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Recent Longevity News for the week ending 7/13/22

Cutting Dietary Simple Sugars May Relieve GERD Symptoms - Science Daily, 7/11/22 - "There was a significant effect of diet on the two primary outcomes, total esophageal acid exposure time, and total number of reflux episodes, as measured by 24-hour ambulatory pH monitoring. The change in total acid exposure time was significantly greater for the high total/low simple group compared with the high total/high simple group."

Ketamine for psychedelic mental health healing grows in popularity - 10News, 7/11/22 - "In 1999, ketamine became a schedule III non-narcotic substance with accepted medical uses. In 2019, the FDA approved a ketamine nasal spray for treatment-resistant depression, and now doctors and therapists use it regularly in a clinical setting ...And while the DEA restricts many other psychedelics, researchers have found great benefits in substances like MDMA and psilocybin, or magic mushrooms ... The Johns Hopkins psychedelic research unit found psilocybin is effective in easing anxiety and depression, even treating veterans with post-traumatic stress disorder (PTSD)"

Vitamin K Antagonists and TBI: A Deadly Combination? - Medscape, 7/11/22 - "vitamin K antagonists (VKA) ... Preinjury use of direct oral anticoagulants (DOAC) was also associated with worse outcomes, although not nearly as high as use of VKA. Adenosine diphosphate inhibitors (ADPi) were not linked to higher rates of death or surgery at 30 days ... To explore the issue, researchers analyzed data from 57,056 patients with TBI, most of whom were diagnosed with concussion or mild TBI. Overall, 0.9% were treated with DOAC, 7.1% with VKA (all warfarin), and 2.3% an ADPi ... Mortality at 30 days was 15.4% in the VKA group, 8.4% in the DOAC group, and 7.1% in patients without OAC"

• Direct oral anticoagulants (DOACs) - Vascular Medicine - "The four DOACs currently available in the United States are dabigatran, rivaroxaban, apixaban, and edoxaban"

Heart-healthy, lower sodium version of traditional Chinese cuisine lowered blood pressure - Science Daily, 7/11/22 - "The heart-healthy Chinese diet reduced sodium intake in half, from nearly 6,000 mg daily to about 3,000 mg daily, and featured reduced fat, increased protein and carbohydrates, twice as much dietary fiber and increased potassium ... Participants who ate the Chinese heart-healthy diet had lower blood pressure, with the systolic (top number) blood pressure lowered by an average 10 mm Hg, and diastolic blood pressure fell by an average 3.8 mm Hg, compared to the group who ate regular cuisine ... In the heart-healthy group, calorie intake from carbohydrates (8%) and protein (4%) increased and from fat decreased (11%). Consumption of fiber (14 grams), potassium (1,573 mg), magnesium (194 mg) and calcium (413 mg) increased, while sodium decreased (2,836 mg). The nutrient intake of the group that consumed regular diets, however, remained almost unchanged from the start to the end of the study ... hese findings suggest the effects achieved by the heart-healthy Chinese diet, if sustained, may reduce major cardiovascular disease by 20%; heart failure by 28% and all-cause death by 13% ... Health professionals should recommend a heart-healthy diet with low sodium and high potassium, fiber, vegetables and fruits as the first-line treatment to their patients with high blood pressure" - See Morton Lite salt at Amazon.com.

Prenatal exposure to chemicals in consumer and industrial products is associated with rising liver disease in children - Science Daily, 7/6/22 - "researchers measured 45 chemicals in the blood or urine of 1,108 pregnant women from 2003 to 2010. The chemicals included endocrine-disrupting chemicals such as PFAS, organochlorine and organophosphate pesticides, plasticizers (phenols, phthalates), PBDEs, and parabens. When the children reached the ages of 6 to 11 years old, scientists measured the levels of enzymes and cytokeratin-18 that indicate risk for liver disease in the children's blood"

People who practice intermittent fasting experience less severe complications from COVID-19, study finds - Science Daily, 7/7/22 - "COVID-19 patients who practiced regular water-only intermittent fasting had lower risk of hospitalization or dying due to the virus than patients who did not"

Each COVID-19 Reinfection Increases - Medscape, 7/7/22 - "People who get reinfected with the virus that causes COVID-19 have more health risks with each round of reinfection"

Long term high-fat diet expands waistline and shrinks brain - Science Daily, 7/7/22 - "In the study, mice were randomly allocated to a standard diet or a high-fat diet for 30 weeks, starting at eight weeks of age. Food intake, body weight and glucose levels were monitored at different intervals, along with glucose and insulin tolerance tests and cognitive dysfunction ... The mice on the high-fat diet gained a lot of weight, developed insulin resistance and started behaving abnormally compared to those fed a standard diet ... Genetically modified Alzheimer's disease mice showed a significant deterioration of cognition and pathological changes in the brain while fed the high fat diet ... Obese individuals have about a 55 per cent increased risk of developing depression, and diabetes will double that risk"

Toxic ‘forever chemicals’ found in Florida oysters - Hill, 7/7/22 - "When researchers from Florida International University recently tested for the chemicals in 156 oysters from Biscayne Bay, Marco Island, and Tampa Bay, they found detectable levels in every single oyster ... Because oysters are filter feeders, meaning they obtain food by filtering matter and organisms from water that passes through them, the species can reveal a lot about an ecosystem’s overall health ... The findings confirm the pollutants are in multiple water sources and have infiltrated the food chain. The chemicals have been found in human and animal blood and in the natural environment."

The Role of Melatonin in Chronic Kidney Disease and Its Associated Risk Factors: A New Tool in Our Arsenal? - NTK Papers, 6/28/22 - "The combined use of stem cells with melatonin is an appealing therapeutic approach which ought to be assessed further" - See melatonin at Amazon.com.

Uric acid and sodium-glucose cotransporter-2 inhibition with empagliflozin in heart failure with reduced ejection fraction: the EMPEROR-reduced trial - Eur Heart J 2022 Jul 5 - "Hyperuricaemia is common in HF and is an independent predictor of advanced disease severity and increased mortality. Empagliflozin induced a rapid and sustained reduction of SUA levels and of clinical events related to hyperuricaemia. The benefit of empagliflozin on the primary outcome was observed independently of SUA" - See empagliflozin inhousepharmacy.vu.

Hypothyroidism Tied to Increased Risk for Dementia - Medscape, 7/6/22 - "After adjusting for covariates, among participants 65 years and older, a history of hypothyroidism was associated with an 81% increased risk of being diagnosed with dementia (adjusted odds ratio [aOR], 1.81"

The Fatal Flaw of the Pulse Oximeter Racial bias led to faulty product design - ieee.org, 6/24/22 - "the pulse oximeter overestimated blood-oxygen saturation by an average of 1.7 percent for Asian patients, 1.2 percent for Black patients, and 1.1 percent for Hispanic patients ... To qualify for COVID-19 treatment with remdesivir, an antiviral drug, and dexamethasone, a steroid, patients had to have a blood-oxygen saturation of 94 percent or less. Based on the researchers’ model, nearly 30 percent of the 6,673 patients about whom they had enough information to predict their arterial blood-gas measurements met this cutoff. Many of these patients, most of whom were Black or Hispanic, had their treatment delayed for between 5 and 7 hours, with Black patients being delayed on average 1 hour more than white patients"

Abstracts from this week:

Ginsenoside Rg1 Suppresses Non-Small-Cell Lung Cancer via MicroRNA-126-PI3K-AKT-mTOR Pathway - Evid Based Complement Alternat Med 2022 Jul 1 - "As one of the most common cause of cancer death in the world, lung cancer causes approximately 1.6 million deaths annually. Among them, NSCLC accounts for approximately 85% of patients in whole lung cancer patients. Ginsenoside Rg1 has been confirmed to play an important role in various diseases including cancer. As one of miRNAs, miR-126 closely involves in pathogenesis of the several types of cancers including colorectal, prostate, bladder and gastric cancer, and so on ... Inhibition of Ginsenoside Rg1 on growth of lung cancer cells was through miR-126 and mTOR. Thus, the present study confirmed that Ginsenoside Rg1 remarkably inhibit lung cancer, which is through microRNA-126-PI3K-AKT-mTOR pathway" - See ginseng at Amazon.com.

Effect of Levothyroxine Supplementation on the Cardiac Morphology and Function in Patients with Subclinical Hypothyroidism: A Systematic Review and Meta-analysis - J Clin Endocrinol Metab 2022 Jul 10 - "The impact of abnormal thyroid hormone levels on the cardiovascular system has been explored for decades. In recent years, emerging evidence has suggested that subclinical thyroid dysfunction, especially subclinical hypothyroidism (SCH), significantly affects cardiac indices ... Judging from the obvious changes in the CO, LVEF and E/A ratio, LT4 supplementation can effectively improve the cardiac systolic and diastolic dysfunction prevalent in SCH patients. This study provides evidence of the recommendation for LT4 supplementation in adult SCH patients"

Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Berberine in the Treatment of Ischaemic Stroke - Evid Based Complement Alternat Med 2022 Jun 29 - "The potential targets and biological effects of berberine in the treatment of ischaemic stroke were predicted in this study. The lncRNA H19/EGFR/JNK1/c-Jun signalling pathway may be a key mechanism of berberine-induced neuroprotection in ischaemic stroke" - See berberine at Amazon.com.

Melatonin attenuates MPP +-induced apoptosis via heat shock protein in a Parkinson's disease model - Biochem Biophys Res Commun 2022 Jul 1 - "Heat shock proteins (HSPs) play an essential role as molecular chaperones to prevent abnormal protein aggregation and misfolding. Moreover, they protect dopamine neurons from oxidative stress, inflammation, and apoptosis, all well-known pathomechanisms of Parkinson's disease (PD). Melatonin is a potent antioxidant that has the beneficial ability to prevent neurodegenerative diseases like PD ... Our findings revealed the protective roles of melatonin in an in vitro PD model. Melatonin can hinder the toxic effects of MPP + on dopaminergic neuronal cells via upregulation of the HSF1/HSP70 pathway" - See melatonin at Amazon.com.

Non-linear Association between Serum 25-Hydroxyvitamin D and All-cause Mortality in Adults with Inflammatory Bowel Disease in a Prospective Cohort Study - J Nutr 2022 Jul 11 - "We observed a non-linear association, mostly applied to the females, between serum 25(OH)D concentrations and all-cause mortality among individuals with IBD. A concentration range of 44-78 nmol/L of 25(OH)D can serve as a starting point for future research to confirm recommended 25(OH)D concentrations for individuals with IBD" - See vitamin D at Amazon.com.

Association between Vitamin D Deficiency and Levels of Renin and Angiotensin in Essential Hypertension - Int J Clin Pract 2022 Jun 10 - "vitamin D deficiency is common in Urumqi, Xinjiang, China and vitamin D levels are negatively correlated with renin levels. Vitamin D plays an important role in regulating blood pressure by affecting renin levels through the renin-angiotensin-aldosterone system" - See vitamin D at Amazon.com.

The effect of pre-match sexual intercourse on football players' performance: a prospective cross over study - J Sports Med Phys Fitness 2022 Jul 11 - "To the best of our knowledge, this study is the first to show that sexual intercourse the night before a football match may have a negative influence on players' performance"

Efficacy of N-acetylcysteine in Preventing Acute Kidney Injury and Major Adverse Cardiac Events After Cardiac Surgery: A Meta-Analysis and Trial Sequential Analysis - Front Med (Lausanne) 2022 Jun 22 - "Results of subgroup analysis results showed that intravenous infusion instead of oral NAC could significantly reduce the incidence of AKI and arrhythmia (RR = 0.84, 95% CI = 0.71, 0.99, P = 0.03, I 2 = 3% and RR = 0.74" - Note: If the IV worked and the oral didn't, maybe it's a dosage thing?

Adding salt to foods and hazard of premature mortality - Eur Heart J 2022 Jul 10 - "compared with the never/rarely group, always adding salt to foods was related to 1.50 (95% CI, 0.72-2.30) and 2.28 (95% CI, 1.66-2.90) years lower life expectancy at the age of 50 years in women and men, respectively" - [Science Daily] - See Morton Lite salt at Amazon.com.

Implications of Liver Enzymes in the Pathogenesis of Alzheimer's Disease - J Alzheimers Dis 2022 Jun 28 - "alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels had significant positive associations with cognitive performance and were significantly decreased in AD patients. The alkaline phosphatase level and AST to ALT ratio were significantly negatively associated with cognitive performance and were significantly increased in AD patients. This suggests that these liver enzymes might be implicated in the pathogenesis of AD"

Short-term resveratrol treatment restored the quality of oocytes in aging mice - Aging (Albany NY) 2022 Jul 8 - "The quality of oocytes declines by aging, resulting in their low competences for fertility. Here, resveratrol treatment showed increases in the rates of implantation and live offspring as well as decreases in the abortion rate as short as one week after treatment, although the number of ovulated oocytes and the rates of fertilization and blastocyst formation were not changed following resveratrol treatment. Resveratrol treatment did not cause abnormalities mouse estrous cycles and body weights. No abnormality was detected in both fetuses and placentas after 22 weeks of resveratrol treatment and the fetuses had normal fertility. Positive correlations were found between serum resveratrol levels and pregnancy and live offspring rates as well as ovarian expression levels of Sirt1, Sirt3, Sirt4, Sirt5, and Sirt7. The mitochondrial membrane potential and ATP content but not copy number of mitochondrial DNA in oocytes was increased in aging mice with resveratrol treatment. In conclusion, we demonstrated the restoration of oocyte quality in aging mice in addition to the prevention of their quality decline during aging by restoring mitochondrial functions by resveratrol treatment without adverse effects in the animals and their offspring" - See resveratrol products at Amazon.com.

Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis - EBioMedicine 2022 Jul 4 - "Cold exposure is one of the most important risk factors for atrial fibrillation (AF), and closely related to the poor prognosis of AF patients ... Our findings revealed a novel causal role of aberrant gut microbiota and metabolites in pathogenesis of cold-related AF, which raises the possibility of selectively targeting microbiota and microbial metabolites as a potential therapeutic strategy for cold-related AF" - See Akkermansia muciniphila at Amazon.com.

Protective Effects and Molecular Mechanism of Total Flavonoids from Lycium Barbarum Leaves on Photoaged Human Dermal Fibroblasts - Evid Based Complement Alternat Med 2022 Jun 28 - "To investigate the effects and corresponding mechanisms of total flavonoids (TFL) from Lycium barbarum leaves on photoaged human dermal fibroblasts (HDFs) ... TFL could inhibit oxidative stress and apoptosis, promote cell proliferation and the level of ECM-related component proteins, and participate in antiphotoaging in a concentration-dependent manner. The protective role of TFL in photoaged HDFs might be related to its inhibition of MAPK signaling pathways" - See flavonoids at Amazon.com.

Potentialities of Ginkgo extract on toxicants, toxins, and radiation: a critical review - Food Funct 2022 Jul 8 - "Exposure to toxins is a severe threat to human health and life in today's developing and industrialized world. Therefore, identifying a protective chemical could be valuable and fascinating in this case. The purpose of this article was to bring together thorough review of studies on Ginkgo biloba to aid in the creation of ways for delivering its phytoconstituents to treat toxicants and radiation. This review gathered and evaluated studies on the defensive impact of Ginkgo biloba extract (GBE) against toxicities caused by toxic chemical agents (such as lead, cadmium, and aluminum), natural toxins (for example, lipopolysaccharide-induced toxicity and damage, gossypol, latadenes, and lotaustralin), and radiation (for example, gamma, ultra-violet, and radio-frequency radiation). According to this review, GBE has a considerable therapeutic effect by influencing specific pathophysiological targets. Furthermore, GBE has antioxidant, anti-inflammatory, anti-apoptotic, and antigenotoxicity properties against various toxicities. These are due to flavone glycosides (primarily isorhamnetin, kaempferol, and quercetin) and terpene trilactones (ginkgolides A, B, C, and bilobalide) that aid GBEs' neutralizing effect against radiation and toxins by acting independently or synergistically" - See Ginkgo biloba at Amazon.com.

Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review - J Agric Food Chem 2022 Jul 8 - "The morbidity and mortality of diabetes have increased dramatically in recent decades. Novel strategies for treating diabetes and its complications with minimal side effects are in urgent need. New monomeric molecules extracted from herbal medicine, which is a form of alternative medicine, are being sought as drug candidates for the treatment of diabetes and its complications. Hesperetin (Hst), a citrus flavonoid, is of increasing interest in scientific studies recently due to its properties in combating diabetes and its complications, whereas existing studies are scattered and unsystematic" - See hesperidin at Amazon.com.

Role of Ginseng, Quercetin, and Tea in Enhancing Chemotherapeutic Efficacy of Colorectal Cancer - Front Med (Lausanne) 2022 Jun 20 - "As the most common gastrointestinal malignancy, colorectal cancer (CRC) remains a leading cause of cancer death worldwide. Although multimodal chemotherapy has effectively improved the prognosis of patients with CRC in recent years, severe chemotherapy-associated side effects and chemoresistance still greatly impair efficacy and limit its clinical application. In response to these challenges, an increasing number of traditional Chinese medicines have been used as synergistic agents for CRC administration. In particular, ginseng, quercetin, and tea, three common dietary supplements, have been shown to possess the potent capacity of enhancing the sensitivity of various chemotherapy drugs and reducing their side effects. Ginseng, also named "the king of herbs", contains a great variety of anti-cancer compounds, among which ginsenosides are the most abundant and major research objects of various anti-tumor studies. Quercetin is a flavonoid and has been detected in multiple common foods, which possesses a wide range of pharmacological properties, especially with stronger anti-cancer and anti-inflammatory effects. As one of the most consumed beverages, tea has become particularly prevalent in both West and East in recent years. Tea and its major extracts, such as catechins and various constituents, were capable of significantly improving life quality and exerting anti-cancer effects both in vivo and in vitro" - See ginseng at Amazon.com, quercetin at Amazon.com and green tea extract at Amazon.com.

Curcumenol Targeting YWHAG Inhibits the Pentose Phosphate Pathway and Enhances Antitumor Effects of Cisplatin - Evid Based Complement Alternat Med 2022 Jun 26 - "Cervical cancer is a common cancer in women. The drug resistance of chemotherapeutic agents has always been an urgent problem to be solved in clinics. The purpose of this study was to determine the role of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide (YWHAG) in cervical cancer and explore the effect of Curcuma on cervical cancer and its possible mechanism ... Curcumenol can enhance cisplatin to inhibit cancer cell proliferation, migration, and invasion and promote tumor cell apoptosis. The combination of drugs may promote the apoptosis of cervical cancer cells through the YWHAG pathway"

• Curcumenol - Pub Chem - "Curcumenol is a natural product found in Curcuma aeruginosa, Curcuma longa, and other organisms with data available"
• Turmeric - Wikipedia - "Turmeric ... is a flowering plant, Curcuma longa" - See curcumin at Amazon.com.

Comprehensive Rehabilitation Therapy Plus Glucosamine Hydrochloride for Exercise-Induced Knee Injuries and the Effect on Knee Function of Patients - Evid Based Complement Alternat Med 2022 Jun 27 - "To assess the application value of comprehensive rehabilitation therapy plus glucosamine hydrochloride for exercise-induced knee injuries and its effect on knee function ... Comprehensive rehabilitation therapy plus glucosamine hydrochloride effectively improves the clinical efficacy of exercise-induced knee joint injuries and enhances the knee joint rehabilitation of the patients" - See glucosamine hydrochloride at Amazon.com.

Calycosin Improves Intestinal Mucosal Barrier Function after Gastrectomy in Rats through Alleviating Bacterial Translocation, Inflammation, and Oxidative Stress - Evid Based Complement Alternat Med 2022 Jun 26 - "Calycosin is the main bioactive extract of Astragali Radix with anti-inflammation, antioxidant, and anticancer properties. Here, our study evaluated the protective effects and mechanisms of calycosin on intestinal mucosal barrier under gastrectomy ... Altogether, our findings demonstrate that calycosin may improve intestinal mucosal barrier function under gastrectomy via reducing bacterial translocation, inflammation, and oxidative stress"

• Calycosin - Wikipedia - "Calycosin is an O-methylated isoflavone. It can be isolated from Astragalus membranaceus Bge. var. mongholicus[1] and Trifolium pratense L. (red clover)" - See Astragalus at Amazon.com.

Bifidobacterium longum BL-10 with Antioxidant Capacity Ameliorates Lipopolysaccharide-Induced Acute Liver Injury in Mice by the Nuclear Factor-κB Pathway - J Agric Food Chem 2022 Jul 7 - "Bifidobacterium longum is frequently utilized and has broad prospects for preventing liver injury ... lipopolysaccharide (LPS)-induced acute liver injury ... Overall, all the results demonstrated that B. longum BL-10 had excellent efficiency in preventing LPS-induced ALI" - See probiotic supplements at Amazon.com.

Lactobacillus acidophilus LA85 ameliorates cyclophosphamide-induced immunosuppression by modulating Notch and TLR4/NF-κB signal pathways and remodeling the gut microbiota - Food Funct 2022 Jul 6 - "LA85 can be used as a dietary supplement to potentially enhance the immune capacity of patients" - See probiotic supplements at Amazon.com.

Medium-chain triglycerides improve lipid metabolism in obese rats through increasing the browning of adipose tissue via sympathetic regulation - Food Funct 2022 Jul 6 - "This study aimed to determine the effect and mechanism of medium-chain triglycerides (MCTs) on promoting the browning of adipose tissue. A high-fat diet was fed to the Sprague-Dawley rats to induce obesity, then caprylic triglycerides (CYTs), capric triglycerides (CTs) and lauric triglycerides (LTs) were used to treat the obese rats for 12 weeks ... We speculate that the browning process may be related to sympathetic regulation and all the three MCT administration increased the secretion of neurotrophic factors both in the hypothalamus and adipose tissue. Then, intra-adipose sympathetic arborization increased, resulting in the activation of the sympathetic regulatory system in MCT groups, and the LT group also showed the highest sympathetic nerve fiber density, followed by the CT group and CYT group. We have for the first time found that the effect of medium-chain fatty acids on adipose tissue browning might be related to the types of fatty acids" - See medium-chain triglycerides at Amazon.com.

Protective effects of apple polyphenols on bone loss in mice with high fat diet-induced obesity - Food Funct 2022 Jul 5 - "Obesity-induced inflammation can lead to an imbalance in bone formation and resorption. Our previous studies have demonstrated that apple polyphenols (APs) can reduce body weight and inflammation. But their effect on bone is still unclear ... The present study demonstrated that APs prevent loss of bone mass induced by obesity, which has potential implications for the prevention and treatment of obesity-related osteoporosis" - See apple polyphenols at Amazon.com.

Common electrocardiogram measures are not associated with telomere length - Aging (Albany NY) 2022 Jul 5 - "Aging is accompanied by telomere shortening. Increased telomere shortening is considered a marker of premature aging. Cardiac aging results in the development of cardiac pathologies. Electrocardiogram (ECG) measures reflect cardiac excitation, conduction, and repolarization. ECG measures also prolong with aging and are associated with cardiac pathologies including atrial fibrillation. As premature prolongation of ECG measures is observed, we hypothesized that such prolongation may be associated with telomere length ... ECG measures are age-dependent, but not associated with shortened telomere length as a marker of biological aging"

L-citrulline prevents heat-induced mitochondrial dysfunction and cell injury through nitric oxide-mediated Drp1 inhibition in mouse C2C12 myoblasts - Br J Nutr 2022 Jul 6 - "Severe heat exposure causes mitochondrial fragmentation and dysfunction, which contribute to the pathogenesis of heat-related illness. L-citrulline is a naturally occurring amino acid and has been suggested to influence heat shock responses. This study aimed to test whether L-citrulline supplementation would preserve mitochondrial integrity and attenuate heat-induced skeletal muscle injury, and elucidate the underlying mechanisms ... Our results suggest that L-citrulline prevents heat-induced mitochondrial dysfunction and cell injury through NO-mediated Drp1 inhibition in C2C12 myoblasts. L-citrulline may be an effective treatment for heat-related illnesses and other mitochondrial diseases" - See L-citrulline at Amazon.com.

Neat Tech Stuff / "How To's":

I had been shopping for a waterproof iPod for years so I could learn Mandarin while swimming. Apple doesn't make a waterproof iPod so I went with the SYRYN Swimbuds. I'm embarrassed to say it but I went through six of them before I found a company that claimed they did something that made the Apple iPod shuffle waterproof. Whatever they did, it worked because my iPod shuffle is still working after about eight years of swimming for over an hour per day. One day it got lost between the seats in the car. I thought I lost them walking to my car so I bought another SYRYN. Lucky, the iPod showed up and I continued to use that. That said, I don't think the company that waterproofed them is still in business and I've been worried that it might break so I've been planning ahead and searching for other options. Plus, I thought I read somewhere that Apple stopped making the iPods.

I Googled Airpods to see if they were waterproof. They've got an IPX4 rating which means (see article below):  "IPX4 is splash-resistant"

how do I tell if my ipod shuffle is waterproof - apple.com - "No iPod shuffle models have ever been waterproof or water-resistant."

About the sweat and water resistance of AirPods Pro and AirPods (3rd generation) - apple.com - "AirPods Pro and AirPods (3rd generation) were tested under controlled laboratory conditions, and have a rating of IPX4"

Are Your "Waterproof Earbuds" Actually Waterproof? Here's How to Tell - What’s the difference between IPX4 and IPX7? - gearpatrol.com - "The higher the number rises, the more water-resistant the device gets, of course. IPX4 is splash-resistant; IPX5 is resistant to a sustained low-pressure water spray; IPX6 means your earbuds can withstand a sustained high-pressure spray. An IPX7 or IPX8 rating means they can be submerged for 30 minutes and still survive — the only difference being that IPX8-rated buds can go a little deeper ... The Elite 7 Active are fantastic wireless earbuds for working out and exercise. Each earbud is IP57-rated, but they only come with a two-year warranty"

From what I can determine, the Jabra Elite 7 Active Pro in-Ear Bluetooth Earbuds are the best option. I'm assuming that my iPhone Bluetooth will go the length of the swimming pool. For the full line of Jabra's, click here. They're $60 off during Amazon Prime 12 - 13 July.

I bought the used versions of the Pimsleur Mandarin level 1 through 4 for the Mandarin and imported the CDs to Apple iTunes. Also, the earbuds won't last long either if you don't use FitGoo.

Health Focus (Dust Mites):