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Recent Longevity News for the week ending 4/15/15

It is projected that by 2020, HPV-related oropharyngeal cancer will become the most common HPV-related cancer in the US, surpassing cervical cancer - Science Daily, 4/13/15 - "HPV vaccination could save from $8 million to $28 million Canadian dollars over the boys' lifetimes. Factors that could impact the cost savings of HPV vaccination in boys include, among others, vaccine cost, vaccine effectiveness, costs of cancer treatment, and survival of patients with HPV-related oropharyngeal cancers ... It is projected that by 2020, HPV-related oropharyngeal cancer will become the most common HPV-related cancer in the US, surpassing cervical cancer"

Choice of protein- and carbohydrate-rich foods may have big effects on long-term weight gain - Science Daily, 4/9/15 - "diets with a high glycemic load (GL) from eating refined grains, starches, and sugars were associated with more weight gain ... Increasing intakes of red meat and processed meat were most strongly associated with weight gain ... Increasing intakes of yogurt, seafood, skinless chicken, and nuts were most strongly associated with weight loss -- the more people ate, the less weight they gained ... Increasing other dairy products, including full-fat cheese, whole milk, and low-fat milk, did not significantly relate to either weight gain or weight loss ... The fat content of dairy products did not seem to be important for weight gain ... when people consumed more low-fat dairy products, they actually increased their consumption of carbs, which may promote weight gain"

Rats fed a dietary fiber supplement had better weight control - Science Daily, 4/8/15 - "Despite having constant access to food high in fat and sugar, rats given supplemental oligofructose fibre gained about one third less weight than the control group ... microbiota in obese rats given oligofructose were changed to be more similar to those of lean animals. Gut hormones were also affected by the oligofructose, including an increase of a hormone that helps control the sensation of satiety -- the feeling of being full ... In a 2009 human study that she led, adults receiving supplements of oligofructose lost on average one kilogram over a 12 week period -- and perhaps more importantly, didn't continue to gain weight" - See oligosaccharide at Amazon.com.

Abstracts from this week:

Vitamin D3 seems more appropriate than D2 to sustain adequate levels of 25OHD: a pharmacokinetic approach - Eur J Clin Nutr. 2015 Mar 18 - "In the long term, D3 seems more appropriate for sustaining 25OHD, which could be relevant for classic and non-classic effects of vitamin D" - [Nutra USA] - Note:  Several studies have already shown that.  I don't know why they needed another.  I don't think D2 is even in supplements anymore except for the cheapest ones.  See vitamin D at Amazon.com.

Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor - Biochem Biophys Res Commun. 2015 Apr 7 - "Recent studies have shown that metformin inhibits cancer cell proliferation and tumor growth both in vitro and in vivo ... Our results suggest that metformin is a potent inhibitor of the IGF-1/IGF-1R system and may be beneficial in prostate cancer treatment" - See metformin at The Antiaging Store.

Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice - Metabolism. 2015 Mar 19 - "These data demonstrate that adding Leu to Met enables a dose reduction of 66% with improved efficacy and of 83% with comparable efficacy to standard metformin in diet-induced obese mice" - See leucine products at Amazon.com.

Tribulus terrestris (Linn.) Attenuates Cellular Alterations Induced by Ischemia in H9c2 Cells Via Antioxidant Potential - Phytother Res. 2015 Apr 8 - "The overall results of this study partially reveal the scientific basis of the use of T. terrestris L. in the traditional system of medicine for heart diseases" - See Tribulus terrestris at Amazon.com.

Korean Red Ginseng Extract Enhances the Anticancer Effects of Imatinib Mesylate Through Abrogation p38 and STAT5 Activation in KBM-5 Cells - Phytother Res. 2015 Apr 8 - "Although imatinib mesylate (IM) in the treatment of chronic myelogenous leukemia (CML) remains the best example of successful targeted therapy, majority of patients with CML suffer its toxicity profile and develop chemoresistance to existing therapeutic agents ... Korean red ginseng extract broadly suppressed the proliferation of five different cell lines, but KRGE was found to be the most potent inducer of apoptosis against KBM-5 cells ... The combination treatment of KRGE and IM caused pronounced suppression of p38 and signal transducer and activator of transcription 5 phosphorylation and induced phosphorylation of p53 compared with the individual treatment. Our results demonstrate that KRGE can enhance the anticancer activity of IM and may have a substantial potential in the treatment of CML" - See ginseng at Amazon.com.

Thyroid dysfunction, thyroid hormone replacement and colorectal cancer risk - J Natl Cancer Inst. 2015 Apr 8;107(6) - "Long-term THR is associated with a decreased risk of CRC. Hyperthyroidism and untreated hypothyroidism are associated with modestly elevated risk of CRC"

The impact of angiotensin receptor blockers on arterial stiffness: a meta-analysis - Hypertens Res. 2015 Apr 9 - "Taken together, our findings support the important role of ARB treatment in improving arterial stiffness"

Antioxidant Vitamin C Prevents Decline in Endothelial Function during Sitting - Med Sci Monit. 2015 Apr 7;21:1015-1021 - "Eleven men (24.2±4.4 yrs) participated in 2 randomized 3-h sitting trials. In the sitting without vitamin C (SIT) and the sitting with vitamin C (VIT) trial, participants were seated for 3 h without moving their legs. Additionally, in the VIT trial, participants ingested 2 vitamin C tablets (1 g and 500 mg) at 30 min and 1 h 30 min, respectively ... Three hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders - Biochim Biophys Acta. 2015 May;1852(5):951-61 - "these data suggest that curcumin enhances DHA synthesis, resulting in elevated brain DHA content. These findings have important implications for human health and the prevention of cognitive disease, particularly for populations eating a plant-based diet or who do not consume fish, a primary source of DHA, since DHA is essential for brain function and its deficiency is implicated in many types of neurological disorders" - [Nutra USA] - See curcumin products at Amazon.com and Jarrow Max DHA at Amazon.com.

Neat Tech Stuff / "How To's":

Dockers Men's Signature Khaki D3 Classic Fit Pleated Pant, Charcoal Heather - I bought two of these a few weeks ago.  Nice pants for $37.  I like them better than the expensive ones which are too shiny.

Apple's iOS 8.3 enables Wi-Fi calling on Sprint iPhones - PC World, 4/9/15 - "Apple launched Wi-Fi calling for the iPhone last fall as part of iOS 8, but at the time only T-Mobile chose to support the feature. More than six months later, Sprint is following suit and adding Wi-Fi calling support for the iPhone 6, 6 Plus, 5s, and 5c ... Sprint's Wi-Fi calling will also enable subscribers traveling overseas to make free calls back to the U.S. from more than 200 countries ... the other two carriers are expected to get on board soon. AT&T is expected to introduce Wi-Fi calling in 2015, according to LightReading, while Verizon says it will support Wi-Fi calling "in the future.""

Health Focus (Omega-3):