|
|
Recent Longevity News for the seven days ending
5/29/13. You should consult your doctor if you are taking any medications.
Getting to Know Our Microbial Roommates - NYTimes.com, 5/27/13 -
"In a study published in February in the journal
Environmental Microbiology, Dr. Fierer’s lab examined 82 surfaces in four
Boulder kitchens. Predictable patterns emerged. Bacterial species associated
with human skin, like Staphylococcaceae or Corynebacteriaceae, predominated.
Evidence of soil showed up on the floor, and species associated with raw produce
(Enterobacteriaceae, for example) appeared on countertops. Microbes common in
moist areas — including sphingomonads, some strains infamous for their ability
to survive in the most toxic sites — splashed in a kind of jungle above the
faucet ... A hot spot of unrivaled biodiversity was discovered on the stove
exhaust vent ... The microbes living on your pillowcase are not all that
different from those living on your toilet seat"
Scientists find mechanism that causes noise-induced tinnitus and drug that can
prevent it - Science Daily, 5/27/13 - "An epilepsy
drug shows promise in an animal model at preventing tinnitus from developing
after exposure to loud noise ... mice that were treated with retigabine
immediately after noise exposure did not develop
tinnitus"
First
drug to significantly improve heart failure mortality in over a decade -
Science Daily, 5/25/13 - "Coenzyme Q10 decreases all
cause mortality by half ... is the first drug to improve heart failure mortality
in over a decade and should be added to standard treatment ... Double blind
controlled trials have shown that CoQ10 improves symptoms, functional capacity
and quality of life in patients with heart failure with no side effects ...
Other heart failure medications block rather than enhance cellular processes and
may have side effects. Supplementation with CoQ10, which is a natural and safe
substance, corrects a deficiency in the body and blocks the vicious metabolic
cycle in chronic heart failure called the energy starved heart" - See
Jarrow Formulas, Ubiquinol, QH-Absorb, 100 mg, 120 Softgels.
Sunscreens Not Created Equal: Consumer Reports - WebMD, 5/24/13 -
"Six got recommended ratings: ... Target's Up & Up
Sport, at the top spot, costs $1.16 an ounce ... Walmart's Equate Ultra
Protection SPF 50, is just 47 cents an ounce. It won the CR Best Buy award of
the dozen ...
Coppertone Water Babies SPF 50, at $1.38 an ounce ... Walgreens Continuous
Spray Sport SPF 50, at $1.33 an ounce ...
Hawaiian Tropic Sheer Touch SPF 30, at $1.38 an ounce ... Coppertone Sport
High Performance SPF 30, at $1.67 an ounce ... The six that didn't get
recommended ratings include: .. California Baby SPF 30+, at $6.90 an ounce
(discontinued, but may still be available) ... No-Ad with Avobenzone, Aloe, and
Vitamin E SPF 45, at 63 cents an ounce ... Neutrogena Wet Skin SPF 45+, at $3.67
an ounce ... Kiss My Face with Hydresia SPF 40, at $5.33 an ounce ... Badger
Unscented SPF 34, at $5.52 an ounce (discontinued, but may still be available)
... All Terrain AquaSport SPF 30, at $4.33 an ounce"
Biological and Therapeutic
Effects of Ortho-Silicic Acid - Medscape, 5/23/13 -
"In conclusion, we believe that ortho-silicic acid
(H4SiO4) might be a prominent therapeutic agent in humans. Some potential
therapeutic and biological effects on bone formation and bone density, Alzheimer
disease, immunodeficiency, skin, hair, and nails condition, as well as on tumour
growth, have already been documented and are critically discussed in the
presented paper" - See
Jarrow BioSil at Amazon.com, which is another one that I add a few drops to
my coffee everyday the other being iodine.
High CRP Linked to
Late-Onset Schizophrenia - Medscape, 5/22/13 - "CRP
has previously been linked to increased risk for cardiovascular disease, and
more recently, in a study by these same researchers, with risk for depression
... We had up to 19 years of follow-up, and after adjusting for all the other
factors that would also increase CRP ... we still saw significantly increased
risk of schizophrenia; for those who had
even very small elevations of CRP, they still have a 6-times increased risk for
schizophrenia"
Fish Oil
Supplements May Help Fight Against Type 2 Diabetes - Science Daily, 5/22/13
- "Fish oil supplements, also called
omega 3 fatty acid capsules, raise levels of
adiponectin in the bloodstream. Adiponectin
is an important hormone that has beneficial effects on metabolic processes like
glucose regulation and the modulation of inflammation. In long-term human
studies, higher levels of adiponectin are associated with lower risks of type 2
diabetes and
coronary heart disease ... The
meta-analysis reviewed and analyzed results from 14 randomized,
placebo-controlled clinical trials" -
See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
Calcium
Supplements Linked to Longer Lifespans in Women - Science Daily, 5/22/13 -
"Researchers analyzing data from the large-scale
Canadian Multicentre Osteoporosis Study (CaMos) sought to clarify this issue and
found moderate doses of calcium supplements had
a beneficial effect in women ... The benefit was seen for women who took doses
of up to 1,000 mg per day, regardless of whether the supplement contained
vitamin D ... there was no statistical benefit for men ... the same benefits
were seen when the calcium came from dairy foods, non-dairy foods or
supplements"
Fish oil
may help the heart beat mental stress - Science Daily, 5/22/13 -
"volunteers who took fish
oil supplements for several weeks had a blunted response to
mental stress in several measurements of
cardiovascular health, including heart rate and muscle sympathetic nerve
activity (MSNA), part of the "fight or flight" response, compared to volunteers
who took olive oil instead. The results may explain why taking fish oil could be
beneficial to the heart and might eventually help doctors prevent heart disease
in select populations" -
See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
Vitamin
C can kill drug-resistant TB, researchers find - Science Daily, 5/21/13 -
"vitamin C kills drug-resistant tuberculosis (TB)
bacteria in laboratory culture. The finding suggests that vitamin C added to
existing TB drugs could shorten TB therapy"
Mediterranean Diet Good for
Chronic Kidney Disease - Medscape, 5/21/13 -
"followed 1110 Swedish men (mean age, 70 years), 506 of whom had a
glomerular filtration rate below 60 mL/min
per 1.73 m 2 ... Median follow-up was 9.9 years ... High adherents were 42%
less likely to have kidney disease than low adherents ... high adherence was
independently associated with a mortality risk that was 18% lower for every
2-point increase in
Mediterranean Diet Score. For subjects
with adequate dietary intake, the associations were stronger"
Melatonin for Migraine?
- Medscape, 5/21/13 - "Participants were randomly
assigned to 3 mg of melatonin, 25 mg of
amitriptyline, or placebo for 3 months ... The mean reduction in
headache frequency was 2.7 in the melatonin
group, 2.18 in the amitriptyline group, and 1.18 in the placebo group. The
proportion of responders was greatest in the melatonin group at 54% vs 39% for
amitriptyline and 20% for placebo ... Patients gained weight in both the
amitriptyline and placebo groups, but melatonin was associated with weight loss"
- See
melatonin at Amazon.com.
Common
food supplement fights degenerative brain disorders, study suggests -
Science Daily, 5/21/13 - "Widely available in pharmacies
and health stores, phosphatidylserine is a natural
food supplement ... the same supplement improves the functioning of genes
involved in degenerative brain disorders, including Parkinson's disease and
Familial Dysautonomia (FD) ...Not only did phosphatidylserine impact the gene
associated with FD, but it also altered the level of a total of 2400 other genes
-- hundreds of which have been connected to Parkinson's disease in previous
studies ... The researchers believe that the supplement may have a beneficial
impact on a number of degenerative diseases of the brain" - See
phosphatidyl
Serine products at iHerb.
Iodine Deficiency Still a
Concern, Despite Vast Improvements - Medscape, 5/21/13 -
"In the United States, median UIC levels among
individuals aged 6 years and older remained in the normal range, at 144 µg/L,
from 2007 to 2010, but median UIC among adults has been on the decline, with a
drop of more than 50% between the 1970s and 1990s, say the authors ... And the
prevalence of UIC below 50 µg/L among women of childbearing age has increased
nearly 4-fold during the same period, from 4% to 15%, while the median UIC among
pregnant US women has declined to less than 150 µg/L, suggestive of mild
iodine deficiency ... The cause of the decline
among pregnant women is unknown but may have to do with reductions in dairy
intake ... only about 70% of salt is iodized, and about 85% of salt ingested in
the United States is from commercially processed foods that do not contain
iodized salt" - See
iodine at Amazon.com. I put a couple drops in my coffee every
day.
Abstracts from this week's
Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
Treatment
with Metformin is Associated with Higher Remission Rate in Diabetic Patients
with Thyroid Cancer - J Clin Endocrinol Metab. 2013 May 24 -
"complete response (CR) ... progression free survival
(PFS) ... Tumor size is smaller in patients treated with
metformin suggesting inhibition of tumor
growth by the drug. Among diabetics, absence of metformin therapy is an
independent factor for decreased likelihood of CR and increased risk of shorter
PFS" - See
metformin at The Antiaging Store.
Ubiquinol supplementation
enhances peak power production in trained athletes: a double-blind, placebo
controlled study - J Int Soc Sports Nutr. 2013 Apr 29;10(1):24 -
"In this double-blind, placebo-controlled study, 100
young German well trained athletes (53 male, 47 female, age 19.9 +/- 2.3 years)
received either 300 mg Ubiquinol or placebo for 6
weeks ... This study demonstrates that daily supplementation of 300 mg Ubiquinol
for 6 weeks significantly enhanced physical
performance measured as maximum power output by +0.08 W/kg bw (+2.5%) versus
placebo in young healthy trained German Olympic athletes" - See
Jarrow Formulas, Ubiquinol, QH-Absorb, 100 mg, 120 Softgels.
Chemopreventive and anti-cancer efficacy of silibinin against growth and
progression of lung cancer - Nutr Cancer. 2013;65 Suppl 1:3-11 -
"Successful studies conducted so far, have established
that silibinin is effective both alone and in
combination with other agents (e.g., chemotherapeutic and epigenetic agents) in
significantly inhibiting the growth of lung
cancer cells" - See
silymarin at Amazon.com.
Differential
Effect of Grape Seed Extract against Human Non-small-Cell Lung Cancer Cells: The
Role of Reactive Oxygen Species and Apoptosis Induction - Nutr Cancer.
2013;65 Suppl 1:44-53 - "GSE
suppressed growth and induced apoptotic death in
NSCLC cells irrespective of their k-Ras status" - See Jarrow Formulas, OPCs + 95 at Amazon.com.
Prevention
of Familial Adenomatous Polyp Development in APC(min) Mice and
Azoxymethane-Induced Colon Carcinogenesis in F344 Rats by ω-3 Fatty Acid Rich
Perilla Oil - Nutr Cancer. 2013;65 Suppl 1:54-60 -
"The present study explored the preventive effects of perilla oil, rich in
α-linolenic acid, in rodent models of colon
tumorigenesis. Six-week-old male F344 rats were fed diets containing 5% corn
oil or 10 or 20% perilla oil ... Dietary perilla oil produced a dose-dependent
inhibition of AOM-induced colonic ACF formation (by 35-53%, P < 0.01-0.005) and
reduced the number of foci with ≥4 crypts/focus (by 38-50%, P < 0.01-0.001) in
F344 rats. Dietary perilla oil significantly inhibited development of small
intestinal (>69%, P < 0.0001) and colon tumors (>52%, P < 0.03) in APC(min)
mice. Administration of perilla oil produced lower levels of type-2
prostaglandins (38-53%) from COX-activities in polyps of APC(min) mice. These
observations demonstrate that dietary perilla oil rich in ω-3 fatty acids
possesses preventive activity against intestinal neoplastic lesions, both in FAP
in genetically-predisposed tissues, as well as against chemically induced
preneoplastic lesions in the colon" - See
perilla oil products at
iHerb.
Low
Dehydroepiandrosterone Sulfate is Associated With Increased Risk of Ischemic
Stroke Among Women - Stroke. 2013 May 23 - "Between
1989 and 1990, 32 826 women without prior stroke in the Nurses' Health Study, an
observational cohort, provided blood samples and were followed up for
cardiovascular events ... Conditional on matching factors, the lowest
DHEAS quartile exhibited a relative risk of 1.30
for ischemic stroke (95% confidence interval, 0.88-1.94), compared with the
highest quartile and marginally unchanged when adjusted for confounders
(relative risk=1.33; 95% confidence interval, 0.87-2.02). When modeled as a
binary variable dichotomized at the lowest quartile, women with low DHEAS (≤the
lowest quartile) had a significantly increased multivariable adjusted risk of
ischemic stroke compared with those with higher
levels (relative risk=1.41; 95% confidence interval, 1.03-1.92)" - See
DHEA at Amazon.com.
Effect of
Fish Oil on Circulating Adiponectin: A Systematic Review and Meta-Analysis of
Randomized Controlled Trials - J Clin Endocrinol Metab. 2013 May 23 -
"In placebo-controlled RCTs,
fish oil moderately increases circulating
adiponectin" -
See
Mega Twin EPA at Amazon.com
and
Jarrow Max DHA at Amazon.com.
Low-dose
vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and
prevents forearm bone loss in postmenopausal Japanese women - J Bone Miner
Metab. 2013 May 24 - "The participants (aged 50-65
years) were randomly assigned to one of two groups according to the
MK-4 dose received: the placebo-control group
(n = 24) and the 1.5-mg MK-4 group (n = 24). The baseline concentrations of
undercarboxylated osteocalcin (ucOC) were high in both groups (>5.1 ng/ml).
After 6 and 12 months, the serum ucOC concentrations were significantly lower in
the MK-4 group than in the control group. In the control group, there was no
significant change in serum pentosidine concentrations. However, in the MK-4
group, the concentration of pentosidine at 6 and 12 months was significantly
lower than that at baseline. The forearm BMD
was significantly lower after 12 months than at 6 months in the control group.
However, there was no significant decrease in BMD in the MK-4 group during the
study period. These results suggest that low-dose MK-4 supplementation for 6-12
months improved bone quality in the postmenopausal Japanese women by decreasing
the serum ucOC and pentosidine concentrations, without any substantial adverse
effects" - See vitamin K at Amazon.com
and
vitamin K at Amazon.com. See the section in this
article "MK4 versus
MK7 for Bone Health".
Coffee and
risk of prostate cancer incidence and mortality in the Cancer of the Prostate in
Sweden Study - Cancer Causes Control. 2013 May 24 -
"Mean coffee intake was 3.1 cups per day among
both cases and controls. Coffee intake was not associated with overall
prostate cancer risk. Risk of fatal prostate
cancer was inversely, but not statistically significantly, associated with
coffee intake, with an odds ratio of 0.64 [95 % confidence interval (CI)
0.34-1.19, p value for linear trend = 0.81] for men consuming greater than 5
cups per day compared to men drinking less than 1 cup per day. The highest
intake of coffee was associated non-significantly with lower risk of advanced
disease (OR = 0.73, 95 % CI 0.41-1.30, p trend = 0.98) and associated
significantly with lower risk of high-grade cancer (Gleason 8-10; OR = 0.50, 95
% CI 0.26-0.98, p trend = 0.13). Risk of localized, grade 7, and low-grade
cancers was not associated with coffee intake"
Serum folate
and prostate-specific antigen in the United States - Cancer Causes Control.
2013 May 24 - "Using data from the 2007 to 2010 National
Health and Nutrition Examination Survey, a total of 3,293 men aged 40 years and
older with serum PSA and
folate measures were studied ... OR associated
with fifth to first quintile of folate level = 0.42 ... Results of this study
suggest that higher folate status may be protective against elevated PSA levels
among men without diagnosed prostate cancer" - See
folic acid products at Amazon.com.
Male breast cancer and
5-alpha reductase inhibitors, finasteride and dutasteride - J Urol. 2013 May
9 - "No statistically significant associations were
observed between 5ARIs and breast cancer, regardless of exposure assessment
prior to index date"
Lower vitamin E serum
levels are associated with osteoporosis in early postmenopausal women: a
cross-sectional study - J Bone Miner Metab. 2013 Mar 28 -
"BMD of the lumbar
spine was significantly higher in the highest tertile of the
vitamin E:lipid ratio than in the lowest
tertile. The mean vitamin E:lipid ratio was significantly lower in osteoporotic
postmenopausal women (T score ≤-2.5) (3.0 +/- 0.6 μmol/mmol) than normal
(neither osteoporotic nor osteopenic) postmenopausal women (T score >-1) (3.5
+/- 0.7 μmol/mmol) using multivariable-adjusted BMD. These findings highlight
that vitamin E may increase BMD in healthy postmenopausal women" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
Erectile dysfunction may
be the first clinical sign of insulin resistance and endothelial dysfunction in
young men - Clin Res Cardiol. 2013 May 17 - "192
patients and 33 normal controls were enrolled. ED
was evaluated by using the International Index of Erectile Function-5 (IIEF-5)
questionnaire ... Patients with ED had significantly higher levels of systolic
blood pressure (SBP), high-sensitivity C-reactive protein (Hs-CRP), high
Insulin resistance index (HOMA-IR) and carotid
intima-media thickness (IMT), compared with controls"
Role of HDL
cholesterol and estimates of HDL particle composition in future development of
type 2 diabetes in the general population: The PREVEND Study - J Clin
Endocrinol Metab. 2013 May 20 - "High
density lipoproteins (HDL) may directly stimulate β-cell function and
glucose metabolism ... Higher HDL cholesterol, as well as higher
HDL-cholesterol/apoA-I and HDL-cholesterol/apoA-II ratios are strongly and
independently related to lower risk of future type 2 diabetes"
Preventing
Alzheimer's disease-related gray matter atrophy by B-vitamin treatment -
Proc Natl Acad Sci U S A. 2013 May 20 - "Is it possible
to prevent atrophy of key brain regions related to
cognitive decline and Alzheimer's disease
(AD)? One approach is to modify nongenetic risk factors, for instance by
lowering elevated plasma homocysteine using
B vitamins. In an initial, randomized
controlled study on elderly subjects with increased dementia risk (mild
cognitive impairment according to 2004 Petersen criteria), we showed that
high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12
0.5 mg) slowed shrinkage of the whole brain volume over 2 y. Here, we go further
by demonstrating that B-vitamin treatment reduces, by as much as seven fold, the
cerebral atrophy in those gray matter (GM) regions specifically vulnerable to
the AD process, including the medial temporal lobe ... B vitamins lower
homocysteine, which directly leads to a decrease in GM atrophy, thereby slowing
cognitive decline" - See
folic acid products at Amazon.com
and
vitamin B12 at Amazon.com.
Neat Tech Stuff / "How To's":
Health Focus (Co-enzyme
Q10):
Specific Recommendations:
News & Research:
-
Insulin Resistance - Dr. Weil - "Supplements:
... Coenzyme Q10 ... Alpha-lipoic acid ... Magnesium ... Chromium"
-
CoQ10 and
L-carnitine for Statin Myalgia? - Medscape, 1/4/13 -
"In summary, it has been proposed that CoQ10 can
help to treat statin myalgia. While this is not conclusive, there are two
randomized controlled trials showing significant improvements in the
severity of muscle pain with the use of CoQ10 in patients treated with
statins. Thus, it is not unreasonable to supplement a patient who is
experiencing muscle pains on a statin with CoQ10. While there are no
clinical trials showing improvements in muscle pain with the use of
l-carnitine, patients who experience statin myalgia frequently have
carnitine abnormalities. It is too soon to recommend l-carnitine for statin
myalgia, but future trials should test this supplement to see if it has any
place for this adverse effect. Other common alternatives for treating statin
myalgias are supplementation with vitamin D or vitamin B12, especially in
the setting of suboptimal serum levels"
- See
ubiquinol products at Amazon.com,
Jarrow Formulas, GPLC, Glyco Carn, 500 mg, 60 Veggie Caps at iHerb
and
acetyl l-carnitine products at Amazon.com.
-
Cholesterol medicine affects energy production in muscles - Science
Daily, 1/3/13 - "A well-known side effect of statin
therapy is muscle pain. Up to 75 per cent of the physically active patients
undergoing treatment for high cholesterol experience pain. This may keep
people away from either taking their medicine or from taking exercise --
both of which are bad choices ... Scientists also showed that the patients
examined who were being treated with statins had low levels of the key
protein Q10. Q10 depletion and ensuing lower energy production in the
muscles could be the biological cause of the muscle pain that is a problem
for many patients"
-
Antioxidant has potential in the Alzheimer's fight - Science Daily,
12/14/11 - "When you cut an apple and leave it out,
it turns brown. Squeeze the apple with lemon juice, an antioxidant, and the
process slows down ... Simply put, that same "browning" process-known as
oxidative stress-happens in the brain as Alzheimer's disease sets in ... an
antioxidant can delay the onset of all the indicators of Alzheimer's
disease, including cognitive decline. The researchers administered an
antioxidant compound called MitoQ to mice genetically engineered to develop
Alzheimer's. The results of their study were published in the Nov. 2 issue
of the Journal of Neuroscience ... Oxidative stress is believed to cause
neurons in the brain to die, resulting in Alzheimer's ... The brain consumes
20 percent of the oxygen in the body even though it only makes up 5 percent
of the volume, so it's particularly susceptible to oxidative stress ...
MitoQ selectively accumulates in the mitochondria" - Note: I
couldn't find the ingredients but it sounds like a form of co-enzyme Q10.
Here's the form I take:
ubiquinol products at Amazon.com
-
CoQ10 may boost antioxidant defenses in people with atherosclerosis - Nutra
USA, 10/28/11 - "A daily CoQ10 dose of 150 mg was
associated with 29% lower levels of malondialdehyde (MDA - a reactive carbonyl
compound and a well-established marker of oxidative stress) after eight weeks,
compared with the placebo group ... In addition, after 12 weeks of
supplementation, the CoQ10 supplement appeared to stimulate the body’s
antioxidant defenses and levels of the antioxidant enzymes catalase and
superoxide dismutase (SOD) were 230% and 78% higher than the placebo group,
respectively ... blood levels increased of CoQ10 increased in the high dose
group by 189% after 12 weeks, but no significant increases were observed in the
60 mg group" - [Abstract]
-
CoQ10 may reduce muscle damage during intensive exercise - Nutra USA,
10/27/11 - "Twenty ultra-runners participated in the
study and were divided into two equal groups. One group received one 30 mg
capsule of CoQ10 two days before the test, three 30 mg capsules the day before
the test, and one capsule one hour before the test. The other group received
placebo at the same time. The test involved a 50 km distance run across Europe’s
highest road in the Sierra Nevada ... Results showed that the placebo group
displayed a 100% increase in levels of 8-OHdG, which <i>“a sensitive indicator
of DNA damage as a result of oxidative stress”,</i> said the researchers,
compared with an increase of 37.5% in the runners taking the CoQ10 supplements
... The data also indicated that CoQ10 countered the over-expression of certain
pro-inflammatory compounds after exercise ... a reduction in levels of
creatinine in the urine was observed in the CoQ10 group, compared with the
placebo group. Creatinine is produced from creatine and high levels are a marker
of muscle break down (or kidney damage) ... CoQ10 supplementation reduces
creatinine excretion and therefore decrease muscle damage during physical
performance" - [Abstract]
-
Natural
therapies: Cardiologists examine alternatives to halt high blood pressure -
Science Daily, 8/30/11 - "The shining star among
supplements is coenzyme Q10, an enzyme involved in energy production that also
acts as an antioxidant. Patients with
hypertension tend to have lower levels of the enzyme, and a meta-analysis --
an overarching analysis of past studies -- found that treatment with coenzyme
Q10 supplements significantly reduced blood pressure ... Coenzyme Q10 has a
pretty profound effect on blood pressure, but whenever research is based on a
collection of other data you have to have some skepticism ...
potassium helps lower blood pressure, and
there is evidence that increasing the amount of potassium we get through the
foods we eat could carry some of the same mild benefits as taking supplements"
- See
ubiquinol products at Amazon.com
and
potassium citrate at Amazon.com.
-
Pine bark extract plus CoQ10 shows benefits for heart failure patients -
Nutra USA, 6/23/11 - "12 weeks of daily supplementation
with 350 milligrams of CoQ10 (Kaneka) and 105 milligrams of the branded pine
bark extract Pycnogenol ... recruited 53 heart failure patients aged between 54
and 68 were randomly assigned to receive either the PycnoQ10 supplement or
placebo for 12 weeks ... systolic and diastolic blood pressure decreased
following the CoQ10-pine bark combination, from 139.2 to 133.2 mmHg and 82.3 to
77.3 mmHg, respectively. Systolic and diastolic blood pressure decreased from
140.3 to 139.5 mmHg and 83.4 to 81.2 mmHg, respectively, in the placebo group
... In addition to increases in the amount of blood pumped by the heart, the
researchers also reported improvements in heart rate were also observed in the
PycnoQ10 supplement group from 78.4 to 74.2 beats per minute, compared with a
decrease from 79.1 to 78.4 in the placebo group" - [Abstract]
- See
Pycnogenol at Amazon.com
and
ubiquinol products at Amazon.com.
-
CoQ10 may protect against obesity problems: Study - Nutra USA, 10/15/09
- "We propose, in view of our study, that CoQ10,
when given orally, is able to target the liver tissue, and to lessen
inflammatory stress associated with obesity in mice in this tissue,
independent on any action on lipid peroxidation" - [Abstract]
-
CoQ10 may boost sperm quality: Study - Nutra USA, 6/16/09 -
"randomly assigned them to receive a daily CoQ10
supplement (300 mg, Kaneka, Japan) or placebo for 26 weeks. This was
followed by 30 weeks with no intervention ... The Tehran-based researchers
reported a significant improvement in both sperm density and motility
following supplements of the coenzyme. A positive association was also found
with regards to sperm count. Further analysis showed an increase in the
percent of normal forms of sperm" - [Abstract]
-
CoQ10 Improves
Endothelial Dysfunction in Statin-Treated Type 2 Diabetics - Medscape,
5/29/09 - "Study subjects were randomized to receive
either 200 mg/day of oral CoQ10 or placebo for 12 weeks ... Our absolute
improvement in FMD of 1% with CoQ10 supplementation may potentially
translate to a 10-25% reduction in residual cardiovascular risk in these
patients"
-
Taking
Statins? Five Ways to Boost Your Energy - ABC News, 4/14/09 -
"It's a cruel irony that if statins make patients
more lethargic, it could impair their ability to exercise or make dietary
changes that would help them address their high cholesterol ... some studies
have found that patients' energy levels increased while using CoQ10 and
statins together ... Try pomegranate juice or a small chunk of dark
chocolate, both of which have beneficial antioxidants ... Skimping on sleep
has been found to increase calcium deposit build-up in your arteries"
-
Statin study: Lower cholesterol, diminished joy of sex linked - USA
Today, 3/5/09 - "In the study, sexual pleasure sank
along with LDL levels ... Some studies have found that statins improve
sexual function, probably because the pills can improve blood flow to the
genital area, Golomb says. But she says the drugs also may reduce Coenzyme
Q10, a nutrient that helps cells convert oxygen, blood and glucose into
energy. "Orgasm is a high-energy activity," so losing the nutrient could
weaken sexual pleasure, she says" - See
ubiquinol products at Amazon.com.
-
Statins' Adverse Effects Documented - Science Daily, 1/29/09 -
"Coenzyme Q10 ("Q10") is a compound central to the
process of making energy within mitochondria and quenching free radicals.
However, statins lower Q10 levels because they work by blocking the pathway
involved in cholesterol production – the same pathway by which Q10 is
produced. Statins also reduce the blood cholesterol that transports Q10 and
other fat-soluble antioxidants ... "The loss of Q10 leads to loss of cell
energy and increased free radicals which, in turn, can further damage
mitochondrial DNA," said Golomb, who explained that loss of Q10 may lead to
a greater likelihood of symptoms arising from statins in patients with
existing mitochondrial damage – since these people especially rely on ample
Q10 to help bypass this damage" - My favorite is
QH-Absorb by Jarrow.
-
Wrinkle creams:
Your guide to younger looking skin - CNN -
"Coenzyme Q10 is a nutrient that helps regulate
energy production in cells. Some studies have shown reduction in fine
wrinkles around the eyes with no side effects"
-
CoQ10 bioavailability boost from soft gels: Study - Nutra USA, 1/12/09 -
"Researchers from Canada’s KGK Synergize compared
CoQ10 formulations from hard and soft gel capsules, and found the reduced
form from the latter resulted in a 3.3-fold higher blood level of CoQ10 than
the former ... formulated by Soft Gel Technologies" - See
iHerb search of "Soft Gel Technologies". I'm sticking with
QH-Absorb by Jarrow because I don't trust the NOW brand. I feel that it
probably just hasn't been studied yet.
Abstracts:
-
Effect of
Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative
stress of seminal plasma: a double-blind randomised clinical trial -
Andrologia. 2013 Jan 7 - "Sixty infertile men with
idiopathic oligoasthenoteratozoospermia (OAT) were randomised to receive 200 mg
d(-1) of CoQ10 or placebo for 3 months ... CoQ10 levels increased from 44.74 +/-
36.47 to 68.17 +/- 42.41 ng ml(-1) following supplementation in CoQ10 ... There
was a significant positive correlation between CoQ10 concentration and normal
sperm morphology (P = 0.037), catalase (P = 0.041) and SOD (P < 0.001).
Significant difference was shown between the mean of changes in seminal plasma
8-isoprostane in two groups (P = 0.003) after supplementation. Three-month
supplementation with CoQ10 in OAT infertile men can attenuate oxidative stress
in seminal plasma and improve semen parameters and antioxidant enzymes activity"
-
Coenzyme Q10
prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse,
a type 2 diabetes model - Proc Natl Acad Sci U S A. 2012 Dec 24 -
"Diabetic peripheral neuropathy (DPN) is the most common
complication in both type 1 and type 2 diabetes ... Diabetic mice at 8 mo of age
exhibited loss of sensation, hypoalgesia (an increase in mechanical threshold),
and decreases in mechanical hyperalgesia, cold allodynia, and sciatic nerve
conduction velocity. All these changes were virtually completely absent after
the 6-mo, daily CoQ10 treatment in db(-)/db(-) mice when started at 7 wk of age"
-
Effects of
EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels:
a randomised, double-blind trial - Br J Nutr. 2012 Nov 30:1-8 -
"A total of 504 healthy men with serum PSA level ≤ 2.5
ng/ml were recruited into the study ... Participants were randomly assigned to a
daily dietary supplement containing n-3 fatty acids (1.12 g of EPA and 0.72 g of
DHA per capsule) (group 1, n 126), n-6 fatty acid (600 mg γ-linolenic acid (GLA)
each capsule) (group 2, n 126), CoQ10 (100 mg per capsule) (group 3, n 126) or a
similar regimen of placebo (group 4, n 126) for 12 weeks ... EPA treatment
significantly reduced serum PSA level by 30.0 (95 % CI 25, 36) % (P = 0.004)
from baseline. In contrast, GLA therapy significantly increased serum PSA
concentration by 15.0 (95 % CI 11, 20) % (P = 0.02). CoQ10 therapy also
significantly reduced serum PSA level by 33.0 (95 % CI 27, 40) % (P = 0.002). In
multivariable analysis, serum values of PSA were strongly correlated with
duration of EPA (r - 0.62; 95 % CI - 0.42, - 0.77; P = 0.003), n-6 (r 0.42; 95 %
CI 0.31, 0.58; P = 0.02) and CoQ10 use (r - 0.77; 95 % CI - 0.56, - 0.87; P =
0.001). There were also significant correlations between serum values of DHA,
EPA, GLA and CoQ10 and serum PSA levels. The present study demonstrates that
dietary supplements containing EPA, GLA or CoQ10 may significantly affect serum
PSA levels" - See
ubiquinol products at Amazon.com
and
Mega Twin EPA at Amazon.com.
-
Effects of
coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of
randomized controlled trials - Atherosclerosis. 2011 Oct 25 -
"Coenzyme Q10 supplementation is associated with
significant improvement in endothelial function. The current study supports a
role for CoQ10 supplementation in patients with endothelial dysfunction"
-
Rosuvastatin combined with regular exercise preserves coenzyme Q10 levels
associated with a significant increase in high-density lipoprotein cholesterol
in patients with coronary artery disease - Atherosclerosis. 2011 Mar 31 -
"Atorvastatin significantly decreased serum ubiquinol
(731+/-238 to 547+/-219nmol/L, p=0.001), but rosuvastatin (680+/-233 to
668+/-299nmol/L, p=0.834) did not" - See
Jarrow Formulas,
Ubiquinol QH-Absorb, 100 mg, 60 Softgels at iHerb.
-
Reversal of
mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial
function in patients with ischaemic left ventricular systolic dysfunction: A
randomized controlled trial - Atherosclerosis. 2011 Feb 17 -
"Coronary artery disease (CAD) is associated with
endothelial dysfunction and mitochondrial dysfunction (MD) ... brachial
flow-mediated dilation (FMD) in patients with ischaemic LVSD (left ventricular
ejection fraction <45%) ... In patients with ischaemic LVSD, 8weeks supplement
of CoQ improved mitochondrial function and FMD; and the improvement of FMD
correlated with the change in mitochondrial function, suggesting that CoQ
improved endothelial function via reversal of mitochondrial dysfunction in
patients with ischaemic LVSD"
-
Improved
Survival in Patients with End-stage Cancer Treated with Coenzyme Q(10) and Other
Antioxidants: a Pilot Study - J Int Med Res. 2009;37(6):1961-1971 -
"This pilot study evaluated the survival of patients
with end-stage cancer who received supplements of coenzyme Q(10) and a mixture
of other antioxidants (e.g. vitamin C, selenium, folic acid and beta-carotene)
... Median predicted survival was 12 months (range 3 - 29 months), whereas
median actual survival was 17 months (1 - 120 months), which is > 40% longer
than the median predicted survival. Mean actual survival was 28.8 months versus
11.9 months for mean predicted survival. Ten patients (24%) survived for less
time than predicted, whereas 31 (76%) survived for longer. Treatments were very
well tolerated with few adverse effects"
-
Coenzyme Q
addition to an n-6 PUFA-rich diet resembles benefits on age-related
mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart
- Mech Ageing Dev. 2009 Nov 27 - "Age-related changes in
cardiomyocytes reduce the capacity to recover from acute injury or to adapt
during chronic disease in advanced age. N-6 Polyunsaturated fatty acids
(n-6PUFA) lead to higher lipid peroxidation during aging than the less
oxidizable monounsaturated fatty acids (MUFA); and coenzyme Q (CoQ)-supplemented
n-6PUFA lengthens the lifespan and reduces peroxidation in comparison to
non-supplemented n-6PUFA ... The lowest hydroperoxide levels for aged animals
were found for n-6 PUFA+CoQ, which also showed lower concentrations than did n-6
PUFA ... The results suggest that MUFA can protect mitochondria from age-related
changes, and that CoQ supplementation to n-6 PUFA partially resembles MUFA
benefits. Moreover, under our experimental conditions, lipid-derived oxidative
damage appears to be more important than the pure protein-derived oxidative
damage during aging"
-
Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation
associated with diet-induced obesity in mice - Biochem Pharmacol. 2009 Dec
1;78(11):1391-400 - "CoQ10 supplementation decreased the
global hepatic mRNA expression of inflammatory and metabolic stresses markers
without changing obesity and tissue lipid peroxides compared to HFF mice"
-
Efficacy of coenzyme Q10
on semen parameters, sperm function and reproductive hormones in infertile men
- J Urol. 2009 Jul;182(1):237-48 - "were randomly
assigned to receive 300 mg coenzyme Q10 (Kaneka, Osaka, Japan) orally daily (106
in group 1) or a similar placebo regimen (106 in group 2) during a 26-week
period, followed by a 30-week treatment-free phase ... Coenzyme Q10
supplementation resulted in a statistically significant improvement in certain
semen parameters"
-
Coenzyme
Q(10) An Independent Predictor of Mortality in Chronic Heart Failure - J Am
Coll Cardiol. 2008 Oct 28;52(18):1435-1441 - "Plasma
CoQ(10) concentration was an independent predictor of mortality in this cohort.
The CoQ(10) deficiency might be detrimental to the long-term prognosis of CHF,
and there is a rationale for controlled intervention studies with CoQ(10)"
-
Reducing exercise-induced muscular injury in kendo athletes with
supplementation of coenzyme Q10 - Br J Nutr. 2008 Feb 20;:1-7 -
"Subjects in the CoQ10 group took 300 mg CoQ10 per d
for 20 d ... These results indicate that CoQ10 supplementation reduced
exercise-induced muscular injury in athletes"
-
Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated
postmenopausal breast cancer women with special reference to blood chemistry
profiles - Breast Cancer Res Treat. 2008 Apr 22 -
"Tamoxifen (TAM) ... TAM also has estrogenic
activity on liver and endometrium causing severe oxidative stress with
various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin
(CoRN) are well-known potent antioxidants and protective agents against many
diseases including cancer ... A statistically significant alteration in
various blood chemistry parameters, such as serum total bilirubin (S. BIL),
serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate
transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid
(UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases
(LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group,
was favorably reverted back to near normal levels on combinatorial therapy
with CoRN"
-
Reducing exercise-induced muscular injury in kendo athletes with
supplementation of coenzyme Q10 - Br J Nutr. 2008 Feb 20;:1-7 -
"These results indicate that CoQ10 supplementation
reduced exercise-induced muscular injury in athletes"
-
Effect of Co-enzyme Q10 and Alpha-Lipoic Acid on Response of Rabbit Urinary
Bladder to Repetitive Stimulation and In Vitro Ischemia - Urology. 2008
Feb 15 - "CoQ10 showed no protective effect.
alpha-LA resulted in increased contractile responses of the control bladder
and showed a moderate protective effect for all forms of stimulation. The
combination, however, showed a significantly greater increase in the
contraction of the control bladder and a greater protective effect than
alpha-LA alone"
-
Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and
liver and muscle enzyme levels in hypercholesterolemic patients treated with
atorvastatin: A randomized double-blind study - Atherosclerosis. 2007
Aug 4 - "All patients showed definite reductions of
plasma CoQ10 levels in the placebo group, by 42%. All patients supplemented
with CoQ10 showed striking increases in plasma CoQ10 by 127%. In conclusion
atorvastatin definitely decreased plasma CoQ10 levels and supplementation
with CoQ10 increased their levels"
-
Effect of coenzyme Q10 administration on endothelial function and
extracellular superoxide dismutase in patients with ischaemic heart disease:
a double-blind, randomized controlled study - Eur Heart J. 2007 Jul 19 -
"endothelium-dependent (ED) vasodilation ...
improvements elicited by CoQ(10) supplementation were remarkable in subjects
presenting low initial endothelium-bound ecSOD and thus more prone to
oxidative stress ... The enhancement of peak VO(2) and of O(2) pulse is
likely due to the bioenergetic effect of CoQ(10); on the other end, the
improved VO(2) could also depend on the observed enhanced peripheral
endothelial function"
-
Coenzyme Q(10) in the treatment of hypertension: a meta-analysis of the
clinical trials - J Hum Hypertens. 2007 Feb 8 -
"We conclude that coenzyme Q(10) has the potential
in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg
and diastolic blood pressure by up to 10 mm Hg without significant side
effects"
-
Effect of coenzyme q10 on myopathic symptoms in patients treated with
statins - Am J Cardiol. 2007 May 15;99(10):1409-12 -
"coenzyme Q10 supplementation may decrease muscle
pain associated with statin treatment. Thus, coenzyme Q10 supplementation
may offer an alternative to stopping treatment with these vital drugs"
-
Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the
clinical trials - J Hum Hypertens. 2007 Apr;21(4):297-306 -
"coenzyme Q10 has the potential in hypertensive
patients to lower systolic blood pressure by up to 17 mm Hg and diastolic
blood pressure by up to 10 mm Hg without significant side effects"
- See
ubiquinol at Amazon.com.
-
Coenzyme Q10 and exercise training in chronic heart failure - Eur Heart
J. 2006 Aug 1 - "CoQ10 main effect was: peak VO2+9%,
EDDBA +38%, systolic wall thickening score index (SWTI) - 12%"
-
Myocardial dysfunction in mitochondrial diabetes treated with Coenzyme Q10
- Diabetes Res Clin Pract. 2006 Apr;72(1):100-3 -
"In our patient, after the introduction of Coenzyme
Q10 150 mg/day, there was a gradual improvement on left ventricular function
evaluated by echocardiography. The fractional shortening (FS) and ejection
fraction (EF) increased from 26 to 34% and from 49 to 64%, respectively. No
side effects were noted. Three months after CoQ10 discontinuation, the
parameters of systolic function evaluated by echocardiography decreased,
suggesting that CoQ10 had a beneficial effect"
-
Clinical aspects of coenzyme Q10: an update - Curr Opin Clin Nutr Metab
Care. 2005 Nov;8(6):641-6 - "A 4-year follow-up on
10 Friedreich's Ataxia patients treated with coenzyme Q10 and vitamin E
showed a substantial improvement in cardiac and skeletal muscle
bioenergetics and heart function"
-
Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at
Risk for Cardiovascular Disease and Stroke - Arch Neurol.
2004;61:889-892 -
"Even brief exposure to atorvastatin causes a marked
decrease in blood CoQ10 concentration. Widespread inhibition of CoQ10
synthesis could explain the most commonly reported adverse effects of
statins, especially exercise intolerance, myalgia, and myoglobinuria"
-
Combined effect of coenzyme Q(10) and fenofibrate on forearm
microcirculatory function in type 2 diabetes - Atherosclerosis 2003
May;168(1):169-79 -
"CoQ did not change plasma isoprostanes, but
significantly lowered systolic blood
pressure and HbA(1c)"
-
Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of
the Functional Decline - Archives of Neurology, 10/02 -
"Less disability developed in subjects assigned to
coenzyme Q10 than in those assigned to placebo, and the benefit was greatest
in subjects receiving the highest dosage"
-
Randomized, double-blind placebo-controlled trial of coenzyme Q10 in
patients with acute myocardial infarction - Cardiovasc Drugs Ther. 1998
Sep;12(4):347-53
-
Progress on therapy of breast cancer with vitamin Q10 and the regression of
metastases - Biochem Biophys Res Commun 1995 Jul 6;212(1):172-7 -
"The numerous metastases in the liver of a
44-year-old patient "disappeared," and no signs of metastases were found
elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10,
revealed no signs of tumor in the pleural cavity after six months, and her
condition was excellent. A 75-year-old patient with carcinoma in one breast,
after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or
metastases"
-
Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in
isolated systolic hypertension - South Med J 2001 Nov;94(11):1112-7 -
"conducted a 12-week randomized, double-blind,
placebo-controlled trial with twice daily administration of 60 mg of oral
CoQ ... The mean reduction in systolic blood pressure of the CoQ-treated
group was 17.8"
-
Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin
resistance in hypertensive patients with coronary artery disease - J Hum
Hypertens. 1999 Mar;13(3):203-8 -
"the following indices were reduced in the coenzyme
Q10 group: systolic and diastolic blood pressure, fasting and 2-h plasma
insulin, glucose, triglycerides, lipid peroxides, malondialdehyde and diene
conjugates. The following indices were increased: HDL-cholesterol, vitamins
A, C, E and beta-carotene ... treatment with coenzyme Q10 decreases blood
pressure possibly by decreasing oxidative stress and insulin response in
patients with known hypertension receiving conventional antihypertensive
drugs"
-
Partial and complete regression of breast cancer in patients in relation to
dosage of coenzyme Q10 - Biochem Biophys Res Commun 1994 Mar
30;199(3):1504-8 -
"Six of the 32 patients showed partial tumor
regression. In one of these 6 cases, the dosage of CoQ10 was increased to
390 mg. In one month, the tumor was no longer palpable and in another month,
mammography confirmed the absence of tumor. Encouraged, another case having
a verified breast tumor, after non-radical surgery and with verified
residual tumor in the tumor bed was then treated with 300 mg. CoQ10. After 3
months, the patient was in excellent clinical condition and there was no
residual tumor tissue"
|
|