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Recent Longevity News for the week ending 4/29/15

Women Put an Average of 168 Chemicals on Their Bodies Each Day, Consumer Group Says - ABC News - ABC News, 4/27/15 - "From shampoo to lotion, the use of personal care products is widespread, however, there are very few protections in place to ensure their safety ... women use an average of 12 products a day, containing 168 different chemicals. Men use fewer products, but still put 85 chemicals on their bodies. Teens on average use 17 personal care products a day, according to the group, which tested 20 teens' blood and urine seven years ago to find out which chemicals from these products were ending up in their bodies. They said they found 16 hormone-altering chemicals, including parabens and phthalates" - See chemical free shampoos at Amazon.com, chemical free cosmetics at Amazon.comchemical free makeup at Amazon.comchemical free soap at Amazon.com, chemical free moisturizer at Amazon.com and chemical free detergent at Amazon.com.

Drinking just one or two alcoholic drinks a day linked to liver disease - Science Daily, 4/25/15 - "This new research concluded that heavy daily drinkers most significantly and independently influence a country's cirrhosis burden" - Note:  The article doesn't even mention one or two drinks as indicated in the title.  That said, it's probably true.  I may have had a few beers myself when I was younger but I never did buy off on the premise that even a little was good.  I don't see how it couldn't damage your cells and accelerate aging.  It may or may not improve blood flow and hence decrease coronary heart disease but that’s different from things like damage to your skin and wrinkles.

Pooled analysis confirms vitamin E as a treatment for non-alcoholic steatohepatitis - Science Daily, 4/23/15 - "A pooled analysis of data from two randomised trials comparing vitamin E versus placebo, and the placebo group from another trial comparing vitamin E use versus non-use, demonstrates that the efficacy of vitamin E is comparable to other treatments for NASH, including pioglitazone, metformin and obeticholic acid. In addition, treatment with vitamin E is associated with significant improvements in both NASH histology (45% vs 22% in those not treated with vitamin E) and resolution of disease (38% vs 20% in those not treated with vitamin E)" - See vitamin E products at Amazon.com.

Strength vs. endurance: Does exercise type matter in the fight against obesity? - Science Daily, 4/23/15 - "In addition to the diet, participants were randomly assigned to follow one of three different types of exercise training programs or to follow the American College of Sports Medicine recommendations for weekly physical activity. Subjects assigned to exercise training groups performed either endurance exercise alone (their choice of running, elliptical or cycling); strength exercises alone (shoulder press, squats, barbell row, biceps curl, lateral split, front split, bench press and French press); or a combination of strength and endurance exercises ... Perhaps surprisingly, the outcomes for the participants -- including significant reductions in body weight, body mass index, waist circumference, total fat mass, and a significant increase in lean mass -- were positive across the board despite the differences in the type of exercise performed ... One calorie burned in exercise is not the same as one not ingested"

Sugar and carbs, not physical inactivity, behind surge in obesity, say experts - Science Daily, 4/22/15 - "Recent research indicates that cutting down on dietary carbohydrate is the single most effective approach for reducing all of the features of the metabolic syndrome and should be the primary strategy for treating diabetes, with benefits occurring even in the absence of weight loss"

Caloric restriction: A fountain of youth for aging muscles? - Science Daily, 4/22/15 - "while 14 weeks of calorie restriction did not significantly affect the middle-aged rats, it reduced muscle mass in the young rats. Calorie restriction slowed the glycolytic rate in the muscles and increased the cells' dependency for OXPHOS versus glycolysis in older rats, which was linked to improvement of normalized muscle mass. The team also found that "14 weeks of CR reprogrammed cellular metabolism, where the relative contribution of OXPHOS and glycolysis in muscles of middle-aged rats with CR was similar to that in muscles of young rats"

Coffee protects against breast cancer recurrence, detailed findings confirm - Science Daily, 4/21/15 - "unlike in the previous study, we have combined information about the patients' lifestyle and clinical data from 1090 breast cancer patients with studies on breast cancer cells. The study shows that among the over 500 women treated with tamoxifen, those who had drunk at least two cups of coffee a day had only half the risk of recurrence of those who drank less coffee or none at all ... Just two cups a day is sufficient to make a difference"

Abstracts from this week:

Effect of Vitamin D3 supplementation in combination with weight loss on inflammatory biomarkers in postmenopausal women: a randomized controlled trial - Cancer Prev Res (Phila). 2015 Apr 23 - "In conclusion, Vitamin D3 supplementation in combination with weight-loss of at least 5% of baseline weight was associated with significant reductions in levels of IL-6" - See vitamin D at Amazon.com.

Acute mood but not cognitive improvements following administration of a single multivitamin and mineral supplement in healthy women aged 50 and above: a randomised controlled trial - Age (Dordr). 2015 Jun;37(3):9782 - "This study investigated the acute effects of a single multivitamin and mineral and herbal (MVMH) supplement versus placebo on self ratings of mood and the performance of an effortful computerised cognitive battery in a sample of 76 healthy women aged 50-75 years. Mood was assessed using the depression anxiety stress scale (DASS), state trait anxiety inventory-state anxiety scale and visual analogue scales (VAS). Mood was rated at 1 h post supplementation and again after the competition of the cognitive assessments at 2 h post supplementation. It was demonstrated that the MVMH supplement improved overall DASS mood ratings; however, the most prominent effects appeared to be a reduction in ratings of perceived mental stress ... Supplementation with a single multivitamin, mineral and herbal supplement reduces stress several hours after intake in healthy older people"

Garlic for hypertension: A systematic review and meta-analysis of randomized controlled trials - Phytomedicine. 2015 Mar 15 - "A total of seven randomized, placebo-controlled trials were identified. Compared with the placebo, this meta-analysis revealed a significant lowering effect of garlic on both systolic BP (WMD: -6.71 mmHg; 95% CI: -12.44 to -0.99; P = 0.02) and diastolic BP (WMD: -4.79 mmHg; 95% CI: -6.60 to -2.99; P < 0.00001). No serious adverse events were reported in any of the trials" - [Nutra USA] - See garlic supplements at Amazon.com.

Quercetin ameliorates polychlorinated biphenyls-induced testicular DNA damage in rats - Andrologia. 2015 Apr 19 - "Polychlorinated biphenyls (PCBs) are a group of environmental contaminants widely reported to cause gonadal toxicity in both humans and animals ... Quercetin cotreatment significantly improved the testicular antioxidant status, decreased DNA fragmentation and restored the testicular histology, thus demonstrating the protective effect of quercetin in PCBs-treated rats" - See quercetin at Amazon.com.

Hormone replacement therapy and longevity - Andrologia. 2015 Apr 19 - "It was found that testosterone replacement therapy of men suffering from late onset hypogonadism increased survival rate by 9-10% in 5 years, similar to that of eugonadal, non-LOH men with normal endogenous testosterone secretion. Oestrogen replacement therapy resulted in increased survival by 2.6% in 5 years. It is concluded that hormone replacement therapy increases longevity"

Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells - Cytokine. 2015 Apr 15 - "Dysfunction of the retinal pigment epithelium (RPE) resulting from chronic inflammation is implicated in the pathogenesis of age-related macular degeneration (AMD) ... Resveratrol substantially inhibited the proinflammatory cytokines-induced CXCL11 production while partially blocking nuclear factor-κB activation. This inhibitory action of resveratrol was also observed for the cytokines-induced expression of chemokines CXCL9, CCL2 and CCL5. Our results indicate that resveratrol could potentially attenuate RPE inflammatory response implicated in the pathogenesis of AMD"  - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.

Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats - Age (Dordr). 2015 Jun;37(3):9777 - "We analyzed the in vivo effects of chronic administration of resveratrol (20 mg/kg/day for 4 weeks) in old male rats (Wistar, 20 months), on tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) activities which mediate central monoaminergic neurotransmitters synthesis, and besides, on hippocampal-dependent working memory test (radial maze). Our results show an age-related decline in neurochemical parameters that were reversed by resveratrol administration. The resveratrol treatment enhances serotonin (5-HT) levels in pineal gland, in hippocampus, and in striatum, and those of noradrenaline (NA) in hippocampus and also dopamine (DA) in striatum. These changes were largely due to an increased activity of TPH-1 (463 % in pineal gland), TPH-2 (70-51 % in hippocampus and striatum), and TH (150-36 % in hippocampus and striatum). Additionally, the observed hippocampal effects correlate with a resveratrol-induced restorative effect on working memory (radial maze)" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.

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