses, these inverse associations between risk and dietary n-3 PUFAs were more evident among premenopausal women and women with ER+, PR+ and ER+PR+ tumors. A decreased risk of breast cancer was significantly associated with increasing n-3 PUFA intake in obese/overweight women, but not in women of normal weight. There was a significant interaction between linoleic acid and marine n-3 PUFAs ... High intake of n-3 PUFAs and n-3 PUFA subtypes was associated with a lower risk of breast cancer, especially among premenopausal women and women with ER+ and/or PR+ subtype breast cancer" - See omega-3 supplements at Amazon.com.

Effects of Amino Acids Supplementation on Lipid and Glucose Metabolism in HepG2 Cells - Nutrients 2022 Jul 25 - "Taken together, the effect of SAMe on glucose and lipid metabolism is significant especially on inhibiting hepatic lipogenesis and gluconeogenesis under the metabolic syndrome environment" - See SAM-e at Amazon.com.

Ginseng oligosaccharides protect neurons from glutamate-induced oxidative damage through the Nrf2/HO-1 signaling pathway - Food Funct 2022 Jul 27 - "The effects of ginseng oligosaccharides (GSOs) on neuronal oxidative injury induced by glutamate (GLU) and the molecular mechanisms involved were investigated ... These findings indicate that GSOs protect against GLU-induced neuronal oxidative damage through Nrf2/HO-1 activation" - See ginseng at Amazon.com.

Ginsenoside Rh4 Suppresses Metastasis of Esophageal Cancer and Expression of c-Myc via Targeting the Wnt/β-Catenin Signaling Pathway - Nutrients 2022 Jul 25 - "The metastasis of esophageal squamous cell carcinoma (ESCC) is a leading cause of death worldwide, however, it has a poor prognosis. Ginsenoside Rh4 is a rare saponin that has been shown to have potential antitumor effectiveness in ESCC ... In this study, we found that Rh4 could inhibit ESCC metastasis by regulating the Wnt/β-catenin signaling pathway and the level of c-Myc, which is an important transcription factor in cancer" - See ginseng at Amazon.com.

Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial - Am J Clin Nutr 2022 Jul 26 - "Osteoarthritis (OA) is a major cause of chronic pain and disability worldwide. Treatment generally focuses on symptom relief through nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, which may incur side effects. Krill oil, rich in anti-inflammatory long-chain (LC) omega-3 ( ω-3) PUFAs and astaxanthin, may be a safe and effective alternative treatment ... Krill oil was safe to consume and resulted in modest improvements in knee pain, stiffness, and physical function in adults with mild to moderate knee OA" - See krill oil products at Amazon.com.

Curcumin Alleviates D-Galactose-Induced Cardiomyocyte Senescence by Promoting Autophagy via the SIRT1/AMPK/mTOR Pathway - Evid Based Complement Alternat Med 2022 Jul 16 - "Oxidative stress and impaired autophagy are the hallmarks of cardiac aging. However, there are no specific drugs available to prevent cardiac aging. Curcumin is a natural polyphenolic drug with antioxidant, antiaging, and autophagy-promoting effects. Here, we describe the preventive role of Curcumin in cardiac aging through the induction of autophagy and the restoration of autophagy via the SIRT1/AMPK/mTOR pathway. The number of cells positive for senescence-associated β-galactosidase, P53, P16, and intracellular ROS increased significantly in senescent cardiomyocytes, stimulated using D-galactose. Curcumin reversed this effect in a dose-dependent manner. Curcumin-induced autophagy increased the expression of SIRT1and phosphorylated AMPK and decreased phosphorylated mTOR in a dose-dependent manner. SIRT1-siRNA-mediated knockdown inhibited the antioxidation, antiaging, the promotion of autophagy, and the SIRT1/AMPK/mTOR pathway activation effect of curcumin. Therefore, curcumin could be an effective anticardiac aging drug" - See curcumin at Amazon.com.

Methionine can subside hair follicle development prejudice of heat-stressed rex rabbits - FASEB J 2022 Aug; - "The results show that heat stress decreases the hair follicle density of Rex rabbits, and the diet methionine addition significantly increases the hair follicle density of heat-stressed Rabbits" - See methionine at Amazon.com.

I started a webpage on increasing left ventricle ejection fraction.

Neat Tech Stuff / "How To's":

Jabra's Elite 7 Pro ANC earbuds drop to a new low of $130 - Engadget, 8/1/22 - "$10 less than what they were selling for just ahead of Prime Day." - They've got a water rating of IP57. Wear them swimming and learn a foreign language.

Health Focus (HbA1c):