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Recent Longevity News for the seven days ending 1/25/12. You should consult your doctor if you are taking any medications. Dutasteride Is Seen to Curtail Cancer Left in Prostate - NYTimes.com, 1/23/12 - "Two previous studies suggested that dutasteride and a similar drug, finasteride, could actually protect men from prostate cancer ... Three years later, the cancer had progressed in 54 men in the dutasteride group, or 38 percent, and in 70 men in the placebo group, or 48 percent" New Treatment for Cushing's Disease - Medscape, 1/23/12 - "Pasireotide is a somatostatin analogue that attaches to somatostatin receptors in the pituitary and block the release of adrenocorticotrophin. In clinical trials, pasireotide was shown to reduce the levels of cortisol in the urine by at least 50% in 41% of patients treated with a 900-μg dose, and in 34% of patients treated with a 600-μg dose" What’s the Germiest Place in Your Kitchen? - ABC News, 1/23/12 - it's a 4 minute video. Top Tips for Fighting Fatigue - ABC News, 1/23/12 - it's a 5 minute video. Greek yogurt on a marathon-like growth spurt - USATODAY.com, 1/23/12 - "Greek yogurt is made a bit differently than the thinner, more watery product that dominated U.S. supermarket shelves for decades. The whey is strained off, leaving a creamier yogurt high in protein and low in fat" Study suggests new treatment for bloody noses - USATODAY.com - "injecting tiny pieces of polyvinyl alcohol (PVA)—the same chemicals found in kitchen sponges—helps block arteries that supply blood to the nose during a nosebleed that won't stop on its own" - Note: I used to get these and twice I had to go to a doctor because they wouldn't stop. The second was a military doctor and he said he doesn't take nosebleeds lightly because he almost lost someone because of it. More fiber may reduce breast cancer risk: Meta-analysis - Nutra USA, 1/23/12 - "Every 10 gram per day increase in soluble fiber intake was associated with a 26% reduction in the risk of breast cancer, but no such effect was observed for insoluble fiber" - [Abstract]
No More Swabbing: Spit Sampling Gets a Whole Lot Easier - Science Daily, 1/20/12 - "The new Whole Saliva Collection Device -- available for use in February -- is a small, polypropylene collection tube with an integral adapter that comes individually wrapped in a clean, foil pouch with ready-to-go instructions, and is a universal fit with common cyro vials" Tiny amounts of alcohol dramatically extend a worm's life, but why? - Science Daily, 1/20/12 - "How little ethanol is that? ... The concentrations correspond to a tablespoon of ethanol in a bathtub full of water or the alcohol in one beer diluted into a hundred gallons of water ... The scientists found that when they raised the ethanol level by a factor of 80, it did not increase the life span of the worms" Violent Sex Crimes by U.S. Soldiers Rise - Medscape, 1/19/12 - "One violent sex crime was committed by a soldier every six hours and 40 minutes in 2011 ... The top five violent felony offenses committed by soldiers in 2011 were aggravated assault, rape, aggravated sexual assault, forcible sodomy, and child pornography" Lithium's Safety Examined - Medscape, 1/19/12 - "Lithium is linked to thyroid and parathyroid abnormalities, weight gain, and an increased risk for reduced urinary concentrating ability ... lithium is the most effective long-term therapy for bipolar disorder, protecting against both depression and mania and reducing the risk of suicide and short-term mortality ... lithium has always been an unpatented, cheap drug, it is not commercially promoted ... lithium reduced glomerular filtration rate by an average of −6.22 mL/min (95% confidence interval [CI], −14.65 to 2.20, P = 0.148) and urinary concentrating ability by 15% of normal maximum (weighted mean difference ... There was an increase in the prevalence of clinical hypothyroidism in patients taking lithium ... lithium increased thyroid stimulating hormone by an average of 4.00 iU/mL" An easier way to remove gallstones - Science Daily, 1/18/12 - "A tiny ultrasonic probe at the tip of the endoscope locates gallstones, even small ones embedded in the organ's lining. Surgeons can use the horn-shaped "absorbing box" to get rid of fine, difficult-to-remove "sludge-like" gallstones - which the authors say can be compared with "sand sprinkled on a carpet" - by sucking them out like a vacuum cleaner ... Approximately ten percent of the population suffers from gallstones" Preop Intervention Maximizes QOL in Head and Neck Cancer - Medscape, 1/18/12 - "At 5 years, more than half of patients had difficulty eating, 28.5% reported symptoms of depression, and 17.3% reported "substantial" pain" Lack of sleep makes your brain hungry - Science Daily, 1/18/12 - "a specific brain region that contributes to a person's appetite sensation is more activated in response to food images after one night of sleep loss than after one night of normal sleep. Poor sleep habits can therefore affect people's risk of becoming overweight in the long run" First link between potentially toxic PFCs in office air and in office workers' blood - Science Daily, 1/18/12 - "the indoor air in offices is an important source of worker exposure to potentially toxic substances released by carpeting, furniture, paint and other items ... PFCs, used in water-repellent coatings on carpet and furniture, may have adverse effects on human health. The substances are widespread in the environment and in humans around the world. Scientists know that potential sources of exposure include food, water, indoor air, indoor dust and direct contact with PFC-containing objects ... They found concentrations of a PFC called fluorotelomer alcohol (FTOH) in office air that were 3-5 times higher than those reported in previous studies of household air" How Much Iodine Is Too Much? - Medscape, 1/18/12 - "at relatively higher doses -- 400 mcg a day and up -- study participants began developing subclinical hypothyroidism ... people -- at least in China -- should get no more than 800 mcg a day" Pearls of wisdom from Lucy Liu - USATODAY.com, 1/17/12 - "Drink water; eat healthy; take vitamins; avoid the sun, exercise and stay clear of donuts (and other carbohydrates) which make you lethargic" No alcohol intake safe during pregnancy, especially first trimester - USATODAY.com, 1/17/12 - "For every one-drink increase in the daily average number of drinks consumed during this stage of pregnancy, there was a 25 percent higher risk for having a smooth ridge between the nose and upper lip; a 22 percent higher chance of having an abnormally thin upper lip; a 12 percent elevated risk of having a smaller-than-normal head; a 16 percent greater risk of reduced birth weight; and an 18 percent higher chance of reduced birth length" Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top): Melatonin prevents testicular damage in hyperlipidaemic mice - Andrologia. 2012 Jan 20 - "Hyperlipidaemia was induced in ApoE-knockout C57BL/6J male mice fed with high-fat diet alone (group A), or with high-fat diet and melatonin (group B) ... The results suggest that melatonin may be potential to attenuate testicular damage by improving histopathological changes and reducing germ cell apoptosis in hyperlipidaemic mice" - See Source Naturals, Melatonin, Peppermint Flavored Sublingual, 1 mg, 300 Tablets at iHerb. Dietary Intakes of Zinc and Heme Iron from Red Meat, but Not from Other Sources, Are Associated with Greater Risk of Metabolic Syndrome and Cardiovascular Disease - J Nutr. 2012 Jan 18 - "Participants, 45-84 y at baseline (2000-2002), were followed through 2010 ... Participants, 45-84 y at baseline (2000-2002), were followed through 2010. Diet was assessed by FFQ. After adjusting for demographics and behavioral confounders, including BMI, dietary vitamin E intake was inversely associated with incident MetS and CVD [HR for extreme quintiles: MetS = 0.78 (95% CI = 0.62, 0.97), P-trend = 0.01; CVD: HR = 0.69 (95% CI = 0.46, 1.03), P-trend = 0.04]. Intakes of heme iron and Zn from red meat, but not from other sources, were positively associated with risk of MetS [heme iron from red meat: HR = 1.25 (95% CI = 0.99,1.56), P-trend = 0.03; Zn from red meat: HR = 1.29 (95% CI = 1.03,1.61), P-trend = 0.04] and CVD [heme iron from red meat: HR = 1.65 (95% CI = 1.10,2.47), P-trend = 0.01; Zn from red meat: HR = 1.51 (95% CI = 1.02, 2.24), P-trend = 0.01]. Dietary intakes of nonheme iron, Mg, vitamin C, and β-carotene were not associated with risk of MetS, T2D, or CVD"
Antiapoptotic and Antioxidant Effects of Grape Seed Proanthocyanidin Extract
(GSPE) in Preventing Cyclosporine A-induced Nephropathy - Nephrology
(Carlton). 2012 Jan 18 - "The study demonstrates the
abilty of GSPE to attenuate cyclosporine
nephrotoxicity in rats, via its
anti-oxidant and anti-apoptotic properties. GSPE is a natural product containing
high amounts of polyphenols with known anti-inflammatory properties ... We
demonstrated that GSPE prevents CsA nephropathy and that this effect is achieved
by antiapoptotic and antioxidant activity. We also achieved a significant
recovery in kidney functions without affecting CsA plasma levels" - See
grape seed extract at Amazon.com Effects of Swimming Training on Blood Pressure and Vascular Function in Adults >50 Years of Age - Am J Cardiol. 2012 Jan 11 - "Forty-three otherwise healthy adults >50 years old (60 +/- 2) with prehypertension or stage 1 hypertension and not on any medication were randomly assigned to 12 weeks of swimming exercise or attention time control ... Casual systolic BP decreased significantly from 131 +/- 3 to 122 +/- 4 mm Hg in the swimming training group. Significant decreases in systolic BP were also observed in ambulatory (daytime) and central (carotid) BP measurements. Swimming exercise produced a 21% increase in carotid artery compliance (p <0.05). Flow-mediated dilation and cardiovagal baroreflex sensitivity improved after the swim training program"
Associations
between frequency of tea consumption and health and mortality: evidence from old
Chinese - Br J Nutr. 2012 Jan 16:1-12 - "The present
study examines how self-reported frequency of tea
consumption in daily life is associated with health and
mortality among very old adults in China ... A total of four measurements
between 1998 and 2005 resulted in 51 668 observations. Hazard regressions showed
that men who drink tea almost every day have a 10-20 % lower risk of death
compared to their counterparts who seldom drink tea, after adjusting for
numerous confounders including baseline health. This relationship was stronger
in younger male elders aged 65 to 84 years than in the oldest-old men aged 85
years and older. However, frequency of tea consumption was not significantly
associated with mortality in women. Our analyses further show that high
frequency of tea consumption is significantly associated with reduced OR of
disability in activities of daily living, cognitive impairment, self-rated poor
health, cumulative health deficits and CVD in both young elders and the
oldest-old, and in both men and women" - See
green tea extract at Amazon.com Meat Consumption, Cooking Methods, Mutagens, and Risk of Squamous Cell Carcinoma of the Esophagus: A Case-Control Study in Uruguay - Nutr Cancer. 2012 Jan 13 - "Red meat, lamb, and boiled meat were directly associated with the risk of ESCC, whereas total white meat, poultry, fish, and liver were mainly protective against this malignancy"
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