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Recent Longevity News for the week ending 2/11/15

Year One of Colorado's Marijuana Law - RealClearPolitics, 2/8/15 - "The Proceedings of the National Academy of Sciences reported brain abnormalities in chronic users, while (beyond the 2012 study documenting an 8 point IQ loss from heavy use), the Journal of Neuroscience reported that even occasional use produces alterations in the brain ... The British medical journal, The Lancet, showed that the effects of marijuana include increased odds of school drop-out and suicidal propensity, while a 20-year review of research in the journal Addiction confirmed marijuana’s “gateway” effect to other illicit drugs, as well as its link to schizophrenia. Finally, in June the Obama administration’s top addiction scientist, Dr. Nora Volkow, summarized the adverse consequences in the New England Journal of Medicine, emphasizing not only the risk of psychosis, but marijuana’s destructive effects on memory, cognition, and learning"

Low vitamin D predicts more severe strokes, poor health post-stroke - Science Daily, 2/5/15 - "Stroke patients with low vitamin D levels were found to be more likely than those with normal vitamin D levels to suffer severe strokes and have poor health months after stroke ... Overall, patients who had low vitamin D levels -defined as less than 30 nanograms per milliliter (ng/mL) -- had about two-times larger areas of dead tissue resulting from obstruction of the blood supply compared to patients with normal vitamin D levels ... For each 10 ng/mL reduction in vitamin D level, the chance for healthy recovery in the three months following stroke decreased by almost half, regardless of the patient's age or initial stroke severity" - See vitamin D at Amazon.com.

Compound found in grapes, red wine may help prevent memory loss - Science Daily, 2/4/15 - "treatment with resveratrol had apparent benefits in terms of learning, memory and mood function in aged rats ... for the control rats who did not receive resveratrol, spatial learning ability was largely maintained but ability to make new spatial memories significantly declined between 22 and 25 months. By contrast, both spatial learning and memory improved in the resveratrol-treated rats ... neurogenesis (the growth and development of neurons) approximately doubled in the rats given resveratrol compared to the control rats. The resveratrol-treated rats also had significantly improved microvasculature, indicating improved blood flow, and had a lower level of chronic inflammation in the hippocampus" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.

New York AG: Many Popular Store-Brand Supplements Are Phony - Fox, 2/3/15 - "New York Attorney General Eric Schneiderman is going after four major retailers - GNC, Walmart, Target and Walgreens - for selling store-brand supplements that are mislabeled and contaminated ... Wal-Mart fared the worst, with only 4% of its products containing the plant listed ... At Target, 41% of the supplements had the ingredient advertised, compared with 22% at GNC and 18% at Walgreens"

New study postulates the role of dietary advanced glycation end products in the risk of Alzheimer's disease - Science Daily, 2/3/15 - "meat made the highest contribution of AGEs, followed by vegetable oils, cheese, and fish. Foods such as cereals/grains, eggs, fruit, legumes, milk, nuts, starchy roots, and vegetables generally make low contributions to the total amount of AGEs in a diet, either because they are generally prepared at low temperatures or since they comprise smaller portions of diets ... This epidemiological study supports our previous findings in animals and humans of an important role for dietary AGEs in Alzheimer's disease. We found that mice kept on a diet high in AGEs, similar to Western diet, had high levels of AGEs in their brains together with deposits of amyloid-β, a component of the plaques characteristic of Alzheimer's disease, while at the same time developed declines in cognitive and motor abilities. The mice fed a low AGE diet remained free of these conditions. In addition, clinical studies have shown that subjects with higher blood AGE levels, in turn resulting from high AGE diets, are more likely to develop cognitive decline on follow up"

Abstracts from this week:

Ginseng Protects Against Respiratory Syncytial Virus by Modulating Multiple Immune Cells and Inhibiting Viral Replication - Nutrients. 2015 Feb 4;7(2):1021-1036 - "Ginseng has been used in humans for thousands of years but its effects on viral infection have not been well understood. We investigated the effects of red ginseng extract (RGE) on respiratory syncytial virus (RSV) infection using in vitro cell culture and in vivo mouse models ... Taken together, these results provide evidence that ginseng has protective effects against RSV infection through multiple mechanisms, which include improving cell survival, partial inhibition of viral replication and modulation of cytokine production and types of immune cells migrating into the lung" - See ginseng at Amazon.com and Cold FX, 300mg 168 Capsules at Amazon.com.

The effect of a decaffeinated green tea extract formula on fat oxidation, body composition and exercise performance - J Int Soc Sports Nutr. 2015 Jan 21;12(1):1 - "caffeinated green tea (GT) ... decaffeinated green tea extract (dGTE) ... Participants were randomly assigned capsulated dGTE (571 mg·d(-1); n = 7) or placebo (PL; n = 7) for 4 weeks ... Body fat significantly decreased with dGTE by 1.63 ± 0.16% in contrast to PL over the intervention period (P < 0.001; ηp(2) = 0.84). No significant changes for FFA or blood pressure between groups were observed. dGTE resulted in a 10.9% improvement in performance distance covered from 20.23 ± 0.54 km to 22.43 ± 0.40 km by week 4 (P < 0.001; ηp(2) = 0.85)" - See green tea extract at Amazon.com.

A meta-analysis of the effects of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers on insulin sensitivity in hypertensive patients without diabetes - Diabetes Res Clin Pract. 2014 Dec - "In patients showing no significant difference in blood pressure control, the comparison between ACEI and ARB showed that the former type of drug more effectively relieved IS in hypertensive patients without diabetes"

Resveratrol attenuates lipopolysaccharide-induced acute kidney injury by suppressing inflammation driven by macrophages - Mol Nutr Food Res. 2015 Jan 27 - "Our studies suggest that resveratrol might represent a novel therapeutic agent to prevent and treat sepsis induced AKI" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.

Effect of Curcumin Supplementation on Physiological Fatigue and Physical Performance in Mice - Nutrients. 2015 Jan 30;7(2):905-921 - "Curcumin (CCM) ... CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue" - See curcumin products at Amazon.com.

Serum 25-Hydroxy Vitamin D and Survival in Advanced Colorectal Cancer: A Retrospective Analysis - Nutr Cancer. 2015 Feb 3:1-7 - "Higher levels were associated with prolonged survival in categorical variable analysis: adequate vs. deficient, hazard ratio = 0.61 ... A majority of newly diagnosed Stage IV CRC patients are vitamin D-deficient. Our data suggest that higher 25(OH)D levels are associated with better overall survival" - See vitamin D at Amazon.com

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