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Recent Longevity News for the week ending 5/31/17
Recommended daily protein intake too low for the elderly - Science Daily,
5/23/17 - "The RDA you will find on the nutrition labels
on your food, however, were set in 1968, and the ones used by researchers and
professionals were set in 2003. A recent review published in Frontiers in
Nutrition points out that both these values do not do justice to the
protein needs of the elderly and critically ill
... A big disservice is being done. The prescribed 0.8 g/kg/day just isn't
enough protein for the elderly and people with a clinical condition .... he
points out that the quality of proteins should be considered when setting the
RDA guidelines and recommending protein supplements. He argues that there should
be a stronger focus on leucine; an indispensable
amino acid and building block for proteins. The elderly have a higher need for
leucine to build muscle proteins, and milk-based proteins (e.g. milk and whey)
are a good source for this" - See BulkSupplements Pure L-Leucine Powder (1 Kilogram)
Chondroitin sulfate as good as widely used anti-inflammatory for knee
osteoarthritis - Science Daily, 5/23/17 - "They
conclude that a daily dose of 800 mg of pharmaceutical-grade
chondroitin sulfate is better than a dummy
product and as good as celecoxib in reducing pain and improving joint function
in symptomatic knee osteoarthritis" -
See
chondroitin sulfate at Amazon.com
Vitamin
D supplements could improve fertility - Science Daily, 5/23/17 -
"Research from her group and others suggests vitamin D
affects many aspects of fertility in both genders, including influencing
production and maturation of sperm cells in men, egg cell and uterine lining
maturation in women, and sex hormone production in both sexes. Vitamin D levels
have been associated with in-vitro fertilisation (IVF) outcome, some features of
PCOS and endometriosis in women. In men, levels of vitamin D have been linked to
semen quality and male hormone levels in both fertile and infertile men"
- See
vitamin D at Amazon.com Fiber-rich diet linked to lowered risk of painful knee osteoarthritis - Science Daily, 5/23/17 - "eating more fibre was associated with a lower risk of painful knee osteoarthritis. Compared with the lowest intake (bottom 25 per cent of participants), the highest intake (top 25 per cent) was associated with a 30 per cent lower risk in the OAI and a 61 per cent lower risk in the Framingham study"
Probiotic use linked to improved symptoms of depression - Science Daily,
5/23/17 - "twice as many adults with
irritable bowel syndrome (IBS) reported improvements
from co-existing depression when they took a
specific probiotic than adults with IBS who took a
placebo ... The study provides further evidence of the microbiota environment in
the intestines being in direct communication with the brain" - [Abstract]
[Nutra
USA] - See
probiotic products at Amazon.com A drink a day tied to higher breast cancer risk, report says - CNN, 5/23/17 - "Sipping an average of 10 grams of alcohol a day -- equivalent to a small glass of wine, an 8-ounce beer or 1 ounce of hard liquor -- is associated with a 5% increased breast cancer risk in premenopausal women and 9% increase in postmenopausal women" Abstracts from this week:
Effects of
supplementation with quercetin on plasma C-reactive protein concentrations: a
systematic review and meta-analysis of randomized controlled trials - Eur J
Clin Nutr. 2017 May 24 - "The meta-analysis of seven
RCTs (10 treatment arms) showed a significant reduction of circulating
CRP levels (WMD: -0.33 mg/l; 95% CI:
-0.50 to -0.15; P<0.001) following quercetin
supplementation" - See
quercetin at Amazon.com Folic Acid Modulates DMBA/TPA-Induced Changes in Skin of Mice: A Study Relevant to Carcinogenesis - J Diet Suppl. 2017 May 17:16 - "FA decreased the expression of ODC and PCNA in skin and activity of serum lactate dehydrogenase, suggesting inhibitory effects on cell proliferation and cell damage" - See methylfolate at Amazon.com.
Vitamin D Supplementation
Trials Aimed at Reducing Mortality Have Much Higher Power When Focusing on
People with Low Serum 25-Hydroxyvitamin D Concentrations - J Nutr. 2017 May
24 - "An inverse association between
serum 25(OH)D and mortality was observed only
for participants with vitamin D insufficiency or deficiency and was strongest
for the latter. Accordingly, the expected effects were much stronger and the
expected power was much higher for interventions that targeted these groups than
for untargeted interventions ... For example, a targeted intervention study with
10,000 older adults (age 50-75 y) with serum 25(OH)D <50 nmol/L that increases
serum 25(OH)D concentrations by 20 nmol/L in the intervention group (n = 5000)
would be expected to yield a 26% reduction of all-cause mortality that could be
detected with 89% power within 5 y of follow-up compared with a 10% mortality
reduction and 20% power in an untargeted intervention study of the same size"
- See
vitamin D at Amazon.com The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials - Nutr J. 2017 May 19;16(1):30 - "Available evidence from adequately controlled randomised controlled trials suggest replacing SFA with mostly n-6 PUFA is unlikely to reduce CHD events, CHD mortality or total mortality. The suggestion of benefits reported in earlier meta-analyses is due to the inclusion of inadequately controlled trials"
Lutein exerts
anti-inflammatory effects in patients with coronary artery disease -
Atherosclerosis. 2017 May 6;262:87-93 - "stable angina
(SA) ... peripheral blood mononuclear cells (PBMCs) ... Only
lutein + zeaxanthin were inversely
correlated with IL-6 in SA patients at baseline (r = -0.366, p < 0.001) and
follow-up (r = -0.546, p < 0.001). Ex vivo, lutein was taken up by PBMCs from SA
patients in a dose- and time-dependent manner. Pre-treatment with lutein
dose-dependently lowered LPS-induced secretion of IL-6, IL-1β (p < 0.01) and TNF
(p < 0.05), and also reduced IL-6, IL-1β and TNF mRNA expression (p < 0.05)"
- See
lutein at Amazon.com Health Focus (Quercetin):
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