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Recent Longevity News for the seven days ending 2/1/12. You should consult your doctor if you are taking any medications.
Maternal omega-3 reduces eczema risk in children: Study - Nutra USA, 1/31/12
- "children whose mothers had consumed
omega-3 daily had 36% less risk of developing
eczema, a 38% reduction in the chance of being sensitised to egg, and 50%
less chance of having egg allergy" - See
Mega Twin EPA at Amazon.com
Grape
seed extract kills head and neck cancer cells, leaves healthy cells unharmed
- Science Daily, 1/27/12 - "Nearly 12,000 people will
die of head and neck cancer in the
United States this year and worldwide cases will exceed half a million ...
grape seed extract both damages cancer cells'
DNA (via increased reactive oxygen species) and stops the pathways that allow
repair (as seen by decreased levels of the DNA repair molecules Brca1 and Rad51
and DNA repair foci) ... we saw absolutely no toxicity to the mice ... the grape
seed extract killed the cancer cells but not the healthy cells" - See
grape seed extract at Amazon.com
Green tea may reduce functional disability risk: Study - Nutra USA, 1/27/12
- "Compared to people who drank less than one cup per
day, at least five cups of the green tea was
associated with a 33% reduction in functional disability" - [Abstract]
- See
green tea extract at Amazon.com Oral HPV More Common in Men Than Women - NYTimes.com, 1/26/12 - "Over all, 10.1 percent of men were infected orally with HPV of one type or another, compared with 3.6 percent of women. The reason for the higher rate among men was unclear ... One line of speculation was that hormonal differences in women might play a protective role, or that oral sex on women for some reason causes a greater likelihood of transmission ... the finding that men had triple the rate of infection dovetailed with earlier research on HPV-related throat cancers, which are about three times as common in men as they are in women, a difference that until now had not been explained"
Aged garlic reduces cold and flu severity: RCT data - Nutra USA, 1/26/12 -
"Supplements of an aged
garlic extract may reduce the number of days a person suffers from
cold and ‘flu by 61% ... Ninety days of consuming
the garlic supplement also produced a 21% reduction in the number of symptoms of
colds or flu" - [Abstract]
- See
garlic supplements at Amazon.com
Study unlocks Pycnogenol’s skin health mechanism - Nutra USA, 1/26/12 -
"Daily supplements of an extract from French maritime
pine bark may boost skin elasticity by 25% and skin hydration by 8% ... the
pine bark extract was also associated with a 3% reduction in
skin wrinkles"
- [Abstract] - See
Pycnogenol at Amazon.com Working too much is correlated with two-fold increase in likelihood of depression - Science Daily, 1/25/12 - "The odds of a major depressive episode are more than double for those working 11 or more hours a day compared to those working seven to eight hours a day" Fiber may boost pancreatic health: Study - Nutra USA, 1/25/12 - "The greatest intakes of soluble fiber were linked to a 60% reduction in pancreatic cancer risk, while insoluble fiber intake was linked to a 50% reduction in risk" - [Abstract] - See Jarrow Formulas, Fiber Perfect, 150 Veggie Caps at iHerb. Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):
Supplementation with aged garlic extract improves both NK and γδ-T cell function
and reduces the severity of cold and flu symptoms: A randomized, double-blind,
placebo-controlled nutrition intervention - Clin Nutr. 2012 Jan 24 -
"After 45 d of consuming an encapsulated aged garlic
extract, γδ-T cells (p = 0.039, n = 56) and NK cells (p = 0.043, n = 56) were
shown to proliferate better compared to placebo. After 90 d of supplementation,
illness diary entries showed that the incidence of colds and flu, a secondary
outcome, were not statistically different; however, the group consuming the aged
garlic extract appeared to have reduced severity as noted by a reduction in the
number of symptoms reported (21% fewer, p < 0.001, z-test of proportions), a
reduction in the number of days (61% fewer, p < 0.001, z-test) and incidences
(58% fewer p < 0.001, z-test) where the subjects functioned sub-optimally and
the number of work/school days missed due to illness (58% fewer, p = 0.035,
z-test) ... These results suggest that supplementation of the diet with aged
garlic extract may enhance immune cell function and that this may be
responsible, in part, for reduced severity of colds and flu" - See
garlic supplements at Amazon.com Low Testosterone as an Independent Predictor of Mortality in Men with Chronic Liver Disease - Clin Endocrinol (Oxf). 2012 Jan 27 - "in a Cox proportional hazard model, both low total (p= 0.02) and free testosterone (p= 0.007) remained predictive of death independently of established prognostic factors, such as the Model for End Stage Liver Disease (MELD) score, and serum sodium levels. A decrease in TT by 1 nmol/L and in cFT by 10 pmol/L was associated with an 8% increase in mortality"
Association
of Plasma Phospholipid Long-Chain Omega-3 Fatty Acids with Incident Atrial
Fibrillation in Older Adults: The Cardiovascular Health Study - Circulation.
2012 Jan 26 - "In multivariable Cox models adjusted for
other risk factors, the RR in the top versus lowest quartile of total
n-3 PUFA (EPA+DPA+DHA) levels was 0.71
(95%CI=0.57-0.89, P-trend=0.004); and of DHA levels, 0.77 (95%CI=0.62-0.96,
P-trend=0.01). EPA and DPA levels were not significantly associated with
incident AF. Evaluated
non-parametrically, both total n-3 PUFA and DHA showed graded and linear inverse
associations with incidence of AF" - See
Mega Twin EPA at Amazon.com
Vitamin E is
a MIF Inhibitor - Biochem Biophys Res Commun. 2012 Jan 18 -
"Macrophage migration inhibitory factor (MIF) is known
to contribute to the pathogenesis of inflammatory hyperalgesia and
neuropathic pain ...
Vitamin E inhibits not only the enzymatic
activity of MIF but more importantly the biological function of MIF. Our
findings suggest that Vitamin E may be attenuating hyperalgesia and reducing
neuropathic pain at least in part by inhibiting MIF activity"
- See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com Increased Serum Ferritin Predicts the Development of Hypertension Among Middle-Aged Men - Am J Hypertens. 2012 Jan 26 - "After adjustment for age and body mass index (BMI), the odds ratios (OR) was substantially higher for new hypertension (OR 1.54, 95% confidence intervals (CIs) 1.26-1.88; P for trend <0.001) in subjects with the highest ferritin quartiles compared with those in the lowest quartiles"
(n-3) Fatty
Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or
Complementary? - J Nutr. 2012 Jan 25 - "We reviewed
evidence for dietary and endogenous sources and cardiovascular effects on
biologic pathways, physiologic risk factors, and clinical endpoints of EPA
[20:5(n-3)], docosapentaenoic acid [DPA, 22:5(n-3)], and DHA [22:6(n-3)]. DHA
requires direct dietary consumption, with little synthesis from or
retroconversion to DPA or EPA. Whereas EPA is also largely derived from direct
consumption, EPA can also be synthesized in small amounts from plant (n-3)
precursors, especially stearidonic acid. In contrast, DPA appears principally
derived from endogenous elongation from EPA, and DPA can also undergo
retroconversion back to EPA. In experimental and animal models, both EPA and DHA
modulate several relevant biologic pathways, with evidence for some differential
benefits. In humans, both fatty acids lower TG levels and, based on more limited
studies, favorably affect cardiac diastolic filling, arterial compliance, and
some metrics of inflammation and oxidative stress. All three
(n-3) PUFA reduce ex vivo platelet
aggregation and DHA also modestly increases LDL and HDL particle size; the
clinical relevance of such findings is uncertain. Combined EPA+DHA or DPA+DHA
levels are associated with lower risk of fatal cardiac events and DHA with lower
risk of atrial fibrillation, suggesting direct or indirect benefits of DHA for
cardiac arrhythmias (although not excluding similar benefits of EPA or DPA).
Conversely, EPA and DPA, but not DHA, are associated with lower risk of nonfatal
cardiovascular endpoints in some studies, and purified EPA reduced risk of
nonfatal coronary syndromes in one large clinical trial. Overall, for many
cardiovascular pathways and outcomes, identified studies of individual (n-3)
PUFA were relatively limited, especially for DPA. Nonetheless, the present
evidence suggests that EPA and DHA have both shared and complementary benefits.
Based on current evidence, increasing consumption of either would be
advantageous compared to little or no consumption. Focusing on their combined
consumption remains most prudent given the potential for complementary effects
and the existing more robust literature on cardiovascular benefits of their
combined consumption as fish or fish oil for cardiovascular benefits" -
See
Mega Twin EPA at Amazon.com
Dietary
intake of PUFAs and colorectal polyp risk - Am J Clin Nutr. 2012 Jan 25 -
"n-6 PUFAs were not associated with adenomatous or
hyperplastic polyps in either men or women. Marine-derived
n-3 PUFAs were associated with reduced risk
of colorectal adenomas in women only, with an
adjusted OR of 0.67 (95% CI: 0.47, 0.97) for the highest quintile of intake
compared with the lowest quintile of intake (P-trend = 0.01). Dietary intake of
α-linolenic acid was associated with an increased risk of hyperplastic polyps in
men (P-trend = 0.03), which was not seen in women" - See
Mega Twin EPA at Amazon.com
Fifteen-Year Effects of Helicobacter pylori, Garlic, and Vitamin Treatments on Gastric Cancer Incidence and Mortality - J Natl Cancer Inst. 2012 Jan 23 - "Garlic and vitamin treatments were associated with non-statistically significant reductions in gastric cancer incidence and mortality. Vitamin treatment was associated with statistically significantly fewer deaths from gastric or esophageal cancer, a secondary endpoint (HR = 0.51, 95% CI = 0.30 to 0.87; P = .014)" Beneficial effects of combined olive oil ingestion and acute exercise on postprandial TAG concentrations in healthy young women - Br J Nutr. 2012 Jan 23:1-7 - "Foods high in monounsaturated fat, such as olive oil, and endurance exercise are both known to independently reduce postprandial TAG concentrations. We examined the combined effects of exercise and dietary fat composition on postprandial TAG concentrations in nine healthy pre-menopausal females (age 26.8 (sd 3.3) years, BMI 22.3 (sd 2.0) kg/m2). Each participant completed four, 2 d trials in a randomised order: (1) butter-no exercise, (2) olive oil-no exercise, (3) butter-exercise, (4) olive oil-exercise. On day 1 of the exercise trials, participants walked or ran on a treadmill for 60 min. On the no-exercise trials, participants rested on day 1. On day 2 of each trial, participants rested and consumed an olive oil meal (saturated fat 15 % and unsaturated fat 85 %) or a butter meal (saturated fat 71 % and unsaturated fat 29 %) for breakfast ... A significant main effect on physical activity (exercise or control) was obtained for plasma TAG concentration (three-way ANOVA, P = 0.043), and the total area under the concentration v. time curve for TAG was 26 % lower on the olive oil-exercise trial (4.40 (sd 0.40) mmol × 6 h/l) than the butter-no exercise trial (5.91 (sd 1.01) mmol × 6 h/l) (one-way ANOVA, P = 0.029). These findings suggest that the combination of exercise and a preference for monounsaturated dietary fat intake in the form of olive oil may be most beneficial for reducing postprandial TAG concentrations"
Associations
of plasma n-3 polyunsaturated fatty acids with blood pressure and cardiovascular
risk factors among Chinese - Int J Food Sci Nutr. 2012 Jan 20 -
"Our results suggest that plasma PL
n-3 PUFA was significantly inversely
associated with hypertension in Chinese. It
would seem appropriate for hypertensive subjects to increase their dietary n-3
PUFA which may help reduce BP" - See
Mega Twin EPA at Amazon.com Health Focus (Gallstones): Popular Supplements:
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