Recent Longevity News for the week ending 3/18/20

A more balanced protein intake can reduce age-related muscle loss - Science Daily, 3/16/20 - "old people, compared to young and middle-aged individuals, people were more likely to eat a lower-quality protein source, such as bread, at lunchtime ... We know that older people show a blunted response to muscle building when consuming a certain amount of protein. Therefore, older individuals need to eat more protein to get the same muscle building response as younger and middle-aged people"

Ouch: Patients prescribed opioids after tooth extraction report worse pain - Science Daily, 3/13/20 - "Surprisingly, patients in the opioid group actually reported worse pain than the non-opioid group for both types of extractions ... Alternatives such as nonsteroidal anti-inflammatory drugs or acetaminophen appear to control pain better, and patient satisfaction remains high ... Nalliah gives two possible reasons for this. First, dentists may have prescribed opioids in only the toughest cases, which would have resulted in more pain regardless ... Or alternatively, and this is the reason I tend to accept, is that our study concurs with previous studies that suggest opioids are not the most effective analgesic for acute dental pain"

Effects of Omega-3 Fatty Acid Supplements on Arrhythmias - Medscape, 3/13/20 - "In conclusion, evidence from large trials now suggests that omega-3 FA supplementation may have a dose-related protective effect on coronary events. However, systematic reporting of arrhythmia outcomes in existing and future trials is required to clarify whether supplementation also has any adverse effects on nonfatal arrhythmias" - See omega-3 supplements at Amazon.com.

How intermittent fasting changes liver enzymes and helps prevent disease - Science Daily, 3/10/20 - "every-other-day-fasting -- where no food was consumed on alternate days -- changed the metabolism of fatty acids in the liver, knowledge that could be applied to improvements in glucose tolerance and the regulation of diabetes ... Last year we published research into the impact of every-other-day-fasting on humans. Using these mouse data, we can now build up improved models of fasting for better human health"

Growing Evidence Links Air Pollution Exposure to Risk of Alzheimer's Disease and Related Dementia - Medscape, 3/11/20 - "Alzheimer's disease and related dementia (ADRD) ... Within the context of the existing literature, the Younan et al. paper in this issue of Brain provides additional support for the hypothesis that higher exposure to PM2.5 is related to increased risk of ADRD and related outcomes, and suggests that this is mediated by observable changes to the grey matter. However, the implications of this investigation and the growing body of similar work on air pollution and late-life cognitive health go beyond whether air pollution is a modifiable risk factor for ADRD and related outcomes. As a class, environmental exposures represent an understudied set of potential risk factors for neurological conditions. Further consideration of the impact of an expanded set of exposures on the brain is warranted"

Low-Dose Naltrexone: An Inexpensive Medicine for Many Ills? - Medscape, 3/11/20 - "Raknes and Småbrekke examined data from the Norwegian Prescription Database and found that the number of naltrexone users increased from 14 in 2012 to more than 11,000 in 2013 ... Further analysis showed that 71% of the country's GPs had prescribed LDN, at a median daily dose of 3.7 mg, to 15,297 individuals (0.3% of the entire population), during 2013–2014 ... Among individuals with rheumatoid and seropositive arthritis who filled four or more LDN prescriptions, there was a significant 13% reduction in the total number of doses dispensed of all examined medicines and a significant 13% relative reduction in the number of users of disease-modifying antirheumatic drugs (DMARDs) ... In the psychiatry/neurology category, significant reductions were seen in use of antipsychotics between the highest and lowest LDN use (P = .007), and in the number of users of antiepileptics (P < .001), antipsychotics (P < .001), and antidepressants (P = .001)." - See naltrexone at ReliableRx.

Going Off Beta Blockers an Option in Selected Low-Risk LQTS, Group Proposes - Medscape, 3/9/20 - "Not everyone diagnosed with long-QT syndrome (LQTS) needs to take beta blockers to cut their risk for sudden death, despite guidelines that recommend all such patients be given the drugs ... Such patients who are judged to be at exceptionally low risk from their LQTS and who want to avoid the often oppressive side effects of beta blockers can safely follow an "intentional nontherapy" strategy ... Most of the nontreated patients in the analysis had started on beta blockers, "hated it, then moved to intentional nontherapy,"" - Note: Nebivolol has the least side effects but it's also the most expensive.  Seems like doctors prescribe whatever's cheap but what's quality of life worth?

• Real-world efficacy and safety of nebivolol in Korean patients with hypertension from the BENEFIT KOREA study - J Hypertens. 2019 Nov 5 - "heart rate (HR) ... Nebivolol significantly decreased mean SBP and DBP at 12 and 24 weeks compared with baseline (P < 0.0001). A significant reduction in HR was also observed at 12 and 24 weeks (P < 0.0001). The reductions of SBP and DBP were notably greater when nebivolol was used as monotherapy in de novo patients (P < 0.0001) and as add-on therapy to existing antihypertensives (angiotensin II receptor blockers, angiotensin-converting enzyme inhibitors and calcium channel blockers; P < 0.0001). Majority of the reported adverse events were mild; the most common adverse events were dizziness (1.3%), headache (1.0%) and dyspnea (0.9%)" - Note: ReliableRx sells nebivolol.

Olive Oil Intake Linked to Reduced CVD - Medscape, 3/9/20 - "Replacing about 1 teaspoon per day (5 g/day) of margarine, butter, mayonnaise, or dairy fat with an equivalent amount of olive oil was associated with a 5% to 7% lower risk for total CVD and CHD ... After adjusting for other dietary and lifestyle factors, those with higher olive oil intake (>½ tablespoon per day or >7 g/day) had a 14% lower risk for CVD and an 18% lower risk for CHD compared to those who did not consume olive oil ... given the limitations of the methods," but is "entirely unconvincing" and provides no basis on which to make any changes to dietary recommendations ... When you change one thing in diet, you don't expect to see big changes, so the 5% to 7% lower risk they found is within what's plausible, but it's also within the limits of error of the method, so it's really neither here nor there ... the results were similar when olive oil was compared with other plant oils combined (eg, corn, safflower, soybean, canola) ... As observational studies go, this is as good as they get, done by one of the best groups in the world, but it’s still an observational study, and the differences seen are so small"

Does consuming fruit during pregnancy improve cognition in babies? - Science Daily, 3/4/20 - "Results show that infant animal models of mothers who had their diets supplemented with fruit juice performed significantly better on tests of memory -- consistent with the previous study"

Low blood pressure linked to high mortality in older adults - Science Daily, 3/7/20 - "people aged 75 or over with low blood pressure (below 130 / 80) had increased mortality rates in the follow-up, compared to those with normal blood pressure. This was especially pronounced in 'frail' individuals, who had 62 per cent increased risk of death during the ten year follow-up ... Although high blood pressure increased risk of cardiovascular incidents, such as heart attacks, it was not linked to higher mortality in frail adults over 75. Older people aged 85 and over who had raised blood pressure actually had reduced mortality rates, compared to those with lower blood pressure, regardless of whether they were frail or not"

Caffeine boosts problem-solving ability but not creativity, study indicates - Science Daily, 3/5/20 - "For the study, 80 volunteers were randomly given either a 200mg caffeine pill, equivalent to one strong cup of coffee, or a placebo. They were then tested on standard measures of convergent and divergent thinking, working memory and mood. In addition to the results on creativity, caffeine did not significantly affect working memory, but test subjects who took it did report feeling less sad ... "The 200mg enhanced problem solving significantly, but had no effect on creative thinking," said Zabelina. "It also didn't make it worse, so keep drinking your coffee; it won't interfere with these abilities.""

Marijuana Allergies on the Rise - Medscape, 3/6/20 - "As business flourishes for operators in the cannabis industry and for the legal profession, Burnham said she worries that there isn't enough protection for workers. "Do workers exposed to plant material on a daily basis have adequate workplace protection," such as masks and gowns? "There's a downstream effect that impacts people that nobody has really thought about," she pointed out ... If the cannabis industry becomes driven by money, with a lobby like the tobacco industry, there will be no way to keep people who are vulnerable from using cannabis ... Is an occasional joint, much like an occasional glass of wine, okay? "We don't know," said Burnham. "We just don't have enough information about it.""

Consuming more olive oil associated with less heart disease in Americans - AHA, 3/5/20 - "After accounting for diet and lifestyle factors, researchers found that those who ate more than half a tablespoon per day of olive oil had a 15% lower risk of having any kind of cardiovascular disease and a 21% lower risk of coronary heart disease. However, higher consumption of olive oil did not show an impact on stroke risk ... The researchers also found that replacing one teaspoon of butter, margarine, mayonnaise or dairy fat with the same amount of olive oil lowered the risk of any cardiovascular disease by 5% and lowered the risk of coronary heart disease by 7%. However, when the study began in 1990, many margarines contained substantial amounts of trans-fatty acids, so the results may not apply to vegetable margarines currently available"

Is caffeine really bad for you? A doctor weighs in - CNET, 3/5/20 - "The bottom line? As long as your doctor clears you to drink moderate amounts of caffeine, it's a very safe substance that might even have powerful health benefits. Just make sure you're in it for the right reasons"

Frequent Tooth Brushing Tied to Lower Diabetes Risk - NYT, 3/5/20 - "Using Korean government health records and self-reports, researchers gathered health and behavioral data on 188,013 men and women, average age 53, who were free from diabetes. More than 17 percent had periodontal disease. Over the course of the 10-year study, 31,545 developed diabetes ... After controlling for age, sex, socioeconomic status, smoking, alcohol consumption, physical activity, lipid levels, hypertension and other factors, they found that people with periodontal disease had a 9 percent increased risk for developing diabetes ... Compared with people who did not brush or brushed only once a day, those who brushed twice a day had a 3 percent reduced risk for diabetes, and those who brushed three times a day an 8 percent reduced risk. The loss of 15 or more teeth was associated with a 21 percent increased risk for developing diabetes"

Unscrambling the Egg Data: One a Day Looks OK - WebMD, 3/5/20 - "The study participants were followed for 32 years, during which their diets and other lifestyle habits were recorded ... The researchers also analyzed 28 studies with up to 1.7 million people. This meta-analysis supported the finding that moderate egg consumption is not associated with increased risk of heart disease in Americans and Europeans ... The investigators also found some evidence suggesting that moderate egg consumption may be associated with lower heart disease risk in Asian populations, but the finding may be affected by their overall dietary habits"

Can’t find hand sanitizer? Make your own! - CBS8, 3/3/20 - "Ingredients ... Alcohol (Forbes recommends 91 percent isopropyl, but cheap Vodka will work in a pinch) ... Aloe vera gel ... Essential oils (if you want to be fancy. This is what Good Housekeeping suggests) ... Instructions ... Pour the alcohol into a small bottle until it’s between a quarter and third full ... Fill the rest of the bottle with aloe vera gel ... Add a few drops of your favorite essential oils ... Mix together" - See aloe vera gel at Amazon.com.  Note: I used to used cheap Vodka from the commissary because I worried about the detrimental affects of rubbing alcohol being absorbed into the skin. If you bought a case of 6 you got 10% off. It came to $8 or $9 per half gallon. People thought I was crazy. That said, hand sanitizer is a lot more than $9 for a half gallon.

Some articles argue that the CDC guidelines are for hand sanitizer to be at least 60% alcohol. Purell says that the active ingredient is 70% alcohol. But Purell is diluted with a lot of other ingredients. The main ingredient is water. I would think that would bring it down to a lot lower than 60% alcohol.  There's a lot of confusion on whether the active ingredient should be 60% or if it should be 60% after everything is added.  The later makes no sense.  Some are capitalizing on this confusion and selling hand sanitizer for $50 per gallon.  Using the logic that only the active ingredient has to be 60% is like saying you can have one cup of 100% alcohol and 99 cups of water and it's still going to be effective.  All the scholarly pro and con articles on hand sanitizer and homemade hand sanitizer need to clarify that.  With straight 120 proof alcohol, you meeting the more stringent interpertation.

If you’re worried about having at least 60% alcohol, buy 120 proof vodka and use it straight. They sell the Everclear brand at BevMo. It’s $22 for 750 ml, about what hand sanitizer cost if you could get it. I just worry about using the rubbing alcohol in Purell every day. It gets into your bloodstream and rubbing alcohol is poison. Plus I don't like the sticky felling it leaves on your hands. Carry it in a small container. If you go to a restaurant, after you touch to door, read the menu, etc., use the alcohol when you get served.

• Why you shouldn't make your own hand sanitizer - CNET, 3/5/20 - "The key is to get the right ratio of ingredients. The Centers for Disease Control recommends using a hand sanitizer that contains at least 60% alcohol, which store-bought hand sanitizers have. But trying to replicate that on your own can be tricky ... Most of the countless recipes out there use a mix of 91% or 99% isopropyl alcohol (or rubbing alcohol) and aloe vera gel, which is necessary to add moisture to your skin because alcohol will dry it out. The typical ratio is 60% alcohol to 40% aloe vera gel by volume, or 2/3 rubbing alcohol to 1/3 cup aloe vera gel."

• Fight COVID-19 on the go with homemade hand sanitizer - Popular Science, 3/5/20 - "Instructions for the WHO formulation ... Ingredients ... 1 cup of 99% isopropyl alcohol ... 1 tablespoon of 3% hydrogen peroxide ... 1 teaspoon of 98% glycerin ... ¼ cup, 1 tablespoon, and 1 teaspoon (or 85 milliliters) of sterile distilled or boiled cold water" - Note:  Someone on the local news in San Diego said you could replace the glycerin with aloe vera gel.

Alzheimer's: Can an amino acid help to restore memories? - Science Daily, 3/3/20 - "supplying a specific amino acid as a nutritional supplement in a mouse model of Alzheimer's restores spatial memory affected early. This is a promising path for reducing memory loss related to that disease ... With the identification of the role of L-serine in memory disorders and the experimental efficacy of nutritional supplementation, new strategies appear that may complement medical treatment, to combat early symptoms of Alzheimer's disease and other diseases that display metabolic deficits, like Parkinson's and Huntington's. Since L-serine is available as a nutritional supplement, this compound should be rigorously tested in humans, through controlled clinical trials" - See L-serine at Amazon.com.

Can't sleep? Prebiotics could help - Science Daily, 3/3/20 - "Most people are familiar with probiotics, friendly bacteria present in fermented foods like yogurt and sauerkraut. More recently, scientists have taken an interest in prebiotics -- dietary compounds that humans cannot digest but serve as nourishment for our microbiome, or the trillions of bacteria residing within us. While not all fibers are prebiotics, many fibrous foods like leeks, artichokes, onions and certain whole grains are rich in them ... rats on the prebiotic diet had a substantially different "metabolome," or make-up of metabolites. Theirs was higher in dozens of them, including fatty acids, sugars and steroids which may, via gut-brain signaling pathways, influence behavior. The rats' metabolome also looked different after stress ... For instance, the rats on the standard chow diet saw dramatic spikes in allopregnanolone precursor and Ketone Steroid, potentially sleep-disrupting metabolites, while those on the prebiotic diet saw no such spike ... The rats were fed very high doses of four specific prebiotics, including: galactooligosaccharides, which are present in lentils and cabbage; polydextrose (PDX) an FDA-approved food additive often used as a sweetener; lactoferrin, found in breast milk; and milk fat globular protein, abundant in dairy products." - [Nutra USA] - See prebiotic supplements at Amazon.com.

Abstracts from this week:

The effects of omega-3 fatty acids on diabetic nephropathy: A meta-analysis of randomized controlled trials - PLoS One. 2020 Feb 11 - "Omega-3 fatty acids could help ameliorate proteinuria among type 2 DM who received omega-3 supplementation for at least 24 weeks without adverse effects on HbA1C, total serum cholesterol and LDL-cholesterol" - [Nutra USA] - See omega-3 supplements at Amazon.com.

Olive Oil Consumption and Cardiovascular Risk in U.S. Adults - J Am Coll Cardiol. 2020 Feb 27 - "We included 61,181 women from the Nurses' Health Study (1990-2014) and 31,797 men from the Health Professionals Follow-up Study (1990-2014) who were free of cancer, heart disease, and stroke at baseline. Diet was assessed using food frequency questionnaires at baseline and then every 4 years ... Higher olive oil intake was associated with lower risk of CHD and total CVD in two large prospective cohorts of U.S. men and women. The substitution of margarine, butter, mayonnaise, and dairy fat with olive oil could lead to lower risk of CHD and CVD"

Dietary and Serum Omega-6/Omega-3 Fatty Acids Are Associated with Physical and Metabolic Function in Stroke Survivors - Nutrients. 2020 Mar 6 - "six-minute walk distance (6MWD) ... The dietary intake ratio of omega-6/omega-3 fatty acids averaged 12.6 ± 7.1 and the serum concentration ratio was 1.21 ± 0.37, which were correlated (r = 0.88, p < 0.01). Higher dietary intake and serum concentrations of omega-6/omega-3 fatty acids were associated with lower 6MWD and higher HOMA-IR, while a higher serum omega-6/omega-3 concentration index was associated with lower VO2peak (p's < 0.05). These preliminary data suggest that both dietary omega-6 and omega-3 fatty acids (quantitated as their intake ratio) and the serum concentration ratio of omega-6/omega-3 may be important indices of physical dysfunction and insulin resistance in chronic stroke survivors"

Glutamine-stimulated in vitro hypertrophy is preserved in muscle cells from older women - Mech Ageing Dev. 2020 Mar 3 - "Age-related loss of muscle mass may result from reduced protein synthesis stimulation in response to anabolic stimuli, such as amino acid (AA) supplementation. The exact etiology of anabolic resistance to AA remains unclear ... Altogether, our data support the idea that the intrinsic capacity of muscle cells to respond to glutamine stimulation is preserved in healthy older women" - See L-glutamine at Amazon.com.

The Effect of L-Carnitine Supplementation on Exercise-Induced Muscle Damage: A Systematic Review and Meta-Analysis of Randomized Clinical Trials - J Am Coll Nutr. 2020 Mar 10:1-12 - "Accumulating evidence of previous experimental studies indicated that L-Carnitine positively ameliorates muscle damage ... Pooled data from seven studies showed that L-Carnitine resulted in significant improvements in muscle soreness (MS) at the five follow-up time points (0, 24, 48, 72 and 96 hours (h)) compared to placebo. Also, pooled data indicated that L-Carnitine significantly reduced creatine kinase (CK), myoglobin (Mb), and lactate dehydrogenase (LDH) levels at one follow-up period (24 h). However, no effects have been observed beyond this period. Our outcomes indicate that L-Carnitine supplementation improves delayed-onset muscle soreness (DOMS) and markers of muscle damage" - See L-carnitine at Amazon.com.

The influence of green coffee bean extract supplementation on blood glucose levels: A systematic review and dose-response meta-analysis of randomized controlled trials - Phytother Res. 2020 Mar 11 - "The results of present study support the use of GCE for the enhancement of blood glucose, while subgroup analysis highlighted significant improvements in insulin levels when GCE is supplemented in doses ≥400 mg/day." - See green coffee bean extract at Amazon.com.

A randomized, double-blind, placebo-controlled clinical trial, evaluating the garlic supplement effects on some serum biomarkers of oxidative stress, and quality of life in women with rheumatoid arthritis - Int J Clin Pract. 2020 Mar 11 - "Seventy women with RA participated in this randomized, double-blind, placebo-controlled, parallel-design trial. The patients were randomly divided into two groups, receiving two tablets of either 500 mg garlic or placebo daily for eight weeks ... total antioxidant capacity (TAC) and malondialdehyde (MDA) ... health assessment questionnaire (HAQ) ... At the end of the study, there was a significant increase in serum levels of TAC in the garlic group as compared to the placebo group (26.58±77.30 nmol of Trolox equivalent/ml vs. 16.11±0.92 nmol of Trolox equivalent/ml; P=0.026). In addition, MDA levels were significantly decreased in the intervention group compared with the control group (-0.82±1.99 nmol/ml vs. 0.36±2.57 nmol/ml; P=0.032). Pain after activity and HAQ scores decreased in the garlic group compared to the placebo (-11.96±13.43 mm vs. -0.06±13.41 mm; P<0.001, 0.17±20 vs. 0.05±0.15; P<0.001, respectively)" - See garlic supplements at Amazon.com.

The Role of Probiotics in Colorectal Cancer Management - Evid Based Complement Alternat Med. 2020 Feb 14 - "The recent scientific evidence suggested that probiotic supplementation protects the CRC patients from treatment-associated adverse effects. The manuscript summarizes the influence of probiotic supplementation on the health status of CRC patients and discusses the possible mechanism behind the protective effect of probiotics against CRC. The literature survey revealed that beneficial impact of probiotic supplementation depends on several factors such as strain, dosage, duration of the intervention, host physiology, and other food supplements. The probiotic intervention improves the microbiota, releases antimicrobials and anticarcinogenic agents, helps to remove carcinogens, and improves the intestinal permeability, tight junction function, and enzyme activity in CRC patients. Besides, not all probiotic strains exhibit anti-CRC activities; it is necessary to screen the potent strain for the development of a probiotic-based therapeutic agent to control or prevent the incidence of CRC." - See probiotic supplements at Amazon.com.

Effects of substituting eggs for high-carbohydrate breakfast foods on the cardiometabolic risk-factor profile in adults at risk for type 2 diabetes mellitus - Eur J Clin Nutr. 2020 Mar 9 - "Subjects incorporated into their habitual diets breakfast meals containing either 2 eggs/day for 6 days/week (Egg condition), or energy-matched, non-egg, higher-CHO-based foods (Non-Egg condition) ... Thirty men and women with mean age 54.1 ± 1.9 years and body mass index 31.9 ± 0.7 kg/m2 provided data. Neither diet condition significantly altered insulin sensitivity indices, but the homeostasis model assessment for insulin resistance was significantly (p = 0.028) higher after the Non-Egg vs. the Egg condition. Low-density lipoprotein cholesterol (LDL-C) was decreased from baseline (119 mg/dL) by 2.9 and 6.0% with Egg and Non-Egg breakfasts, respectively (p = 0.023). Systolic blood pressure was reduced from baseline (127 mm Hg) by 2.7 and 0.0% with Egg and Non-Egg, respectively"

Effect of 4 weeks daily wild blueberry supplementation on symptoms of depression in adolescents - Br J Nutr. 2020 Mar 10:1-22 - "we investigated the effects of four weeks, daily wild blueberry supplementation (containing ~253mg anthocyanins) on transient and chronic mood in adolescents. Healthy 12-17-year old (N = 64, 35 females) were recruited and randomly assigned to receive either a wild blueberry or matched placebo supplementation. Depression and anxiety symptoms were assessed before and after the intervention period using the Mood and Feeling Questionnaire and Revised Child Anxiety and Depression Scale. Transient affect was assessed before, two weeks, and at four weeks using Positive and Negative Affects. Following the intervention period there were significantly fewer self-reported depression symptoms in participants who were supplemented with the wild blueberry intervention compared to those who received the matched placebo (p=0.02, 95% CI -6.71 to -5.35). There was no between group effect on anxiety symptoms or on transient affect" - See blueberry extract at Amazon.com.

Effects of High-Dose, Short-Duration β-Alanine Supplementation on Cognitive Function, Mood, and Circulating Brain-Derived Neurotropic Factor (BDNF) in Recreationally-Active Males Before Simulated Military Operational Stress - J Diet Suppl. 2020 Mar 6:1-22 - "β-alanine (BA) supplementation may improve cognition and mitigate symptoms of anxiety and depression associated with aging, neurological disorders, and physical exertion, which has been attributed to increases in brain carnosine and/or brain-derived neurotropic factor (BDNF). BA also provides beneficial effects on cognition, mood, and physical performance during military operations; however, whether BA can attenuate mood disruptions and cognitive dysfunction associated with the anticipatory stress prior to simulated military operations is unknown ... After POST testing, subjects underwent a 24h simulated military operation.Results: No change in measures of cognitive function or BDNF concentrations were observed (p > 0.05). However, BA experienced significant reductions (p = 0.046) in subjective feelings of depression, while PL experienced significant reductions (p = 0.021) in feelings of vigor from PRE to POST.Conclusions: High-dose, short-duration BA supplementation does not appear to affect cognitive function or circulating BDNF, but may mitigate the onset of negative mood states in healthy, recreationally-active males prior to a simulated military operation" - See beta-alanine at Amazon.com.

Effect of Tart Cherry Concentrate on Endurance Exercise Performance: A Meta-analysis - J Am Coll Nutr. 2020 Jan 27:1-8 - "Tart cherry concentrate has been shown to improve muscle function, and reduce muscle damage, oxidative stress/inflammation, and muscle soreness in athletes ... Interventions included tart cherry supplementation and placebo ingested before, and/or on the day of exercise. Ten studies were included (totaling 127 males and 20 females) ... Tart cherry concentrate in juice or powdered form, ingested for 7 days to 1.5 hours before exercise performance testing significantly improved endurance exercise performance (SMD: 0.36; 95% CI: 0.07 to 0.64; p = 0.01; I2 = 0%) upon pooling of the ten studies ... Tart cherry concentrate has a significant benefit for endurance exercise performance. Key teaching pointsTart cherry concentrate has a significant benefit for endurance exercise performance.Tart cherry concentrate may enhance endurance exercise performance via its low glycemic index, anti-inflammatory and anti-oxidative capacity, and blood flow enhancing effects" - [Nutra USA] - See tart cherry concentrate at Amazon.com.

The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK - J Lipid Res. 2020 Mar;61(3):387-402 - "The flavonoid nobiletin displays potent lipid-lowering and insulin-sensitizing properties in mice with metabolic dysfunction ... In mice fed a high-fat diet, nobiletin robustly prevented obesity, hepatic steatosis, dyslipidemia, and insulin resistance, and it improved energy expenditure in Ampkβ1 -/-, AccDKI, and iβ1β2AKO mice to the same extent as in WT controls. Thus, the beneficial metabolic effects of nobiletin in vivo are conferred independently of hepatic or adipocyte AMPK activation. These studies further underscore the therapeutic potential of nobiletin and begin to clarify possible mechanisms" - See nobiletin at Amazon.com.

Neat Tech Stuff / "How To's":

Amazon is selling out of stuffing mix fast. On automatic reorder it's only $1.19 per 6-ounce box. Get the mashed potatoes while you're at it. Who would have thunk?

I purchased the Graco Ultra Cordless Airless Handheld Paint Sprayer 17M363 and love it.  My first project with it was my master bathroom cabinets.  The below picture is an example.  That was taken in the garage early in the morning and the sun from the east caused those reflections.  First I tested it on stucco and was ready to throw it out until I figured out what I was doing wrong.  First, thin the paint by about 8%.  I used 10 ounces of water for a 128 ounce (gallon) of paint.  Also, make sure you use a strainer for the paint.  The pressure was 3 (out of 10).  The paint is Sherwin Williams Emerald Urethane Trim Enamel in Riverway.  I got that idea from this YouTube video: https://youtu.be/WgaAnASHOXE.  It's expensive, about $95 per gallon but they always have a coupon on their website for 30% off plus if you join their newsletter you get a coupon for another $10 off.  Home Depot has a similar color, Pine Mountain.  See https://youtu.be/81hJHT-u_Uo.  When you're done, run water through the sprayer them run some Klean-Strip Paint Sprayer Cleaner through it.  You also might want to take out the spray nozzle and clean it with the Klean-Strip and a toothbrush.  Here's the setup I used:

I can't believe I went through my whole life with a paintbrush or roller.  This door took less than a minute.  I missed a few spots with the sanding but other than that, the finish looks like it was done at a car body shop.

Amazon is still selling nitrile gloves:

I bought a body temperature monitor similar to this just before the coronavirus scare.  It was the Vigorun brand.  Amazon doesn't list it anymore.  It cost something like $27.  Now they're a hundred dollars more.  Terrible price gouging.

Health Focus (Alpha Lipoic Acid)