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Recent Longevity News for the week ending 7/26/17 How physical exercise prevents dementia - Science Daily, 7/21/17 - "As expected, physical activity had influenced brain metabolism: it prevented an increase in choline. The concentration of this metabolite often rises as a result of the increased loss of nerve cells, which typically occurs in the case of Alzheimer's disease. Physical exercise led to stable cerebral choline concentrations in the training group, whereas choline levels increased in the control group. The participants' physical fitness also improved: they showed increased cardiac efficiency after the training period. Overall, these findings suggest that physical exercise not only improves physical fitness but also protects cells"
New
supplement can repair, rejuvenate muscles in older adults - Science Daily,
7/18/17 - "The deterioration of muscle mass and strength
that is a normal part of aging -known as sarcopenia -- can increase the risk for
falls, metabolic disorders and the need for assisted living ... While a number
of isolated nutritional ingredients have been shown to fight sarcopenia, this is
the first time such ingredients -- which include whey protein,
creatine, vitamin
D, calcium and fish oil -- have been combined and tested for this purpose ...
The results were more impressive than we expected ... Most notable, the findings
showed improvements in deteriorating muscle health and overall strength for
participants both before and after the exercise regimen. In the first six weeks,
the supplement resulted in 700 grams of gains in lean body mass -- the same
amount of muscle these men would normally have lost in a year" - See
whey protein at Amazon.com
Using
omega 3 fatty acids to treat Alzheimer's and other diseases? - Science
Daily, 7/18/17 - "Docosahexaenoic
acid (DHA), a key essential Omega-3 fatty acid, produces signaling molecules
called docosanoids in response to disruptions in the state of equilibrium within
cells caused by injury or disease. Neuroprotectin D1 (NDP1) is a docosanoid that
the Bazan lab discovered and found protects neurons by controlling which and how
certain genes in the retina and brain respond ... The Minireview summarizes the
effects of the essential fatty acid family member DHA and its bioactive
derivative NPD1 in the context of a specific target of gene regulation. The
authors also describe the mechanism of a pathway of regulation by a bioactive
lipid that has a significant impact on cellular homeostasis -- how NPD1
activates pro-survival genes and suppresses pro-death genes" - See
docosahexaenoic acid at Amazon.com
Abstracts from this week:
The effect of magnesium
supplementation on blood pressure in individuals with insulin resistance,
prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized
controlled trials - Am J Clin Nutr. 2017 Jul 19 -
"Magnesium supplementation resulted in a mean reduction of 4.18 mm Hg in SBP and
2.27 mm Hg in DBP" - See
Magtein at Amazon.com
Nephroprotective Effects of Anthocyanin from the Fruits of Panax ginseng (GFA) on Cisplatin-Induced Acute Kidney Injury in Mice - Phytother Res. 2017 Jul 21 - "Cisplatin is an effective anticancer chemotherapeutic agent, but the use of cisplatin in the clinic is severely limited by side effects. Nephrotoxicity is a major factor that contributes to the side effects of cisplatin chemotherapy. The aim of this research was to survey the nephroprotective effects of anthocyanin from the fruits of Panax ginseng (GFA) in a murine model of cisplatin-induced acute kidney injury ... In conclusion, the findings from the present investigation demonstrate that GFA pre-administration can significantly prevent cisplatin-induced nephrotoxicity, which may be related to its antioxidant, anti-apoptotic and antiinflammatory effects" - See Panax ginseng at Amazon.com.
Efficacy and safety of
sugarcane policosanol on dyslipidemia: A meta-analysis of randomized controlled
trials - Mol Nutr Food Res. 2017 Jul 20 - "The
pooled results showed that compared with placebo, sugarcane
policosanol could significantly reduce
total cholesterol (TC, 95% CI: -0.87 to
-0.30 mmol/L) and low density lipoprotein cholesterol (LDL-c, 95% CI: -1.02 to
-0.40mmol/L) and increase high density lipoprotein cholesterol; however, no
significant effects were observed on triglyceride (TG) and body weight" -
See
policosanol at Amazon.com
Inulin-type fructans and
whey protein both modulate appetite but only fructans alter gut microbiota in
adults with overweight/obesity: a randomized controlled trial - Mol Nutr
Food Res. 2017 Jul 21 - "125 adults with
overweight/obesity were randomly assigned to receive isocaloric snack bars of:
1) Control; 2) Inulin-type fructans (ITF); 3)
Whey protein; 4) ITF + Whey protein ... Compared to
Control, body fat was significantly reduced in the Whey protein group at 12wks.
Hunger, desire to eat and prospective food consumption were all lower with ITF,
Whey protein and ITF + Whey protein compared to Control at 12 wks. Microbial
community structure differed from 0 to 12 wks in the ITF and ITF +Whey Protein
groups (i.e. increased Bifidobacterium) but not Whey Protein or Control ...
Adding ITF, whey protein or both to snack bars improved several aspects of
appetite control. Changes in gut microbiota may explain in part the effects of
ITF but likely not whey protein" - See
whey protein at Amazon.com and
Inulin at Amazon.com
Aged garlic extract suppresses inflammation in apolipoprotein E-knockout mice - Mol Nutr Food Res. 2017 Jul 20 - "The anti-atherosclerotic effect of AGE involves the suppression of inflammation by reducing the serum level of CRP and TXB2 , and the protein level of TNF-α and IRAK4, and increasing AMPK activity in liver" - See aged garlic at Amazon.com.
Amelioration of the Development of Osteoarthritis by Daily Intake of β-Cryptoxanthin - Biol Pharm Bull. 2017;40(7):1116-1120 - "Our results suggest that oral supplementation of β-cryptoxanthin would be beneficial for the maintenance of joint health and as prophylaxis against osteoarthritis" - See beta cryptoxanthin at Amazon.com.
Effect of Valerian/Hop
Mixture on Sleep-Related Behaviors in Drosophila melanogaster - Biol Pharm
Bull. 2017;40(7):1101-1110 - "Xanthohumol (Cascade:
827.49 µg/g, Hallertau: 763.60 µg/g, Saaz: 186.93 µg/g) ... This study
demonstrates that a Valerian/Cascade mixture extract improves sleep-related
behaviors, including sleeping time, by modulating GABAergic/serotonergic
signaling" - See
valerian root at Amazon.com
The Effect of Iron Status
on Risk of Coronary Artery Disease: A Mendelian Randomization Study -
Arterioscler Thromb Vasc Biol. 2017 Jul 6 - "We find
evidence of a protective effect of higher iron
status on CAD risk (iron odds ratio, 0.94 per SD unit increase" - [Nutra
USA] - See
iron supplements at Amazon.com Health Focus (Mediterranean Diet):
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