Recent Longevity News for the week ending 5/25/22

Dr. Eric Berg gets fact-checked by MD PhD doctor - YouTube - MD calls out Dr. Berg's misinformation. I've been pointing out Dr. Berg's and Dr. Campbell's misinformation for a long time yet they put out a video and it will get half a million views in the first 12 hours. They're feeding on peoples' ignorance for their seven-figure income. The big money is in bullshit. Dr. Oz is another one. It's the same with politics. People believe the bullshitters over the honest ones.

SGLT-2 inhibitors as First-Line Therapy in Type 2 Diabetes? - Medscape, 5/23/22 - "only two SGLT-2 inhibitors, canagliflozin and empagliflozin, were shown to have a statistically significant association with decreased major adverse cardiovascular events ... In contrast, neither dapagliflozin nor ertugliflozin showed significant benefit regarding those outcomes ... those four major SLGT-2 inhibitor cardiovascular outcomes trials were placebo-controlled rather than head-to-head trials in which they were compared to an active comparator such as metformin ... The majority of patients were followed for a year or less. This is probably sufficient to assess the impact of some pharmacological mechanisms, for example, the beneficial impact to decrease risk of heart failure by promoting urinary sodium excretion. However, it's probably insufficient time to observe a beneficial impact on atherosclerosis. For example, there is typically a lag of several years before statins demonstrate efficacy with respect to adverse cardiovascular events ... Incidence rates per 1000 person-years for the composite of hospitalization for MI, hospitalization for ischemic or hemorrhagic stroke, or all-cause mortality (MI/stroke/mortality) were 15.0 vs 16.2 for SLGT-2 inhibitors vs metformin, not a significant difference (hazard ratio [HR], 0.96) ... However, for the composite of heart failure hospitalization or all-cause mortality, the rates were 18.3 vs 23.5, a significant difference, with an HR of 0.80. The benefit was seen beginning at about 6 months ... Compared with metformin, SGLT-2 inhibitors showed a significantly lower risk for heart failure hospitalization (HR, 0.78), a numerically (but not significantly) lower risk for MI (HR, 0.70), and similar risks for stroke, mortality, and MI/stroke/HHF/mortality ... Metformin is considerably less costly than any of the SGLT-2 inhibitors ― roughly $10 to $20 per month, compared to more than $500 a month" - See empagliflozin inhousepharmacy.vu.

Drinking More Coffee May Reduce Acute Kidney Injury Risk - Medscape, 5/19/22 - "Participants who drank any quantity of coffee every day had an 11% lower risk of acute kidney injury than those who never drank coffee ... but the largest reductions were seen in the group that drank two to three cups a day ... > 3 cups daily: hazard ratio (HR), 0.83 (95% CI, 0.71 - 0.96) ... 2-3 cups daily: HR, 0.83 (95% CI, 0.72 - 0.95) ... 1 cup daily: HR, 1.08 (95% CI, 0.94 - 1.24) ... < 1 cup daily: HR, 0.92 ... Coffee is often demonized, and this is a nice little piece of data saying that a lot of the consensus of what we think about coffee really is not well deserved"

Gout medicine improves survival for heart failure patients, study finds - Science Daily, 5/19/22 - "Researchers reviewed the records of more than 1,000 patients admitted to University of Virginia Medical Center between March 2011 and February 2020 for worsening heart failure. Patients who received colchicine for a gout flare had a survival rate of 97.9%, compared with a 93.5% survival rate for patients not receiving colchicine ... While colchicine is a well-established treatment for gout, the UVA research team believes the medication's anti-inflammatory properties may also be key to improving outcomes for heart failure patients. They think that colchicine may modulate inflammation in the heart and blood vessels with potential for improving outcomes, especially in the acute phases of heart failure hospitalizations"

How cranberries could improve memory and ward off dementia - Science Daily, 5/19/22 - "The research team investigated the impact of eating cranberries for 12 weeks on brain function and cholesterol among 60 cognitively healthy participants ... Half of the participants consumed freeze-dried cranberry powder, equivalent to a cup or 100g of fresh cranberries, daily. The other half consumed a placebo ... the participants who consumed the cranberry powder showed significantly improved episodic memory performance in combination with improved circulation of essential nutrients such as oxygen and glucose to important parts of the brain that support cognition -- specifically memory consolidation and retrieval ... the participants who consumed the cranberry powder showed significantly improved episodic memory performance in combination with improved circulation of essential nutrients such as oxygen and glucose to important parts of the brain that support cognition -- specifically memory consolidation and retrievaln ... The findings of this study are very encouraging, especially considering that a relatively short 12-week cranberry intervention was able to produce significant improvements in memory and neural function" - See cranberry extract at Amazon.com.

Statins may provide protection against depression - Science Daily, 5/17/22 - "Participants taking statins were less likely to recognize fearful or angry faces and more likely to report them as positive, indicating they had reduced negative emotional bias ... taking a statin medication was associated with significantly lower levels of negative emotional bias when interpreting facial expressions; this was not seen with other medications, such as blood pressure medications ... It remains unclear exactly how statins could protect against mental illness, but one possibility is that they may work through anti-inflammatory mechanisms, which have also been implicated in depression" - See red yeast rice at Amazon.com.

Emerging research about psychedelic mushrooms pushes legalization efforts - 10News, 5/12/22 - "So far they say the data regarding benefits to mental health has been pretty strong" - See my psilocybin page.

Ultra-High Dose Drug Slows Functional Decline in Early ALS, Phase 3 Data Show - Medscape, 5/12/22 - "Methylcobalamin, an active form of vitamin B12 analogue, helps eliminate homocysteine, which is neurotoxic and induces oxidative stress, mitochondrial dysfunction, inflammation, and motor neuron death. Plasma homocysteine levels are reported to be elevated in patients with ALS ... In the 90% of patients taking riluzole concomitantly, the difference in favor of methylcobalamin was even greater (–2.11 ... The results suggest that riluzole and ultrahigh-dose methylcobalamin not only have an additive but possibly also a synergistic effect"

Cannabis-Related ED Visits Increased 18-fold for Older Californians - Medscape, 5/12/22 - "Researchers in California found an 18-fold increase in the rate cannabis-related trips to the emergency department visits among adults over age 65 in the state from 2005 to 2019 ... "very little" is understood about the risks and benefits of cannabis use in the elderly"

Large study in Botswana finds daily micronutrient supplementation during pregnancy reduces complications at birth - Science Daily, 5/12/22 - "iron and folic acid supplementation (IFAS), as well as iron and folic acid plus essential vitamins and trace minerals (multiple micronutrient supplementation, or MMS), are associated with significantly lower rates of babies born at low birthweight and other complications at birth, compared to iron or folic acid alone ... Compared to IFAS, women who initiated MMS use saw significantly lower rates of preterm delivery, very preterm delivery, low birthweight, very low birthweight, and caesarean delivery. The rate of low-birthweight birth, for example, was 10.48 percent for women on MMS. Similarly, the rate of preterm birth was 12.68 percent for the women taking IFAS, and 11.63 percent for those taking MMS" - See prenatal supplements at Amazon.com.

Another Ivermectin-COVID-19 Paper Is Retracted - Medscape, 5/11/22 - "A paper on the potential use of ivermectin to treat Covid-19 has been retracted for a litany of flaws, joining at least 10 other articles on the therapy some liked to promote without evidence to fall"

My Choice? Unvaccinated Pose Outsize Risk to Vaccinated - Medscape, 5/10/22 - "The unvaccinated increasingly became the source of infection, however ... When the vaccinated and unvaccinated mix, indirect protection is conferred upon the unvaccinated by the buffering effect of vaccinated individuals, and by contrast, risk in the vaccinated goes up" - Note: This is why I get so pissed at the anti-vaxxers. It's all about them. When they spread it to people with underlying conditions, it's a death sentence.

Columbia University Medical Center Cuts Ties With Dr Oz - Medscape, 5/6/22 - "Columbia has faced heat for its affiliation with Oz for years, extending beyond his decision to run for a Senate seat. In 2015, when he testified before the Senate about his endorsement of "miracle" cures, a group of medical professionals sent a letter to Columbia that demanded that Oz be fired ... Dr. Oz has repeatedly shown disdain for science and for evidence-based medicine, as well as baseless and relentless opposition to the genetic engineering of food crops ... Worst of all, he has manifested an egregious lack of integrity by promoting quack treatments and cures in the interest of personal financial gain ... Oz has drawn criticism from the medical community for years for supporting sham supplements and weight loss products ... he appeared on Fox News nearly two dozen times to back hydroxychloroquine" - Note: It goes along with what I've been saying nearly every day. Lies sell. They feed on peoples' ignorance for financial gain, all the requirements for being a politician. Too bad they can't go after people like Dr. Campbell and Dr. Berg who are also promoting snake oil and going by their views on YouTube, they're making $300,000 per year selling their lies.

Probiotic Improves Symptoms of Irritable Bowel Syndrome - Medscape, 5/9/22 - "After the 30-day treatment period with B longum 35624, a significant decrease in IBS severity was observed, compared with baseline. The IBS-SSS score went from 303 to 208 (P < .001). More than half of the patients (57%) experienced an overall decrease in their symptoms. The rate of severe symptoms decreased from 46.6% to 20%; moderate symptoms decreased from 48.1% to 36.1%; mild symptoms increased from 4.7% to 35.2%; and 8.7% of patients were in remission after the treatment vs 0.9% before. A significant improvement in disease severity (more than a 50-point decrease in the IBS-SSS score) was observed in 65.7% of patients, regardless of the IBS subtype ... After 30 days of treatment, a significant improvement in quality of life was noted in the patients (IBS-QOL score 68.8 vs 60.2, P < .001), and more than 6 out of 10 (63%) were satisfied with the treatment" - See probiotic supplements at Amazon.com.

Can Fecal Transplants Help Reverse Aging? - Medscape, 5/12/22 - "Transplanting fecal microbiota from young mice into older mice can reverse signs of aging in the gut, brain, and eyes, a team of scientists from the United Kingdom has found. Conversely, transplanting microbiota from old mice to young mice has the opposite effect ... Age-related changes in diversity, composition, and function of the gut microbiota are associated with low-grade systemic inflammation, declining tissue function, and increased susceptibility to age-related chronic diseases ... Targeting the gut-brain axis in aging, by modification of microbial composition to modulate immune and metabolic pathways, may therefore be a potential avenue for therapeutic approaches to age-associated inflammatory and functional decline" - See probiotic supplements at Amazon.com.

Gut Bacteria Linked to Stroke Severity, Risk - Medscape, 5/6/22 - "Gut microbiota have been implicated in dementia risk, cardiovascular disease, and multiple sclerosis relapse. Prior research has also pointed to a possible link between gut bacteria and stroke ... A potential future development of our study would be to investigate the effects of altering the gut microbiota of patients at high risk of stroke by giving them probiotics, prebiotics, or performing fecal matter transplants and measuring whether their risk of stroke is reduced ... The exact mechanisms by which gut bacteria might influence neurologic conditions such as stroke are uncertain, but one possibility is that they could cause changes to the immune system" - See probiotic supplements at Amazon.com and prebiotic supplements at Amazon.com.

Abstracts from this week:

Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients - Support Care Cancer 2022 May 21 - "Paclitaxel and doxorubicin are associated with neurotoxicity and cardiotoxicity respectively ... Patients were assessed by National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE version 4.0) for grading of neuropathy and by 12-item neurotoxicity questionnaire (Ntx-12) ... As compared to placebo, ALA provoked significant improvement in NCI-CTCAE neuropathy grading and Ntx-12 score after the end of 9th and 12th weeks of paclitaxel intake ... Alpha-lipoic acid may represent a promising adjuvant therapy to attenuate paclitaxel-associated neuropathy and doxorubicin-induced cardiotoxicity in women with breast cancer" - See alpha lipoic acid at Amazon.com.

Comparative evaluation of flavonoids reveals the superiority and promising inhibition activity of silibinin against SARS-CoV-2 - Phytother Res 2022 May 21 - "Flavonoids are phenolic compounds naturally found in plants and commonly consumed in diets ... The results obtained revealed 10 flavonoids with potential antiviral activity. Out of them, silibinin showed promising selectivity index against SARS-CoV-2 in vitro. Screening against S protein discloses the highest inhibition activity of silibinin ... Silibinin was tested safe on human mammalian cells at >7-fold its IC50(SARS-CoV-2) . Additionally, silibinin exhibited >90% virucidal activity at 0.031 μM. Comparative molecular docking (MD) showed that silibinin possesses the highest binding affinity to S protein and RdRP at -7.78 and -7.15 kcal/mol, respectively. MDs showed that silibinin exhibited stable interaction with key amino acids of SARS-CoV-2 targets. Collectively, silibinin, an FDA-approved drug, can significantly interfere with SARS-CoV-2 entry and replication through multi-targeting activity" - See silibinin at Amazon.com.

Vitamin D levels during pregnancy are associated with offspring telomere length: a longitudinal mother-child study - J Clin Endocrinol Metab 2022 May 19 - "Childhood LTL was positively correlated with total maternal 25(OH)D (0.048 ± 0.017)(p=0.004) and maternal 3-epi-25(OH)D3 (0.05 ± 0.017)(p=0.003), even after adjustment for covariates" - See vitamin D at Amazon.com.

The Relationship between Dietary Copper intake and Telomere Length in Hypertension - J Nutr Health Aging 2022;26(5): - "one unit increasing log-transformed dietary copper in hypertension was associated with longer telomere length (β = 237.95, 95% CI: 114.39, 361.51) in the age group >45 years. The grouping was based on whether the participants take medication for hypertension. We found that one unit increasing log-transformed dietary copper in hypertension was associated with longer telomere length (β = 116.47, 95% CI: 0.72, 232.21) in the group that takes medication for hypertension" - See copper supplements at Amazon.com.

Canagliflozin and Atrial Fibrillation in Type 2 Diabetes Mellitus: A secondary analysis from the CANVAS Program and CREDENCE trials and meta-analysis - Diabetes Obes Metab 2022 May 19 - "atrial fibrillation/flutter (AF/AFL) ... Meta-analysis suggests SGLT2 inhibition reduces AF/AFL incidence" - See empagliflozin inhousepharmacy.vu.

Oral anticoagulants and outcomes in adults ≥80 years with atrial fibrillation: A global federated health network analysis - J Am Geriatr Soc 2022 May 19 - "oral anticoagulation (OAC) ... non-vitamin-K antagonist oral anticoagulant (NOAC) ... Use of a NOAC was associated with improved outcomes compared to warfarin, and compared to no OAC, except for a small but statistically significant higher risk of major bleeding"

Skin dryness induced in the KK-Ay/TaJcl type 2 diabetes mouse model deteriorates following dapagliflozin administration - Biol Pharm Bull 2022 May 17 - "SGLT-2 inhibitors cause skin dryness ... Dapagliflozin treatment decreased collagen type I and hyaluronic acid levels in mice; additionally, it affected the TGF-β/hyaluronan synthase pathway, further reducing hyaluronic acid levels. The results indicate that the reduction in hyaluronic acid levels plays an important role in the occurrence of dry skin in diabetes" - See collagen supplements at Amazon.com and hyaluronic acid at Amazon.com.

Impact of curcumin, quercetin, or resveratrol on the pathophysiology of endometriosis: A systematic review -  Phytother Res 2022 May 18 - "Endometriosis, a gynecological disease that affects reproductive age women is difficultly controlled in the long term by currently available treatments, prompting patients to adopt self-controlled interventions including dietary changes ... By acting on mechanisms of inflammation, oxidative stress, cell proliferation, invasion and adhesion, apoptosis, angiogenesis and glucose and lipid metabolism, curcumin, quercetin, and resveratrol showed to have beneficial effects, evidencing their potential application in the endometriosis treatment" - See curcumin at Amazon.com, quercetin at Amazon.com and resveratrol products at Amazon.com.

The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects - Phytother Res 2022 May 18 - "The prevalence of chronic diseases has increased significantly with the rising trend of sedentary lifestyles, reduced physical activity, and dietary modifications in recent decades. Inflammation and oxidative stress play a key role in the pathophysiology of several chronic diseases, such as type II diabetes, cardiovascular diseases, and hepatic conditions. Therefore, reducing inflammation and oxidative stress may be beneficial in the prevention and treatment of various chronic disorders ... Complementary therapies and the use of natural antioxidant and antiinflammatory compounds are among these novel approaches. Pycnogenol (PYC) is a natural compound that could control inflammation and oxidative stress. Furthermore, some previous studies have shown that PYC could effectively reduce inflammation through signaling the downstream of insulin receptors, inhibiting the phosphorylation of the serine residues of insulin receptor substrate-1, reducing pro-inflammatory cytokines and oxidative stress indices through the stimulation of antioxidant pathways, increasing free radical scavenging activities, preventing lipid peroxidation, and protecting the erythrocytes in glucose-6-phosphate dehydrogenase-deficient individuals, although these effects have not been fully proved" - See Pycnogenol at Amazon.com.

Spermidine Ameliorates Nonalcoholic eatohepatitis through Thyroid Hormone-Responsive Protein Signaling and the Gut Microbiota-Mediated Metabolism of Bile Acids - J Agric Food Chem 2022 May 18 - "Spermidine, a natural polyamine and physiological autophagy inducer, is involved in various physiological processe ... We found that daily spermidine intake was significantly lower in volunteers with liver dysfunction than the healthy controls, and the serum and fecal spermidine levels were negatively correlated with the NASH phenotypes. Spermidine supplementation significantly attenuated hepatic lipid accumulation, insulin resistance, hepatic inflammation, and fibrosis in NASH mice induced by a western diet. The ameliorating effect of spermidine on lipid accumulation might be partly regulated by thyroid hormone-responsive protein (THRSP) signaling and autophagy. Moreover, spermidine altered the profile of hepatic bile acids (BAs) and microbial composition and function. Furthermore, spermidine reversed the progression of hepatic steatosis, inflammation, and fibrosis in mice with preexisting NASH. Therefore, spermidine ameliorates NASH partly through the THRSP signaling and the gut microbiota-mediated metabolism of BAs, suggesting that spermidine might be a viable therapy for NASH" - See spermidine at Amazon.com.

Dietary soybeans worsen dextran sodium sulfate-induced colitis by disrupting intestinal ecology - Food Funct 2022 May 18 - "the intake of soybeans and soybean carbohydrates is not conducive to recovery from IBDs based on changes in gut microbiota and metabolites affecting the activities of macrophages."

The impact of prebiotic fructooligosaccharides on gut dysbiosis and inflammation in obesity and diabetes related kidney disease - Food Funct 2022 May 18 - "Recent studies have reported that gut dysbiosis aggravates the progression of obesity and diabetes by increasing the production of uremic toxins in conjunction with gut barrier dysfunction which then leads to increased passage of lipopolysaccharides (LPS) into the blood circulatory system eventually causing systemic inflammation. Therefore, the modification of gut microbiota using a prebiotic supplement may assist in the restoration of gut barrier function and reduce any disturbance of the inflammatory response ... The evidence confirms that FOS supplementation could improve the pathological changes associated with obesity and diabetes related kidney disease, however, knowledge concerning the mechanisms involved is still limited and needs further elucidation" - See inulin at Amazon.com.

Circulating free testosterone and risk of aggressive prostate cancer: prospective and Mendelian randomization analyses in international consortia - Int J Cancer 2022 May 17 - "In blood-based analyses there was no association with aggressive disease overall, but there was heterogeneity by age at blood collection (OR for men aged <60 years 1.14, CI=1.02-1.28; Phet =0.0003: inverse association for older ages). Associations for free testosterone were positive for overall prostate cancer (MR:1.20,1.08-1.34; blood-based:1.03,1.01-1.05) and early-onset prostate cancer (MR:1.37,1.09-1.73; blood-based:1.08,0.98-1.19). SHBG and total testosterone were inversely associated with overall prostate cancer in blood-based analyses, with null associations in MR analysis. Our results support free testosterone, rather than total testosterone, in the development of prostate cancer, including aggressive subgroups"

Pleiotropic effects of SGLT2 inhibitors and heart failure outcomes - Diabetes Res Clin Pract 2022 May 13 - "Heart failure (HF) represents a major public health concern with increasing prevalence among aging populations, with multifactorial pathophysiology including inflammation, oxidative stress, endothelial dysfunction, and fibrosis, among others. Lately, the use of sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally destined for the treatment of type 2 diabetes mellitus, have revolutionized the treatment of HF ... Owing to the results of experimental studies, several pleiotropic effects of SGLT2 inhibitors have been proposed, including the restoration of autophagy which may be significant in the reversal of the aforementioned HF pathophysiology according to a latest hypotheses. Additional mechanisms consist of the regulation of inflammatory, oxidative, and fibrotic pathways, together with the improvement of endothelial function and reduction of epicardial adipose tissue. Other than their role as antidiabetic agents, a reduction in heart failure hospitalizations has been noted following their use in clinical trials, irrespective of DM status and degree of systolic dysfunction" - See empagliflozin at ihouseepharmacy.

The association between caffeine intake and testosterone: NHANES 2013-2014 - Nutr J 2022 May 17 - "These findings suggest a potential role for caffeine's contribution to the etiology of low testosterone and biochemical androgen deficiency" - Note: Caffeine increase SHBG which binds with testosterone. They might be the pathway.

Arginine catabolism metabolites and atrial fibrillation or heart failure risk: two case-control studies within the PREDIMED trial - Am J Clin Nutr 2022 May 16 - "Inverse associations with incident AF were observed for arginine [OR per 1 SD (95% CI): 0.83 (0.73, 0.94)]) and homoarginine [0.87 (0.76, 0.98)], whereas positive associations were found for the asymmetric dimethylarginine/symmetric dimethylarginine ratio (ADMA/SDMA) [1.15 (1.01, 1.31)] and citrulline [1.19 (1.01, 1.39)]. For HF, inverse associations were found for arginine [0.82 (0.69, 0.97)] and homoarginine [0.81 (0.68, 0.96)], and positive associations for the ADMA/SDMA ratio [1.19 (1.02, 1.41)], N1-acetylspermidine [1.34 (1.12, 1.60)], and diacetylspermine [1.20 (1.02, 1.41)]. In the stratified analysis according to the dietary intervention, the lower HF risk associated with arginine was restricted to participants in the MedDiet groups" - See arginine products at Amazon.com.

Effects of vitamin C supplementation on gout risk: results from the physicians' health study II trial - Am J Clin Nutr 2022 May 16 - "The incidence rate of new gout diagnoses during follow-up was 8.0 per 1,000 person-years among those assigned vitamin C versus 9.1 per 1,000 person-years among those assigned placebo. The vitamin C assignment reduced new gout diagnoses by 12% (HR 0.88; 95% CI: 0.77, 0.99; P = 0.04). These effects were greatest among those with a BMI <25 kg/m2" - See vitamin C products at Amazon.com.

Serum Omega-3 Fatty Acids and Cognitive Domains in Community-Dwelling Older Adults From the Nuage Study: Exploring the Associations with Other Fatty Acids and Sex - J Nutr 2022 May 16 - "Higher n-3 PUFA concentrations were associated with better non-verbal memory and processing speed in fully adjusted models not including other LCFAs (betas of 0.21 and 0.19, respectively). The magnitude of these associations varied when other LCFAs were entered in the model (betas of 0.27 and 0.32, respectively) or when FA-PCA factors were considered (betas of 0.27 and 0.21, respectively). Associations with verbal episodic memory were limited to higher concentrations of eicosapentaenoic acid whereas there was no association between n-3 PUFAs and executive functioning. Higher n-3 PUFAs were associated with better verbal and non-verbal episodic memory in females, and with better executive functioning and processing speed in males" - See omega-3 supplements at Amazon.com.

Molecular Mechanism of Curcumin and Its Analogs as Multifunctional Compounds against Pancreatic Cancer - Nutr Cancer 2022 May 18 - "Research evidence suggests that curcumin can influence PC development through multiple molecular mechanisms. The synthesis of novel curcumin analogs and preparation of curcumin nano-formulations are effective strategies to overcome the low bioavailability of curcumin in the treatment of PC. This review aims to summarize the mechanisms of action of curcumin in preclinical and clinical studies on PC and research progress in enhancing its bioavailability" - See curcumin at Amazon.com.

The effect of curcumin supplementation on delayed-onset muscle soreness, inflammation, muscle strength, and joint flexibility: A systematic review and dose-response meta-analysis of randomized controlled trials - Phytother Res 2022 May 16 - "To quantify the effects of curcumin supplementation on exercise-induced muscle damage, muscle soreness, inflammatory biomarkers, muscle strength, and joint flexibility via assessment of creatine kinase (CK), visual analogue scale (VAS) score, maximal voluntary contraction (MVC), and range of motion (ROM), respectively ... Meta-analysis showed that curcumin supplementation significantly reduced serum CK activity [WMD = -65.98 IU/L, 95% CI (-99.53 to -32.44)], muscle soreness [WMD = -0.56, 95% CI (-0.84 to -0.27)], and TNF-α concentration [WMD = -0.22 pg/ml, 95% CI (-0.33 to -0.10)]. Also, curcumin supplementation elicited significant improvements in MVC [WMD = 3.10 nm, 95% CI (1.45-4.75)] and ROM [WMD = 6.49°, 95% CI (3.91-9.07)], although no significant changes in IL-6 and IL-8 levels were found. Dose-response analysis indicated that there is a significant non-linear association between the daily dose and the final effect size regarding TNF-α. Curcumin supplementation may improve some aspects of DOMS, including muscle damage, muscle soreness, inflammation, muscle strength, and joint flexibility" - See curcumin at Amazon.com.

Prenatal choline supplementation improves biomarkers of maternal docosahexaenoic acid status among pregnant participants consuming supplemental DHA: a randomized controlled trial - Am J Clin Nutr 2022 May 16 - "Prenatal choline supplementation improves hepatic DHA export and biomarkers of DHA status by bolstering methyl group supply for PEMT activity among pregnant participants consuming supplemental DHA" - See citicholine at Amazon.com nad docosahexaenoic acid at Amazon.com.

Docosahexaenoic acid-acylated curcumin diester alleviates cisplatin-induced acute kidney injury by regulating the effect of gut microbiota on the lipopolysaccharide- and trimethylamine- N-oxide-mediated PI3K/Akt/NF-κB signaling pathway in mice - Food Funct 2022 May 16 - "An increasing number of studies have reported the effects of curcumin (Cur) and docosahexaenoic acid (DHA) on alleviating acute kidney injury (AKI) ... An increasing number of studies have reported the effects of curcumin (Cur) and docosahexaenoic acid (DHA) on alleviating acute kidney injury (AKI). In this work, we have performed a comparative investigation to determine the effect of dietary DHA-acylated Cur esters, ester derivatives of Cur, and recombination of curcumin and DHA on alleviating acute kidney injury in a mouse model induced by a single intraperitoneal injection with cisplatin (20 mg kg-1). The results showed that the DHA-acylated Cur diesters significantly decreased the abnormally increased blood urea nitrogen, creatinine, lipopolysaccharide (LPS) and trimethylamine-N-oxide (TMAO) in serum caused by AKI ... the DHA-acylated Cur diester treatment remarkably changed the relative abundance of microbiota related to LPS and TMAO/trimethylamine (TMA) metabolism. Moreover, dietary DHA-acylated Cur diesters clearly reduced the MDA content and elevated GSH levels in the kidney of AKI mice, as well as changed the fatty acid composition in the kidney. Further mechanism studies showed that DHA-acylated Cur diesters significantly inhibited inflammation, apoptosis and oxidative stress by preventing the LPS and TMAO-mediated PI3K/Akt/NF-κB signaling pathway. The above results indicate that DHA-acylated Cur diesters are a potentially novel candidate or targeted dietary pattern to prevent and treat drug-induced acute kidney injury" - See docosahexaenoic acid at Amazon.com and curcumin at Amazon.com.

Berberine Alleviates Gastroesophageal Reflux-Induced Airway Hyperresponsiveness in a Transient Receptor Potential A1-Dependent Manner - Evid Based Complement Alternat Med 2022 May 9 - "gastroesophageal reflux-induced airway hyperresponsiveness (GERAHR) ... Berberine, especially at the middle dose tested (MB, 150 mg/kg), significantly improved lung function, suppressed inflammatory cell infiltration, and protected inflammation-driven tissue damage in the lung, trachea, esophagus, and nerve tissues in GERAHR guinea pigs. MB reduced the expression of TRPA1, SP, and tumor necrosis factor-alpha (TNF-α) in evaluated organs and tissues. Meanwhile, the MB-mediated protective effects were attenuated by simultaneous TRPA1 activation ... Mechanistically, berberine was found to suppress GERAHR-induced upregulation of TRPA1, SP, and TNF-α in many tissues. Our study has highlighted the potential therapeutic value of berberine for the treatment of GERAHR" - See berberine at Amazon.com.

Berberine as a Potential Agent for the Treatment of Colorectal Cancer - Front Med (Lausanne) 2022 Apr 28 - "Numerous studies have shown that berberine (BBR) is a safe and effective agent presenting significant antitumor effects ... The review emphasizes several therapeutic effects of BBR and confirms that BBR could suppress CRC by modulating gene expression, the cell cycle, the inflammatory response, oxidative stress, and several signaling pathways. In addition, BBR also displays antitumor effects in CRC by regulating the gut microbiota and mucosal barrier function" - See berberine at Amazon.com.

Lactiplantibacillus plantarum J-15 reduced calcium oxalate kidney stones by regulating intestinal microbiota, metabolism, and inflammation in rats - FASEB J 2022 Jun - "The prevention role of Lactiplantibacillus plantarum against the formation of kidney stones has been increasingly recognized; its mechanism, however, has mainly been focused on inhibiting the inflammation in the colon in the gastrointestinal (GI) system, and the intestinal metabolites from microflora have not been revealed fully with regarding to the stone formation ... L. plantarum J-15 effectively reduced renal crystallization and urinary oxalic acid. Ten microbial genera, including anti-inflammatory and SCFAs-related Faecalibaculum, were enriched in the J-15 treatment group. There are 136 metabolites from 11 categories significantly different in the J-15 supplementation group compared with CaOx model rats, most of which were enriched in the amino acid metabolic and secondary bile acid pathways. The expression of intestinal tight junction protein Occludin and the concentration of pro-inflammatory cytokines and prostaglandin were decreased in the intestine, which further reduced the translocated lipopolysaccharide and inflammation levels in the blood upon J-15 treatment. Thus, the inflammation and injury in the kidney might be alleviated by downregulating TLR4/NF-κB/COX-2 signaling pathway. It suggested that L. plantarum J-15 might reduce kidney stone formation by restoring intestinal microflora and metabolic disorder, protecting intestinal barrier function, and alleviating inflammation. This finding provides new insights into the therapies for renal stones" - See Lactiplantibacillus plantarum at Amazon.com.

EEffect of Probiotic Bifidobacterium breve in Improving Cognitive Function and Preventing Brain Atrophy in Older Patients with Suspected Mild Cognitive Impairment: Results of a 24-Week Randomized, Double-Blind, Placebo-Controlled Trial - J Alzheimers Dis 2022 May 7 - "Probiotics consumption for 24 weeks suppressed brain atrophy progression, suggesting that B. breve MCC1274 helps prevent cognitive impairment of MCI subjects" - See probiotic supplements at Amazon.com.

Gut Microbiota and Subjective Memory Complaints in Older Women - J Alzheimers Dis 2022 May 9 - "Our findings support an association between alterations in the gut bacterial composition and cognitive dysfunction" - See probiotic supplements at Amazon.com.

Alterations in Bacterial Metabolism Contribute to the Lifespan Extension Exerted by Guarana in Caenorhabditis elegans - Nutrients 2022 May 9 - "Guarana (Paullinia cupana) is a widely consumed nutraceutical with various health benefits supported by scientific evidence ... guarana was found to decrease E. coli folate production, revealing one possible route for its beneficial effects" - See guarana at Amazon.com.

Adherence to the Mediterranean-style diet and high intake of total carotenoids reduces the odds of frailty over 11 years in older adults: Results from the Framingham Offspring Study - Am J Clin Nutr 2022 May 12 - "Our findings suggest that adherence to a Mediterranean-style diet and higher total carotenoid intake is associated with frailty prevention over time, particularly in adults <60y" - See mixed carotenoids at Amazon.com.

T cells: a ‘hidden corner’ to be explored for treating heart failure - European Heart Journal, ehac241 , 13 May 22 - Interesting article. I think it's saying that t-cells inhibit the repair of the heart. I've been taking rapamycin for anti-aging but I was worried because it inhibits t-cells but ever since I've been taking it, I've felt on top of the world. Maybe the t-cell inhibition and the subsequent heart repair is the reason. See rapamycin at ReliableRXPharmacy.

• Adult T-cells impair neonatal cardiac regeneration - European Heart Journal, ehac188 13 Apr 22 - "Patients who survive a myocardial infarction (MI) often develop chronic heart failure due to the heart’s poor regeneration capacity. We hypothesized that the cardiac ‘regenerative-to-scarring’ transition might be driven by the perinatal shifts observed in the circulating T-cell compartment ... The perinatal loss of myocardial regenerative capacity was paralleled by a baseline increase in αβ-T cell (CD4+ and CD8+) numbers ... The perinatal loss of myocardial regenerative capacity was paralleled by a baseline increase in αβ-T cell (CD4+ and CD8+) numbers. Strikingly, P1-infarcted mice reconstituted with adult T-cells shifted to an adult-like healing phenotype, marked by irreversible cardiac functional impairment and increased fibrosis. Infarcted neonatal mice harbouring adult T-cells also had more monocyte-derived macrophage recruitment, as typically seen in adults. At the transcriptome level, infarcted P1 hearts that received isolated adult T-cells showed enriched gene sets linked to fibrosis, inflammation, and interferon-gamma (IFN-γ) signalling ... Physiological T-cell development or adoptive transfer of adult IFN-γ-producing T-cells into neonates contributed to impaired cardiac regeneration and promoted irreversible structural and functional cardiac damage. These findings reveal a trade-off between myocardial regenerative potential and the development of T-cell competence"

The Increasing Role of Rhythm Control in Patients With Atrial Fibrillation: JACC State-of-the-Art Review - J Am Coll Cardiol 2022 May 17 - "typically antiarrhythmic drugs and/or AF ablation ... rhythm control may effectively reduce irreversible atrial remodeling and prevent AF-related deaths, heart failure, and strokes in high-risk patients. It has the potential to halt progression and potentially save patients from years of symptomatic AF; therefore, it should be offered more widely"

Anti-invasive and anti-metastatic activity of capsaicin and natural capsaicin-like compounds in lung adenocarcinoma - FASEB J 2022 May - "Lung adenocarcinoma (LAC) accounts for about 65% of all non-small cell lung cancer (NSCLC) cases. A considerable proportion of LAC patients present (in the clinic) with local and distant metastasis at the time of their diagnosis. One of the earliest events of the metastatic pathway is the invasion of malignant cells through the surrounding extracellular basement membrane into the neighboring blood vessels and lymph nodes ... Capsaicin is the pungent ingredient of chili peppers. Published reports have revealed that capsaicin inhibits the invasion and metastasis of several types of human cancers including melanoma, prostate cancer, and cholangiosarcoma ... capsaicin inhibits the invasion of human LAC cells via the TRPV6 receptor and the tyrosine phosphatase activity pathway" - See capsicum at Amazon.com.

Consumption of flavonoids and risk of hormone-related cancers: a systematic review and meta-analysis of observational studies - Nutr J 2022 May 11 - "The present study suggests evidence that intake of total flavonoids, flavonols, flavones, flavanones, flavan-3-ols and isoflavones would be associated with a lower or higher risk of HRCs, which perhaps provides guidance for diet guidelines to a certain extent" - See blueberry extract at Amazon.com.

Lactoferrin modulates gut microbiota and Toll-like receptors (TLRs) in mice with dysbiosis induced by antibiotics - Food Funct 2022 May 1 - "Antibiotic administration can result in gut microbiota and immune system alterations that impact health. Bovine lactoferrin is a milk protein with anticancer, anti-inflammatory, antimicrobial and immune modulatory activities ... In a situation of intestinal dysbiosis induced by clindamycin, lactoferrin restores the normal levels of some anti-inflammatory bacteria and TLRs and, therefore, could be a good ingredient to be added to functional foods" - See lactoferrin at Amazon.com.

Triad3A-Dependent TLR4 Ubiquitination and Degradation Contributes to the Anti-Inflammatory Effects of Pterostilbene on Vascular Dementia - J Agric Food Chem 2022 May 9 - "Pterostilbene, a methylated stilbene derived from many plant foods, has significant anti-inflammatory activity. Meanwhile, vascular dementia (VaD) is the second most common subtype of dementia, in which inflammation is one of the major pathogenic contributors ... Y-maze and Morris water maze tests showed pterostilbene-attenuated cognitive impairment in mice with bilateral common carotid artery occlusion (BCCAO). The hippocampal neuronal death and microglial activation in BCCAO mice were also reduced by pterostilbene treatment. Further, pterostilbene inhibited the expression of TLR4 and downstream inflammatory cytokines in these mice, with similar results observed in an oxygen-glucose deprivation and reperfusion (OGD/R) BV-2 cell model. In addition, its anti-inflammatory effect on OGD/R BV-2 cells was partially blocked by TLR4 overexpression. Moreover, Triad3A-TLR4 interactions were increased by pterostilbene following enhanced ubiquitination and degradation of TLR4, and the inhibitory effect of pterostilbene on inflammation was blocked by Triad3A knockdown in OGD/R-stimulated BV-2 cells. Together, these results reveal that pterostilbene could reduce vascular cognitive impairment and that Triad3A-mediated TLR4 degradation might be the key target" - See pterostilbene at Amazon.com.

Neat Tech Stuff / "How To's":

I saw one of these advertised on Facebook but this one on Amazon looks to be much better quality./span>

Like Dr. Berg and Dr. Campbell "succeed with fraud". I'll bet they're making seven figures on YouTube pushing snake oil while I work hard showing scientific evidence. I see responsible YouTube channels getting 6.000 views in a year then see the ones selling snake oil getting that many views in five minutes.

Health Focus (Silica):