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Recent Longevity News for the week ending 5/15/19 A High Serum Cortisol/DHEA-S Ratio Is a Risk Factor for Sarcopenia in Elderly Diabetic Patients - Medscape, 5/9/19 - "A relative increase in cortisol may reflect the presence of stress and stimulate muscle catabolism, whereas a relative decrease in DHEA-S may cause a decrease in the anabolic action of DHEA on muscle; the combination of these factors may lead to sarcopenia" - See 7-keto DHEA at Amazon.com.
Broccoli sprout compound may restore brain chemistry imbalance linked to
schizophrenia - Science Daily, 5/8/19 - "It's
possible that future studies could show sulforaphane to be a safe supplement to
give people at risk of developing schizophrenia as a way to prevent, delay or
blunt the onset of symptoms ... The researchers used MRS again to monitor three
brain regions for glutathione levels in the healthy volunteers before and after
taking sulforaphane. They found that after seven days, there was about a 30%
increase in average glutathione levels in the subjects' brains. For example, in
the hippocampus, glutathione levels rose an average of 0.27 millimolar from a
baseline of 1.1 millimolar after seven days of taking sulforaphane" - See
sulforaphane at Amazon.com
New treatment for severe dry eye disease promising in early clinical trials - Science Daily, 5/7/19 - ""In dry eye disease, several things happen," Jain explained. "There is an increase in the number of white blood cells called neutrophils that gather on the surface of the eye. Neutrophils release DNA which forms webs on the cornea called neutrophil extracellular traps, which cause inflammation of the ocular surface and attract additional neutrophils in a vicious cycle." ... Participants were given eye drops containing either DNase or a placebo formulation and instructed to administer one drop of the solution to each eye four times per day for eight weeks ... participants in the DNase group had a statistically significant and clinically meaningful reduction in corneal damage at eight weeks compared with the placebo group. Questionnaire scores related to symptoms also reflected significant improvement among patients in the DNase group compared with placebo, who also had reduced amounts of corneal DNA webs and other material on the surface of the eye. ... DNase is currently approved by the U.S. Food and Drug Administration to treat cystic fibrosis ... There are currently only two approved drugs to treat dry eye, and they don't work for everyone, especially those with severe disease, so having a new drug that can treat the disease is very important" Could Common Heart Meds Lower Prostate Cancer Risk? - WebMD, 5/3/19 - "a beta blocker called atenolol cut men's risk of intermediate-grade prostate cancer about in half, compared with men not taking a beta blocker ... It also appeared to significantly reduce the risk of low-grade prostate cancer, the findings showed" Plant-based Diet Linked to Lower Heart Failure Risk - Medscape, 5/2/19 - "They found that the plant-based diet was associated with a 41% lower risk for incident HF with the highest vs lowest adherence, while the Southern diet was associated with a 71% higher risk for HF with higher vs lower adherence, after adjustment for potential demographic, lifestyle, and medical confounders" Erectile dysfunction drug 'effective' as heart failure treatment - Science Daily, 5/1/19 - "The study of Tadalafil -- which is in the same class as Viagra -- proves that the drug is biologically effective as a treatment for heart failure in sheep ... When the animals had heart failure -- induced by pace makers -- which was sufficiently advanced to need treatment, the team administered the drug. Within a short period the progressive worsening of the heart failure was stopped and, importantly the drug reversed the effects of heart failure ... And the biological cause of breathlessness in heart failure- the inability of the heart to respond to adrenaline was almost completely reversed" Abstracts from this week:
Cardiovascular Benefits
of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China
- J Am Coll Cardiol. 2019 Apr 30;73(16):2076-2085 - "The
authors observed beneficial effects of fish-oil supplementation on 5 biomarkers
of blood inflammation, coagulation, endothelial function, oxidative stress, and neuroendocrine stress response in the fish-oil group at a false discovery rate
of <0.05" - [Nutra
USA] - See
omega-3 supplements at Amazon.com
Association the 25(OH)
Vitamin D status with upper respiratory tract infections morbidity in water
sports elite athletes - J Sports Med Phys Fitness. 2019 May 2 -
"Study
participants included 40 elite athletes and 30 control individuals ...
VD
insufficiency is quite pronounced among elite athletes engaged in synchronized
swimming and swimmers. It is accompanied with a decrease of IFN-γ, increase of
TNF-α, IL-4 and IL-6 level, and elevation of URTI morbidity. Seasonal monitoring
and correction of the VD level for normalization of cytokine profile and
decrease of URTI morbidity is definitely advised" - See
vitamin D at Amazon.com
Use of statin medications following diagnosis in relation to survival among women with ovarian cancer - Cancer Epidemiol Biomarkers Prev. 2019 May 7 - "Over a mean follow-up of 2.2 years, 796 (36%) women died from ovarian cancer. The adjusted hazard ratio (aHR) for ovarian cancer mortality comparing statin users to non-users was 0.74"
Benefits of Hesperidin
for Cutaneous Functions - Evid Based Complement Alternat Med. 2019 Apr
2;2019:2676307 - "Hesperidin is a bioflavonoid, with high concentration in
citrus fruits. In addition to its well-known benefits for cardiovascular
function, type II diabetes, and anti-inflammation, recent studies have
demonstrated multiple benefits of hesperidin for cutaneous functions, including
wound healing, UV protection, anti-inflammation, antimicrobial, antiskin cancer,
and skin lightening. In addition, hesperidin enhances epidermal permeability
barrier homeostasis in both normal young and aged skin. The mechanisms by which
hesperidin benefits cutaneous functions are attributable to its antioxidant
properties, inhibition of MAPK-dependent signaling pathways, and stimulation of
epidermal proliferation, differentiation, and lipid production. Because of its
low cost, wide availability, and superior safety, hesperidin could prove useful
for the management of a variety of cutaneous conditions" - See
hesperidin at Amazon.com
Comparative effects of ACE inhibitors and ARBs on response to a physical activity intervention in older adults: results from Lifestyle Interventions for Elders (LIFE) study - J Gerontol A Biol Sci Med Sci. 2019 May 9 - "Participants age 70-89 years were randomized to a physical activity (PA) or health education (HE) intervention. Outcomes included incident and persistent major mobility disability (MMD), injurious falls, Short Physical Performance Battery (SPPB), and gait speed ... Compared to ACEi users, ARB users had 28% lower risk (HR=0.72 [0.60-0.85]) of incident MMD and 35% (HR=0.65 [0.52-0.82]) lower risk of persistent MMD while no interaction between medication use and intervention was observed. Risk of injurious falls and changes in SPPB or gait speed were not different between ARB and ACEi users"
Safety and toxicity of
silymarin, the major constituent of milk thistle extract: An updated review
- Phytother Res. 2019 May 8 - "It is most commonly known for its hepatoprotective effect. Also, studies have shown other therapeutic effects such
as anticancer, anti-Alzheimer, anti-Parkinson, and anti-diabetic, so its safety
is very important. It has no major toxicity in animals ...
Silymarin is safe in
humans at therapeutic doses and is well tolerated even at a high dose of 700 mg
three times a day for 24 weeks. Some gastrointestinal discomforts occurred like
nausea and diarrhea. One clinical trial showed silymarin is safe in pregnancy,
and there were no anomalies. Consequently, caution should be exercised during
pregnancy, and more studies are needed especially in humans. Silymarin has
low-drug interactions, and it does not have major effects on cytochromes P-450.
Some studies demonstrated that the use of silymarin must be with caution when
co-administered with narrow therapeutic window drugs" - See
silymarin at Amazon.com
Using trehalose to
prevent and treat metabolic function: effectiveness and mechanisms - Curr
Opin Clin Nutr Metab Care. 2019 Apr 24 - "Trehalose and its analogues are
promising cardiometabolic therapeutic agents with pleiotropic effects across
tissue types. It is likely that we are only beginning to uncover the broad
efficacy and complex mechanisms by which these compounds modulate host
metabolism" - See
trehalose at Amazon.com
Low serum
25-hydroxyvitamin D increases cognitive impairment in elderly people - J
Bone Miner Metab. 2019 Mar;37(2):368-37 - "The average subject age was 68.1
years, the average MMSE- J score was 25.9, and the average 25(OH)D level was
24.6 ng/mL. Significant ORs for cognitive impairment were observed for both high
age and low serum 25(OH)D. The adjusted OR for the lowest versus highest serum
25(OH)D quartiles was 2.70 (95% confidence interval 1.38-5.28, P = 0.0110). Low
serum 25(OH)D levels were independently associated with a higher prevalence of
cognitive impairment" - See
vitamin D at Amazon.com Theaflavin-3, 3'-digallate inhibits ovarian cancer stem cells via suppressing Wnt/β-Catenin signaling pathway - J Funct Foods. 2018 Nov;50:1-7 - "Recent evidence indicates that ovarian cancer stem cells (CSCs) are responsible for ovarian cancer recurrence and drug resistance, resulting in the low long-term survival rate of patients with advanced ovarian cancer. We aimed to study the inhibitory effect of theaflavin-3, 3'-digallate (TF3), a black tea polyphenol on ovarian CSCs. Here, we showed that TF3 inhibited the proliferation of A2780/CP70 and OVCAR3 tumorshpere cells by suppressing their cell viability and colony formation capacity. TF3 inhibited the tumorsphere formation capacity of A2780/CP70 and OVCAR3 CSCs in serum-free and non-adherent conditions. TF3 inhibited A2780/CP70 and OVCAR3 CSCs isolated from tumorspheres by decreasing their cell viability and upregulating the protein expression of caspase-3 and -7 in the cells. We also revealed that TF3 inhibited ovarian CSCs through Wnt/β-catenin signaling pathway. Our results suggested that TF3 could inhibit ovarian CSCs and might be a potential agent for eradicating ovarian cancer" - See black tea extract at Amazon.com.
Omega-3 intake is
associated with attenuated inflammatory response and cardiac remodeling after
myocardial infarction - Nutr J. 2019 May 6;18(1):29 -
"Omega-3
polyunsaturated fatty acids (ω-3) bear anti-inflammatory effects, which may
mitigate the inflammatory response during MI ... The intake of ω-3 below the
median (< 1.7 g/day) was associated with a short-term increase in hs-C-reactive
protein [OR:1.96(1.24-3.10); p = 0.004], Interleukin-2 [OR:2.46(1.20-5.04);
p = 0.014], brain-type natriuretic peptide [OR:2.66(1.30-5.44); p = 0.007],
left-ventricle end-diastolic volume [OR:5.12(1.11-23.52)]; p = 0.036] and
decreases in left-ventricle ejection fraction [OR:2.86(1.47-6.88); p = 0.017]
after adjustment for covariates" - See
omega-3 supplements at Amazon.com
An omega-3 fatty acid
plasma index ≥4% prevents progression of coronary artery plaque in patients with
coronary artery disease on statin treatment - Atherosclerosis. 2019 Apr
13;285:153-162 - "EPA and DHA added to statins prevented coronary plaque
progression in nondiabetic subjects with mean LDL-C <80 mg/dL, when an omega-3
index ≥4% was achieved. Low omega-3 index <3.43% identified nondiabetic subjects
at risk of coronary plaque progression despite statin therapy. These findings
highlight the importance of measuring plasma levels of omega-3 fatty acids early
and at trial conclusion. Targeting an omega-3 index ≥4% maximizes cardiovascular
benefit" - See
omega-3 supplements at Amazon.com Association between depression and the risk of developing ventricular arrhythmias: A meta-analysis - Int J Clin Pharmacol Ther. 2019 Apr 16 - "Overall, participants with depression, as compared to those who had no depression, experienced a significantly increased risk of developing ventricular arrhythmia (combined HR, 1.33; 95% CI, 1.02 - 1.73; p = 0.037). In a subgroup analysis, a statistically-significant relation between depression and risk of ventricular arrhythmia was observed in coronary heart disease (CHD) patients and in studies with adjustment for confounding factors, with pooled HR at a 95% CI of 1.78 (1.31 - 2.42) and 1.52 (1.11 - 2.08), respectively"
Citrulline stimulates
muscle protein synthesis, by reallocating ATP consumption to muscle protein
synthesis - J Cachexia Sarcopenia Muscle. 2019 May 8 - "Animal studies and
clinical data support the interest of citrulline as a promising therapeutic for
sarcopenia ... Under certain stress conditions, citrulline increases muscle
protein synthesis by specifically reallocating mitochondrial fuel to the protein
synthesis machinery" - See
citrulline at Amazon.com
Lactobacillus plantarum
DR7 alleviates stress and anxiety in adults: a randomised, double-blind,
placebo-controlled study - Benef Microbes. 2019 Apr 19 -
"One hundred and eleven (n=111; DR7 n=56, placebo n=55)
stressed adults were recruited based on moderate stress levels using the PSS-10
questionnaire. The consumption of DR7 (1×109 cfu/day) for 12 weeks reduced
symptoms of stress (P=0.024), anxiety (P=0.001),
and total psychological scores (P=0.022) as early as 8 weeks among stressed
adults compared to the placebo group as assessed by the DASS-42 questionnaire.
Plasma cortisol level was reduced among DR7 subjects as compared to the placebo,
accompanied by reduced plasma pro-inflammatory cytokines, such as interferon-γ
and transforming growth factor-α and increased plasma anti-inflammatory
cytokines, such as interleukin 10 (P<0.05). DR7 better improved cognitive and
memory functions in normal adults (>30 years old), such as basic attention,
emotional cognition, and associate learning (P<0.05), as compared to the placebo
and young adults (<30 years old). The administration of DR7 enhanced the
serotonin pathway, as observed by lowered expressions of plasma dopamine β-hydroxylase
(DBH), tyrosine hydroxylase (TH), indoleamine 2,3-dioxygenase and tryptophan
2,3-dioxygenase accompanied by increased expressions of tryptophan hydroxylase-2
and 5-hydroxytryptamine receptor-6, while stabilising the dopamine pathway as
observed via stabilised expressions of TH and DBH over 12 weeks as compared to
the placebo" - [Nutra
USA] - See
probiotic products at Amazon.com
Effects of phytosomal
curcumin on anthropometric parameters, insulin resistance, cortisolemia and
non-alcoholic fatty liver disease indices: a double-blind, placebo-controlled
clinical trial - Eur J Nutr. 2019 Feb 22 - "Subjects
were randomized to be treated with indistinguishable tablets (2 per day, to be
taken after dinner) containing 800 mg phytosomal curcumin (Curserin®: 200 mg
curcumin, 120 mg phosphatidylserine, 480 mg phosphatidylcholine and 8 mg
piperine from Piper nigrum L. dry extract) for 8 weeks ... After 56-day
treatment, the curcumin-treated group experienced a significant improvement in
fasting plasma insulin (FPI), HOMA index, waist circumference, blood pressure,
triglycerides (TG), HDL-C, liver transaminases, gamma-GT, index of liver
steatosis and serum cortisol compared to the baseline. FPI, TG, liver
transaminases, fatty liver index and serum cortisol level also significantly
improved compared with the placebo-treated group. Compared to the baseline, at
the end of the study placebo group experienced an improvement only in FPG and TG
... supplementation with a phytosomal preparation of curcumin containing
phosphatidylserine and piperine could improve glycemic factors, hepatic function
and serum cortisol levels in subjects with overweight and impaired fasting
glucose" - [Nutra
USA] - See
curcumin products at Amazon.com Fighting against Skin Aging - Cell Transplant. 2018 May; 27(5): 729–73 - "Stem Cell Therapy ... Stem cell transplantation is a promising therapy for the treatment of skin aging. Adipose tissue transplantation could improve skin quality at the recipient site in addition to increasing skin volume75. Further experiments demonstrate that adipose-derived stem cells (ADSCs) contribute to the regeneration of skin during aging76,77. In recent clinical tests, autologous fat grafting rejuvenates aging skin and enhances the volume of periocular and perioral skin in recipients with an average age of 50 years78,79. Data show that ADSCs produce a series of growth factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), transforming growth factor (TGF)-β1, TGF-β2, hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), platelet-derived growth factor AA (PDGF-AA), and placental growth factor (PGF)80, reminding us that ADSCs may influence surrounding cutaneous cells through these secretions. It seemed that ADSC may also transdifferentiate into epithelial stem cells that express epithelial stem cell marker p63 after fat grafting81. This work provides clues into the understanding of how fat grafts may rejuvenate overlying skin." - Note: It seems like all these doctors have a Jihad against supplements. They make claims that it doesn’t help or makes things worse. Where are these studies they talk about? There are a few but the overwhelming amount of studies show the opposite (http://qualitycounts.com/fpwrinkles.htm and http://qualitycounts.com/fpskincare.html). It just gets my goat when they accuse others of making claims based on scientific studies when they make the opposite claims without evidence to back it up. I'm betting that most doctors that make the negative claims have their heads buried in medical books on diseases and have spent little or no time reading the studies on supplements. My wife keeps commenting on how I don’t have any wrinkles and I’ve been taking supplements all my life.
AliveCor’s FDA-cleared 6-lead ECG aims to detect more than the Apple Watch - CNET, 3/13/19 - "The $150 iOS and Android-compatible KardiaMobile 6L is the only consumer-sold six-lead ECG (other portable devices, like AliveCor's nearly identical-looking KardiaMobile, can only record one lead). It can record heart activity on six different leads at once (I, II, II, aVL, aVR and aVF). It can detect atrial fibrillation (AFib), bradycardia (abnormally low heart rate) and tachycardia (abnormally high heart rate), but promises to also detect other arrhythmias that could indicate heart disease ... The little device has three electrodes, and requires thumbs from each hand to make contact, as well as an ankle or knee on the bottom. The completion of all of those contact points allows a 30-second timed reading that can be shared with a doctor afterward." - Note: I don't see where Amazon has the 6L yet. Here the one lead one:
Health Focus (BPH/Prostate Cancer):
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