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Recent Longevity News for the week ending 3/16/22

What Is the Healthiest Salt for You? - Medscape, 2/28/22 - "Potassium chloride substitution in staple foods such as bread and bread products have serious and potentially fatal consequences for people who need to restrict dietary potassium. Improved food labeling is required for consumers to avoid excessive consumption" -  Note: It's true that people on some medications can retain too much potassium but in most people they don't get enough potassium. I feel that nearly everyone should be using Lite salt and not even have regular salt in their household. There was a study about a couple of months ago that said that you potassium should be in the upper third of normal. 4.5 to 5.0. See Morton Salt Lite Salt, 11 oz, 2 pk at Amazon.com.

Eating protein from a greater variety of sources may lower risk of high blood pressure - Science Daily, 3/10/22 - "Participants were given a protein "variety score" based on the number of different sources of protein eaten out of 8 reported: whole grains, refined grains, processed red meat, unprocessed red meat, poultry, fish, egg and legumes. One point was given for each source of protein, with a maximum variety score of 8. The researchers then evaluated the association for new onset hypertension in relation to the protein variety score ... Compared to participants with the lowest variety score for protein intake (less than 2), those with the highest variety score (4 or higher) had a 66% lower risk of developing high blood pressure."

High Fructose Intake May Trigger Fatty Liver Disease - Medscape, 3/7/22 - "A high intake of fructose may increase the risk of nonalcoholic fatty liver disease, in which too much fat is stored in liver cells ... Researchers found that consuming a high-fructose diet for long periods can lead to a deterioration of the layer of cells that creates the intestinal barrier that prevents bacteria and toxins from leaking into the bloodstream and affecting the liver ... Fatty liver disease can lead to liver inflammation and liver damage, resulting in nonalcoholic steatohepatitis, a more aggressive disease that in turn can progress to scarring of the liver (cirrhosis), liver cancer, and liver failure ... Severe fatty liver disease and liver tumors from the gut barrier deterioration created by excessive fructose intake can be prevented with medications"

Dietary Fiber Tied to Lower Dementia Risk - Medscape, 3/7/22 - "Investigators administered a dietary survey to 3700 healthy adults at midlife and then followed them for up to 20 years. They found that participants who consumed the most fiber had approximately a 25% lower risk of developing dementia in later life ... This study showed that people with a high intake of dietary fiber, especially soluble fiber, have a lower risk of dementia ... Brain-gut interaction has recently received attention for its potential involvement in the development of dementia ... A diet high in soluble fiber attenuates neuroinflammation in mouse models. Other animal studies have suggested that insoluble fiber might also have a beneficial effect on the microbiome"

  • Nutrition and healthy eating - Mayo Clinic - "Soluble fiber. This type of fiber dissolves in water to form a gel-like material. It can help lower blood cholesterol and glucose levels. Soluble fiber is found in oats, peas, beans, apples, citrus fruits, carrots, barley and psyllium ... Insoluble fiber. This type of fiber promotes the movement of material through your digestive system and increases stool bulk, so it can be of benefit to those who struggle with constipation or irregular stools. Whole-wheat flour, wheat bran, nuts, beans and vegetables, such as cauliflower, green beans and potatoes, are good sources of insoluble fiber."

More alcohol, less brain: Association begins with an average of just one drink a day - Science Daily, 3/4/22 - "Researchers analyzed data from more than 36,000 adults that found a link between drinking and reduced brain volume that begins at an average consumption level of less than one alcohol unit a day -- the equivalent of about half a beer -- and rises with each additional drink"

In my last three newsletters I’ve been pointing out how people prefer BS over the truth and that that’s where the money is. This CNN 3/3/22 segment says the exact same thing. Look at Fox News, Trump, the 64-year-old U.K. nurse with a Ph.D., Dr. John Campbell, who looks like he’s 85 who puts out misinterpretations and lies praising ivermectin and downplaying vaccines and gets millions of views on YouTube every day, etc. CNN claims people just want to believe in miracles. They’re being too kind, they’re gullible.

More on how BS sells. 700,000 views in 22 hours. Same for people like Tucker Carlson, Sean Hannity, Trump, Fox News in general, etc. Dr. Campbell even comes across as deranged yet just like Trump, people love him. He has to be the biggest snake oil salesman in history. I just don't get it but that's were the big money is. Garry IQ of 190 Kasparov might have the answer. In layman terms, he thinks it's deterioration of the mind from poor life style such as drinking, smoking, poor diet, etc. That said, would I do it over again and become rich selling lies? Nope.

Athletes Face Twice the Odds for A-Fib - WebMD, 7/13/21 - "Overall, athletes had about a 2.5 times higher risk of a-fib than non-athletes. But when the researchers focused on participants without heart disease risk factors (such as type 2 diabetes and high blood pressure), they found that athletes had nearly four times the risk of a-fib compared to non-athletes" Note: I’ve probably out-jogged and out-swam the average athlete by a factor of 4 so my odds of afib should be about 10 times higher than the average non-athlete. I've got premature ventricular contractions (PVCs) which is an electrical problem in the lower chamber of the heart vs. afib which is the upper chamber.  Here's my store along with two stories of old athletes like me with the same problem:

  • Thought that I’d breathed my last on Tuesday, 3/8/22. I was baking a pumpkin pie when my premature ventricular contractions kicked in. I knew I’d pass out if I didn’t hit the floor. I waited but this time they weren’t going away. No one was home so I literally crawled upstairs to get the FOB for my Tesla and crawled all the way to the Tesla and drove to the emergency room with my head spinning the whole time. When I got to the ER, I lucked out. There was a perfect parking place just across the ramp for the ambulance drop-off, but I was too far gone to even get across the ramp. I got down on my hands and knees again and called for help. Someone saw me and brought a wheelchair.

    Then the check-in. You must go through two people. About a year ago, Scripps’ servers were hacked, and they refused to pay the ransom, so they rebuild their system from scratch. I don’t think they bought enough servers because ever since their computers have been very slow plus they crash a lot. I’m barely maintaining consciousness while it seems like those ladies at the computer were just staring at the screen.

    They gave me an EKG in the hallway but then there was no emergency room available. Probably because of Covid. As a matter of fact, while I was waiting, a lady came in with Covid symptoms. They asked her if she was vaccinated, and she said “no”. Err!! All this time, I’m barely maintaining consciousness and there are no rooms, most likely because of the people that wouldn’t get the vaccine. Why do they think that their ignorance is more important than peoples’ lives?

    I finally got a room. My cardiologist just happened to be in the E.R. and heard that I was there and came in. She said she’d talk to the ablation doctor to see if he could get me in right away. The ablation doctor came in about an hour later. In my records, it said that a 2019 MRI showed a scar on my heart. Because of that, he didn’t want to do it and tried to talk me into some new medicine that was out. I wasn’t buying it and I gave an emotional appeal of how I collapsed on the kitchen floor and literally had to crawl, inch by inch, to my upstairs bedroom to get the fob for my Tesla to drive to the hospital all the time thinking I wouldn't make it. After that, he agreed to the procedure, and they squeezed me in the next day.

    It turned out that they couldn’t find any scar, but he found four areas that needed treatment. I’m home and seems to be recovering well. They say it takes several weeks for the scar tissue to form before the ablation works. The follow-up appointment isn’t for over a month from now with the nurse practitioner so they must have confidence in their work.
  • Outrunning AFIB: A Testimonial - YouTube - Hit me in the heart because he's an athlete like me. It took three ablations.
  • A Life Without Afib: Victor’s Story - YouTube - A retired military officer like me who also worked out all his life.

Abstracts from this week:

Sodium-glucose co-transporter 2 inhibitor therapy: use in chronic kidney disease and adjunctive sodium restriction - Intern Med J 2022 Mar 7 - "Hence, blood pressure (BP) reduction is a vital component of CKD management. Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a relatively novel class of medications developed to treat T2DM by inducing glycosuria and hence, lowering glycaemia. Additionally, SGLT2 inhibitors are antihypertensive, renoprotective and cardioprotective, even in individuals without T2DM, making them promising therapeutic agents for CKD, regardless of aetiology" - See empagliflozin at ihouseepharmacy.

The effect of an mRNA vaccine against COVID-19 on endothelial function and arterial stiffness - Hypertens Res 2022 Mar 10 - "Our study shows that the mRNA vaccine causes a prominent increase in inflammatory markers, especially after the 2nd dose, and a transient deterioration of endothelial function at 24 h that returns to baseline at 48 h"

Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife - Am J Psychiatry 2022 Mar 8 - "Long-term cannabis users showed IQ decline from childhood to midlife (mean=-5.5 IQ points), poorer learning and processing speed relative to their childhood IQ, and informant-reported memory and attention problems ... Long-term cannabis users showed smaller hippocampal volume"

Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications - Evid Based Complement Alternat Med 2022 Feb 28 - "Ginkgo biloba is an ancient plant species that is thought to provide a variety of health benefits to living organisms and contains plenty of bioactive components, making it a chemically diversified plant. G. biloba has been shown to have a variety of medicinal and pharmacological properties, including anticancer, antidementia, antidiabetic, antiobesity, antilipidemic, antimicrobial, antioxidant, antilipid peroxidation, antiplatelet, anti-inflammatory, hepatoprotective, antidepressant, antiaging, immunomodulatory, antihypertensive, and neuroprotective effects and is frequently used to treat neurological, cardiovascular, and respiratory diseases, such as tardive dyskinesia ... The capacity of G. biloba components to act as free radical scavengers is critical, and combining its extract with other plant extracts has been shown to synergistically boost antioxidant properties. G. biloba used long-term or at high doses that resulted in some adverse effects. Severe drug interactions have also been reported in both animals and humans when combined with other medications" - See Ginkgo biloba at Amazon.com.

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging - Aging Cell 2022 Mar 8 - "Nicotinamide adenine dinucleotide (NAD) levels decline during aging, contributing to physical and metabolic dysfunction. The NADase CD38 plays a key role in age-related NAD decline. Whether the inhibition of CD38 increases lifespan is not known. Here, we show that the CD38 inhibitor 78c increases lifespan and healthspan of naturally aged mice. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between sexes. Our study is the first to investigate the effect of CD38 inhibition in naturally aged animals" - See nicotinamide adenine dinucleotide at Amazon.com.

Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload - Aging Cell 2022 Mar 8 - "At 1 week after iron injection, D-DHA provided nearly complete protection against iron-induced retinal autofluorescence and retinal degeneration, as determined by in vivo imaging, electroretinography, and histology" - See docosahexaenoic acid at Amazon.com.

Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function - Food Funct 2022 Feb 21 - "Kidney Disease Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline has recommended treatment decisions for patients with chronic kidney disease (CKD) with osteoporosis and/or high risk of fracture. Bisphosphonates, the first-line anti-osteoporosis drugs have the concern of worsening kidney functions. Moreover, despite impaired bone formation in CKD patients, teriparatide, the formation-stimulating drug is not recommended. Thus, there is an urgent need for safe and effective treatment of osteoporosis in CKD patients ... Fibroblast growth factor-23 and parathyroid hormone were increased in CKD and diosmin suppressed both. CKD reduced bone mass and deteriorated the microarchitecture of trabecular bones, and diosmin maintained both to control levels. Bone formation and strength were impaired in the CKD and diosmin maintained these levels to control levels. Nanoindentation of bone showed that diosmin significantly increased tissue hardness over the control. Diosmetin, the metabolic surrogate of diosmin had comparable pharmacokinetic profiles between the control and CKD groups. Furthermore, diosmetin (50 mg kg-1) protected against CKD-induced bone loss. These data suggest that diosmin and its metabolic surrogate, diosmetin protect against CKD-induced osteopenia. Since diosmin has no renal adverse effect and protected bone mass and strength in CKD rats, we propose assessing its anti-osteoporosis effect in CKD patients" - See diosmin at Amazon.com.

Impact of high-intensity interval training with or without l-citrulline on physical performance, skeletal muscle, and adipose tissue in obese older adults - J Cachexia Sarcopenia Muscle 2022 Mar 7 - "Aging is associated with a progressive decline in skeletal muscle mass and strength as well as an increase in adiposity. These changes may have devastating impact on the quality of life of older adults ... High-intensity interval training is effective in improving functional capacities, lean mass, muscle power, and waist circumference in obese older adults. HIIT also increases markers of mitochondrial biogenesis, mitochondrial fusion, and mitophagy. Importantly, adding CIT to HIIT results in a greater increase in muscle strength and a significant decrease in fat mass. The present study therefore positions HIIT combined with CIT as an effective intervention to improve the health status of obese older adults" - See l-citrulline at Amazon.com.

Ginsenoside compound K inhibits obesity-induced insulin resistance by regulation of macrophage recruitment and polarization via activating PPARγ - Food Funct 2022 Mar 8 - "The results showed that CK could dose-dependently reduce macrophage M1-type inflammatory factor expression in serum and adipose tissue, improve insulin resistance and glucose tolerance effectively, upregulate PPARγ expression and block TLR4/TRAF6/TAK1/NF-κB activation in obese mice. In addition, CK promoted the expression of IRS1/PI3K/AKT. Furthermore, our study showed that ginsenoside CK could improve insulin resistance by reducing inflammation through the PPARγ/NF-κB signaling pathway, which implies that ginsenoside CK may be an effective agent against obesity or early diabetes" - See ginseng at Amazon.com.

Exploring the Mechanism of Astragalus propinquus Schischkin and Panax Notoginseng (A&P) Compounds in the Treatment of Renal Fibrosis and Chronic Kidney Disease Based on Integrated Network Analysis - Evid Based Complement Alternat Med 2022 Feb 27 - "Astragalus propinquus Schischkin and Panax notoginseng (A&P) has been widely used in clinical practice to treat chronic kidney disease (CKD) for many years and achieved a remarkable improvement of these outcomes ... What's more, the effect of A&P and potential genes was furthermore verified by using unilateral ureteral ligation (UUO) in rodent model. The results showed that the expression of HSF1 and RELA both at transcript and protein level was significantly upregulated in UUO model, but the expression was markedly reversed after A&P intervention. To further guide the interpretation of active ingredients from A&P on the effect of HSF1 and RELA, we performed a molecular docking assay and the results showed that active ingredients such as coptisine docked well into HSF1 and RELA. In total, these results suggest that A&P may improve RF in CKD by regulating HSF1 and RELA, which provides a basis for further understanding the mechanism of A&P in the treatment of RF and CKD" - See astragalus at Amazon.com and Panax ginseng at Amazon.com.

Astragalus Flavone Induces Proliferation and Differentiation of Neural Stem Cells in a Cerebral Infarction Model - Med Sci Monit 2022 Mar 7 - "Ischemic cerebrovascular disease leads to the activation and differentiation of neural stem cells (NSCs) into mature neurons and glia cells to repair nerve damage. Astragalus flavone (ASF) has shown its potential role in proliferation and differentiation into dopamine neurons of NSCs ... ASF therapy can improve the neurologic functions and reduce the cerebral infarction volume in a cerebral infarction model. Moreover, ASF promoted the proliferation of NSCs and induced differentiation into neurons and oligodendrocytes, which might be involved in regulating factors in Notch signaling" - See astragalus at Amazon.com.

N-Acetylcysteine alleviates high fat diet-induced hepatic steatosis and liver injury via regulating the intestinal microecology in mice - Food Funct 2022 Mar 1 - "N-Acetylcysteine (NAC), a well-accepted antioxidant, has been shown to protect against high fat diet (HFD)-induced obesity-associated non-alcoholic fatty liver disease (NAFLD) in mice. However, the underlying mechanism(s) of the beneficial role of NAC is still not fully understood ... These results suggested that the homeostasis of the gut microbiota plays an important role in NAC-improved NAFLD by affecting the enterohepatic axis" - See n-acetyl cysteine at Amazon.com.

Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha) - Hypertension 2022 Mar 2 - "Sustained Hif1α (hypoxic-inducible factor-1 alpha) accumulation plays a central role in osteogenic transdifferentiation and subsequent calcification. Capsaicin, the potent agonist of TRPV1 (transient receptor potential vanilloid type 1), was found to mitigate hypoxic-related injury and reverse phenotypic switch of vascular smooth muscle cells. However, its role in arterial calcification and the underlying mechanisms remain unexplored ... Capsaicin facilitates deacetylation and degradation of Hif1α by upregulating SIRT6, which inhibits osteogenic transdifferentiation and protects against arterial calcification" - See capsicum at Amazon.com.

The Use of Psilocybin in the Treatment of Psychiatric Disorders with Attention to Relative Safety Profile: A Systematic Review - J Psychoactive Drugs 2022 Feb 28 - "Oral psilocybin is showing itself to be clinically efficacious by producing statistically significant reductions in depression and anxiety symptoms over time versus control in multiple clinical trials. It has also been shown to reduce cigarettes per day and drinks per day in patients with substance use disorders. Thus far, there have been no significant adverse clinical events from psilocybin and there also have been no verifiable recorded deaths reported. Larger studies need to be performed before the drug can potentially become approved for use in the general population"

Effects of different doses of canagliflozin on blood pressure and lipids in patients with type 2 diabetes: a meta-analysis - J Hypertens 2022 Feb 25 - "Compared with placebo, canagliflozin 100 mg reduced SBP by 3.43 mmHg and DBP by 1.05 mmHg. Canagliflozin 100 mg increased LDL-C by 0.10 mmol/l and HDL cholesterol (HDL-C) by 0.05 mmol/l. Compared with placebo, canagliflozin 300 mg reduced SBP by 4.75 mmHg and DBP by 1.69 mmHg. Canagliflozin 300 mg increased LDL-C by 0.16 mmol/l and HDL-C by 0.06 mmol/l. Compared with canagliflozin 100 mg, canagliflozin 300 mg further reduced SBP by 1.21 mmHg and DBP by 0.64 mmHg, and further increased LDL-C by 0.06 mmol/l and HDL-C by 0.02 mmol/l. Compared with placebo and canagliflozin 100 mg, canagliflozin 300 mg increased the risk of UTI" - See canagliflozin at ReliableRXPharmacy.

Kaempferol exerts a neuroprotective effect to reduce neuropathic pain through TLR4/NF-ĸB signaling pathway - Phytother Res 2022 Mar 2 - "We found that kaempferol treatment can significantly reduce NP and proinflammatory cytokine production. Kaempferol attenuated the activation of TLR4/NF-κB pathways in LPS-activated BV2 cells. The analgesic effects of kaempferol on NP may be due to inhibition of microglia activation and switching the M1 to M2 phenotype" - See Kaempferia parviflora at Amazon.com.

Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review - Phytother Res 2022 Mar 2 - "Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha-lipoic acid (α-LA) possesses various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemia actions. It exhibits reactive oxygen species scavenger properties against oxidation and age-related inflammation and refines MetS components. Also, α-LA activates the 5' adenosine monophosphate-activated protein kinase and inhibits the NFκb. It can decrease cholesterol biosynthesis, fatty acid β-oxidation, and vascular stiffness. α-LA decreases lipogenesis, cholesterol biosynthesis, low-density lipoprotein and very low-density lipoprotein levels, and atherosclerosis. Moreover, α-LA increases insulin secretion, glucose transport, and insulin sensitivity. These changes occur via PI3K/Akt activation. On the other hand, α-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation" - See alpha lipoic acid at Amazon.com.

Molecular Targets of Curcumin and Its Therapeutic Potential for Ovarian Cancer - Nutr Cancer 2022 Mar 10 - "Ovarian cancer is the fifth most common gynecological cancer in women globally. Conventional chemotherapy is the first therapeutic approach in the treatment of ovarian cancer, but its success is limited by severe side effects, transient response, and the high prevalence of relapse. Curcumin is a natural product found in the rhizome extract of Curcuma longa and has been extensively used over the last decades for its unique biological and medicinal properties, which include: having antioxidant, analgesic, anti-inflammation, and anti-tumor activities. Curcumin exerts its anticancer properties against ovarian cancer via multiple mechanisms: interfering with cellular interactions necessary for metastasis and recurrence of OC cells, increasing pro-apoptotic proteins as well as inducing or suppressing generation of different molecules such as cytokines, transcription factors, enzymes, protein kinases, and growth factors. Moreover, curcumin down-regulates various signaling pathways such as PI3K/Akt, Wnt/β-catenin, JAK/STAT3, and MEK/ERK1/2 axes, which at least in part have a role in inhibiting further tumor proliferation, growth, and angiogenesis" - See curcumin at Amazon.com.

Curcumin regulates the homeostasis of Th17/Treg and improves the composition of gut microbiota in type 2 diabetic mice with colitis - Phytother Res 2022 Mar 2 - "Diabetes mellitus (DM) is one of the most common complications in patients with ulcerative colitis (UC). Curcumin has a wide range of bioactive and pharmacological properties and is commonly used as an adjunct to the treatment of UC and DM ... In this study, curcumin (100 mg/kg/day) significantly improved the symptoms of diabetes complicated by UC, with a lower insulin level, heavier weight, longer and lighter colons, fewer mucosal ulcers and less inflammatory cell infiltration. Moreover, compared to untreated DB mice with colitis, curcumin-treated mice showed weaker Th17 responses and stronger Treg responses. In addition, curcumin regulated the diversity and relative abundance of intestinal microbiota in mice with UC complicated by DM at the phylum, class, order, family and genus levels. Collectively, curcumin effectively alleviated colitis in mice with type 2 diabetes mellitus by restoring the homeostasis of Th17/Treg and improving the composition of the intestinal microbiota" - See curcumin at Amazon.com.

Curcumin alleviates hepatic steatosis by improving mitochondrial function in postnatal overfed rats and fatty L02 cells through the SIRT3 pathway - Food Funct 2022 Feb 21 - "It was concluded that postnatal overfeeding damaged mitochondrial biogenesis and antioxidant response, and increased hepatic lipids and the severity of high-fat-induced NAFLD, while CUR alleviated hepatic steatosis, at least partially, by enhancing mitochondrial function through SIRT3" - See curcumin at Amazon.com.

Alpha-ketoglutarate attenuates colitis in mice by increasing Lactobacillus abundance and regulating stem cell proliferation via Wnt-Hippo signaling - Mol Nutr Food Res 2022 Feb 26 - "Collectively, the data provided herein demonstrated that α-KG administration attenuated mucosal inflammation, barrier dysfunction, and gut microflora dysbiosis. This beneficial effect was associated with increased Lactobacillus levels and regulated colon hyperplasia by the Wnt-Hippo signaling pathway" - See alpha ketoglutarate at Amazon.com.

Inulin activates FXR-FGF15 signaling and further increases bile acids excretion in non-alcoholic fatty liver disease mice - Biochem Biophys Res Commun 2022 Feb 10 - "Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder defined as the presence of intrahepatic lipid deposition and steatosis as well as chronic inflammation without excessive alcohol consumption. Our previous studies found that inulin could dramatically improve lipid metabolism disorders in NAFLD murine models ... we found that inulin treatment significantly reversed the abnormal accumulation of bile acids in high-fat-induced NAFLD mice. Furthermore, our data confirmed that inulin supplementation attenuates NAFLD via restoring the activity of FXR accompanied by increasing hepatic bile acids de novo synthesis and further enhancing bile acids excretion in mice" - See inulin at Amazon.com.

5-alpha reductase inhibitors and prostate cancer mortality among men with regular access to screening and health care - Cancer Epidemiol Biomarkers Prev 2022 Mar 4 - "Men using 5-ARIs underwent more PSA testing, prostate exams and biopsies. Over 20 years of follow-up, 509 men developed lethal disease (metastases or prostate cancer death). Among men initially free from prostate cancer, 5-ARI use was not associated with developing lethal disease (HR 1.02, 0.71-1.46), but was associated with reduced rates of overall and localized disease (HR 0.71, 0.60-0.83). Among men diagnosed with prostate cancer, there was no association between 5-ARI use and cancer-specific (HR 0.78, 0.48-1.27) or overall survival (HR 0.88" - See saw palmetto at Amazon.com.

Hexanic Extract of Serenoa repens (Permixon ®): A Review in Symptomatic Benign Prostatic Hyperplasia - Drugs Aging 2022 Mar 3 - "The hexanic extract (HE) of Serenoa repens (Permixon®) is indicated for the symptomatic treatment of benign prostatic hyperplasia (BPH). The drug is the n-hexane lipidosterolic extract of the American dwarf palm tree (also known as saw palmetto). The anti-inflammatory activity of HE S. repens has been demonstrated in vitro, in vivo and in men with prostatic inflammation. In randomized clinical trials, the efficacy of HE S. repens was similar to that of an α-blocker in terms of improving voiding and storage symptoms, increasing urinary flow rate and reducing prostate volume in men with BPH. HE S. repens was also as effective as 5α-reductase inhibitors and/or α-blockers at improving lower urinary tract symptoms (LUTS) and quality of life (QOL) in real-world observational studies. HE S. repens was generally well tolerated, with a lesser impact on male sexual function compared with other available therapies. Thus, HE S. repens is a useful option for the treatment of symptomatic BPH" - See saw palmetto at Amazon.com.

Effect of omega-3 polyunsaturated fatty acids on left ventricular remodeling in chronic heart failure: a systematic review and meta-analysis - Br J Nutr 2022 Mar 4 - "Accumulating evidence suggests that supplementation of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) was associated with reduction in risk of major cardiovascular event ... Compared with placebo groups, ω-3 PUFAs supplementation improved LV ejection fraction (LVEF) (11 trials, 2112 participants, WMD=2.52, 95%CI 1.25 to 3.80, I2=87.8%) and decreased LV end-systolic volume (LVESV) (5 studies, 905 participants, WMD=-3.22, 95%CI -3.67 to -2.77, I2=0.0%) by using the continuous variables analysis. Notably, the high accumulated ω-3 PUFAs dosage groups (≥600g) presented a prominent improvement in LVEF, while the low and middle accumulated dosage (≤300g and 300-600g) showed no effects on LVEF. In addition, ω-3 PUFAs supplementation decreased the levels of pro-inflammatory mediators including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and hypersensitive-c-reactive protein (Hs-CRP). Therefore, the present meta-analysis demonstrated that ω-3 PUFAs consumption was associated with a substantial improvement of LV function and remodeling in patients subjected to CHF. The accumulated dosage of ω-3 PUFAs intake is vital for its cardiac protective role" - See omega-3 supplements at Amazon.com.

Omega-3 Polyunsaturated Fatty Acids can Reduce IL-6 and TNF Levels in Patients with Cancer - Br J Nutr 2022 Mar 7 - "Omega-3 PUFAs can reduce circulating IL-6 and TNF levels in patients with cancer. Results supported the recommendation of omega-3 PUFAs as adjuvant therapy for patients with cancer, possibly excluding head and neck cancer, owing to their anti-inflammatory properties" - See omega-3 supplements at Amazon.com.

Resveratrol drives cancer cell senescence via enhancing p38MAPK and DLC1 expressions - Food Funct 2022 Mar 2 - "Pro-senescence therapy is a recently proposed anti-cancer strategy and has been shown to effectively inhibit cancer. Resveratrol is gaining attention for its cancer preventive and suppressive properties ... resveratrol induced cell senescence along with an increase of SA-β-Gal activity and inhibition of colony formation in breast and lung cancer cells. The underlying mechanisms were that resveratrol induced ER-stress by increasing SIRT1 to promote p38MAPK expression and by reducing NO level to up-regulate DLC1 expression, and ER-stress further resulted in DNA damage and mitochondrial dysfunction, eventually leading to cancer cell senescence. Our findings on resveratrol's induction of cancer cell senescence via activating ER-stress through the SIRT1/p38MAPK and NO/DLC1 pathways provide a solid base for its clinical application and its preventive application as a food additive" - See resveratrol products at Amazon.com.

Resveratrol Inhibits High Glucose-Induced H9c2 Cardiomyocyte Hypertrophy and Damage via RAGE-Dependent Inhibition of the NF- κ B and TGF- β 1/Smad3 Pathways - Evid Based Complement Alternat Med 2022 Feb 25 - "Hyperglycaemia is associated with the development of cardiac vascular disease. Resveratrol (RES) is a naturally occurring polyphenolic compound that possesses many biological properties, including anti-inflammatory properties and antioxidation functions ... high glucose (HG)-induced H9c2 cells ... Collectively, the results implied that RES might help alleviate HG-induced cardiotoxicity via RAGE-dependent downregulation of the NF-κB and TGF-β/Smad3 pathways" - See resveratrol products at Amazon.com.

Resveratrol Blunts Mitochondrial Loss in Slow and Mixed Skeletal Muscle Phenotypes of Non-Human Primates following a Long-Term High Fat/Sugar Diet - J Diet Suppl 2022 Mar 1 - "Mitochondrial biogenesis and destruction in skeletal muscle are coordinated by distinct signaling pathways that are influenced by internal and exogenous variables including, but not limited to, muscle phenotype, physical activity, dietary composition, or drug administration. Previously we found that long-term resveratrol administration (up to 480 mg/day) ameliorates the slow-to-fast phenotypic shift in soleus muscles and promotes the expression in slow myosin heavy chain in the mixed plantaris muscle of non-human primates consuming a high fat/sugar (HFS) diet ... Taken together, resveratrol appears to blunt mitochondrial losses with a high fat/sugar diet by tempering mito/autophagy rather than promoting mitochondrial biogenesis, suggesting that the quantity of daily resveratrol supplement ingested and/or its long-term consumption are important considerations" - See resveratrol products at Amazon.com.

Phycocyanin ameliorates mouse colitis via phycocyanobilin-dependent antioxidant and anti-inflammatory protection of the intestinal epithelial barrier - Food Funct 2022 Mar 4 - "Phycocyanin, phycocyanobilin and a positive drug mesalazine were intragastrically administered to C57BL/6 mice daily for 7 days during and after 4-day DSS exposure. Clinical signs and colon histopathology revealed that phycocyanin and phycocyanobilin had an equivalent anti-colitis efficacy that was even superior to mesalazine. Based on biochemical analysis of colonic tight junction proteins, mucus compositions and goblet cells, and colonic and peripheral proinflammatory cytokines, phycocyanin and phycocyanobilin displayed equivalent intestinal epithelial barrier-protecting and anti-inflammatory potential that was evidently superior to that of mesalazine ... Overall, our results demonstrate the phycocyanobilin-dependent anti-colitis role of phycocyanin via antioxidant and anti-inflammatory mechanisms" - See phycocyanin at Amazon.com.

  • Phycocyanin - Wikipedia - "Phycocyanin is a pigment-protein complex from the light-harvesting phycobiliprotein family, along with allophycocyanin and phycoerythrin.[1] It is an accessory pigment to chlorophyll. All phycobiliproteins are water-soluble, so they cannot exist within the membrane like carotenoids can"

Enhanced co-culture and enrichment of human natural killer cells for the selective clearance of senescent cells - Aging (Albany NY) 2022 Mar 4 - "In the context of aging and age-associated diseases, Natural Killer (NK) cells have been revealed as a key cell type responsible for the immune clearance of senescent cells. Subsequently, NK cell-based therapies have emerged as promising alternatives to drug-based therapeutic interventions for the prevention and treatment of age-related disease and debility. Given the promise of NK cell-mediated immunotherapies as a safe and effective treatment strategy, we outline an improved method by which primary NK cells can be efficiently enriched from human peripheral blood across multiple donors (ages 20-42 years old), with a practical protocol that reliably enhances both CD56dim and CD56bright NK cells by 15-fold and 3-fold, respectively. Importantly, we show that our co-culture protocol can be used as an easily adaptable tool to assess highly efficient and selective killing of senescent cells by primary NK cells enriched via our method using longer co-culture durations and a low target to effector ratio, which may be more physiological than has been achieved in previous literature"

Restorative effects of probiotics on memory impairment in sleep-deprived mice - Nutr Neurosci 2022 Mar 3 - "These findings demonstrate that Lpc-37 and the multi-strain may play a role in alleviating memory impairments and improve cognitive function in partially sleep-deprived mice" - See probiotic supplements at Amazon.com.

Influence of the Microbiota-Gut-Brain Axis on Cognition in Alzheimer's Disease - J Alzheimers Dis 2022 Mar 2 - "few of these interventions, such as probiotics, are promising candidates for the improvement of cognition in Alzheimer 's disease and are the focus of this review" - See probiotic supplements at Amazon.com.

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