Recent Longevity News for the week ending 7/7/21

Antibiotic Link to Rise in Early Onset Colon Cancer? - Medscape, 7/5/21 - "The team conducted a nested case-control study using data from primary care in Scotland, which involved almost 8000 cases of CRC and over 30,000 healthy controls ... The analysis suggests that a history of antibiotic use among individuals younger than 50 appeared to increase the risk of developing colon cancer (but not rectal) by 49%."

Iron-Clad Benefits of CRT Seen in Reduced-EF Heart Failure - Medscape, 7/2/21 - "a small randomized trial may highlight a potential mechanism for those benefits by demonstrating what appears to be a direct salutary effect of the injectable iron preparation ferric carboxymaltose (Ferinject / Injectafer), or FCM, on reverse remodeling in iron-deficient patients with HFrEF ... Its patients, who were already receiving "very robust background medical therapy and robust device therapy consisting of CRT," Martens observed, benefited with significant new cardiac reverse remodeling after 3 months of FCM treatment, compared to similar patients assigned to a standard-care control group. Their left-ventricular ejection fractions (LVEFs) went up and left-ventricular end-systolic volumes (LVESVs) went down. They also showed relative gains in exercise capacity and higher scores on the Kansas City Cardiomyopathy Questionnaire (KCCQ), which measures functional status ... Iron deficiency can impair the reverse-remodeling benefit of CRT and blunt the heart's positive force-frequency relationship (FFR) ― a measure of contractile mechanics that normally climbs exponentially with accelerating heart rate. Put another way, cardiac output at exercise testing tends to go up less in HFrEF patients with iron deficiency compared to those who aren't iron deficient ... The IRON-CRT trial suggests that FCM iron repletion in such patients "improves cardiac performance and is capable of transforming the negative FFR into a positive FFR," thereby boosting cardiac output and exercise capacity"

High physical activity levels may counter serious health harms of poor sleep - Science Daily. 6/29/21 - "Participants supplied information on their normal weekly physical activity levels, which were measured in Metabolic Equivalent of Task (MET) minutes. These are roughly equivalent to the amount of energy (calories) expended per minute of physical activity ... For example, 600 MET minutes a week is the equivalent of 150 minutes of moderate intensity activity, or more than 75 minutes of vigorous intensity physical activity a week ... Compared with those with the high physical activity + healthy sleep score combination, those at the other end of the scale, with the no moderate to vigorous physical activity + poor sleep combination, had the highest risks of death from any cause (57% higher) ... They also had the highest risk of death from any type of cardiovascular disease (67% higher), from any type of cancer (45% higher), and from lung cancer (91% higher) ... Lower levels of physical activity amplified the unfavourable associations between poor sleep and all health outcomes, with the exception of stroke."

Consuming a diet with more fish fats, less vegetable oils can reduce migraine headaches, study finds - Science Daily, 7/1/21 - "The diet lower in vegetable oil and higher in fatty fish produced between 30% and 40% reductions in total headache hours per day, severe headache hours per day, and overall headache days per month compared to the control group. Blood samples from this group of participants also had lower levels of pain-related lipids" - See omega-3 supplements at Amazon.com and iHerb.

Keep your friends close, cortisol levels low for life - Science Daily, 6/30/21 - "Across both age groups, those working with familiar partners had consistently lower cortisol levels than those working with unfamiliar partners"

Magnesium Strongly Tied to Lower Risk for Intracranial Aneurysm - Medscape, 6/30/21 - "The effects may be partially mediated by magnesium's influence on systolic blood pressure ... These results suggest that raising serum magnesium levels ― through a magnesium-rich diet or magnesium supplementation ― "may play a role in the primary prevention of intracranial aneurysm and associated hemorrhage,"" - See magnesium supplements at Amazon.com.

Maternal diets rich in Omega-3 fatty acids may protect offspring from breast cancer, study suggests - Science Daily, 6/28/21 - "Researchers noticed a three-week delay in mortality in mice whose mothers were fed canola oil versus corn oil. The early delay in mortality was significantly different, but the ultimate overall survival rate was not. Eventually, all the mice developed tumors, but the ones fed canola oil had tumors that were slower-growing and smaller than the mice fed corn oil. Translated to human time scale, the duration of the protective effect linked to the maternal diet would be equivalent to several months" - See omega-3 supplements at Amazon.com and iHerb.

Starchy Snacks, ‘Western-Style’ Lunches May Harm Heart Health - WebMD, 6/28/21 - "Eating a Western lunch (typically containing refined grains, cheese, and cured meat) was associated with a 44% increased risk of dying from heart and vascular disease ... Eating a fruit-based lunch was associated with a 34% reduced risk of dying from heart and vascular disease ... Eating a vegetable-based dinner was associated with a 23% lower risk of dying from heart disease and a 31% lower risk of dying from any cause ... Eating a snack high in starch after any meal was associated with a 50% to 52% increased risk of dying from any cause and a 44% to 57% increased risk of dying from heart disease"

Probiotic Supplementation Regulates Newborn Immune System - Medscape, 6/28/21 - "Supplementing breastfed infants with bifidobacteria promotes development of a well-regulated immune system, theoretically reducing risk of immune-mediated conditions like allergies and asthma ... These findings support the importance of early gut colonization with beneficial microbes, an event that may affect the immune system throughout life"

Statins Linked to Lower Cancer Rate in Heart Failure Patients - Medscape, 6/24/21 - "In this large-population study in heart failure patients, we found a 16% reduction in the incidence of cancer and a 36% reduction in cancer deaths in patients taking statins compared to those not taking statins"

Higher selenium and manganese levels during pregnancy may protect babies from future high blood pressure - Science Daily, 6/23/21 - "Although a preponderance of earlier evidence linked lead, mercury, and cadmium to high blood pressure and heart diseases in adults, the researchers did not find a link between these toxic metals with childhood blood pressure in this study. They did, however, observe a link between the mothers' levels of selenium and lower blood pressure in their offspring during childhood. For every doubling of maternal selenium levels, children's systolic blood pressure was found on average to be 6.23 points lower. Manganese showed a similar albeit weaker relationship to blood pressure: A doubling of exposure was associated with 2.62 points lower systolic blood pressure on average" - See se-methyl l-selenocysteine at Amazon.com and manganese at Amazon.com.

Key Driver of Fish Oil's Antidepressant Effects Revealed - Medscape, 6/23/21 - "The findings were replicated in 22 patients with major depression given either EPA (3 g/day) or DHA (1.4 g/day) for 12 weeks. In both groups, EPA or DHA treatment was associated with an increase in their respective metabolites and significant improvement in depressive symptoms ... The average reduction in symptom scores was 64% and 71% in the EPA and DHA groups, respectively, and there was some evidence that higher levels of the same metabolites correlated with less severe depressive symptoms." - See omega-3 supplements at Amazon.com.

Milk protein could help boost blueberries' healthfulness - Science Daily, 6/23/21 - "In studies, anthocyanins have been shown to have antioxidant properties, lower blood pressure and reduce the risk of developing some cancers. However, only small amounts of these nutrients are absorbed from blueberries during digestion, despite their abundance in the fruit. Previous researchers have reported that consuming foods with ingredients such as citrus pectin, capcasin, capsicate and some proteins improve the uptake of anthocyanins. For instance, Bin Li and colleagues found that α-casein and β-casein proteins from cow's milk protected blueberry anthocyanins in simulated digestion experiments ... The researchers fed rats purified blueberry anthocyanin extracts, adding α-casein to the solution given to one group of rats. During the next 24 hours, anthocyanin and metabolite concentrations were 1.5 to 10.1 times higher in the α-casein group than in the control rats" - [Nutra USA]

It's true: Stress does turn hair gray (and it's reversible) - Science Daily, 6/22/21 - "Hair re-pigmentation only possible for some ... Reducing stress in your life is a good goal, but it won't necessarily turn your hair to a normal color"

Coffee Could Perk Up Your Liver - WebMD, 6/22/21 - "data on nearly 500,000 people with "known coffee consumption" who were followed for a median of about 11 years. Median means half were followed longer, half for less time ... Compared with non-coffee drinkers, those who drank coffee had a 21% lower risk of chronic liver disease and a 20% lower risk of chronic or fatty liver disease. Their risk of dying from chronic liver disease fell 49%, researchers found ... The biggest benefit was seen among devotees of ground coffee, which has high levels of kahweol and cafestol, natural chemical compounds from coffee beans. Both have been shown to protect against chronic liver disease in animals. However, instant coffee, which has low levels of kahweol and cafestol, also reduced the risk of chronic liver disease, researchers said, implying that there may be a complex relationship between various ingredients in coffee" - See Touch Essential Single Serve Coffee Brewer at Amazon.com.

Marijuana Use Tied to Higher Odds for Thoughts of Suicide - WebMD, 6/22/21 - "14% of men and 18% of women with cannabis use disorder thought about suicide, compared with 4% for either sex not diagnosed with problematic pot use ... Nearly 9% of men and 13% of women who were daily or near-daily users thought about suicide, compared with 6.5% of men and 9% of women who were occasional users and 3% of both sexes who were non-users ... 51% of men and 57% of women with cannabis use disorder thought about suicide, compared with about 40% for either sex not diagnosed with problematic pot use ... 56% of men and 55% of women who were daily or near-daily users thought about suicide, compared with 43.5% of men and 47% of women who were occasional users and 38% of men and 34% of women who were non-users."

Inventor Says His New Straw Will Cure Hiccups - WebMD, 6/22/21 - "According to results published in JAMA Open Network, 92% of the volunteers said the HiccAway worked for them" - See HiccAway : A Natural Remedy Proven to Stop Hiccups Instantly at Amazon.com.

Abstracts from this week:

Dietary Supplementation with Inulin Modulates the Gut Microbiota and Improves Insulin Sensitivity in Prediabetes - Int J Endocrinol 2021 Jun 29 - "Inulin supplementation improves insulin resistance of prediabetes and exerts beneficial effects on modulating the intestinal microbiota composition" - [Nutra USA] - See

Prebiotic Food Intake May Improve Bone Resorption in Japanese Female Athletes: A Pilot Study - Sports (Basel) 2021 Jun 4 - "The aim of the present study was to clarify the influence of inulin and lactulose-fortified prebiotic food intakes on bone metabolism turnover among Japanese female athletes. The participants included 29 female athletes aged 18-25 years. They were requested to consume their habitual foods or drinks with one pack of prebiotic food every day for 12 weeks ... The occupation ratio of Bifidobacterium spp. was significantly increased at 3 and 4 weeks (18.0 ± 8.3% and 17.6 ± 8.5%, respectively) compared to that of pre-intervention (11.7 ± 7.3%) (p = 0.019 and p = 0.035, respectively). The serum TRACP-5b level was significantly decreased at 12 weeks (363 ± 112 mU/dL) compared to that at baseline (430 ± 154 mU/dL) (p = 0.018). These results suggest that the prebiotic food used in this study might have beneficial effects on bone health and gut microbial environment among female athletes" - [Nutra USA] - See inulin at Amazon.com.

Evaluation of Omega-3 Status in Professional Basketball Players - J Strength Cond Res 2021 Jul 1 - "Omega-3 polyunsaturated fatty acids (PUFA) has been shown to promote muscle remodeling, improve immune status, decrease muscle soreness, and help maintain explosive power ... Dietary intake of players showed that 31% of players reported consuming no fish in their diet per week, with 61% of players reported consuming less than 2 servings of fish per week. Only 12 of the 119 players reported supplementing with omega-3 PUFA, which varied widely for dosage and frequency of supplementation. A moderate correlation was shown for O3i and dietary fish consumption per week (r = 0.58; p < 0.01) and fish consumption per month (r = 0.57; p < 0.01). A large number of players reported consuming less than the recommend amount of dietary fish per week and very few players reported supplementing with omega-3 PUFA. The low intake of omega-3 PUFA likely contributed, in part, to the majority of players having an O3i of less than 8%" - [Nutra USA] - See omega-3 supplements at Amazon.com and iHerb.

Magnesium intake was inversely associated with hostility among American young adults - Nutr Res 2021 May;89:35-44 - "We hypothesize that high total magnesium intake is associated with lower levels of hostility because of its putative antidepressant mechanisms. To test the hypothesis, we prospectively analyzed data in 4,716 young adults aged 18-30 years at baseline (1985-1986) from four U.S. cities over five years of follow-up using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study ... After adjustment for socio-demographic and major lifestyle factors, a significant inverse association was observed between magnesium intake and hostility level over 5 years of follow-up. Beta coefficients (95% CI) across higher quintiles of magnesium intake were 0 (reference), -1.28 (-1.92, -0.65), -1.45 (-2.09, -0.81), -1.41 (-2.08, -0.75) and -2.16 (-2.85, -1.47), respectively (Plinear-trend<.01). The inverse association was independent of socio-demographic and major lifestyle factors, supplement use, and depression status at year 5. This prospective study provides evidence that in young adults, high magnesium intake was inversely associated with hostility level independent of socio-demographic and major lifestyle factors" - [Nutra USA] - See magnesium supplements at Amazon.com.

Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study - Neurology 2021 Jun 22 - "Magnesium has been implicated in regulating blood pressure and vascular endothelial cell function, but its role in the pathophysiology of intracranial aneurysm is not know ... This study provides evidence to support that increased serum magnesium concentrations reduce the risk of intracranial aneurysm and associated hemorrhage" - See magnesium supplements at Amazon.com.

Caffeine consumption improves motor and cognitive performances during dual tasking in middle-aged women - Behav Brain Res 2021 Jun 25 - "The aim of the present study was to explore the effect of caffeine consumption (CC) on cognitive motor interference while walking and maintaining balance in middle-aged women. Twenty middle-aged women (52 ± 2.0 years; height 158 ± 2.0 cm; body mass 77 ± 14.9 kg; body mass index ±3.4 kg/m2, mean ± SD) participated in this study. Participants completed measures of a single task (ST) cognitive, a ST motor and a dual task (DT) cognitive-motor tests before and after either caffeine (100 mg) or placebo ingestion. Results showed that before CC, both motor (P < 0.0005) and cognitive (P < 0.05) performances decreased in the DT condition compared to the ST one. After CC, no significant difference in the motor performances between ST and DT conditions was observed. In fact, both standing and walking DT performances were improved as indicated by a significant (P < 0.05) decrease in the dual task cost (DTC) of motor performances. In conclusion, middle-aged women showed difficulties to manage DT situations in which a cognitive and a motor task must be performed concurrently. Caffeine is an effective ergogenic aid to improve both cognitive and motor performances during DT conditions and could be an alternative to nullify the deteriorating effect of DT when maintaining balance and walking in middle-aged women. These enhancements could offer great potential for everyday functioning" - See

• Which Coffee Maker Makes the Hottest Coffee? [SCAA-Certified] - coffeelifious.com, 1/6/21 - "No other coffee machine brews the coffee at higher temperatures, meaning that the Touch Plus coffeemaker brews the hottest coffee out there" - See Touch Essential Single Serve Coffee Brewer at Amazon.com.

High coffee consumption, brain volume and risk of dementia and stroke - Nutr Neurosci 2021 Jun 24 - "There were inverse linear associations between habitual coffee consumption and total brain (fully adjusted β per cup -1.42, 95% CI -1.89, -0.94), grey matter (β -0.91, 95% CI -1.20, -0.62), white matter (β -0.51, 95% CI -0.83, -0.19) and hippocampal volumes (β -0.01, 95% CI -0.02, -0.003), but no evidence to support an association with white matter hyperintensity (WMH) volume (β -0.01, 95% CI -0.07, 0.05). The association between coffee consumption and dementia was non-linear (Pnon-linearity = 0.0001), with evidence for higher odds for non-coffee and decaffeinated coffee drinkers and those drinking >6 cups/day, compared to light coffee drinkers. After full covariate adjustment, consumption of >6 cups/day was associated with 53% higher odds of dementia compared to consumption of 1-2 cups/day (fully adjusted OR 1.53, 95% CI 1.28, 1.83), with less evidence for an association with stroke (OR 1.17, 95% CI 1.00, 1.37, p = 0.055)"

Correlative Analysis of Vitamin D and Omega-3 Fatty Acid Intake in Men on Active Surveillance for Prostate Cancer - Urology 2021 Jun 15 - "Sixty-eight patients with biopsy-proven NCCN very-low or low-risk prostate cancer were enrolled in the prostate cancer nutrition and genetics clinic at the Cleveland Clinic from July 2013-December 2019. Patients adhered to a specific dietary regimen devoid of animal-based products and foods containing omega-6 polyunsaturated fatty acids (PUFAs). The supplement regimen consisted of: Omega-3 PUFAs 720mg (three/day); curcumin 2000 mg/day; vitamin D3 dose titrated to achieve serum level of 60 ng/ml; and vitamin B-complex 1000 mg (four times weekly) ... Patients with higher initial vitamin D levels were twice as likely to have a downward PSA trend (OR=2.04, 95% CI 1.04-4.01, p=0.04). Fifty-five patients underwent follow-up biopsy, all showing no progression of disease. Three patients had loose bowel movements that required omega-3 and or curcumin dose adjustments" - See vitamin D at Amazon.com and iHerb and omega-3 supplements at Amazon.com and iHerb.

Taurine ameliorates cytotoxic effects of Di(2-ethylhexyl) phthalate on Leydig cells - Andrologia 2021 Jun 24 - "It has been revealed that di(2-ethylhexyl)phthalate (DEHP) has toxic impacts on the male reproductive system. Taurine (TAU) is an amino acid with antioxidant property and beneficial impacts on the male reproductive system ... DEHP could significantly decrease the cell viability percentage, reduce testosterone level, increase apoptosis, elevate Bax/ Bcl-2 ratio and enhance caspase-3 and -9 activity in the TM3 cells. Additionally, DEHP significantly elevated malondialdehyde contents and reactive oxygen species levels. It also augmented superoxide dismutase and catalase activity in the Leydig cells. Co-treatment of DEHP with TAU increased viability and testosterone level, while oxidative stress and apoptosis significantly reduced. TAU could decrease Bax/Bcl-2 ratio and caspase-3 and -9 activity in the DEHP-intoxicated cells. Our results have clearly shown that TAU protects TM3 cells against oxidative stress and apoptosis induced by DEHP" - See taurine at Amazon.com and iHerb.

Protective role of vitamin E in testicular development of mice exposed to valproic acid - Andrologia 2021 Jun 21 - "Valproic acid (VPA) is a teratogenic antiepileptic, causing alterations in oxidative stress in prenatal development, being altered the development of the male reproductive system. The purpose of this study was to determine the protective effect of vitamin E (VE) on the testicular development in embryos, foetuses and pubertal mice exposed to VPA, VPA+VE and only VE ... VE reduces the effects caused by VPA throughout testicular development, from embryonic stages, continuing until pubertal stages" - See vitamin E at Amazon.com and iHerb.

Protective Effects of Vitamin E on Chemotherapy-Induced Peripheral Neuropathy: A Meta-Analysis of Randomized Controlled Trials - Ann Nutr Metab 2021 Jun 18 - "Chemotherapy-induced peripheral neuropathy (CIPN) is a common symptom, but prophylactic measures cannot still be carried out effectively ... Available data in this meta-analysis showed that vitamin E supplementation can confer modest improvement in the prevention of CIPN" - See vitamin E at Amazon.com and iHerb.

Association of measures of body fat with serum alpha-tocopherol and its metabolites in middle-aged individuals - Nutr Metab Cardiovasc Dis 2021 May 18 - "The accumulation of fat increases the formation of lipid peroxides, which are partly scavenged by alpha-tocopherol (α-TOH) ... Opposite to our research hypothesis, higher abdominal adiposity was moderately associated with lower levels of oxidized α-TOH metabolites, which might reflect lower vitamin E antioxidative activity in individuals with higher abdominal fat instead" - See vitamin E at Amazon.com and iHerb.

Effectiveness of Sacubitril/Valsartan Versus Aldosterone Antagonists in Heart Failure with reduced Ejection Fraction: A Retrospective Cohort Study - Pharmacotherapy 2021 Jun 25 - "aldosterone antagonists (ARAs) ... Compared with ARAs, SAC/VAL was associated with lower risk of HF-related and all-cause hospitalizations"

The Role of Zinc Homeostasis in the Prevention of Diabetes Mellitus and Cardiovascular Diseases - J Atheroscler Thromb 2021 Jun 19 - "Zinc is an essential micronutrient for human health and is involved in various biological functions, such as growth, metabolism, and immune function ... Numerous animal and human studies have shown that zinc deficiency may be associated with the risk factors for diabetes and cardiovascular diseases (CVDs) and zinc administration might be beneficial for the prevention and treatment of these diseases" - See zinc supplements at Amazon.com and iHerb.

Short- and Long-Term Effects of Dietary Supplementation with Fish Oil on Inflammatory Pain in Rats - J Am Coll Nutr 2021 Jun 22 - "Dietary supplementation with fish oil is promising as a complementary therapy for inflammatory pain ... Together, these findings support that fish oil decreases inflammatory pain either when consumed during adult life or during prenatal development" - See omega-3 supplements at Amazon.com and iHerb.

Pterostilbene Attenuates High-Fat Diet and Dextran Sulfate Sodium-Induced Colitis via Suppressing Inflammation and Intestinal Fibrosis in Mice - J Agric Food Chem 2021 Jun 30 - "The worldwide prevalence of obesity has significantly increased over the past few decades. It is currently believed that obesity is a risk factor for developing inflammatory bowel disease. Pterostilbene (PTS), a naturally occurring stilbene from blueberries, is known to have anticancer, anti-inflammation, antifibrosis, and antiobesity effects. ... the results of the present study suggest that PTS is of significant interest for the prevention of HFD/DSS-induced colitis in C57BL/6J mice" - See pterostilbene at Amazon.com and iHerb.

Plasma choline and betaine and risks of cardiovascular events and recurrent stroke after ischemic stroke - Am J Clin Nutr 2021 Jun 22 - "Choline and betaine have been suggested to play a pivotal role in neurotransmitter synthesis, cell membrane integrity, and methyl-group metabolism, exerting neuroprotective effects in patients with various neurological disorders ... Plasma choline and betaine were inversely associated with cardiovascular events and recurrent stroke after ischemic stroke. Specifically, in fully adjusted models, each additional SD of choline and betaine was associated with 35% (95% CI: 20%-48%) and 30% (95% CI: 14%-43%) decreased risks of subsequent cardiovascular events, respectively, and 34% (95% CI: 16%-48%) and 29% (95% CI: 12%-43%) decreased risks of recurrent stroke, respectively" - See choline at Amazon.com and betaine anhydrous (TMG) at Amazon.com.

Regular consumption of cod liver oil is associated with reduced basal and exercise-induced C-reactive protein levels; a prospective observational trial : A NEEDED (The North Sea Race Endurance Exercise Study) 2014 sub-study - J Int Soc Sports Nutr 2021 Jun 28 - "Dietary supplement use among recreational athletes is common, with the intention of reducing inflammation and improving recovery ... Basal CRP levels were reduced, and the exercise-induced CRP response was attenuated in healthy recreational cyclists who used omega-3 fatty acid supplements regularly" - See cod liver oil at Amazon.com.

Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study - J Int Soc Sports Nutr 2021 Jun 21 - "Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits ... Twenty untrained men were randomized to ingest 12 mg Capsiate (CAP) or placebo in a parallel, double-blind design ... Chronic Capsiate supplementation combined with resistance training during short period (6 weeks) increased fat-free mass and upper body strength but not inflammatory response and performance in young untrained men" - See capsicum at Amazon.com and iHerb.

Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism - Phytother Res 2021 Jun 22 - "Quercetin is the major representative of the flavonoid subgroup of flavones, with good pharmacological activities for the treatment of liver diseases, including liver steatosis, fatty hepatitis, liver fibrosis, and liver cancer. It can significantly influence the development of liver diseases via multiple targets and multiple pathways via antifat accumulation, anti-inflammatory, and antioxidant activity, as well as the inhibition of cellular apoptosis and proliferation ... quercetin inhibited inflammation of the liver mainly through NF-κB/TLR/NLRP3, reduced PI3K/Nrf2-mediated oxidative stress, mTOR activation in autophagy, and inhibited the expression of apoptotic factors associated with the development of liver diseases. In addition, quercetin showed different mechanisms of action at different stages of liver diseases, including the regulation of PPAR, UCP, and PLIN2-related factors via brown fat activation in liver steatosis. The compound inhibited stromal ECM deposition at the liver fibrosis stage, affecting TGF1β, endoplasmic reticulum stress (ERs), and apoptosis. While at the final liver cancer stage, inhibiting cancer cell proliferation and spread via the hTERT, MEK1/ERK1/2, Notch, and Wnt/β-catenin-related signaling pathways" - See quercetin at Amazon.com and iHerb.

Beetroot and leaf extracts present protective effects against prostate cancer cells, inhibiting cell proliferation, migration, and growth signaling pathways - Phytother Res 2021 Jun 16 - "Beet (Beta vulgaris L.) has high nutritional value, containing bioactive compounds such as betalains and flavonoids. Scientific evidence points to the use of these natural compounds in the treatment of several types of cancer, such as prostate cancer, one of the main causes of morbidity and mortality in men. Here, we compared beet roots and leaves extracts, and their main compounds, apigenin, and betanin, respectively, in DU-145 and PC-3 prostate cancer cell lines. Both cells presented the proliferation decreased for beetroot and beet leaves extracts. The apigenin treatment also reduced the proliferation of both cell lines. Regarding cell migration, beet leaves extract was able to decrease the scratch area in both cell lines, whereas apigenin affected only PC-3 cells' migration. In colony formation assay, both extracts were effective in reducing the number of colonies formed. Besides, the beet leaves extracts and apigenin presented strong inhibition of growth-related signaling pathways in both cell lines, and the beetroot extract and betanin presented effects only in DU-145 cells" - See beet root powder at Amazon.com.

Oral Nutritional Supplement with β-hydroxy-β-methylbutyrate (HMB) Improves Nutrition, Physical Performance and Ameliorates Intramuscular Adiposity in Pre-Frail Older Adults: A Randomized Controlled Trial - J Nutr Health Aging 2021;25(6):767-773 - "Supplementation of high protein oral nutrition shakes supplemented with β-hydroxy-β-methylbutyrate (HP-HMB) has been shown to improve muscle mass, muscle strength, and physical performance in older adults ... enrolled 70 community-dwelling pre-frail older persons without active or uncontrolled conditions, disability or dementia. The intervention group was provided with two services of HP HMB (Ensure® Plus Advance containing 3g HMB) per day for 12 weeks, and the control group was provided with professional nutritional counselling for sufficient protein intake ... The 12-week supplementation with high protein oral nutrition shake supplemented with 3g HMB per day significantly increased muscle mass, as well as nutritional status and physical performance, and ameliorated the intramuscular adiposity of pre-frail older persons" - See HMB at Amazon.com and iHerb.

Implementation of Christian Orthodox fasting improves plasma adiponectin concentrations compared with time-restricted eating in overweight premenopausal women - Int J Food Sci Nutr 2021 Jun 21 - "In the OF group, there was an increase in adiponectin values at 12 weeks compared with baseline (9815.99 vs 8983.52 mg/ml, p = 0.02) and a reduction in body fat mass between baseline and 12 weeks (35.44 vs 32.17%, p = 0.004) and between 7 and 12 weeks (35.33 vs 32.17%, p = 0.003). In the same group, an inverse correlation between adiponectin and waist circumference values was observed over the entire study period. Our results provide novel evidence that Orthodox fasting has favourable metabolic effects related to improved adiponectin concentrations."

A new high protein-to-energy enteral formula with a whey protein hydrolysate to achieve protein targets in critically ill patients: a prospective observational tolerability study - Eur J Clin Nutr 2021 Jun 24 - "The HP:E formula containing 33% whey protein hydrolysate is well tolerated in this tolerability study. Due to the HP:E ratio protein targets can be reached faster" - See whey protein at Amazon.com and iHerb.

Effects of L-citrulline supplementation on nitric oxide and antioxidant markers after high-intensity interval exercise in young men: a randomized controlled trial - Br J Nutr 2021 Jun 17 - "L-citrulline (L-Cit) is a nonessential amino acid that stimulates nitric oxide (NO) production and improves exercise performance by reducing muscle damage indices ... nine young men (21 ± 1 years) participated in a double-blind crossover study in which they received 12 g of L-Cit and placebo (PL) an hour prior to high-intensity interval exercise on two occasions, separated by a seven-day washout period ... Our data indicate that L-Cit supplementation (single 12 g dose pre-exercise) induces improvements in antioxidant markers following a session of high-intensity interval exercise in young men" - See l-citrulline at Amazon.com.

Therapeutic effects of saffron extract on different memory types, anxiety, and hippocampal BDNF and TNF-α gene expressions in sub-chronically stressed rats - Nutr Neurosci 2021 Jun 24 - "Compared to the low saffron dose, the high dose had a latent but long-lasting impact. Cognitive and spatial memories remained unaffected by either stress or saffron treatment. In addition, only the high saffron dose reversed anxiety in the sub-chronically stressed group. These findings suggest that various doses of saffron act differently on different brain functions under sub-chronic stress condition" - See saffron supplements at Amazon.com.

Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort - Am J Clin Nutr 2021 Jun 16 - "In this community-based population in their mid-60s, RBC FA patterns were as predictive of risk for death during the next 11 y as standard risk factors" - [Nutra USA] - See omega-3 supplements at Amazon.com and iHerb.

Neat Tech Stuff / "How To's":

Health Focus (Mediterranean Diet):