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Recent Longevity News for the week ending 8/4/21

Testosterone Therapy for Hypogonadism With Diabetes? - Medscape, 8/2/21 - "among men with hypogonadism and type 2 diabetes, from baseline to 12 years, mean A1c decreased from 9.4% to 5.6% in the group that received testosterone undecanoate injections (T-group) and increased from 7.8% to 10.4% in the control group ... But in the T4DM trial, a safety trigger for a hematocrit >54% was met by 22% of patients receiving testosterone, vs 1% of patients in the control group, "and it is known that an elevated hematocrit is a risk factor for thromboembolic events," he pointed out ... during follow-up, fewer patients in the T-group than in the control group died (15 patients [8.2%] vs 61 patients [34%]) ... None of the patients in the T-group had an MI or stroke, compared to 56 cases of MI (31.5%) and 56 cases of stroke (31.5%) in the control group" - Note:  I'm always having a pissing contest with endocrinologists.  One question they should be asking themselves is whether the cutoff for free testosterone being low is black and while or whether there is a gray area when you approach that point.

Feel free to enjoy that coffee without worrying about your heart, new research says - Washington Post, 7/29/21 - "The latest study analyzed data from more than 380,000 people and found that coffee drinking habits were not associated with an increased risk of arrhythmias. Neither was an individual’s ability to metabolize caffeine"

Effects of Testosterone Treatment, With and Without Exercise Training, on Ambulatory Blood Pressure in Middle-Aged and Older Men - Medscape, 7/30/21 - "Average 24-h systolic blood pressure (SBP) increased with T treatment (testosterone*time, p = .035). Average 24-h SBP increased in T+Ex ... Ex increased average 24-h pulse pressure (PP, exercise*time, p = .022), largely during daytime hours ... There was a main effect of T to increase 24-h SBP, primarily seen when T was combined with Ex. Exercise alone decreased 24-h and night-time DBP; an effect attenuated by T. BP should be carefully assessed and monitored, when prescribing T treatment to middle-aged and older men, especially when combined with exercise training"

Inflammatory Diet Linked to Increased All-Cause Dementia Risk - Medscape, 7/30/21 - "If we take a closer look at five components of the DII which are most anti-inflammatory, these components are present in green leafy vegetables, vegetables, fruit, soy, whole grains, and green and black tea. Most of these components are included in the Mediterranean diet. When we look at the three most proinflammatory components, they are present in high caloric products; such as butter or margarine, pastries and sweets, fried snacks, and red or processed meat. These components are present in 'Western diets,' which are discouraged ... compared with quartile 1, there was an increased risk of all-cause dementia for those in quartile 3 (HR, 1.69; P =.020) and quartile 4 (HR, 1.84"

Second-hand marijuana smoke exposure associated with respiratory infections in children - Science Daily, 7/29/21 - "parents who regularly smoked or vaped marijuana reported that their children experienced more viral respiratory infections in the year prior to the survey, compared to children whose parents did not smoke tobacco or marijuana"

Fruit compound may have potential to prevent and treat Parkinson's disease - Science Daily, 7/29/21 - "the compound farnesol, found naturally in herbs, and berries and other fruits, prevents and reverses brain damage linked to Parkinson's disease in mouse studies ... The compound, used in flavorings and perfume-making, can prevent the loss of neurons that produce dopamine in the brains of mice by deactivating PARIS, a key protein involved in the disease's progression. Loss of such neurons affects movement and cognition, leading to hallmark symptoms of Parkinson's disease such as tremors, muscle rigidity, confusion and dementia ... the mice fed a farnesol-supplemented diet had twice as many healthy dopamine neurons than mice not fed the farnesol-enriched diet. The farnesol-fed mice also had approximately 55% more of the protective protein PGC-1alpha in their brains than the untreated mice"

Adding color to your plate may lower risk of cognitive decline - Science Daily, 7/29/21 - "The people in the group that represented the highest 20% of flavonoid consumers, on average, had about 600 milligrams (mg) in their diets each day, compared to the people in the lowest 20% of flavonoid consumers, who had about 150 mg in their diets each day. Strawberries, for example, have about 180 mg of flavonoids per 100 gram serving, while apples have about 113 ... After adjusting for factors like age and total caloric intake, people who consumed more flavonoids in their diets reported lower risk of cognitive decline. The group of highest flavonoid consumers had 20% less risk of self-reported cognitive decline than the people in the lowest group."

High-Fructose Corn Syrup Ups CRC Risk, More Data Suggest - Medscape, 7/27/21 - "Compared with consumption of less than one serving/week of SSB in adulthood, a higher intake was associated with a 2.2 times increased risk. Each serving/day increment of SSB intake in adolescents (13-18 years) was associated with a 32% increased risk of early-onset CRC. Furthermore, replacing each serving/day of SSB with other beverages (eg, coffee, milk, artificially sweetened beverages) in adulthood was associated with a risk reduction for early-onset CRC of 17%-36%"

ARBs Equal ACE Inhibitors for Hypertension, but Better Tolerated - Medscape, 7/26/21 - "side effects were notably lower with ARBs" - But does anyone not already know that?

PUFAs a Promising Add-On for Borderline Personality Disorder - Medscape, 7/26/21 - "Marine omega-3 fatty acids may be a promising add-on therapy for improving symptoms of borderline personality disorder (BPD), new research suggests ... A meta-analysis of four randomized controlled trials showed that adjunctive omega-3 fatty polyunsaturated fatty acids (PUFAs) significantly reduced overall BPD symptom severity, particularly affect dysregulation and impulsive behavior" - See omega-3 supplements at Amazon.com and iHerb.

A doctor on YouTube claims that he sees a lot of cases of high total testosterone and high SBHG in older men and he blames it on liver damage in the past.  I went to at least two endocrinologists about my high SHBG. Both basically told me that there was nothing they could do. That said, I was ready for them the second time. I asked them to follow up on the formula I was taking to lower it. That formula worked plus it actually lowered my liver enzymes. The formula is at the top of my SHBG page.


Dapagliflozin Safe, Protective in Advanced - Medscape, 7/23/21 - "During a median follow-up of 2.4 years, patients who received dapagliflozin as opposed to placebo had a lower risk of the primary efficacy outcome – a composite of a 50% or greater sustained decline in eGFR, end-stage kidney disease, or death from cardiovascular or renal causes (hazard ratio, 0.73" - See

'Good cholesterol' may protect liver - Science Daily, 7/22/21 - "the researchers identified a special type of HDL called HDL3 that, when produced by the intestine, blocks gut bacterial signals that cause liver inflammation. If not blocked, these bacterial signals travel from the intestine to the liver, where they activate immune cells that trigger an inflammatory state, which leads to liver damage"

New study finds drinking too much coffee can shrink your brain, increase dementia risk significantly - Hill, 7/23/21 - "participants who consumed more than six cups of coffee each day had a 53-percent increased risk of dementia and smaller total brain volumes compared with those who consumed one to two cups a day ... Healthy adults are advised to limit their daily coffee intake to about four or five cups, which is roughly 400 milligrams of caffeine" - [Science Daily]

Higher levels of omega-3 acids in the blood increases life expectancy by almost five years - Science Daily, 7/22/21 - "Having higher levels of these acids in the blood, as a result of regularly including oily fish in the diet, increases life expectancy by almost five years ... In contrast, "Being a regular smoker takes 4.7 years off your life expectancy, the same as you gain if you have high levels of omega-3 acids in your blood" - See omega-3 supplements at Amazon.com and iHerb.

Scientists reverse age-related memory loss in mice - Science Daily, 7/22/21 - "Recent evidence has emerged of the role of perineuronal nets (PNNs) in neuroplasticity -- the ability of the brain to learn and adapt -- and to make memories. PNNs are cartilage-like structures that mostly surround inhibitory neurons in the brain. Their main function is to control the level of plasticity in the brain. They appear at around five years old in humans, and turn off the period of enhanced plasticity during which the connections in the brain are optimised. Then, plasticity is partially turned off, making the brain more efficient but less plastic ... PNNs contain compounds known as chondroitin sulphates. Some of these, such as chondroitin 4-sulphate, inhibit the action of the networks, inhibiting neuroplasticity; others, such as chondroitin 6-sulphate, promote neuroplasticity. As we age, the balance of these compounds changes, and as levels of chondroitin 6-sulphate decrease, so our ability to learn and form new memories changes, leading to age-related memory decline"

C is for Vitamin C -- a key ingredient for immune cell function - Science Daily, 7/21/21 - "Regulatory T cells (Tregs) help control inflammation and autoimmunity in the body. Tregs are so important, in fact, that scientists are working to generate stable induced Tregs (iTregs) in vitro for use as treatments for autoimmune diseases as well as rejection to transplanted organs ... Now scientists at La Jolla Institute for Immunology and Emory University School of Medicine report that Vitamin C and TET proteins can work together to give Tregs their life-saving power" - See vitamin C products at Amazon.com and iHerb.com.

Coffee, Veggies May Lower Your Odds for COVID - WebMD, 7/21/21 - "The study included nearly 38,000 participants who had received a COVID-19 test. About 17% tested positive for the virus ... The team found that nutrition might confer a modest degree of protection ... consuming one or more cups of coffee a day was associated with a 10% decrease in risk of COVID-19 when compared to consuming less than one cup daily. Consuming at least two-thirds of a serving of cooked or raw vegetables daily (excluding potatoes) was also linked with reduced risk ... However, even eating less than half a serving of processed meat daily — think hot dogs and deli meat — was associated with higher risk. Like coffee, being breastfed as an infant was associated with a 10% reduced risk ... The reason why coffee seems protective while tea is not could be the greater amount of caffeine in coffee, Cornelis suggested ... Alternatively, it could be other constituents of coffee that are unique and make it distinct from tea. For example, tea is often rich in flavonoids. Whereas with coffee, it's more polyphenols, specifically chlorogenic acid, which is actually a relatively unique constituent of coffee"

Abstracts from this week:

Beverages Containing Plant-Derived Polyphenols Inhibit Growth and Biofilm Formation of Streptococcus mutans and Children’s Supragingival Plaque Bacteria - Beverages 2021, 7(3) - "Polyphenols in edible berries and tea plant (Camellia sinensis) suppressed virulence factors of oral pathogens. We investigated if the commercially marketed plant polyphenols-containing beverages inhibited growth and biofilm formation of Streptococcus mutans and children’s dental plaque ... Test beverages included 26 marketed packaged teas, ready-to-drink bottled raspberry flavored teas and cranberry juice cocktails with and without added sugars ... Brewed infusions from black, green and cinnamon or raspberry flavored teas bags inhibited growth and biofilm formation of children’s plaque bacteria. Compared to controls, bottled raspberry flavored teas and cranberry juice cocktails significantly inhibited growth and biofilm formation of test bacteria. Added sugar did not significantly impact the inhibition (p > 0.05). Biofilms formed in these beverages were loosely attached and easily dislodged from surfaces"

From Bush Medicine to Modern Phytopharmaceutical: A Bibliographic Review of Devil’s Claw (Harpagophytum spp.) -Pharmaceuticals 2021, 14(8) - "Devil’s claw (Harpagophytum spp., Pedaliaceae) is one of the best-documented phytomedicines. Its mode of action is largely elucidated, and its efficacy and excellent safety profile have been demonstrated in a long list of clinical investigation ... Close to 700 sources published over the course of two centuries were identified, confirmed, and cataloged. The purpose of the review is three-fold: to trace the historical milestones in devil’s claw becoming a modern herbal medicine, to point out gaps in the seemingly all-encompassing body of research, and to provide the reader with a reliable and comprehensive bibliography. The review covers aspects of ethnobotany, taxonomy, history of product development and commercialization, chemistry, pharmacology, toxicology, as well as clinical efficacy and safety. It is concluded that three areas stand out in need of further investigation. The taxonomical assessment of the genus is outdated and lacking. A revision is needed to account for intra- and inter-specific, geographical, and chemo-taxonomical variation, including variation in composition. Further research is needed to conclusively elucidate the active compound(s). Confounded by early substitution, intermixture, and blending, it has yet to be demonstrated beyond a reasonable doubt that both (or all) Harpagophytum spp. are equally (and interchangeably) safe and efficacious in clinical practice" - [Nutra USA] - See Devil's claw at Amazon.com.

The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial - Int J Environ Res Public Health 2021 Apr 30 - "It has been shown that specific collagen peptides combined with resistance training (RT) improves body composition and muscle strength in elderly sarcopenic men. The main purpose of this RCT study was to investigate the efficacy of the identical specific collagen peptides combined with RT on body composition and muscle strength in middle-aged, untrained men ... Ninety-seven men completed this study and participated in a 12-week RT program. They ingested 15 g of specific collagen peptides (n = 30; CP-G), placebo (n = 31; P-G), or whey protein (n = 36; WP-G) daily ... All participants had significantly (p < 0.01) improved levels in fat free mass (ΔCP-G = 3.42 ± 2.54 kg; ΔP-G = 1.83 ± 2.09 kg; ΔWP-G = 2.27 ± 2.56 kg), fat mass (Δ CP-G = −5.28 ± 3.19 kg; ΔP-G = −3.39 ± 3.13 kg; ΔWP-G = −4.08 ± 2.80 kg) and leg strength (ΔCP-G = 163 ± 189 N; ΔP-G = 100 ± 154 N; ΔWP-G = 120 ± 233 N). The main analysis revealed a statistically significantly higher increase in fat free mass (p = 0.010) and decrease in fat mass (p = 0.023) in the CP-G compared with the P-G. The exploratory analysis showed no statistically significant differences between WP-G and CP-G or P-G, regarding changes of fat free mass and fat mass. In conclusion, specific collagen peptide supplementation combined with RT was associated with a significantly greater increase in fat free mass and a decrease in fat mass compared with placebo. RT combined with whey protein also had a positive impact on body composition, but the respective effects were more pronounced following the specific collagen peptide administration" - [Nutra USA] - See collagen supplements at Amazon.com.

Changes in Dietary Magnesium Intake and Risk of Type 2 Diabetes Mellitus in Middle School Students: Using Data from the HEALTHY Study - J Nutr 2021 Jul 27 - "The difference in dietary magnesium intake was significantly related to changes in BMI percentile from 6th to 8th grade in intervention and in control schools ... We conclude that a multi-component intervention was associated with reduced risk in T2DM, and may be modulated, in part, by magnesium. The differences in dietary magnesium intake from 6th to 8th grade were negatively related to changes in BMI percentile among middle school students" - See magnesium supplements at Amazon.com.

Higher Habitual Flavonoid Intakes Are Associated With A Lower Incidence Of Diabetes - J Nutr 2021 Jul 27 - "These findings suggest that a diet abundant in flavonoid-rich foods may help to ameliorate diabetes risk, in part through a reduction in body fat" - See flavonoids at Amazon.com and flavonoids at iHerb.com.

Docosahexaenoic Acid in the Inhibition of Tumor Cell Growth in Preclinical Models of Ovarian Cancer - Nutr Cancer 2021 Jul 21 - "There is a strong rationale for investigating nutritional interventions with docosahexaenoic acid (DHA) in cancer prevention and therapy; however, the effects of DHA on ovarian cancer (OC) have not been well studied. Here, we investigated if DHA alone and in combination with carboplatin reduces OC cell growth in vitro ... In vivo, feeding mice a diet supplemented with 3.9% (w/w of fat) DHA resulted in a significant reduction in PDX growth with and without carboplatin (P < 0.05). This reduction in tumor growth was accompanied by an increased tumor necrotic region (P < 0.05) and improved survival. Plasma membranes in tumors and livers excised from mice fed a DHA diet had ∼ twofold increase in DHA incorporation as compared with mice fed a control diet. Our findings indicate that DHA supplementation reduces cancer cell growth and enhances the efficacy of carboplatin in preclinical models of OC through increased apoptosis and necrosis" - See docosahexaenoic acid at Amazon.com and and iHerb.

Glucosinolate-Enriched Fractions from Maca ( Lepidium meyenii) Exert Myrosinase-Dependent Cytotoxic Effects against HepG2/C3A and HT29 Tumor Cell Lines - Nutr Cancer 2021 Jul 20 - "The consumption of glucosinolate (GL)-rich foods, including Brassica vegetables, such as mustard, broccoli, and maca, is associated with decreased risk of developing cancer. The GL content in maca, which is recognized as a "superfood", is approximately 100-times higher than that in other brassicas. Although maca is a potential dietary source of GLs, limited studies have examined the bioactivity of maca GLs using the combination of chemical characterization and bioassays ... These results suggest that the anticancer properties of maca can be attributed to GLs and corroborate the categorization of maca as a "superfood."" - See maca extract at Amazon.com.

Epigenetic Effects of Blackberry Extract on Human Colorectal Cancer Cells - Nutr Cancer 2021 Jul 20 - "Treatment with berry extract induced the expression of SIRT1 gene in HCT116 and HT29/219 cells and increased the expression of two colonic epithelial cell differentiation markers, carcinoembryonic antigen (CEA) and alkaline phosphatase in LS180 cells in a time-dependent manner. This study is the first to report the epigenetic effects of blackberry in cancer cells" - See blackberry extract supplements at Amazon.com.

Quercetin Impairs HuR-Driven Progression and Migration of Triple Negative Breast Cancer (TNBC) Cells - Nutr Cancer 2021 Jul 19 - "the present results demonstrate that elevated HuR levels are associated with TNBC progression and relapse, and the ability of quercetin to inhibit cytoplasmic HuR protein provides a rationale for using it as an anticancer agent for the treatment of aggressive TNBCs" - See quercetin at Amazon.com and iHerb.

Quercetin and vitamin E attenuate diabetes-induced testicular anomaly in Wistar rats via the mitochondrial-mediated apoptotic pathway - Andrologia 2021 Jul 18 - "The role of quercetin and vitamin E treatment against streptozotocin (STZ)-induced testicular abnormalities in diabetic rats and the possible mechanism of action they use for protection were investigated ... The study showed a positive correlation in the levels of LH, FSH and testosterone; it was further established that all treatments normalised diabetes-induced alterations. Treatment with quercetin and vitamin E resulted in 34% decrease of apoptogenic cytochrome c release. This protected the testes against excessive apoptosis by decreasing caspase 3 and caspase 9 activation by up to 30 and 28% respectively (p < .05). Histology also showed that treatment prevented testicular cell death. The findings show that quercetin/vitamin E possess free radical scavenging properties that protected against testicular damage in diabetes. This suggests the possibility of pharmaco-therapeutic intervention" - See quercetin at Amazon.com and iHerb and Vitamin E at Amazon.com and iHerb.

Quercetin and Luteolin Improve the Anticancer Effects of 5-Fluorouracil in Human Colorectal Adenocarcinoma In Vitro Model: A Mechanistic Insight - Nutr Cancer 2021 Jul 26 - "The aim of this study was to investigate the antitumor effects of quercetin and luteolin combined with 5-Fluorouracil (5-FU) in HT-29 human colorectal cancer cells ... These findings suggested that quercetin and luteolin synergistically enhanced the anticancer effect of 5-FU in HT 29 cells and may therefore minimize the toxic effects of 5-FU in the clinical treatment of colorectal cancer" - See quercetin at Amazon.com and iHerb and luteolin products at Amazon.com.  Note:  The cream form of fluorouracil is what they use to remove the pre-cancerous sun damage to your face.  I used it and enjoyed going up to people and asking them in their face if they knew whether smallpox was contagious.  It makes you look that bad until it heals but then you end up with baby skin for a while but if you're not careful it can cause scarring.

Effects of heavy metal, vitamin, and curry consumption on metabolic syndrome during menopause: a Korean community-based cross-sectional study - Menopause 2021 Jul 19 - "High curry consumption reduced the risk of MetS significantly more than low curry consumption (OR 0.60; 95% CI, 0.39-0.91, P = 0.017) in premenopausal women. Furthermore, an increase in daily vitamin B2 intake by 1 mg reduced the risk of MetS by 45% (OR 0.55; 95% CI, 0.32-0.94, P = 0.028) in postmenopausal women" - See curcumin at Amazon.com and iHerb and vitamin B2 at Amazon.

Pioglitazone even at low dosage improves NAFLD in type 2 diabetes: clinical and pathophysiological insights from a subgroup of the TOSCA.IT randomised trial - Diabetes Res Clin Pract 2021 Jul 23 - "Non-Alcoholic Fatty Liver Disease (NAFLD) and type 2 diabetes (T2D) share pathophysiological mechanisms and possible therapeutic strategies. We evaluated the effects of 1-year treatment with pioglitazone or sulphonylureas on indirect indices of NAFLD in people with T2D and the role of insulin-resistance and glucotoxicity in determining these effects ... one-year treatment with pioglitazone even at low dosage significantly improved liver steatosis and inflammation, systemic and adipose tissue insulin resistance in patients with T2D. The beneficial effects of pioglitazone on NAFLD were independent of blood glucose control" - See pioglitazone at ReliableRXPharmacy.

The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus - Diabetes Res Clin Pract 2021 Jul 21 - "metformin was associated with significantly decreased mortality and severity in COVID-19 patients with diabetes (OR = 0.64, 95% CI = 0.51 - 0.79 for mortality, and OR = 0.81, 95% CI = 0.66 - 0.99 for severity)" - See metformin at ReliableRX.

Metformin reduces oxandrolone- induced depression-like behavior in rats via modulating the expression of IL-1β, IL-6, IL-10 and TNF-α - Behav Brain Res 2021 Jul 17 - "Oxandrolone (OXA) is an androgen and anabolic steroid (AAS) that is used to reverse weight loss associated with some medical conditions. One of the side effects of OXA is its potential to induce depressive symptoms. Growing evidence suggested that neuroinflammation and cytokines play crucial roles in sickness behavioral and associated mood disturbances. Previous studies showed that metformin attenuated neuroinflammation. This study investigated the potential protective role of metformin against OXA-induced depression-like behavior and neuroinflammation ... oxandrolone induced depression-like behavior and dysregulated pro-/anti-inflammatory cytokines, while metformin attenuated these effects. These findings suggest that metformin is a potential treatment to reverse the depressive effects induced by oxandrolone that involve neuroinflammatory effects" - See metformin at ReliableRX.

Evaluation of the effects of glycated hemoglobin on cardiac function in patients with short-duration type 2 diabetes mellitus: a cardiovascular magnetic resonance study - Diabetes Res Clin Pract 2021 Jul 14 - "Poor blood glucose control is an independent predictor of LV myocardial dysfunction for patients with short-term T2DM"

The effects of Ramadan intermittent fasting on liver function in healthy adults: A systematic review, meta-analysis, and meta-regression - Diabetes Res Clin Pract 2021 Jul 14 - "liver function tests (LFT) ... Ramadan diurnal intermittent fasting (RDIF) ... RDIF induces significant but small (AST, ALP, BLU) to medium (GGT) positive changes on LFT, and may confer a transient, short-term protection against fatty liver disease in healthy subjects"

Self-reported periodontal health and incident hypertension: longitudinal evidence from the NutriNet-Santé e-cohort - J Hypertens 2021 Jul 13 - "Self-reported assessed periodontitis was associated with incident arterial hypertension over an 8-year period. The present results highlight the importance of considering periodontal health when assessing an individual's risk of arterial hypertension"

Periodontal disease as a predictor of chronic kidney disease (CKD) stage in older adults - J Int Med Res 2021 Jul - "Community Periodontal Index of Treatment Needs (CPITN) ... The highest CPITN values (CPITN-3 and CPITN-4) were associated with CKD stages 2 and 3. Thus, periodontal disease may be associated with progression of CKD"

Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice - J Agric Food Chem 2021 Jul 26 - "Our previous study demonstrated that ginsenoside Rg5 (Rg5) could attenuate renal injury in diabetic mice but its underlying mechanism in mitochondrial biogenesis and insulin sensitivity remains poorly understood. In this study, we found that Rg5 intervention significantly inhibited blood glucose increases in db/db mice, improved liver function damage and hepatocyte apoptosis, and activated the IRS-1/phosphatidylinositol 3-kinase/AKT insulin metabolism signaling pathway. Rg5 treatment also increased the level of glycogen synthesis and activated sirtuin1 (Sirt1) to increase glucose uptake and insulin sensitivity in insulin-resistant HepG2 (IR-HepG2) cells. Rg5 intervention also effectively improved liver oxidative stress and inflammation in db/db mice and increased mitochondrial biogenesis caused by T2DM. Additionally, the Rg5 treatment increased the mitochondrial mass in IR-HepG2 cells and activated Sirt1 to regulate the Sirt1/PGC-1α/mitofusin-2 mitochondrial biosynthesis pathway. Our findings demonstrated that Rg5 enhanced liver mitochondrial biogenesis and insulin sensitivity in db/db mice by activating the Sirt1/PGC-1α signaling pathway, suggesting the potential of Rg5 as a natural product for T2DM interventions" - See ginseng at Amazon.com and iHerb.

Omega-3 phospholipids and obesity-associated NAFLD: Potential mechanisms and therapeutic perspectives - Eur J Clin Invest 2021 Jul 22 - "Prevalence of non-alcoholic fatty liver disease (NAFLD) increases in line with obesity and type 2 diabetes, and there is no approved drug therapy. Polyunsaturated fatty acids of n-3 series (omega-3) are known for their hypolipidemic and anti-inflammatory effects. Existing clinical trials suggest varying effectiveness of triacylglycerol- or ethyl ester-bound omega-3 in the treatment of NAFLD, without affecting advanced stages such as non-alcoholic steatohepatitis ... Multiple mechanisms are likely involved in the overall antisteatotic effects, involving not only the liver, but also adipose tissue and the gut. Robust preclinical evidence for strong antisteatotic effects of omega-3 phospholipids in the liver should be confirmed in clinical trials" - See omega-3 supplements at Amazon.com and iHerb.

Long-term dietary protein intake and subjective cognitive decline in US men and women - Am J Clin Nutr 2021 Jul 22 - "subjective cognitive decline (SCD) ... Higher protein intake was associated with lower odds of SCD when compared isocalorically with carbohydrate. Plant protein sources were also associated with lower odds when compared with animal protein sources. Our findings suggest that adequate protein intake, and choices of protein sources could play a role in the maintenance of cognition and should be studied further"

Standardized astragalus extract for attenuation of the immunosuppression induced by strenuous physical exercise: randomized controlled trial - J Int Soc Sports Nutr 2021 Jul 16 - "This paper aimed to verify how a supplementation of rower's diet with Astragalus Membranaceus Root (AMR) modulated their immune system response to maximal physical exertion ... 18 members of the Polish Rowing Team assigned to the supplemented group (n = 10), and the placebo group (n = 8). The participants performed a 2000 m test on a rowing ergometer at the beginning and at the end of the six-week of intensive training camp during which the supplemented group received 500 mg of AMR ... AMR restored the immunological balance in strenuously trained athlets through a stabilization of NK and Treg cells with a positive trend in Tδγ towards Th1 response during restitution by cytokine IL2 modulation" - See astragalus at Amazon.com.

A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents - Phytother Res 2021 Jul 26 - "Turmeric (Curcuma longa) and its constituent, curcumin, have been used for their therapeutic properties for a long time. Most of the medicinal impacts of turmeric and curcumin might be attributed to their anti-inflammatory, antinociceptive, and antioxidant effects ... Several documents and patents disclosed the significance of turmeric and curcumin to apply in several therapeutic, medicinal, and pharmaceutical fields. These phytocompounds could be applied as a supplementary therapy in phytotherapy, inflammatory disorders such as arthritis, inflammatory bowel diseases, osteoarthritis, psoriasis, dermatitis, and different types of pain including neuropathic pain. However, because of inadequate clinical trials, further high-quality studies are needed to firmly establish the clinical efficacy of the plant" - See curcumin at Amazon.com and iHerb.

Flavan-3-ol Microbial Metabolites Modulate Proteolysis in Neuronal Cells Reducing Amyloid-beta (1-42) Levels - Mol Nutr Food Res 2021 Jul 28 - "Alzheimer's disease (AD) is a progressive neurodegeneration characterized by extensive protein aggregation and deposition in the brain, associated with defective proteasomal and autophagic-lysosomal proteolytic pathways. Since current drugs can only reduce specific symptoms, the identification of novel treatments is a major concern in AD research. Among natural compounds, (poly)phenols and their derivatives/metabolites are emerging as candidates in AD prevention due to their multiple beneficial effects. Here, we investigated the ability of a selection of phenyl-γ-valerolactones, gut microbiota-derived metabolites of flavan-3-ols, to modulate the functionality of cellular proteolytic pathways ... Our findings establish, for the first time, that these metabolites exert a neuroprotective activity by regulating intracellular proteolysis and confirm the role of autophagy and cathepsin B as possible targets of AD preventive/therapeutic strategies" - See flavonoids at Amazon.com and flavonoids at iHerb.com.

Vitamin B 12 Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions - Mol Nutr Food Res 2021 Jul 22 - "Vitamin B12 deficiency presents various neurological manifestations, such as cognitive dysfunction, mental retardation, or memory impairment ... The decrease in SAM levels resulting from vitamin B12 deficiency was associated with m6 A reduced levels in mRNAs. This was also potentially mediated by the overexpression of the eraser FTO. We further investigated mRNA methylation of some genes involved in neurological functions targeted by the m6A reader YTH proteins. We notably observed a m6A hypermethylation of Prkca mRNA and a consistently increased expression of PKCα, a kinase involved in brain development and neuroplasticity, in the two cellular models" - See vitamin B12 at Amazon.com.

Pectic Oligogalacturonide Facilitates the Synthesis and Activation of Adiponectin to Improve Hepatic Lipid Oxidation - Mol Nutr Food Res 2021 Jul 15 - "Adiponectin (ADPN), a kind of adipokines, plays an important role in the regulation of lipid metabolism ... POS can act as an ADPN activator to improve lipid metabolism, leading it to the applications of biomedical and functional foods for ameliorating chronic liver diseases resulted from a high-energy diet"

High-density Lipoprotein Cholesterol Is Negatively Correlated with Bone Mineral Density and Has Potential Predictive Value for Bone Loss - Lipids Health Dis 2021 Jul 25 - "Many studies have shown that lipids play important roles in bone metabolism ... This study demonstrated that HDL-C levels exhibit an inverse correlation with BMD. Especially in females, clinicians need to be alert to patients with high HDL-C levels, which may indicate an increased risk of osteoporosis or osteopenia. For these patients, close monitoring of BMD and early intervention may be necessary"

Association between high-density lipoprotein cholesterol and type 2 diabetes mellitus among Chinese: the Beijing longitudinal study of aging - Lipids Health Dis 2021 Jul 17 - "When research participants were separated into four groups on the basis for quartiles of their levels of HDL-C measured at baseline, and incidence of diabetes declined with higher baseline HDL-C levels at 12.60, 9.70, 5.38, and 5.22 per 1000 person-years, respectively" -

Attenuation of chronic tension headache frequency and severity with daily L-arginine and aged garlic extract dietary supplementation - Eur J Clin Nutr 2021 Jul 23 - "A 74-year-old female subject with suboptimal management of episodic tension headache was treated with a daily dose of 1.5 g L-arginine and 1.2 g aged garlic extract (AGE) ... Within 6 weeks of commencing treatment, her self-reported symptoms improved markedly and were sustained at 2 years following commencement. We propose that the putative beneficial effect of L-arginine and AGE in this patient is because of the well-established systemic vasodilatory effects of L-arginine and aged garlic extract. On the hypothesis that migraine is precipitated by cerebral microvascular constriction, we recommend a double-blind randomised controlled trial to clinically test this hypothesis in migraine patients" - See l-arginine products at Amazon.com and l-arginine at iHerb and garlic supplements at Amazon.com and garlic at iHerb.com.

Association of Time-Updated Anion Gap With Risk of Kidney Failure in Advanced CKD: A Cohort Study - Am J Kidney Dis 2021 Jul 16 - "High anion gap acidosis frequently develops in patients with advanced chronic kidney disease (CKD) and might be involved in kidney injury ... kidney failure with replacement therapy (KFRT) ... Among patients with advanced CKD, high anion gap was associated with an increased risk of progression to KFRT and death"

Does coffee, tea and caffeine consumption reduce the risk of incident breast cancer? A systematic review and network meta-analysis - Public Health Nutr 2021 Jul 27 - "low-dose coffee intake and high-dose tea intake may exhibit efficacy in preventing ER(estrogen receptor)- BC, particularly in postmenopausal women. Then, we performed another pairwise and network meta-analysis and determined that the recommended daily doses were 2-3 cups/d of coffee or ≥5 cups/d of tea, which contained a high concentration of caffeine, particularly in postmenopausal women"

Neuroprotective effects of rutin on ASH neurons in Caenorhabditis elegans model of Huntington's disease - Nutr Neurosci 2021 Jul 26;1-14 - "Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disease. It occurs due to a mutated huntingtin gene that contains an abnormal expansion of cytosine-adenine-guanine repeats, leading to a variable-length N-terminal polyglutamine (polyQ) chain. The mutation confers toxic functions to mutant huntingtin protein, causing neurodegeneration. Rutin is a flavonoid found in various plants, such as buckwheat, some teas, and apples ... we investigated the effects of rutin in a Caenorhabditis elegans model of HD, focusing on ASH neurons and antioxidant defense ... our data demonstrate that chronic rutin treatment maintains the function of ASH neurons, and decreases the degeneration of their sensory termination ... Our findings provide new evidence of rutin's potential neuroprotective role in the C. elegans model and should inform treatment strategies for neurodegenerative diseases and other diseases caused by age-related protein aggregation" - See rutin at Amazon.com and rutin at iHerb.com.

A Double-Blind, Randomized, Placebo-Controlled Trial to Evaluate the Efficacy of a Hydrolyzed Chicken Collagen Type II Supplement in Alleviating Joint Discomfort - Nutrients 2021, 13(7) - "We enrolled adults aged 40–65 (65.5% were women) who had joint discomfort, but had no co-morbidities, and who were not taking pain medications. The participants were randomized to receive either the HCII supplement (n = 47) or a placebo (n = 43) for eight weeks ... In the WOMAC stiffness and physical activity domains and in the overall WOMAC score, the HCII group had a significant reduction in joint-related discomforts compared with the placebo group. For example, at week 4, the HCII group had a 36.9% reduction in the overall WOMAC score, compared with a 14.3% reduction in the placebo group (p = 0.027). This HCII product is effective in reducing joint pain and stiffness and in improving joint function among otherwise healthy adults" - [Nutra USA] - See collagen supplements at Amazon.com.

Effect of coenzyme Q10 supplementation on oxidative stress and clinical outcomes in patients with low levels of coenzyme Q10 admitted to the intensive care unit - J Nutr Sci 2021 Jul 12 - "CoQ10 administration caused a considerable reduction in the Malondialdehyde (MDA) and Interleukin 6 (IL-6) concentrations (P < 0⋅001), Glasgow Coma Score (GCS; P = 0⋅02), ICU and hospital length of stay and mechanical ventilation (MV) duration (P < 0⋅001). We found that CoQ10 administration could increase Fat-Free Mass (P < 0⋅001) (FFM; P = 0⋅04), Skeletal Muscle Mass (SMM; P = 0⋅04) and Body Cell Mass (BCM) percent" - [Nutra USA] - See ubiquinol products at Amazon.com and iHerb.

Neat Tech Stuff / "How To's":

I drilled holes in the can. It didn’t work as far as getting the ants to feed from the can but when I poured some out on the pavement, it worked much faster than Terro (about half a day). Recipe: with a food scale, mix 75 grams of borax (https://amzn.to/3eSPuaY), 225 grams of sugar and 150 grams of hot water.


I ordered a Tesla so I've been watching a lot of YouTube video.  What an idiot this guy is. He talks about Tesla not having a spare tire and all the hassle. He could have plugged it in five minutes with a tire plug kit without even removing the tire from the car. I've plugged hundreds of tires with that method at my grandfather's garage when I was a kid and never had one come back with a leak. I carry the kit in my car along with a tire inflator. The glue they use is basically rubber cement.  It's included in the kit but that's what you need if you run out. 


Health Focus (Green Tea):