Recent Longevity News for the week ending 3/2/22

A professor who hates Dr. John Campbell's lies and distortions almost as much as me. See my comments in my last newsletter. The misinformation that Dr. Campbell puts out causes people to die. Dr. Campbell is so full of sh** yet he gets millions of IQ-challenged viewers. I'm already getting hate mail for speaking up but when I was a kid, sins of commission and sins of omission were imbedded in my brain even though I'm not that religious. Not speaking up and hence, causing people to die, is a sin of omission.

• Freedom of misinformation: Dr. John Campbell's misuse and manipulation of Covid-19 deaths - Biotech and Bioinformatics with Prof Greg, YouTube
• Three questions for Dr. John Campbell -  Biotech and Bioinformatics with Prof Greg, YouTube

Cholesterol-lowering drugs may slow down metastases - Science Daily, 2/28/22 - "Cancer patients rarely die from the primary tumor but rather from the metastases -- even after successful tumor surgery. This is because cancer cells sometimes spread to other parts of body early in the disease, when the tumor is still very small and may not have even been discovered yet ... Patients taking statins had only half the incidence of cancer compared to the general population"

FDA Okays Empagliflozin for HF Regardless of Ejection Fraction - Medscape, 2/24/22 - "That means the SGLT2 inhibitor, once considered primarily an antidiabetic agent, is approved for use in patients with HF per se without regard to ventricular function ... The study saw a significant 21% relative reduction in that composite endpoint over about 2 years in patients with NYHA class II-IV heart failure and an LVEF greater than 40% who received empagliflozin along with other standard care" - See empagliflozin at ihouseepharmacy.

Healthy gut microbiome improves success of cancer treatment - Science Daily, 2/28/22 - "The largest study to date has confirmed the link between the gut microbiome and the response to cancer immunotherapy therapy for melanoma ... The presence of three types of bacteria (Bifidobacterium pseudocatenulatum, Roseburia spp. and Akkermansia muciniphila) seem to be associated with a better immune response. An additional finding was that the microbiome itself is strongly influenced by factors including patient constitution, use of proton pump inhibitors and diet that should be considered in future longitudinal studies" - See probiotic supplements at Amazon.com.

Ivermectin Not Effective in Stopping Severe COVID, Study Finds - WebMD, 2/22/22 - "The trial took place at 20 public hospitals and a COVID-19 quarantine center in Malaysia between May 31 and Oct. 25 ... Among 241 patients who received ivermectin, 52 developed severe COVID-19, compared to 43 of 249 patients who did not take the drug ... Just more than half of participants (51.8%) were fully vaccinated with two doses of COVID-19 vaccines. Among the vaccinated patients, 17.7% in the ivermectin group and 9.2% in the control group developed severe disease"

Is It Time to Redefine Iron Deficiency? - Medscape, 2/22/22 - "before you just say, "This is the heart failure getting worse," investigate the iron. I think we're going to find some very interesting relationships" - See iron supplements at Amazon.com.

How Sugar Substitutes Stack Up - National Graphics, 7/17/13 - "Xylitol is five percent less sweet than sugar, but it has 40 percent fewer calories (9 calories versus sugar's 16) and a low glycemic index" - Note: Sounds like a no-brainer. Add 5% more if you want the same sweetness. I snack on pumpkin pie. For the sugar part, I replace it with a third inulin, a third trehalose and a third xylitol. See inulin at Amazon.com, trehalose at Amazon.com and xylitol at Amazon.com. Inulin has a glycemic index of 14, trehalose is 32 and xylitol is 7.

Micronutrient Supplementation to Prevent, Improve HF? - Medscape, 2/29/22 - "A new review suggests that micronutrient supplementation — particularly a combination of coenzyme Q10 (CoQ10), zinc, copper, selenium, and iron — might be a potential strategy to improve myocardial function in patients with heart failure (HF) by improving mitochondrial function" - See ubiquinol products at Amazon.com, zinc supplements at Amazon.com, copper supplements at Amazon.com, Selenium at Amazon.com and iron supplements at Amazon.com.

Scientists characterize the imbalanced gut bacteria of patients with myocardial infarction, angina and heart failure - Science Daily, 2/18/22 - "However, the early microbiome changes persisted in patients with heart disease who in addition showed specific heart disease related alterations in the composition and function of the gut microbiome. Both at the early dysmetabolic stage and at the later stages of diagnosed heart disease, the diseased microbiome was characterized by a loss of bacterial cells and bacterial competences. In addition, the patients showed a shift towards fewer types of bacteria known to produce health promoting compounds like short chain fatty acids and more bacteria types producing unhealthy compounds from the metabolism of certain dietary amino acids, choline and L-carnitine. Analyses of the blood compounds mirrored the imbalance of the gut microbiome ... Intervention in both humans and rodents have shown that an imbalanced gut microbiome at various stages of heart disease development can be modified and partly restored by eating a more plant-based and energy-controlled diet, avoidance of smoking and compliance with daily exercise" - See probiotic supplements at Amazon.com.

Ivermectin Does Not Stop Progression to Severe COVID: Randomized Trial - Medscape, 2/18/22 - "Ivermectin treatment given to high-risk patients with mild-to-moderate COVID-19 during the first week of illness did not prevent progression to severe disease"

Psilocybin's Antidepressant Effects Rapid, Durable - Medscape, 2/17/22 - "For most participants, GRID-HAMD scores decreased from 22.8 at baseline to 8.7 at 1 week, 8.9 at 4 weeks, 9.3 at 3 months, 7 at 6 months and 7.7 at 12 months after treatment ... Compared to standard antidepressants, which must be taken for long stretches of time, psilocybin has the potential to enduringly relieve the symptoms of depression with one or two treatments"

Vitamin D Supplements Cut Risk for Autoimmune Disease in VITAL - Medscape, 2/16/22 - "We tested vitamin D 2000 IUs daily and marine omega-3 fatty acids 1 g daily in a study population of more than 25,000 US adults who were older than age 50 years and were treated for more than 5 years ... We found that vitamin D significantly reduced the risk for a composite of autoimmune disorders — a 22% significant reduction. When compared with a reference group who received double placebos (placebo for vitamin D and placebo for omega-3s), the reduction in composite autoimmune diseases was greater than 30% with vitamin D. Then accounting for latency, among those who were in the trial for at least 2 years, the reduction was closer to 40%. For the omega-3s, we didn't see a statistically significant reduction, but there was a promising signal — about a 15% reduction" - See vitamin D at Amazon.com.

SGLT2 Inhibitors May Cut Repeat Syncope in Type 2 Diabetes - Medscape, 2/16/22 - "vaso-vagal syncope (VVS) ... Patients treated with an SGLT2 inhibitor at entry had a significant (45%) reduction in their incidence of VVS during 1-year follow-up compared with the patients not on SGLT2 inhibitor treatment in a Cox multiple regression analysis that included multiple potential demographic and clinical confounders, including age, smoking status, body mass index, heart rate, and beta blocker use" - See empagliflozin at ihouseepharmacy.

• What to know about vasovagal syncope - medicalnewstoday.com - "The term vasovagal syncope (VVS) describes fainting that occurs in response to a sudden drop in heart rate or blood pressure. The resulting lack of blood and oxygen to the brain is what causes a person to pass out"

Statin intolerance is 'over-estimated and over-diagnosed' - Science Daily, 2/15/22 - "statin intolerance is over-estimated and over-diagnosed, with the result that patients are at greater risk of heart and blood vessel problems, including death, caused by high cholesterol levels ... They found that the overall prevalence was 9.1%. Prevalence was even less when assessed according to diagnostic criteria from the National Lipid Association, the ILEP and the European Atherosclerosis Society: 7%, 6.7% and 5.9% respectively ... people who were older, female, of Black or Asian race, obese, or suffering from diabetes, under-active thyroid glands, or chronic liver or kidney failure were more likely to be statin intolerant. In addition, drugs to control irregular heartbeat (arrhythmia), calcium channel blockers (often prescribed for chest pain and high blood pressure), alcohol use and higher statin doses were associated with a higher risk of statin intolerance. The increased risk of statin intolerance ranged from 22% (high alcohol consumption) to 48% (being female) in these groups"

AHA Statement Reviews Marijuana's Effects on Brain Health - Medscape, 2/15/22 - "Numerous research studies challenge the idea that marijuana use is harmless, and instead demonstrate that cannabis, especially Δ9-tetrahydrocannabinol (THC), has adverse effects on brain health ... Findings collected from animal studies demonstrate that THC interferes with normal development of signaling pathways and hinders synaptic plasticity. The authors also point out that these studies show connections between neurons are affected in the short-term, whereas in the long-haul, this contributes to changes in how neuronal networks work ... Prenatal THC affects neuroanatomic areas associated with cognition and emotional regulation, including the prefrontal cortex, limbic system, and ventral tegmentum of the midbrain ... cute marijuana use affects impulsivity, memory, and behaviorial disinhibition, they note, that "can affect performance in real-world activities," such as driving. The long-term effects of cannabis on cognition are "less well established." ... Neuroimaging research has highlighted structural changes in the brain, but these data are inconsistent ... Functional MRI studies show cannabis users may experience functional changes in regions of the brain that play a role in cognition, particularly with prolonged use ... A relation between cannabis use and increased risk for stroke"

US Underuse of GLP-1RA, SGLT-2i in Type 2 Diabetes Persists - Medscape, 2/15/22 - "Only 11% to 14% of US adults with type 2 diabetes received treatment with a glucagon-like peptide-1 receptor agonist (GLP-1RA) or with a sodium glucose cotransporter-2 (SGLT2) inhibitor from 2018 to 2020 despite clear indications for their use ... Why This Matters ... Agents from both the GLP-1RA and SGLT-2 inhibitor classes confer protection against major atherosclerosis-based adverse cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD). SGLT-2 inhibitors also lower the risk of hospitalization for heart failure and prevent worsening kidney function in patients with type 2 diabetes and ASCVD risk or with diabetic kidney disease" -

High levels of hazardous chemicals found in Canadian nail salons - Science Daily, 2/14/22 - "These chemicals have been associated with adverse health effects including neurological and reproductive effects, with some evidence that in utero exposure may be important" - Note: But is the U.S. any different?

Abstracts from this week:

Differences in the prophylactic effect of serum lithium levels on depression and mania in bipolar disorder: A dose-response meta-analysis - Eur Neuropsychopharmacol 2022 Feb 11 - "The dose-response curve showed that increased serum concentrations were associated with a gradual decrease in the risk of any mood episodes (OR 0.50 at 0.60 mmol/l, OR 0.15 at 1.20 mmol/l). The risk of depression decreased slightly with a concentration of 0.60 mmol/l (OR 0.83) but dropped rapidly as the concentration increased to 1.20 mmol/l (OR 0.39). By contrast, the risk for mania initially decreased steadily (OR 0.44), but decreased only marginally (OR 0.30) as the concentration increased. To reduce the recurrence risk to 56%, prevention of depression required a higher concentration than that required for mania (1.13 mmol/l vs. 0.60 mmol/l). Our results suggest a negative dose-response relationship between serum lithium levels and risk of recurrence. In particular, the different preventive effects of serum concentration on depression and mania will be an important clinical reference" - See lithium supplements at Amazon.com.

Chlorogenic Acid Ameliorates High-Fat and High-Fructose Diet-Induced Cognitive Impairment via Mediating the Microbiota-Gut-Brain Axis - J Agric Food Chem 2022 Feb 21 - "Chlorogenic acid (CGA) displays cognition-improving properties, but the underlying mechanisms remain unclear. Herein, CGA supplementation (150 mg/kg body weight) for 14 weeks significantly prevented obesity and insulin resistance, cognitive-behavioral disturbances, and synaptic dysfunction induced by a high-fat and high-fructose diet (HFFD). Moreover, CGA supplementation enhanced the expression of genes enriched in the neuroactive ligand-receptor interaction pathway and reduced inflammatory factor expressions. Furthermore, CGA treatment increased gut microbiota diversity and the level of bacterial genera producing SCFAs. CGA also decreased the concentration of energy metabolism substrates, while it increased phosphorylcholine. Finally, we observed a significant correlation among synaptic transmission genes, gut microbiota, and neurotransmission in the CGA supplementation group by targeted multiomics analysis" - See chlorogenic acid at Amazon.com.

Effects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials - Drugs Aging 2022 Feb 21 - "The findings demonstrate that there are still few studies in humans, but they showed that this polyphenol acts in the delay of cognitive impairment in patients with AD, when administered alone or in combination with glucose and malate" - See resveratrol products at Amazon.com.

Twelve Weeks of Additional Fish Intake Improves the Cognition of Cognitively Intact, Resource-Limited Elderly People: A Randomized Control Trial - J Nutr Health Aging 2022 - "Participants in the intervention group had a significantly higher post intervention (P=0.036) CASI score than the control group, when the model was fitted with imputation and controlled for baseline scores. Participants in the intervention group also had a significantly higher intake of calculated dietary omega 3 PUFA and higher levels of RBC eicosapentaenoic acid and docosapentaenoic acid content than the control group (P < 0.05) ... Conclusion: Twelve weeks of fish intake in the context of a modified MIND diet may improve the cognition of cognitively intact, resource-limited elderly people" - See omega-3 supplements at Amazon.com.

Fish oil supplementation may improve attention, working memory, and ADHD symptoms in adults with autism spectrum disorder: A randomized crossover trial - Br J Nutr 2022 Feb 11 - "Our results did not show any effects on ASD symptoms, but suggest that FO may improve attention and working memory in adults with ASD and ameliorate ADHD symptoms in those with comorbid ADHD" - See omega-3 supplements at Amazon.com.

Use of Marijuana: Effect on Brain Health: A Scientific Statement From the American Heart Association - Stroke 2022 Feb 10 - "Marijuana is perceived as a harmless drug, and its recreational use has gained popularity among young individuals. The concentration of active ingredients in recreational formulations has gradually increased over time, and high-potency illicit cannabinomimetics have become available. Thus, the consumption of cannabis in the general population is rising. Data from preclinical models demonstrate that cannabinoid receptors are expressed in high density in areas involved in cognition and behavior, particularly during periods of active neurodevelopment and maturation. In addition, growing evidence highlights the role of endogenous cannabinoid pathways in the regulation of neurotransmitter release, synaptic plasticity, and neurodevelopment. In animal models, exogenous cannabinoids disrupt these important processes and lead to cognitive and behavioral abnormalities. These data correlate with the higher risk of cognitive impairment reported in some observational studies done in humans. It is unclear whether the effect of cannabis on cognition reverts after abstinence. However, this evidence, along with the increased risk of stroke reported in marijuana users, raises concerns about its potential long-term effects on cognitive function"

Effect of turmeric supplementation on the pharmacokinetics of paclitaxel in breast cancer patients: A study with population pharmacokinetics approach - Phytother Res 2022 Feb 18 - "Turmeric is one of the most used herbal supplements among cancer patients. It reportedly modulates the function of CYP450 enzymes and drug transporters. This study investigates the effect of turmeric on the pharmacokinetics of paclitaxel in breast cancer patients ... turmeric at the recommended dose can be combined safely with paclitaxel" - See turmeric extract at Amazon.com.

Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial - Phytother Res 2022 Feb 17 - "Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to cartilage damage with mostly accompanied by metabolic disorders. This study aimed to investigate the effects of curcumin supplementation on metabolic parameters (lipid profile and glycemic indices), inflammatory factors, visfatin levels, and obesity values in women with RA ... 48 women with RA. The patients were treated with curcumin (500 mg once a day) or placebo for 8 weeks ... Curcumin supplementation significantly decreased homeostatic model assessment for insulin resistance (HOMA-IR), erythrocyte sedimentation rate, serum levels of high-sensitivity C-reactive protein and triglycerides, weight, body mass index, and waist circumference of patients compared with the placebo at the end of the study (p < .05 for all). HOMA-IR and triglyceride levels significantly increased within the placebo group ... These results support the consumption of curcumin, as a part of an integrated approach to modulate metabolic factors, inflammation, and adiposity in women with RA" - See curcumin at Amazon.com.

Curcumin Mitigates TNFα-Induced Caco-2 Cell Monolayer Permeabilization Through modulation of NF-κB, ERK1/2 and JNK Pathways - Mol Nutr Food Res 2022 Feb 19 - "The inhibition of NF-κB, ERK1/2 and JNK activation could be in part involved in the capacity of curcumin to mitigate intestinal inflammation, oxidant production, activation of redox-sensitive pathways, and prevention of monolayer permeabilization. These results support an action of dietary curcumin in sustaining gastrointestinal tract physiology" - See curcumin at Amazon.com.

Berberine as a natural modulator of inflammatory signaling pathways in the immune system: Focus on NF-κB, JAK/STAT, and MAPK signaling pathways - Phytother Res 2022 Feb 10 - "Three main inflammatory signaling pathways include nuclear factor-κB (NF-κB), Janus kinases/Signal transducer and activator of transcriptions (JAKs/STATs), and mitogen-activated protein kinases (MAPKs) play crucial roles in inducing, promoting, and regulating inflammatory responses in the immune system. Importantly, the breakdown of mechanisms that tightly regulate inflammatory signaling pathways can be the underlying cause of uncontrolled inflammatory responses and be associated with the generation and development of several inflammatory diseases ... Studies over the past two decades have provided important information on the polytrophic pharmacological and biochemical properties of berberine (BBR) as a naturally occurring compound, such as antioxidant, antitumor, antimicrobial, and antiinflammatory activates. Interestingly, the modulatory effects of BBR on inflammatory signaling cascades, which lead to the inhibition of inflammation, have been widely investigated in several in vitro and in vivo studies. For the first time, herein, this comprehensive review attempts to put together these studies and provide important insight into the modulatory effects of BBR on NF-κB, JAKs/STATs, and MAPKs signaling pathways in vitro in various types of immune cells and in vivo in several experimental inflammatory diseases. As the second achievement of this review, we also explore the therapeutic efficacy and antiinflammatory effects of BBR regarding its modulatory action" - See berberine at Amazon.com.

Urolithin A attenuates diabetes-associated cognitive impairment by ameliorating intestinal barrier dysfunction via N-glycan biosynthesis pathway - Mol Nutr Food Res 2022 Feb 20 - "This study aimed to investigate the effect of Urolithin A (UA) on diabetes-associated cognitive impairment in type 2 diabetes mellitus (T2DM) mouse model induced by high-fat diet (HFD) and streptozotocin (STZ) ... Although UA shares similar beneficial effects on diabetes with metformin, unlike metformin, the effect of UA is independent of gut microbiome and short chain fatty acids. Taken together, these data suggested that feeding UA can attenuate diabetes-associated cognitive impairment by ameliorating systemic inflammation and intestinal barrier dysfunction via N-glycan biosynthesis pathway. The study implied UA as a potential novel pharmaceutic target for diabetes therapy via manipulating gut-brain axis and N-glycan metabolism" - See urolithin a supplement at Amazon.com.

Prebiotic Oligosaccharides Enhance Iron Absorption Via Modulation of Protein Expression and Gut Microbiota in a Dose-response Manner in Iron-deficient Growing Rats - Mol Nutr Food Res 2022 Feb 20 - "Iron deficiency anemia (IDA) in children is one of the most common nutrition-related health conditions worldwide. Prebiotic oligosaccharides, fructo-oligosaccharide (FOS) and galacto-oligosaccharides (GOS), have shown to affect iron absorption in anemic subjects, but the results in previous studies were inconsistent, thus the underlying mechanism and the effective dose of GOS in mitigating anemia remain unclear ... For the first time, the present study provided evidence that GOS supplementation induced a dose-response effect on iron absorption and gut microbiota in the established model, suggesting a positive role of GOS in ameliorating IDA in children" - See fructo-oligosaccharides supplements at Amazon.com and iron supplements at Amazon.com.

Effect of Whey-Derived Lactopeptide β-Lactolin on Memory in Healthy Adults: An Integrated Analysis of Data from Randomized Controlled Trials - J Nutr Health Aging 2022 - "Epidemiological studies have shown that consumption of dairy products reduces the risk of dementia and cognitive decline in older individuals. Tryptophan-tyrosine-related β-lactopeptides and their representative β-lactolin of glycine-threonine-tryptophan-tyrosine tetra-peptide have been identified as agents in dairy products, which improve cognitive function as well as memory function via the activation of the dopaminergic system in a mouse model of amnesia. Previous clinical trials have shown that supplementation with β-lactolin improves memory retrieval in healthy older adults. Specifically, β-lactolin improved the scores in some neuropsychological tests ... Three randomized controlled trials evaluating the effect of β-lactolin on memory in healthy adults were selected for the integrated analysis. The results showed that the score of cued recall among the neuropsychological tests in the β-lactolin group was significantly higher than that in the placebo group (g=0.33; 95% CI: 0.10, 0.55). In addition, the total memory score was higher but this difference was not significant" - See whey protein at Amazon.com.

Adequate Protein Intake on Comprehensive Frailty in Older Adults: Kyoto-Kameoka Study - J Nutr Health Aging 2022 - "actual body weight (BW) ... The association between protein intake and comprehensive frailty was also evaluated using curve fitting with non-linear regression, a weak U-shaped association was found in males and an L-shaped association in females. Men had a low prevalence of frailty at a calibrated protein intake of 15-17% energy from protein, 1.2 g/kg actual BW/day, or 1.4 g/kg ideal BW/day, and women had a low prevalence of frailty at 17-21% energy from protein or 1.6 g/kg ideal BW/day, with the prevalence of frailty remaining unchanged at higher protein intakes. Meanwhile, the inverse relationship between protein intake per ABW and frailty showed a gradual decrease at 1.4 g/kg ABW/day for protein in women"

Research on the Mechanism of Kaempferol for Treating Senile Osteoporosis by Network Pharmacology and Molecular Docking - Evid Based Complement Alternat Med 2022 Feb 3 - "Kaempferol (KP), as a natural anti-inflammatory compound, has been reported to have curative effects on alleviating senile osteoporosis (SOP), which is an inflammation-related musculoskeletal disease, but the molecular mechanisms remain unclear due to scanty relevant studies ... Collectively, various targets and pathways involve in the process of kaempferol treatment against SOP through regulating inflammatory response, oxidative stress, bone homeostasis, etc. Moreover, our study first reported that kaempferol may regulate core targets' expression with involvement of inflammatory response, oxidative stress, and bone homeostasis, thus treating SOP" - See kaempferia parviflora at Amazon.com.

• Senile osteoporosis - Wikipedia - "Senile osteoporosis has been recently recognized as a geriatric syndrome with a particular pathophysiology. There are different classification of osteoporosis: primary, in which bone loss is a result of aging and secondary, in which bone loss occurs from various clinical and lifestyle factors.[1] Primary, or involuntary osteoporosis, can further be classified into Type I or Type II.[1] Type I refers to postmenopausal osteoporosis and is caused by the deficiency of estrogen.[1] While senile osteoporosis is categorized as an involuntary, Type II, and primary osteoporosis, which affects both men and women over the age of 70 years. It is accompanied by vitamin D deficiency, body's failure to absorb calcium, and increased parathyroid hormone."
• Kaempferol - Wikipedia - "Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli."

Metformin and the heart: Update on mechanisms of cardiovascular protection with special reference to comorbid type 2 diabetes and heart failure - Metabolism 2022 Feb 7 - "Recently, the position of metformin as first choice glucose-lowering agent has been supplanted to some extent by the emergence of newer classes of antidiabetic therapy, namely the sodium-glucose co-transporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists. These agents have benefitted through support from large cardiovascular outcomes trials with more modern trial designs than earlier studies conducted to assess metformin. Nevertheless, clinical research on metformin continues to further assess its many potentially advantageous effects. Here, we review the evidence for improved cardiovascular outcomes with metformin in the context of the current era of diabetes outcomes trials. Focus is directed towards the potentially cardioprotective actions of metformin in patients with type 2 diabetes and heart failure (HF), now recognised as the most common complication of diabetes" - See metformin at ReliableRX.

Evidence based mechanistic role of Chrysin towards protection of cardiac hypertrophy & fibrosis in rats - Br J Nutr 2022 Feb 18 - "Cardiac hypertrophy, enlargement of cardiomyocytes in response to persistent release of catecholamine which further leads to cardiac fibrosis. Chrysin, flavonoid from honey is well known for its multifarious properties like anti-oxidant, anti-inflammatory, anti-fibrotic and anti-apoptotic ... Data demonstrated that chrysin attenuated myocardial Hypertrophy and prevented fibrosis via activation of TGF-β/Smad signaling pathway" - See chrysin at Amazon.com.

Glutamate: A Safe Nutrient, Not Just a Simple Additive - Ann Nutr Metab 2022 Feb 16 - "Glutamate should be considered as a safe nutrient before as an additive by risk assessor" - See glutamate supplements at Amazon.com.

δ-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice - Cancer Prev Res (Phila) 2022 Feb 10 - "Vitamin E compounds, consisting of α, β, γ, and δ forms of tocopherols and tocotrienols, display different cancer preventive activities in experimental models. Tocotrienols may have higher potential for clinical use due to their lower effective doses in laboratory studies ... We found that δ-tocotrienol (δT3) was the most effective form in inhibiting cell growth at equivalent doses. Because of this in vitro potency, δT3 was further studied using prostate specific Pten-/- (Ptenp-/-) mice. We found that 0.05% δT3 in diet reduced prostate adenocarcinoma multiplicity by 32.7%, featuring increased apoptosis and reduced cell proliferation. The inhibitory effect of 0.05% δT3 in diet was similar to that of 0.2% δ-tocopherol (δT) in diet reported previously. Our further study on the δT3-induced transcriptome changes indicated that δT3 inhibited genes in blood vessel development in the prostate of Ptenp-/- mice, which was confirmed by immunohistochemistry. Together, our results demonstrate that δT3 effectively inhibits the development of prostate adenocarcinoma in Ptenp-/- mice, which involves inhibition of proliferation and angiogenesis and promotion of apoptosis" - See delta vitamin E at Amazon.com.

Dapagliflozin for nonalcoholic fatty liver disease: a systematic review and meta-analysis - Diabetes Res Clin Pract 2022 Feb 21 - "Compared with the control conditions, dapagliflozin led to a greater decrease in alanine transaminase, aspartate transaminase, gamma-glutamyl transferase, triglyceride, body weight, body mass index, HbA1c, and fasting plasma glucose ... Dapagliflozin can markedly reduce hepatic enzymes and metabolic indicators and improve body composition, indicating its potential therapeutic efficacy" - See dapagliflozin at reliablerxpharmacy.com.

Metabolic Changes Induced by Dapagliflozin, an SGLT2 Inhibitor, in Japanese Patients with Type 2 Diabetes Treated by Oral Anti-diabetic Agents: A Randomized, Clinical Trial - Diabetes Res Clin Pract 2022 Feb 15 - "We aimed to determine whether SGLT2 inhibitor dapagliflozin treatment affects body composition and amino acid (AA) metabolis ... Dapagliflozin treatment causes a reduction in BM mainly by reducing fat mass. AA metabolism shows subtle changes with dapagliflozin treatment" - See dapagliflozin at reliablerxpharmacy.com.

Serum 25-hydroxy vitamin D and the risk of low muscle mass in young and middle-aged Korean adults - Eur J Endocrinol 2022 Feb 1 - "Maintaining sufficient serum 25(OH)D could prevent unfavourable changes in muscle mass in both young and middle-aged Korean adults" - See vitamin D at Amazon.com.

Tip of the iceberg: erectile dysfunction and COVID-19 - Int J Impot Res 2022 Feb 12 - "Current evidence illuminates endothelial dysfunction, direct testicular damage, and the psychological burden of COVID-19 that are of the pathways of ED. Although the proposed underlying mechanisms partly fail to answer the questions by which COVID-19 leads to ED, it is important to monitor men who recovered from COVID-19 regarding the sexual dysfunction sequelae of infection and address the long-term consequences" - Bottom line, get vaccinated!

Association Between Body Mass Index and Incident Dementia Among Community-Dwelling Older Adults: The Shanghai Aging Study - J Alzheimers Dis 2022 Feb 8 - "Compared with moderate BMI (18.5-24.0 kg/m2), low BMI (< 18.5 kg/m2) were related to an increased risk of dementia with the HR as 3.38 (95% CI 1.50-7.63), while high BMI (≥24.0 kg/m2) showed a decreased risk of dementia without statistical significance (HR = 0.91, 95% CI 0.60 to 1.39)"

Hesperidin suppresses ERS-induced inflammation in the pathogenesis of non-alcoholic fatty liver disease - Aging (Albany NY) 2022 Feb 10 - "HSP significantly decreased the weight gain, hepatic steatosis but not serum lipid profile and suppressed the serum levels of inflammatory factors in HFD-fed rats. It was revealed by bioinformatics analysis that the inflammatory response and IRE1α activation were enriched signaling pathways in NAFLD. The expression of ERS-related biomarkers, GRP94, ATF6, ATF4, p-PERK and p- IRE1α, was significantly suppressed by HSP in vivo and in vitro. Moreover, the inflammatory markers, including IL-1β, IL-6, and TNF-α, were also decreased by HSP in vivo and in vitro. Immunofluorescence staining exposed that the expression of GRP94 and p-PERK was decreased by HSP in vitro" - See hesperidin at Amazon.com.

Metformin induces S-adenosylmethionine restriction to extend the Caenorhabditis elegans healthspan through H3K4me3 modifiers - Aging Cell 2022 Feb 11 - "Metformin, a widely prescribed first-line drug for the treatment of type II diabetes mellitus, has been shown to extend lifespan and delay the onset of age-related diseases. The precisely mechanisms by which these effects are realized remain elusive ... Through genetic screening of C. elegans, we find that metformin promotes the healthspan through an H3K4 methyltransferase/demethylase complex to downregulate the targets, including mTOR and S6 kinase. Thus, our studies provide molecular links between meformin, SAM limitation, histone methylation, and healthspan and elucidate the mode action of metformin-regulated healthspan extension will boost its therapeutic application in the treatment of human aging and age-related diseases" - See metformin at ReliableRX.

Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review - Nutr Neurosci 2022 Feb 14 - "New evidence suggests their therapeutic potential in different pain conditions ... these vitamins regulate several inflammatory and neural mediators in nociceptive and neuropathic pain. Some of these processes include aiming the activation of the descending pain modulatory system and in specific intracellular pathways, anti-inflammatory, antioxidative and nerve regenerative effects. Moreover, recent data shows the antinociceptive, antiallodynic, and anti-hyperalgesic effects of the combination of these vitamins, as well as their synergistic effects with known analgesics. Understanding how vitamins B1, B6, and B12 affect several nociceptive mechanisms can therefore be of significance in the treatment of various pain conditions" - See B complex supplements at Amazon.com.

Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials - Nutr Neurosci 2022 Feb 14;1-21 - "B vitamins and vitamin D associated with other compounds also showed significant results, so the improvement in symptoms cannot be attributed strictly to those. Our results suggest that intervention with B vitamins and/or vitamin D may be an effective and well-tolerated adjuvant strategy for improving the symptoms of depression and anxiety, according to the patient's clinical status and nutritional biomarkers" - See B complex supplements at Amazon.com and vitamin D at Amazon.com.

A role for flavonoids in the prevention and/or treatment of cognitive dysfunction, learning, and memory deficits: a review of preclinical and clinical studies - Nutr Neurosci 2022 Feb 12 - "In the preclinical studies, at least there seem to be two main neurological and biological processes in which flavonoids contribute to the improvement and/or prevention of learning, memory deficit and cognitive dysfunction: (1) Regulation of neurotransmission system and (2) Enhancement of neurogenesis, synaptic plasticity and neuronal survival" - See blueberry extract at Amazon.com.

Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy - EBioMedicine 2022 Feb 8 - "Our results suggest that early intervention with probiotics could be considered as an approach to reduce the risk of hepatic side effects of the KD in children who are on the diet for medically indicated reasons" - See probiotic supplements at Amazon.com.

Oolong tea extract alleviates weight gain in high-fat diet-induced obese rats by regulating lipid metabolism and modulating gut microbiota - Food Funct 2022 Feb 18 - "Oolong tea is semifermented, with its chemical composition comprising features of green (unfermented) and black (fermented) tea. Although green tea has anti-obesity properties, studies on the anti-obesity ability of oolong tea are still scarce. In this study, we analyzed the chemical composition of oolong tea extract (OTE) and investigated the effects of OTE on high-fat diet-induced obese rats. OTE contained more (-)-epigallocatechin-3-gallate, (-)-epigallocatechin, and (-)-gallocatechin-3-gallate than theaflavins and theasinensins. Rats fed with a high-fat diet (HFD) and treated with 0.5% OTE exhibited significantly reduced body weight and visceral fat weight compared with the HFD-only group. OTE also decreased adipocyte size, lipogenesis-related protein sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN) protein expression and increased thermogenesis-related protein peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) and uncoupling protein 1 (UCP1) protein expression in epididymal adipose tissue compared with the HFD group. Moreover, the OTE groups had a significantly higher abundance of Candidatus arthromitus and Hydrogenoanaerobacterium and a lower abundance of Ruminococcus1, Oscillibacter, and Odoribacter compared with the HFD group. All these results show that OTE can alleviate weight gain by regulating lipid metabolism and modulating the distribution of the gut microbiota to decrease lipid accumulation in adipose tissue" - See oolong tea at Amazon.com.

Nebivolol and incident cardiovascular events in hypertensive patients compared with nonvasodilatory beta blockers - J Hypertens 2022 Feb 23 - "nebivolol was associated with 17% reduction in incident cardiovascular events compared with all nonvasodilatory beta blockers [hazard ratio 0.83, 95% confidence interval (CI) 0.74-0.94, P = 0.004], and 24% reduction compared with metoprolol ... The vasodilatory beta blocker nebivolol was associated with reduced incident cardiovascular events compared with nonvasodilatory beta blockers. Additional study of other beta blockers is necessary to determine if this is a vasodilatory beta blocker class effect or is specific to nebivolol" - Note: Nebivolol is a third generation beta-blocker. Many cardiologists will tell you that they will only prescribe three brands of beta-blockers because they're the only ones that have been tested for heart failure. Those three just happened to be the first generation which have the most side effects as if the third generation didn't have enough side effects. I've never bought off on their logic but I'm not a doctor. The studies I've seen show that the third generation, with the less side effects, also work better. That said, all beta-blockers have intolerable side effects. If the first generation has so many side effects that the patients don't take them, then that's another reason for choosing nebivolol. Nebivolol is also by far the most expensive. I'd bet those doctors would be singing a different tune if they were the ones living with the side effects. I've got PVCs and I'm waiting for ablation to fix it. I still refuse even the third generation of beta-blockers. They're all the ultimate torture. You're exhausted yet you can't sleep. I've been watching a lot of YouTube videos on it. Lotta people even in their 20s and 30s have that problem: https://youtu.be/gdsUtSJZMVE https://youtu.be/_Z-T9b1a0uo https://youtu.be/fvjl1d8zv7k https://youtu.be/r4H0nd9UJd0  https://youtu.be/7x5iYHkKrXg. See nebivolol at ReliableRxPharmacy.

Garcinia Cambogia Improves High-Fat Diet-Induced Glucose Imbalance By Enhancing Calcium/CaMKII/AMPK/GLUT4-Mediated Glucose Uptake In Skeletal Muscle - Mol Nutr Food Res 2022 Feb 25 - "Garcinia cambogia (G. cambogia) is known to have antiobesity effects ... In an HFD-induced diabetes mouse model, G. cambogia administration resulted in significant blood glucose-lowering effects ... These findings provide new insights into the mechanism by which G. cambogia regulates glucose homeostasis in obesity-induced diabetes" - See Garcinia cambogia at Amazon.com.

Glycine Acts Through Estrogen Receptor Alpha to Mediate Estrogen Receptor Signaling, Stimulating Osteogenesis and Attenuating Adipogenesis in Ovariectomized Rats - Mol Nutr Food Res 2022 Feb 25 - "Glycine is commonly used as an additive in bone health supplements ... we concluded that glycine stimulated osteogenesis and attenuated adipogenesis in OVX rats, a process which may involve the ERα-mediated ER signaling pathway" - See glycine products at Amazon.com.

Quercetin boosts nitric oxide levels and modulates the activities of arginase, acetylcholinesterase and adenosine deaminase in the corpus cavernosum of cyclosporine-treated rats - Andrologia 2022 Feb 25 - "One of the primary causes of erectile dysfunction (ED) in males is cardiovascular disease, such as hypertension (HT). As a result, the goal of this study is to see how quercetin (Q) affects the important biochemical parameters (nitric oxide, endogenous antioxidant enzymes)/specific enzymes (arginase, acetylcholinesterase and adenosine deaminase) linked to be responsible for smooth muscle relaxation in respect to sexual function ... Compared to the control group, Q of both concentrations reduced the activity of these enzymes and improved antioxidant status and NO levels" - See quercetin at Amazon.com.

Exactly what I meant a few weeks ago when I said that BS sells and that’s where the money is. Look at Fox News and/or Trump. I didn’t click on this one because I didn’t want him to benefit from the monetization but it’s implying that the vaccine is going to change your DNA and you'll become Frankenstein. 700,000 views in two days.

Health Focus (Rhodiola rosea):