Recent Longevity News for the seven days ending 6/29/11.  You should consult your doctor if you are taking any medications.

It's not an apple a day after all -- it's strawberries: Flavonoids could represent two-fisted assault on diabetes and nervous system disorders - Science Daily, 6/27/11 - "fisetin, a naturally-occurring flavonoid found most abundantly in strawberries and to a lesser extent in other fruits and vegetables, lessens complications of diabetes. Previously, the lab showed that fisetin promoted survival of neurons grown in culture and enhanced memory in healthy mice ... Mice fed a fisetin-enriched diet remained diabetic, but acute kidney enlargement-or hypertrophy-seen in untreated mice was reversed, and high urine protein levels, a sure sign of kidney disease, fell. Moreover, fisetin ingestion ameliorated anxiety-related behaviors seen in diabetic mice ... blood and brain levels of sugars affixed to proteins known as advanced glycation end-products-or AGEs-were reduced in fisetin-treated compared to untreated Akita mice. These decreases were accompanied by increased activity of the enzyme glyoxalase 1, which promotes removal of toxic AGE precursors ... substantial evidence implicates high blood AGE levels with many if not most diabetic complications ... excessively high AGE levels also correlate with inflammatory activity thought to promote some cancers. In fact, studies published by others confirm that fisetin decreases tumorigenicity of prostate cancer cells both in culture and in animal models ... humans would have to eat 37 strawberries a day ... Rather than through diet, Maher envisions that fisetin-like drugs could be taken as a supplement"

Waistlines in people, glucose levels in mice hint at sweeteners' effects: Related studies point to the illusion of the artificial - Science Daily, 6/27/11 - "In the constant battle to lose inches or at least stay the same, we reach for the diet soda. Two studies presented June 25 and 27 at the American Diabetes Association's Scientific Sessions in San Diego suggest this might be self-defeating behavior ... diet soft drink consumption is associated with increased waist circumference in humans, and a second study that found aspartame raised fasting glucose (blood sugar) in diabetes-prone mice ... The average follow-up time was 9.5 years ... Diet soft drink users, as a group, experienced 70 percent greater increases in waist circumference compared with non-users. Frequent users, who said they consumed two or more diet sodas a day, experienced waist circumference increases that were 500 percent greater than those of non-users ... In the related project ... One group of the mice ate chow to which both aspartame and corn oil were added; the other group ate chow with the corn oil added but not the aspartame. After three months on this high-fat diet, the mice in the aspartame group showed elevated fasting glucose levels but equal or diminished insulin levels, consistent with early declines in pancreatic beta-cell function"

Soluble fiber strikes a blow to belly fat - Science Daily, 6/27/11 - "All fat is not created equal. Unsightly as it is, subcutaneous fat, the fat right under the skin, is not as dangerous to overall health as visceral fat, the fat deep in the belly surrounding vital organs ... the way to zero in and reduce visceral fat is simple: eat more soluble fiber from vegetables, fruit and beans, and engage in moderate activity ... for every 10-gram increase in soluble fiber eaten per day, visceral fat was reduced by 3.7 percent over five years. In addition, increased moderate activity resulted in a 7.4 percent decrease in the rate of visceral fat accumulation over the same time period ... a higher rate of visceral fat is associated with high blood pressure, diabetes and fatty liver disease ... Ten grams of soluble fiber can be achieved by eating two small apples, one cup of green peas and one-half cup of pinto beans; moderate activity means exercising vigorously for 30 minutes, two to four times a week"

BPA-exposed male deer mice are demasculinized and undesirable to females, new study finds - Science Daily, 6/27/11 - "The latest research from the University of Missouri shows that BPA causes male deer mice to become demasculinized and behave more like females in their spatial navigational abilities, leading scientists to conclude that exposure to BPA during human development could be damaging to behavioral and cognitive traits that are unique to each sex and important in reproduction ... In the study, female deer mice were fed BPA-supplemented diets two weeks prior to breeding and throughout lactation. The mothers were given a dosage equivalent to what the U.S. Food and Drug Administration considers a non-toxic dose and safe for mothers to ingest"

Higher Vitamin D Levels Linked to Lower Diabetes Risk - Medscape, 6/25/11 - "The mean follow-up of the 2039-person cohort was 3.2 years ... Participants with vitamin D levels in the highest tertile (median concentration, 30.1 ng/mL) had a hazard ratio of 0.74 (95% confidence interval [CI], 0.59 to 0.93) for developing diabetes, compared with those with vitamin D levels in the lowest tertile (median concentration, 12.8 ng/mL)" - See vitamin D at Amazon.com.

Vitamin D supplements found to be safe for healthy pregnant women - Science Daily, 6/24/11 - "Dr Hollis' team monitored the pregnancies of 350 women, from a variety of ethnic and socio-economic backgrounds, who were all between 12 and 16 weeks into gestation. The women were randomly assigned to one of three groups. One group received 400 IU of vitamin D per day, the second group received 2,000 IU per day and the third received 4,000 IU daily ... women who received the highest level of supplementation (4,000 IU per day) were more likely to achieve and sustain the desired level of circulating levels of vitamin D throughout their pregnancy. Moreover, the researchers found that pregnant women who received lower levels of vitamin D supplementation did not attain the threshold circulating level of the vitamin" - See vitamin D at Amazon.com.

Lithium profoundly prevents brain damage associated with Parkinson's disease, mouse study suggests - Science Daily, 6/24/11 - "lithium has recently been suggested to be neuroprotective in relation to several neurodegenerative conditions including Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis and has been touted for its anti-aging properties in simple animals" - See Nutrient Carriers Incorporated, Advanced Research, Lithium Orotate, 120 mg, 200 Tablets at iHerb.

Explosive Rise in HPV Throat Cancer; Panel Mulls Vaccinating Boys - WebMD, 6/23/11 - "oropharyngeal (OP) cancer ... If current trends continue, OP cancer in men will pass cervical cancer in 2025 ... And HPV is to blame. Only a few decades ago, the major risk factors for throat cancer were smoking and alcohol. Not any more. In the five-year period of 1984-1989, only 16% of OP cancers were linked to HPV. By 2000-2004, HPV was behind 75% of OP cancers ... What are the risk factors? Not all are known, but HPV-related throat cancer risk goes up with increased oral sex and kissing ... Husbands of women with cervical cancer have a threefold higher risk of tonsil cancer. And people who have anal cancer have a fourfold to sixfold higher risk of tonsil cancer ... These findings are tipping the ACIP in favor of recommending routine HPV vaccination for boys"

Drug use involved in 25% of fatal crashes, study finds - USATODAY.com. 6/23/11 - "Among drivers who tested positive for drugs, 22% were positive for marijuana, 22% for stimulants and 9% for narcotics"

Pine bark extract plus CoQ10 shows benefits for heart failure patients - Nutra USA, 6/23/11 - "12 weeks of daily supplementation with 350 milligrams of CoQ10 (Kaneka) and 105 milligrams of the branded pine bark extract Pycnogenol ... recruited 53 heart failure patients aged between 54 and 68 were randomly assigned to receive either the PycnoQ10 supplement or placebo for 12 weeks ... systolic and diastolic blood pressure decreased following the CoQ10-pine bark combination, from 139.2 to 133.2 mmHg and 82.3 to 77.3 mmHg, respectively. Systolic and diastolic blood pressure decreased from 140.3 to 139.5 mmHg and 83.4 to 81.2 mmHg, respectively, in the placebo group ... In addition to increases in the amount of blood pumped by the heart, the researchers also reported improvements in heart rate were also observed in the PycnoQ10 supplement group from 78.4 to 74.2 beats per minute, compared with a decrease from 79.1 to 78.4 in the placebo group" - [Abstract] - See Pycnogenol at Amazon.com and ubiquinol products at Amazon.com.

Potatoes bad, nuts good for staying slim, Harvard study finds - The Washington Post, 6/22/11 - "But is a serving of boiled potatoes really much worse than a helping of nuts? Is some white bread as bad as a candy bar? Could yogurt be a key to staying slim? ... The answer to all those questions is yes, according to the provocative revelations produced by a big Harvard project that for the first time details how much weight individual foods make people put on or keep off ... Although calories remain crucial, some foods clearly cause people to put on more weight than others, perhaps because of their chemical makeup and how our bodies process them ... starches and refined carbohydrates such as potatoes cause blood sugar and insulin to surge, which makes people feel less satisfied and eat more as a result ... Researchers will surely scramble to try to explain why yogurt appears so helpful. It may be because of subtle shifts of microbes in the digestive tract, or perhaps because people who eat more yogurt also tend to do other healthy things"

• You don’t want fries with that - The Washington Post, 6/22/11 - It's the full graphic from the above article.  A must see.
• Study: Some foods help shed pounds, others help pack them on - The Washington Post, 6/22/11 - It's a nine slide slideshow on the above article.  It's a little confusing.  You need to select "Autoplay" plus read what is says on the right.
• To Keep Off Pounds: Pass The Nuts, Hold The Chips - NPR, 6/23/11 - NPR article on the same study.
• Harvard Study Measures Four-Year Weight Gain Associated With One More Daily Serving of Potato Chips, French Fries - WSJ.com, 6/23/11 - "An additional daily serving of certain foods was associated with weight loss over a four year period ... Yogurt -0.82 pounds ... Nuts -0.57 pounds ... Fruits -0.49 pounds ... Whole grains -0.37 pounds ... Vegetables -0.22 pounds ... Source: NEJM"
• See my yogurt recipe at the top of my Yogurt Page.  I practically live on that stuff because I have trouble swallowing after my throat cancer surgery six and a half years ago.  See New way to identify patients at risk of dysphagia after head and neck cancer treatment - Science Daily, 2/25/11 - "Dysphagia may be acute (starting in direct association with treatment) or late (starting months to years after treatment). Risk factors for developing severe acute dysphagia were large tumours, spreading of cancer cells to the lymph nodes"

Dietary leucine may fight pre-diabetes, metabolic syndrome: Study shows improvements in animals with amino acid in diet - Science Daily, 6/22/11 - "mice who had been on a high-fat diet and who also received twice the usual intake of leucine, an amino acid found in protein, showed reductions in their prediabetic conditions with lower blood sugars and less fat in their livers, two of the collection of medical problems associated with insulin resistance that make up what is known as metabolic syndrome ... Their glucose tolerance tests improved ... Their bodies responded to insulin better than they would have before they got the leucine. It improved their ability to metabolize sugar and fats. It markedly improved their pre-diabetic condition. Their metabolic syndrome also improved" - See leucine products at Amazon.com.

‘Level 1’ evidence that probiotics boost ‘transit time’: Danisco & Fonterra - Nutra USA 6/22/11 - "the benefits were “at least equivalent to that of dietary fiber” ... The researchers recruited 100 healthy people with an average age of 44 and randomly assigned them to receive high or low daily doses of B. lactis HN019, or placebo for 14 days. High dose was defined as 17.2 billion colony forming units (CFU), while the low dose was 1.8 billion CFU ... At the end of the study results showed an improvement in transit time in the high dose group of 33 percent, and 25 percent in the low dose group. There was no change in the placebo group, added the researchers" - [Abstract] - See probiotics at Amazon.com.

Phys Ed: To Stretch or Not to Stretch - nytimes.com, 6/22/11 - "So there you have the state of the science on stretching. Hockey goalies, gymnasts, cheerleaders and dancers should be stretching before workouts or performances. The rest of us are unlikely, the latest findings show, to sustain any harm from brief spurts of static stretching — but equally unlikely to gain much advantage" - So lets see, if you stretch for less than 30 seconds, its not going to harm you but you're not getting any benefit.  If you stretch for more than that it does more harm then good.  So what's the point in stretching?  They've been saying that since the '70's but people still do it.

Nutritional Supplement Boosts Cognition in Healthy Women - Medscape, 6/21/11 - "Citicoline, a naturally occurring substance found in the brain and liver and marketed as a nutritional supplement, enhanced aspects of cognition in healthy women and may have a role in mitigating the cognitive decline associated with normal aging ... It may also improve the attention deficits associated with psychiatric disorders ... The women were divided into 3 groups of 20 and randomly assigned to receive a daily oral citicoline dose of 250 mg (low dose) or 500 mg (high dose) or placebo for 28 days ... participants who received low- or high-dose citicoline showed improved attention, demonstrating fewer commission and omission errors on the CPT-II compared with the placebo group" - See citicholine at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive, and angiogenic biomarkers - Int J Cancer. 2011 Jun 23 - "We found that the oral administration of AKBA (50-200 mg/kg) dose-dependently inhibited the growth of CRC tumors in mice, resulting in decrease in tumor volumes than those seen in vehicle-treated mice without significant decreases in body weight. In addition, we observed that AKBA was highly effective in suppressing ascites and distant metastasis to the liver, lungs, and spleen in orthotopically-implanted tumors in nude mice. When examined for the mechanism, we found that markers of tumor proliferation index Ki-67 and the microvessel density CD31; were significantly downregulated by AKBA treatment. We also found that AKBA significantly suppressed NF-κB activation in the tumor tissue and expression of pro-inflammatory (COX2), tumor survival (bcl-2, bcl-xL, IAP-1, survivin), proliferative (cyclin D1), invasive (ICAM-1, MMP-9) and angiogenic (CXCR4 and VEGF) biomarkers. When examined for serum and tissue levels of AKBA, a dose-dependent increase in the levels of the drug was detected, indicating its bioavailability. Thus, our findings suggest that this boswellic acid analogue can inhibit the growth and metastasis of human CRC in vivo through downregulation of cancer-associated biomarkers" - See boswellia at Amazon.com.

Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: the LIFE study - J Hum Hypertens. 2011 Jun 23 - "Short telomeres are associated with aging and age-related diseases ... At baseline, short mean telomere length was associated with coronary artery disease in males (odds ratio (OR) 0.61, 95% confidence interval (CI) 0.39-0.95), and transient ischemic attack in females (OR 0.62 95% CI 0.39-0.99). Proportion of short telomeres (shorter than 5 kb) was associated with Framingham risk score (r=0.07, P<0.05), cerebrovascular disease (OR 1.18, 95% CI 1.01-1.15) and type 2 diabetes in men (OR 1.07, 95% CI 1.02-1.11). During follow-up, proportion of short telomeres was associated with combined cardiovascular mortality, stroke or angina pectoris (hazard ratio 1.04, 95% CI 1.01-1.07). Telomere length was not associated with smoking, body mass index, pulse pressure or self-reported use of alcohol. Our data suggest that reduced leukocyte telomere length is associated with cardiovascular risk factors and diseases as well as type 2 diabetes, and is a predictor of cardiovascular disease in elderly patients with hypertension and LVH"

Diet, Environmental Factors, and Lifestyle Underlie the High Prevalence of Vitamin D Deficiency in Healthy Adults in Scotland and Supplementation Reduces the Proportion That Are Severely Deficient - J Nutr. 2011 Jun 22 - "In regions with low UVB exposure, dietary and supplement intake may be much more important than previously thought and consideration should be given to increasing the current recommended dietary allowance of 0-10 μg/d for adults in Scotland" - See vitamin D at Amazon.com.

Low Serum Vitamin D Is Associated with High Risk of Diabetes in Korean Adults - J Nutr. 2011 Jun 22 - "Compared to individuals with a sufficient serum 25(OH)D concentration ≥75 nmol/L, the OR (95% CI) for diabetes mellitus were 1.73 (1.09-2.74), 1.30 (0.91-1.84), and 1.40 (0.99-1.98) for serum 25(OH)D concentrations <25, 25 to <50, and 50 to <75 nmol/L, respectively, after multiple adjustments (P-trend < 0.0001). Furthermore, the serum 25(OH)D level was inversely associated with HOMA-IR (β = -0.061; P = 0.001) and positively associated with QUICKI (β = 0.059; P = 0.001) in overweight or obese participants. In conclusion, a low serum vitamin D concentration is associated with a high risk of diabetes mellitus in Korean adults and the concentration is inversely associated with insulin resistance in those who are overweight or obese" - See vitamin D at Amazon.com.

Effect of functional yogurt NY-YP901 in improving the trait of metabolic syndrome - Eur J Clin Nutr. 2011 Jun 22 - "This study was aimed to assess the beneficial effects on metabolic syndrome of functional yogurt NY-YP901 (Namyang Dairy Product Co. Ltd and Nutra R&BT Inc., Seoul, Korea) supplemented with mixture of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium infantis and extra-ingredients containing Bifidobacterium breve (CBG-C2), Enterococcus faecalis FK-23, fibersol-2 and so on ... In the treatment group consuming NY-YP901, statistically significant beneficial changes were observed in body weight (treatment group vs control group=-0.24+/-1.50 vs +0.64+/-1.39 kg, P<0.05), BMI (-0.10+/-0.58 vs +0.24+/-0.50 kg/m(2), P<0.05 ) and low-density lipoprotein (LDL)-cholesterol (-7.71+/-14.14 vs -0.43+/-15.32 mg/dl, P<0.05) after 8 weeks. The change in other parameters was not different between the treatment and the control groups.Conclusions:The functional yogurt NY-YP901 reduced LDL-cholesterol, body weight and BMI in the subjects at a 300-ml consumption daily for 8 weeks. From these findings, regular intake of functional yogurt NY-YP901 may be consequently related to improve metabolic syndrome" - So how does that compare as far as active culture to what you actually be able to buy in a local store in the U.S.:

• Activia Ingredients - livestrong.com - "Activia has Lactobacillus bulgaricus, Streptococcus thermophilus and Bifidobacteria lactis, also known as Bifidobacteria regularis"

Serum ferritin levels are associated with metabolic syndrome in postmenopausal women but not in premenopausal women - Menopause. 2011 Jun 18 - "postmenopausal women with ferritin levels in the third tertile had an increased risk of having metabolic syndrome (odds ratio, 1.62; 95% CI, 1.04-2.81) compared with postmenopausal women with levels in the first quartile. No such association was detected in premenopausal women"

Neat Tech Stuff / "How To's":

• Blank Corrugated Sign, 20" x 24" - I had a hard time finding something as simple as it.  I got it to put a sign for a karaoke party on my lawn.
• Tervis 16 oz. 4-pc. Clear Tumbler Set CLEAR 4 Pc Set - These glasses got 5 stars with 52 review. That’s rare. They are freezer safe, dishwasher safe, microwave safe, can be used for both hot and cold, insulated so you don’t need a coaster and basically unbreakable plus they have the optional lids.  There are also several designs.
  • NEW! Tervis Tumblers Assorted Jewel Tones 16oz (Set of 4) Plus Bonus Travel Lid
  • Tervis Tumbler Black 16oz. Tumbler Travel Lid - Lids that fit all of the above.
  • NEW! Tervis Tumbler 16oz Cherry Blossom w/Travel Lid - 3Pack

Health Focus (Osteoporosis):

Popular Medications:

• Actonel (risedronate) / Boniva (ibandronate) / Didronel (etidronate) / Evista (raloxifene) / Forteo (teriparatide) / Fortical / Fosamax (alendronate) / Reclast (zoledronic acid) / HRT

Popular Supplements:

• calcium / magnesium / vitamin D / vitamin K / soy isoflavones / red clover / omega-3 / vitamin C / silicon

Alternative News:

• High levels of vitamin D needed for bone density drugs to work, study shows - Science Daily, 6/6/11 - "To fully optimize a drug therapy for osteoporosis and low bone mineral density (BMD), patients should maintain vitamin D levels above the limits recently recommended by the Institute of Medicine (IOM) ... maintaining a circulating vitamin D level above 33 ng/ml is associated with a seven-fold greater likelihood of having a more favorable outcome with bisphosphonate therapy" - See vitamin D at Amazon.com.
• Before you start bone-building meds, try dietary calcium and supplements, experts urge - Science Daily, 5/2/11 - "For many people, prescription bone-building medicines should be a last resort ... adults who increase their intake of calcium and vitamin D usually increase bone mineral density and reduce the risk for hip fracture significantly ... I suspect that many doctors reach for their prescription pads because they believe it's unlikely that people will change their diets ... prescription bone-building medications are expensive, and many have side effects, including ironically an increase in hip fractures and jaw necrosis. They should be used only if diet and supplements don't do the trick ... For bone health, the researchers also encourage consuming adequate protein, less sodium, and more magnesium and potassium"
• Belly fat puts women at risk for osteoporosis, study finds - Science Daily, 11/30/10
• High-Protein Diet Limits Bone Resorption - Doctor's Guide, 10/19/10 - "The clinical takeaway message is that if you are a postmenopausal woman and dieting, if you can take 24% of your total calories as protein, and have adequate calcium and vitamin D, you can prevent the bone loss that is typically associated with weight loss"
• Resveratrol prevents RANKL induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production - Biochem Biophys Res Commun. 2010 Sep 16 - "The bone protective effects of resveratrol have been demonstrated in several osteoporosis models while the underlying mechanism is largely unclear ... We postulate that the direct inhibitory effects of resveratrol on osteoclastogenesis are mediated via inhibition of ROS generation" - See resveratrol products at Amazon.com.
• Science strengthens for olive extract’s bone benefits - Nutra USA, 9/14/10 - “Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis" - [Abstract] - See olive leaf extract at Amazon.com.
• Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow - Osteoporos Int. 2010 May 21 - "Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis" - See olive leaf extract at Amazon.com.
• Acid diet (high-meat protein) effects on calcium metabolism and bone health - Curr Opin Clin Nutr Metab Care. 2010 Aug 16 - "Increased potential renal acid load resulting from a high protein (intake above the current Recommended Dietary Allowance of 0.8 g protein/kg body weight) intake has been closely associated with increased urinary calcium excretion. However, recent findings do not support the assumption that bone is lost to provide the extra calcium found in urine. Neither whole body calcium balance is, nor are bone status indicators, negatively affected by the increased acid load. Contrary to the supposed detrimental effect of protein, the majority of epidemiological studies have shown that long-term high-protein intake increases bone mineral density and reduces bone fracture incidence. The beneficial effects of protein such as increasing intestinal calcium absorption and circulating IGF-I whereas lowering serum parathyroid hormone sufficiently offset any negative effects of the acid load of protein on bone health"
• T3 affects expression of collagen I and collagen cross-linking in bone cell cultures - Biochem Biophys Res Commun. 2010 Aug 10 - "T3 increased mRNA expressions of procollagen-lysine-1,2-oxoglutarate 5-dioxygenase 2 (Plod2) and of lysyloxidase (Lox), both genes involved in post-translational modification of collagen. Moreover, it stimulated mRNA expression of BMP-1, the processing enzyme of the lysyloxidase-precursor and of procollagen. An increase in the collagen cross-link-ratio Pyr/deDHLNL indicates, that T3 modulated cross-link maturation in the MC3T3-E1 culture system. These results demonstrate that T3 directly regulates collagen synthesis and collagen cross-linking by up-regulating gene expression of the specific cross-link related enzymes, and underlines the importance of a well-balanced concentration of thyroid hormones for maintenance of bone quality" - See T3 at International Anti-aging Systems.
• Low calcium intake linked with increased risk of osteoporosis and hypertension in postmenopausal women - Science Daily, 6/18/10 - "a significantly increased proportion of women (35.4%) who consumed a lower amount of calcium through intake from dairy sources, had a concurrent diagnosis of both hypertension and osteoporosis, compared with women who consumed a higher amount of calcium (19.3% p<0.001) ... Further statistical analyses revealed that a lower calcium intake was associated with an increased risk of developing hypertension or osteoporosis over time when compared with controls (Odds Ratio (OR) hypertension: 1.43; 95%CI: 1.12-1.82, osteoporosis: OR 1.46; CI: 1.15-1.85). Women who consumed a lower amount of calcium were shown to be most likely to develop both conditions over time compared with women consuming a higher amount of calcium (OR 1.60; CI: 1.09-2.34)"
• Vitamin D deficiency and frailty in older Americans - J Intern Med. 2010 Apr 28 - "Nationally representative survey of noninstitutionalized US residents collected between 1988 and 1994. Results. 25-Hydroxyvitamin D deficiency, defined as a serum concentration <15 ng mL(-1), was associated with a 3.7-fold increase in the odds of frailty amongst whites and a fourfold increase in the odds of frailty amongst non-whites. This association persisted after sensitivity analyses adjusting for season of the year and latitude of residence, intended to reduce misclassification of persons as 25-hydroxyvitamin D deficient or insufficient. Conclusion. Low serum 25-hydroxyvitamin D concentrations are associated with frailty amongst older adults" - See vitamin D at Amazon.com.
• Dietary protein may reduce hip fractures in the elderly - Science Daily, 5/5/10 - "individuals who were in the lowest 25 percent of dietary protein intake had approximately 50 percent more hip fractures than those who consumed greater amounts of dietary protein (all within normal intakes). Those who suffered hip fractures consumed less than the 46 grams of dietary protein per day recommended for adults"
• NASA studies find omega-3 may help reduce bone loss - Science Daily, 5/10/10 - "In a series of cell-based studies, scientists documented that adding a specific omega-3 fatty acid to cells would inhibit the activation of factors that lead to bone breakdown. This was true in both typical cell cultures and those designed to mimic weightlessness. The inhibited factor is known as "nuclear factor kappa B" or NFκB. NFκB is involved in immune system behavior and the inflammation process. The activation of NFκB in different tissues can lead to bone and muscle loss" - See Nutra USA article below.  It was DHA, not EPA that worked. See Jarrow Max DHA at Amazon.com.
• Omega-3 linked to healthier, stronger bones: Rat study - Nutra USA, 5/7/10 - "According to findings of a new study with rats, DHA “appears to be a vital constituent of marrow” and enhances bone mineral content (BMC). The findings did not extend to EPA, however ... Scientists from NASA recently reported in the Journal of Bone and Mineral Research that the omega-3 EPA may protect against bone loss during space flight" - [Abstract] - See Jarrow Max DHA at Amazon.com.
• Those who exercise when young have stronger bones when they grow old - 5/3/10 - "those who actively did sports, and also those who used to do sports, had greater bone density than those who had never done sports ... men who had stopped training more than six years ago still had larger and thicker bones in the lower leg than those who had never done sport ... The bones respond best when you're young, and if you train and load them with your own bodyweight during these years, it has a stimulating effect on their development"
• Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats - Br J Nutr. 2010 Apr 27:1-12 - "DHA accumulates in the osteoblast-rich and nerve-abundant periosteum of femur; DHA but not EPA appears to be a vital constituent of marrow and periosteum of healthy modelling bone; and both DHA and total n-3 PUFA strongly correlate to BMC" - See Jarrow Max DHA at Amazon.com.
• Beer is a rich source of silicon and may help prevent osteoporosis - Science Daily, 2/8/10 - "Silicon is present in beer in the soluble form of orthosilicic acid (OSA), which yields 50% bioavailability, making beer a major contributor to silicon intake in the Western diet. According to the National Institutes of Health (NIH), dietary silicon (Si), as soluble OSA, may be important for the growth and development of bone and connective tissue, and beer appears to be a major contributor to Si intake. Based on these findings, some studies suggest moderate beer consumption may help fight osteoporosis, a disease of the skeletal system characterized by low bone mass and deterioration of bone tissue" - See Jarrow BioSil at iHerb (it says "Reduces Fine Lines and Wrinkles by 19%").  I put ten drops of it in my coffee every morning.
• Benefits of calcium and vitamin D in preventing fractures confirmed - Science Daily, 1/14/10 - "both calcium and vitamin D supplements on a daily basis reduces the risk of bone fractures, regardless of whether a person is young or old, male or female, or has had fractures in the past, a large study of nearly 70,000 patients from throughout the United States and Europe has found" - See vitamin D at Amazon.com.
• Vitamin D: What is an adequate vitamin D level and how much supplementation is necessary? - Best Pract Res Clin Rheumatol. 2009 Dec;23(6):789-95 - "Vitamin D modulates fracture risk in two ways: by decreasing falls and increasing bone density. Two most recent meta-analyses of double-blind randomised controlled trials came to the conclusion that vitamin D reduces the risk of falls by 19%, the risk of hip fracture by 18% and the risk of any non-vertebral fracture by 20%; however, this benefit was dose dependent. Fall prevention was only observed in a trial of at least 700IU vitamin D per day, and fracture prevention required a received dose (treatment dose*adherence) of more than 400IU vitamin D per day. Anti-fall efficacy started with achieved 25-hydroxyvitamin D levels of at least 60nmoll(-1) (24 ngml(-1)) and anti-fracture efficacy started with achieved 25-hydroxyvitamin D levels of at least 75nmoll(-1) (30ng ml(-1)) and both endpoints improved further with higher achieved 25-hydroxyvitamin D levels. Founded on these evidence-based data derived from the general older population, vitamin D supplementation should be at least 700-1000IU per day and taken with good adherence to cover the needs for both fall and fracture prevention. Ideally, the target range for 25-hydroxyvitamin D should be at least 75nmoll(-1), which may need more than 700-1000IU vitamin D in individuals with severe vitamin D deficiency or those overweight" - See vitamin D at Amazon.com.
• New Evidence That Green Tea May Help Improve Bone Health - Science Daily, 9/16/09 - "The scientists exposed a group of cultured bone-forming cells (osteoblasts) to three major green tea components — epigallocatechin (EGC), gallocatechin (GC), and gallocatechin gallate (GCG) — for several days. They found that one in particular, EGC, boosted the activity of a key enzyme that promotes bone growth by up to 79 percent. EGC also significantly boosted levels of bone mineralization in the cells, which strengthens bones. The scientists also showed that high concentrations of ECG blocked the activity of a type of cell (osteoclast) that breaks down or weakens bones. The green tea components did not cause any toxic effects to the bone cells, they note" - See green tea extract at Amazon.com.
• Higher sea fish intake is associated with greater bone mass and lower osteoporosis risk in postmenopausal Chinese women - Osteoporos Int. 2009 Aug 6 - "After adjusting for the potential confounders, we observed dose-dependent relations between sea fish intake and BMDs, BMCs, and osteoporosis risk; the mean BMDs were 3.2-6.8% higher, and BMCs 5.1-9.4% higher in the top quintile groups (Q5) of sea fish intake than in the bottom quintile (Q1) at the whole body and hip sites (p < 0.05); the odds ratios (95% confidence interval (CI)) for osteoporosis (T-score < -2.5) in Q5 were 0.23 (0.08-0.66), 0.12 (0.03-0.59), and 0.06 (0.01-0.44) compared with those in Q1 at the whole body, total hip, and femur neck, respectively. No independent association between consumption of freshwater fish or shellfish and bone mass was observed ... Higher intake of sea fish is independently associated with greater bone mass and lower osteoporosis risk among postmenopausal Chinese women" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Green tea extracts linked to healthier bones: Study - Nutra USA, 8/6/09 - "EGC was found to stimulate bone mineralisation, while simultaneously inhibiting the formation of osteoclasts. The other catechins were found to have a significantly weaker effect ... “The present study illustrated that the tea catechins, EGC in particular, had positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations" - [Abstract] - See green tea extract at Amazon.com.
• Effects of Tea Catechins, Epigallocatechin, Gallocatechin, and Gallocatechin Gallate, on Bone Metabolism - J Agric Food Chem. 2009 Aug 4 - "The present study illustrated that the tea catechins, EGC in particular, had positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations" - See green tea extract at Amazon.com.
• Zinc Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A Pilot Study - Ann Nutr Metab. 2009 Jun 9;54(3):218-226 - "These findings indicate that severe zinc deficiency initiated during adolescence may have important implications for future bone health, especially with regards to bone consolidation in the spine"
• Review supports vitamin K's fracture reducing power - Nutra USA, 5/20/09 - "The most important findings in this review are that although supplementation with lower doses of vitamin K may be sufficient to reduce serum ucOC levels, supplementation with higher doses may be required for optimal bone health" - [Abstract] - See vitamin K at Amazon.com.
• High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature - Nutr Res. 2009 Apr;29(4):221-8 - "randomized controlled trials (RCTs) ... The review of the reliable literature confirmed the effect of vitamin K(1) and vitamin K(2) supplementation on the skeleton of postmenopausal women mediated by mechanisms other than bone mineral density and bone turnover" - See vitamin K at Amazon.com.
• A Stronger Backbone: DHEA Hormone Replacement Increases Bone Density In Older Women - Science Daily, 5/17/09 - "Taking a DHEA supplement combined with vitamin D and calcium can significantly improve spinal bone density in older women ... The effects of the treatment differed for men and women. After the first year, women in the test group experienced an approximate 2 percent increase in bone density, while women in the control group did not see an increase. After the second year when both groups took the DHEA supplement, women in the test group experienced an additional 2 percent increase for a total of approximately 4 percent, while women who switched from placebo to DHEA also experienced an approximate 2 percent increase ... The same treatment, however, did not offer similar benefits for older men" - See DHEA at Amazon.com.
• Nonvertebral Fracture Prevention With Vitamin D May Be Dose-Dependent - Medscape, 3/31/09 - "A dose-response relationship between vitamin D and fracture reduction is supported by epidemiologic data showing a significant positive trend between serum 25-hydroxyvitamin D concentrations and hip bone density and lower extremity strength"
• Vitamin D Supplements Associated With Reduced Fracture Risk in Older Adults - Doctor's Guide, 3/23/09 - "The authors then pooled the results of only the 9 trials in which participants received doses of more than 400 international units per day. At this dosage, vitamin D supplements reduced non-vertebral fractures by 20% and hip fractures by 18% ... A greater reduction in risk was also seen among trial participants whose blood levels of 25-hydroxyvitamin D achieved a greater increase" - [Science Daily] - See vitamin D at Amazon.com.
• Moderate Alcohol Intake Associated With Bone Protection - Science Daily, 3/3/09 - "In an epidemiological study of men and post-menopausal women primarily over 60 years of age, regular moderate alcohol intake was associated with greater bone mineral density (BMD). Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University found associations were strongest for beer and wine and, importantly, BMD was significantly lower in men drinking more than two servings of liquor per day"
• Building Strong Bones: Running May Provide More Benefits Than Resistance Training, Study Finds - Science Daily, 2/27/09 - "both resistance training and high-impact endurance activities increase bone mineral density. However, high-impact sports, like running, appear to have a greater beneficial effect"
• Flaxseed combined with low-dose estrogen therapy preserves bone tissue in ovariectomized rats - Menopause. 2009 Jan 29 - "Flaxseed + low-dose estrogen therapy resulted in the highest bone mineral density and peak load at the lumbar vertebrae, with no effect on bone mineral density or strength in the tibia and femur. Flaxseed and flaxseed + low-dose estrogen therapy resulted in significantly higher relative levels of alpha-linolenic acid and eicosapentaenoic acid and lower levels of linoleic acid, arachidonic acid, and n-6/n-3 ratio in the lumbar vertebrae and tibia compared with all other groups" - See flax seed at Amazon.com.
• Nutrient Supports Bone Health Over Time - Science Daily, 1/20/09 - "The results suggest there is a protective effect of carotenoids, particularly of lycopene, against bone loss in older adults. The researchers concluded that carotenoids may explain, in part, the previously observed protective effects of fruit and vegetable consumption on bone mineral density" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
• Genistein Safely Improves Bone Formation in Osteopenic, Postmenopausal Women - Medscape, 1/14/09 - "Usually, the drugs used in the management of osteopenia/osteoporosis have been classified as predominantly 'antiresorptive agents' or as 'bone-forming agents' but, on the basis of our results, genistein might represent the first therapy that overcomes this classification by combining a powerful bone-forming as well as an antiresorptive activity ... All postmenopausal women with bone loss would be ideal candidates for genistein aglycone treatment ... Genistein aglycone has a good safety profile, and in addition it is effective against climacteric syndrome (i.e., hot flushes and night sweats)"
• Calcium And Vitamin D May Not Be The Only Protection Against Bone Loss - Science Daily, 12/3/08 - "Diets that are high in protein and cereal grains produce an excess of acid in the body which may increase calcium excretion and weaken bones ... When fruits and vegetables are metabolized they add bicarbonate, an alkaline compound, to the body ... bicarbonate had a favorable effect on bone resorption and calcium excretion ... 171 men and women aged 50 and older were randomized to receive placebo or doses of either: potassium bicarbonate, sodium bicarbonate, or potassium chloride for three months. Researchers found that subjects taking bicarbonate had significant reductions in calcium excretion, signaling a decrease in bone resorption"
• Tea Drinking May Help Preserve Hip Structure in Elderly Women - Medscape, 10/29/08 - "The cross-sectional analysis revealed that mean total hip aBMD was 2.8% greater in tea drinkers ... Compared with non–tea drinkers, tea drinkers had a significantly higher aBMD at the total hip and trochanter sites but not at the femoral neck and intertrochanter sites" - See green tea extract at Amazon.com.
• Vitamin C linked to Reduced Bone Loss in Older Men - WebMD, 9/19/08 - "If you don't have enough vitamin C, you don't make bones right. Collagen is the principal protein of bones, accounting for nearly half the volume. What the collagen does is prevent bones from coming apart" - See vitamin C products at Amazon.com.
• Calcium With or Without Vitamin D May Help Prevent Osteoporosis - Medscape, 8/27/08 - "For best therapeutic effect, we recommend minimum doses of 1200 mg of calcium, and 800 IU of vitamin D (for combined calcium plus vitamin D supplementation)"
• Vitamin K good for young bones, too: study - Nutra USA, 7/17/08 - "These findings suggest that improvement in vitamin K status, and thus in the amount of active osteocalcin, might significantly improve bone health in children, even in those with arthritis" - See vitamin K at Amazon.com.
• Calcium Alone Does Not Reduce Hip Fracture Risk - Science Daily, 6/29/08 - "a recent analysis of several studies found no reduction in risk of hip fracture with calcium supplementation ... Future studies of fracture prevention should focus on the best combination of calcium plus vitamin D, rather than on calcium supplementation alone"
• Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial - BMC Musculoskelet Disord. 2008 Jun 11;9(1):85 - "There were no ch-OSA related adverse events observed and biochemical safety parameters remained within the normal range ... Combined therapy of ch-OSA and Ca/Vit D3 had a potential beneficial effect on bone collagen compared to Ca/Vit D3 alone which suggests that this treatment is of potential use in osteoporosis" - See Jarrow BioSil at Amazon.com.  I take about 9 drops per day of it with my orange juice.
• Vitamin D status and response to treatment in post-menopausal osteoporosis - Osteoporos Int. 2008 Jun 13 - "The adjusted odds ratio for incident fractures in vitamin D deficient as compared to vitamin D repleted women was 1.77 ... Optimal vitamin D repletion seems to be necessary to maximize the response to anti-resorbers in terms of both BMD changes and anti-fracture efficacy" - See vitamin D at Amazon.com.
• Current Vitamin D Recommendations Fraction Of Safe, Perhaps Essential Levels For Children - Science Daily, 5/27/08 - "The current recommended daily allowance (RDA) of vitamin D for children is 200 International Units (IUs), but new research reveals that children may need and can safely take ten-times that amount ... Only children given the equivalent of 2,000 IUs a day of vitamin D increased 25-OHD levels from the mid-teens to the mid-thirties (ng/ml)--the level considered optimal for adults. None of the children in either trial showed any evidence for vitamin D intoxication"  - Seevitamin D at Amazon.com.  I've gone to the vitamin D 2000 IU at Amazon.com.  If you're worried about that being to high, just skip a day or two per week which most do anyway just by forgetting to take them.
• Relationship of sex steroid hormones with bone mineral density in a nationally-representative sample of men - Clin Endocrinol (Oxf). 2008 May 14 - "Men in the lowest quartile of free estradiol had 70% increased odds (OR=1.69, 95% CI 0.95-2.98) of osteopenia compared with men in the highest quartile. Men in the lowest quartile of free testosterone had nearly four times the odds of osteopenia than those in the highest quartile (OR=3.82; 95% CI 1.87-7.78). Lower concentrations of SHBG appeared protective against osteopenia (p-trend=0.01). Neither total testosterone nor total estradiol was associated with BMD, although men with clinically low estradiol (<20 ng/l) had lower BMD (0.930 g/cm(2), 95% CI 0.88-0.98) than men with normal-range estradiol (1.024 g/cm(2), 1.01-1.04; p=0.004"
• Aggressive Vitamin D Treatment for Osteoporosis - Medscape, 5/19/08 - "Singh called the findings "alarming" and said that although many physicians believe vitamin D deficiency is not a problem, with 41% of study patients found to have a vitamin D level of less than 30 ng/mL, "most likely that is not true," he said" - See vitamin D at Amazon.com.
• Vitamin D, calcium combo may cut exercise-related stress fractures - Nutra USA, 4/25/08 - "randomly assigned the recruits to receive daily supplements of 2,000 mg of calcium and 800 IU of vitamin D, and the other group received a placebo ... Women receiving the vitamin-mineral combination were 20 per cent less likely to experience the fractures" - [Abstract]
• Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits - J Bone Miner Res. 2008 May;23(5):741-9 - "randomized them to 2000 mg calcium and 800 IU vitamin D/d or placebo ... found a 21% lower incidence of fractures in the supplemented versus the control group" - [Nutra USA]
• Effects of conjugated linoleic acid and exercise on bone mass in young male Balb/C mice - Lipids Health Dis. 2006 Mar 23;5:7 - "Conjugated Linoleic Acid (CLA) has been reported to lower body fat mass. However, weight loss is generally associated with negative effects on bone mass, but CLA is reported to have beneficial effects on bone ... a combination therapy of CLA and EX on bone health has not been studied ... although CLA decreased gain in body weight by 35%, it however increased bone mass by both reducing bone resorption and increasing bone formation. EX also decreased gain in body weight by 21% and increased bone mass; but a combination of CLA and EX, however, did not show any further increase in bone mass" - See conjugated linoleic acid at Amazon.com.
• Better Bone Density Test - Dr. Weil, 1/14/08 - "If you’re a woman at risk for osteoporosis, I strongly recommend that you have a DEXA scan ... In addition, I recommend that all women supplement with 500 to 700 mg of calcium citrate in two divided doses taken with meals ... For men, I now suggest aiming for 500 mg from all sources. (Because higher amounts have been linked to increased risks of prostate cancer, men generally should avoid supplemental calcium.) I also recommend that both men and women take 1,000 IU of vitamin D3"
• Effect of dehydroepiandrosterone supplementation on bone mineral density, bone markers, and body composition in older adults: the DAWN trial - Osteoporos Int. 2007 Dec 15 - "Among older healthy adults, daily administration of 50 mg of DHEA has a modest and selective beneficial effect on BMD and bone resorption in women, but provides no bone benefit for men"
• Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials - Clin Nutr. 2007 Dec 4 - "Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women"
• Optimal vitamin d status for the prevention and treatment of osteoporosis - Drugs Aging. 2007;24(12):1017-29 - "Vitamin D deficiency [as defined by a serum 25(OH)D level of <50 nmol/L (<20 ng/mL)] is pandemic. This deficiency is very prevalent in osteoporotic patients. Vitamin D deficiency causes osteopenia, osteoporosis and osteomalacia, increasing the risk of fracture. Unlike osteoporosis, which is a painless disease, osteomalacia causes aching bone pain that is often misdiagnosed as fibromyalgia or chronic pain syndrome or is simply dismissed as depression. Vitamin D deficiency causes muscle weakness, increasing the risk of falls and fractures, and should be aggressively treated with pharmacological doses of vitamin D. Vitamin D sufficiency can be sustained by sensible sun exposure or ingesting at least 800-1000IU of vitamin D(3) daily" - See vitamin D at Amazon.com.
• Tea drinking is associated with benefits on bone density in older women - Am J Clin Nutr. 2007 Oct;86(4):1243-1247 - "In the cross-sectional analysis, total hip aBMD was 2.8% greater in tea drinkers (x: 806; 95% CI: 797, 815 mg/cm(2)) than in non-tea drinkers (784; 764, 803 mg/cm(2)) (P < 0.05). In the prospective analysis over 4 y, tea drinkers lost an average of 1.6% of their total hip aBMD (-32; -45, -19 mg/cm(2)), but non-tea drinkers lost 4.0%" - See green tea extract at Amazon.com.
• Drinking Tea May Slow Bone Loss - WebMD, 10/8/07 - "A new study shows elderly women who drank tea had higher bone density in their hips and less bone loss than women who didn't drink tea ... Previous studies have suggested that phytochemicals in tea, such as flavonoids, may be responsible for the protective effect against bone loss due to their estrogen-like properties"
• New Proof of Genistein's Efficacy and Safety for Osteopenia and Osteoporosis Published in Annals of Internal Medicine - Doctor's Guide, 7/16/07 - "85% of the women taking genistein showed a gain in bone density ... In addition, women taking genistein with calcium and vitamin D achieved a gain in bone density of approximately 3% per year over baseline and 6% per year over those taking the placebo"
• Soy Compound May Bolster Women's Bones - WebMD, 6/18/07 - "After two years, the DEXA scans showed increases in bone mineral density in women taking genistein"
• Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women - J Bone Miner Res. 2007 Apr;22(4):509-19 - "women who took combined vitamin K and vitamin D plus calcium showed a significant and sustained increase in both BMD and BMC at the site of the ultradistal radius"
• Not just calcium and vitamin d: other nutritional considerations in osteoporosis - Curr Rheumatol Rep. 2007 Feb;9(1):85-92 - "Other nutritional considerations include nutrients such as vitamin B-12 and vitamin K that may reduce fracture risk by increasing bone mineral density as well as the improvement of bone microarchitecture. Diets high in fruits and vegetables contribute nutrients such as magnesium associated with bone health and may also produce an alkaline environment, reducing calcium excretion and thus improving bone density"
• Soy isoflavone intake inhibits bone resorption and stimulates bone formation in menopausal women: meta-analysis of randomized controlled trials - Eur J Clin Nutr. 2007 Mar 28 - "Isoflavone intervention significantly inhibits bone resorption and stimulates bone formation"
• n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study - Am J Clin Nutr. 2007 Mar;85(3):803-7 - "The results showed that n-3 fatty acids, especially DHA, are positively associated with bone mineral accrual and, thus, with peak BMD in young men" - See Mega Twin EPA at Amazon.com or Jarrow Max DHA at Amazon.com.
• Vitamin K(2) supplementation improves hip bone geometry and bone strength indices in postmenopausal women - Osteoporos Int. 2007 Feb 8 - "Vitamin K(2) helps maintaining bone strength at the site of the femoral neck in postmenopausal women by improving BMC and FNW, whereas it has little effect on DXA-BMD" - See vitamin K at Amazon.com.
• Beware of Bone Boosters? - Dr. Weil, 2/8/07 - "I also worry about using bisphosphonates on a long-term basis because of new evidence showing that they can lead to very serious problems. Dentists have been observing that some patients on these drugs are at risk of developing an untreatable condition called osteonecrosis of the jaw (ONJ). Osteonecrosis means death of bone tissue. ONJ can cause chronic pain and disfigurement. Symptoms include toothache, jaw pain, loosening of teeth, recurrent infection of the soft tissue of the jaw, and exposed bone"
• Vitamin link to bone loss probed - BBC News, 11/14/06 - "Increased amounts of homocysteine in the blood may increase the risk of developing osteoporosis ... Individuals who have a poor dietary intake of B-vitamins tend to have high homocysteine levels"
• Potassium citrate supplements linked to thicker bones - Nutra USA, 10/12/06 - "Taking potassium citrate supplements could boost bone mineral density by similar amounts as observed with pharmaceuticals ... At the end of the study, women taking the potassium citrate supplement are reported to have a significant, one per cent increase in BMD in the vertebrae of the lower back (lumbar spine), compared to baseline ... However, the bone mineral density of the lumbar spine of women taking the potassium chloride supplement (none alkaline) was found to have significantly decreased after one year of supplementation, by about one per cent" - See iHerb or Vitacost potassium citrate products.
• CLA continues to offer possibilities for bone health - Nutra USA, 10/2/06 - "After 10 weeks of either diet, it was found that the CLA-fed mice had higher bone mineral density (BMD) in specific bone regions than corn oil (CO)-fed mice. This increased BMD was tied to a reduced activity of pro-inflammatory cytokines (such as tumor necrosis factor alpha (TNF-alpha), and interleukin-6 (IL-6)) ... the CLA-fed mice also had significantly lower fat mass and increased muscle mass, compared to CO-fed mice" - See CLA products at iHerb or Vitacost.
• Study Suggests Vitamin K Deficiency as an Osteoporosis Risk Factor - Doctor's Guide, 9/22/06 - "one of the early effects of declining estrogen is the impairment of vitamin K function in bone even before any bone loss that could be attributed to menopause can be measured ... Our study suggests that the generally accepted level of vitamin K in healthy women is inadequate to maintain bone health just at the onset of menopause" - See iHerb or Vitacost vitamin K products.
• Soy Isoflavones Protect Postmenopausal Women From Bone Loss - Medscape, 7/14/06 - "There was a significant, linear dose-related response for isoflavones vs placebo in terms of bone density at the lumbar spine and femoral neck, but not at the trochanter"
• Strong support for vitamin K’s bone health benefits - Nutra USA, 6/27/06 - "Supplementation of vitamin K (MK-4) resulted in reductions in hip fractures of 77 per cent, vertebral fracture of 60 per cent, and all non-vertebral fractures of 81 per cent"
• Increasing Dietary and Supplemental Calcium - Medscape, 6/16/06 - "Postmenopausal women, as reported in many studies, tend to have average serum 25(OH)D values ranging from 50 to 55 nmol/L (20 to 22 ng/mL)[8,10] and are therefore absorbing the calcium they ingest with reduced efficiency ... raising serum 25(OH)D from the typical postmenopausal range up to 75 nmol/L resulted in a 33% reduction in all osteoporotic fractures combined"
• Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : A single-blind randomized, placebo-controlled trial - Eur J Nutr. 2006 Jun 8 - "There is a significantly dose-dependent effect of soy isoflavones on attenuating bone loss at the spine and femoral neck possibly via the inhibition of bone resorption in non-obese postmenopausal Chinese women with high Kuppermann Scale"
• Evaluating vitamin D status. Implications for preventing and managing osteoporosis and other chronic diseases - Joint Bone Spine. 2006 Feb 17 - "recent review articles indicate that current reference ranges for serum 25-OH-vitamin D are too low. An appropriate lower normal limit may be between 50-100 nmol/l (20-40 ng/ml). Standard supplement dosages may fail to provide concentrations above this range" - See iHerb or Vitacost vitamin D products.
• Vitamin K treatment for postmenopausal osteoporosis in Indonesia - J Obstet Gynaecol Res. 2006 Apr;32(2):230-4 - "After 48 weeks of treatment, the mean percentage change of lumbar BMD in the vitamin K(2) group was significantly higher (P < 0.05) than that of the control group" - See iHerb or Vitacost vitamin K products.
• Women with Osteoporosis May Need More Vitamin D - Healthwell, 3/16/06 - "More than half of American women receiving drug therapy for osteoporosis are deficient in vitamin D ... The new research suggests that many women with osteoporosis are using drugs to treat a problem that could be helped simply by getting sun more often or by taking a nutritional supplement"
• Bone care: It's still basic - USA Today, 3/5/06 - "the postmenopausal women in the study weren't typical. Most who were assigned to take supplements also got lots of calcium and vitamin D in their diets, so adding pills didn't make much difference. And many who were assigned placebos also took supplements on their own, something researchers allowed ... It's not surprising there was a blunted response ... The National Osteoporosis Foundation saw nothing in the study to change its endorsement of calcium and vitamin D"
• Calcium Plus Vitamin-D Supplementation Does An Older Body Good - Science Daily, 2/24/06 - "The older the woman, the more likely it is that consistent use of calcium and vitamin-D supplements will play a role in reducing her risk for osteoporosis"
• Study Finds Calcium Supplements Don't Prevent Broken Bones - New York Times, 2/15/06 - "the participants were randomly assigned to take 1000 milligrams of calcium and 400 international units of vitamin D a day ... When they looked only at the women who took 80 percent of their pills, the supplements reduced hip fractures by 29 percent. The annual rate of hip fractures in adherent women taking the supplements was 10 per 10,000, compared with 14 per 10,000 in adherent women taking placebos"
• Calcium, Vitamin D: Help Women's Hips? - WebMD, 2/15/06 - "Calcium and vitamin D supplements may help protect some older women's hips -- but only when taken regularly"
• Magnesium Prevents Osteoporosis - Healthwell, 2/9/06 - "a higher magnesium intake was associated with greater whole-body bone mineral density, after adjusting for calcium and vitamin D intake, level of exercise, use of estrogen medication, and other factors known to be related to bone health"
• Strategies for Preventing Osteoporosis in Men - Life Extension Magazine, 1/06 - "For men, maintaining good bone health starts with regular doctor visits to screen for bone mineral density and prostate cancer. Other essentials are regular, weight-bearing exercise, healthy, moderate-protein diets, and supplements including vitamin D, calcium, magnesium, and isoflavones to help prevent bone mineral losses"
• Dietary Magnesium Could Lead to Stronger Bones - Doctor's Guide, 12/21/05 - "For every 100 milligram per day increase in magnesium intake, data showed a 1% increase in bone density ... this link was only true for the older white men and women" - See iHerb or Vitacost magnesium products.
• Magnesium could reduce osteoporosis risk - Nutra USA, 12/8/05 - "Higher Mg intake through diet and supplements was positively associated with total-body [bone mineral density] BMD in older white men and women. For every 100 mg per day increase in Mg, there was an approximate 2 per cent increase in whole-body BMD"
• Nutritional Interventions in Osteoporosis - Medscape, 12/1/05 - "For adults over 50 years of age, the DASH diet emphasizing fruit and vegetables as well as dairy products and whole grains and beans, together with a calcium and a vitamin D supplement, will provide dietary defense against osteoporosis"
• Silicon may boost calcium/vitamin D bone benefits - Nutra USA, 11/23/05 - "Jarrow Formulas ... The effect was particularly pronounced in the PINP, the most sensitive bone formation marker. In the groups receiving six and 12mg of silicon, the improvements were “significant”" - See Jarrow BioSil at iHerb.
• Leading Osteoporosis Experts Reach Consensus on Role of Vitamin D in Bone Health in Americans Over 50 - Doctor's Guide, 11/22/05 - "over 70% of women ages 51-70 and nearly 90% of women over 70 are not getting the recommended adequate intake of vitamin D ... The roundtable panelists expressed concern that current recommendations do not provide for optimal bone health and recommended that intake levels be increased to 800-1,000 IU per day for patients over age 50" - See iHerb or Vitacost vitamin D products.
• Adequate Vitamin D Status Appears More Important than High Calcium Intake for Maintaining Calcium Metabolism - Doctor's Guide, 11/8/05 - "vitamin D sufficiency may be more important than high calcium intake in maintaining desired values of serum PTH ... Vitamin D supplements are necessary to ensure adequate vitamin D status for most of the year in northern climates" -  See iHerb or Vitacost vitamin D products.
• Most Postmenopausal Women Are Vitamin D Deficient - Doctor's Guide, 9/29/05 - "64% of postmenopausal women with osteoporosis have a vitamin D deficiency" -  See iHerb or Vitacost vitamin D products.
• Prevalence of Vitamin D Inadequacy Among Postmenopausal North American Women Receiving Osteoporosis Therapy - Obstet Gynecol Surv. 2005 Oct;60(10):658-659 - "An adequate intake of vitamin D and calcium is viewed as a necessary part of treating osteoporosis ... At a cutoff point of 30 ng/mL, the prevalence of inadequacy was 63% in women taking less than 400 IU daily and 45% in those taking 400 IU or more" -  See iHerb or Vitacost vitamin D products.
• Potassium, The Hidden Bone Guardian - betterbones.com, 9/29/05
• Women Need More Calcium, Say Experts - WebMD, 9/28/05
• Postmenopausal Women Falling Far Short of Calcium Goals: Presented at ASBMR - Doctor's Guide, 9/28/05 - "A study finds that 85% of postmenopausal women do not consume enough calcium every day, and on average consume about 500 mg less than the US government's recommended daily intake (RDA)"
• Silicon May Play Important Role in Bone Health - Doctor's Guide, 9/27/05 - "Silicon, taken as choline-stabilized orthosilicic acid (ch-OSA) supplementation, might help improve bone health and type I collagen synthesis ... the benefits were especially apparent when evaluating changes in PINP, the most sensitive bone formation marker, and resulted in significant improvements after 12 months amongst the subjects in the six and 12 mg silicon groups" - See Jarrow BioSil at iHerb.
• After Menopause: Eating Soy May Help Bones - WebMD, 9/12/05 - "Within 10 years of menopause, the 20% who ate the most soy foods reported half as many fractures as the 20% who ate the least soy ... The highest level of consumption among Chinese women was about 13 grams of soy protein a day. A cup of soy milk contains about 6.6 grams"
• Taking A Break From Fractures: A Closer Look At Vitamin D - Science Daily, 8/11/05 - "The researchers concluded, though, that higher daily doses, in the range of 700 to 800 IU, may reduce the risk of fracture by approximately 25 percent ... only subjects receiving higher doses of vitamin D supplementation had significantly fewer fractures than did subjects in the comparison groups" - See iHerb or Vitacost vitamin D products.
• Balance of Essential Fats May Prevent Bone Loss After Menopause - Doctor's Guide, 7/13/05 - "After 12 weeks, rats with the lowest ratio of omega-6 to omega-3 fatty acids in their diet experienced significantly less bone loss than rats in the other dietary groups ... A 5-to-1 dietary ratio of omega-6 to omega-3 fatty acids led to a conservation of bone mineral content that we didn't see with a 10-to-1 ratio" -  See Mega Twin EPA at Amazon.com or Vitacost.
• Omega-3, Omega-6 Fatty Acids Can Affect Bone Loss - CBS 2 Chicago, 7/12/05 - "eating foods rich in omega-3 fatty acids -- found in walnuts and salmon -- may prevent bone thinning. While excess amounts of omega-6 -- found in grains and beef -- may actually promote bone loss ... a low ratio of omega-6 to omega-3 appears to be best"
• Vitamin D Deficit: Women's Silent Bone Threat - WebMD, 5/20/05 - "The study included 1,554 postmenopausal U.S. women being treated for osteoporosis ... More than half of the women (52%) had less-than-optimal levels of vitamin D ... Doctors need to pay more attention to vitamin D status"
• Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials - JAMA. 2005 May 11;293(18):2257-64 - "Oral vitamin D supplementation between 700 to 800 IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons. An oral vitamin D dose of 400 IU/d is not sufficient for fracture prevention"
• Homocysteine and vitamin b(12) status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people - J Bone Miner Res. 2005 Jun;20(6):921-9 - "High Hcy and low vitamin B(12) concentrations were significantly associated with low BUA, high markers of bone turnover, and increased fracture risk"
• Osteoporosis: the role of micronutrients - Am J Clin Nutr. 2005 May;81(5):1232S-9S - "Calcium has been shown to have beneficial effects on bone mass at all ages, although the results are not always consistent. Higher doses than the current US recommendation (600 IU) of vitamin D in the elderly (age >/= 65 y) may actually be required for optimal bone health (800-1000 IU/d) ... The other micronutrient needs for optimizing bone health can be easily met by a healthy diet that is high in fruits and vegetables to ensure adequate intakes for magnesium, potassium, vitamin C, vitamin K, and other potentially important nutrients"
• Fight Osteoporosis: Bone Up On B12 - Science Daily, 4/23/05 - "This study suggests adequate vitamin B12 intake is important for maintaining bone mineral density"
• Folate and Vitamin B12 Prevent Hip Fracture in Stroke Patients - Medscape, 3/25/05 - "The magnitude of benefit is similar to that found in trials of alendronate and raloxifene, with considerably less potential risk. The fact that BMD did not change suggests the benefit derives from quality, rather than quantity, of bone"
• Onions May Fight Osteoporosis - WebMD, 4/8/05
• Aerobic Exercise, Weights Boost Bone Strength - WebMD, 4/4/05
• Calcium Supplements: Benefits and Risks - Medscape, 1/26/05 - "Perhaps the most effective method of preventing osteoporosis is ingestion of adequate calcium. Experts suggest the daily requirement for calcium is 1,300 mg for people ages 9 to 18, 1,000 to 1,200 mg for adults 19 to 50, and 1,500 mg for people over 50 ... You should take only the amount of calcium recommended. Ingesting high doses of calcium each day can be harmful and can cause kidney stones"
• Got Fruit? Bones Need More Than Milk - WebMD, 10/26/04 - "Most people eat a diet that generates acids ... This increase in acid levels is thought to reduce bone strength ... Eating foods that buffer the acidic foods builds strong bones ... Nutrients found in fruits and vegetables may be protective for bone health ... The teenage girls who ate a large amount of fruit had the strongest bones"
• Study Says What's Good for the Heart May Be Good for the Bones - Doctor's Guide, 10/7/04 - "The study demonstrated a gain of up to 5% in bone mineral density (BMD) at the hip in postmenopausal women who drank 2 or fewer glasses of wine daily, and up to 7% in men who drank 1 or 2 beers daily"
• Vitamin K, bone turnover, and bone mass in girls - Am J Clin Nutr. 2004 Oct;80(4):1075-80 - "Better vitamin K status was associated with decreased bone turnover in healthy girls consuming a typical US diet"
• Vitamin D Inadequacy Highly Prevalent Among Women Treated for Osteoporosis in North America - Doctor's Guide, 10/4/04 - "More than half of women currently treated for osteoporosis have suboptimal levels of vitamin D"
• Got Exercise? Workouts Better for Bone Health - WebMD, 6/11/04
• Vitamins May Lower Osteoporosis Fractures - Intelihealth, 5/13/04 - "B vitamins are known to reduce levels of homocysteine ... high levels of homocysteine at least double the risk of osteoporosis-related fractures"
• High protein promotes bone health - Nutra USA, 4/5/04
• Low B-12 Levels Linked to Increased Rate of Bone Loss - Medscape, 3/19/04 - "The results of this study raise the possibility that supplementation with vitamin B-12 or, for some elderly women, dietary assessment and modification may slow rates of bone loss" - See iHerb or Vitacost Vitamin B12 products.
• Vitamin B12 levels linked to bone loss - Nutra USA, 3/4/04 - "after adjusting for age, weight and clinic site, women with the lowest levels of B12 (below 280 pg/ml) experienced significantly more rapid hip bone loss than women with higher levels of B12"
• Best Ways To Fight Osteoporosis - CBS News, 9/18/03 - "64 percent of women don't know how much calcium they need every day ... women from 19- to 50-years-old should consume 1,000 mg; and women over 50-years-old should consume 1,200 mg ... a high calcium intake will not protect a person against bone loss caused by estrogen deficiency, physical inactivity, smoking, alcohol abuse or various medical disorders or treatments" - See drugstore.com/GNC calcium products.
• Vitamin D Supplementation and Fracture Prevention - Medscape, 9/11/03 - "Bottom line: Vitamin D supplementation is absolutely critical to bone health in the aging population. Although a number of research questions still need to be addressed, there is currently sufficient evidence to show that all women, living in areas of Northern Latitude, should be taking a vitamin D (and calcium) supplement"
• 60-Minute Workout Stops Bone Loss - WebMD, 9/5/03 - "Postmenopausal women who work out for 60 minutes, three times a week -- and take calcium -- can stop bone loss ... calcium alone isn't enough -- you also need vitamin D"
• Exercise Prevents Bone Loss in Early Post-Menopausal Women - New Hope Natural Media, 8/14/03
• Vitamin D and Calcium Supplementation Effective for Prevention and Treatment of Osteoporosis - Doctor's Guide, 7/18/03 - "Adequate vitamin D and calcium intake is essential to the prevention and treatment of osteoporosis. The Institute of Medicine (IOM) recommends 200 IU/day of vitamin D for women aged 50 or younger years, 400 IU/day for those aged 51-70 years, and 600 IU/day for those older than 70 years ... In women over the age of 65, there is increased risk of osteoporotic fracture of the hip and non-vertebral sites. Daily vitamin D intake between 800 and 900 IU and 1200-1300 mg of calcium for this population results in increased bone density, decreased bone turnover, and decreased non-vertebral fractures ... Studies have linked vitamin D supplementation to a decrease in body sway, suggesting that vitamin D supplementation may protect against fracture by preventing falls" - See drugstore.com/GNC calcium plus vitamin D supplements.
• Effects on bone mineral density of calcium and vitamin D supplementation in elderly women with vitamin D deficiency - Joint Bone Spine. 2003 Jun;70(3):203-208 - "bone mass in older women with vitamin D deficiency increases significantly at the lumbar spine, femur, trochanter, and whole body after calcium and vitamin D supplementation for 1 year, and concomitantly bone markers improved as vitamin D levels returned to normal"
• Protein intake: effects on bone mineral density and the rate of bone loss in elderly women - Am J Clin Nutr. 2003 Jun;77(6):1517-25 - "The highest quartile of protein intake (: 72 g/d) was associated with higher BMD in elderly women at baseline only when the calcium intake exceeded 408 mg/d"
• Calcium Supplementation and Exercise Improves Bone Mineral Status in Adolescent Girls - Doctor's Guide, 4/10/03
• Vitamin D Plus Calcium Supplements Boosts Calcium Absorption - WebMD, 4/1/03 - "We need calcium for good bones, but vitamin D is equally important -- it helps the body with calcium absorption. In fact, calcium supplements plus vitamin D can increase calcium absorption by up to 65%"
• Vitamin K Builds Strong Bones - New Hope Natural Media, 3/28/03 - "Without adequate vitamin K, osteocalcin cannot be produced, and bone formation becomes impaired ... when women with osteoporosis take supplemental vitamin K, the urinary excretion of calcium falls by about 50%, suggesting that less calcium is being leached from the bones ... Some research, however, suggests that the optimal level of intake may be higher, as much as 400 mcg per day. A typical western diet contains 80 to 150 mcg per day" - See iHerb or Vitacost vitamin K products.
• Remember Sodium? We're Still Getting Too Much - Intelihealth, 3/14/03 - "High sodium levels also raise the risk of osteoporosis and kidney problems ... In the case of osteoporosis, potassium appears to offset calcium losses from excessive sodium ... postmenopausal women with diets high in salt lost higher amounts of bone mineral. Eating potassium-rich foods such as bananas, tomatoes and orange juice helped stem the calcium loss"
• Interaction of Dietary Calcium and Protein in Bone Health in Humans - J. Nutr. 133:852S-854S, 3/03 - "Protein has both positive and negative effects on calcium balance, and the net effect of dietary protein on bone mass and fracture risk may be dependent on the dietary calcium intake. In addition to providing substrate for bone matrix, dietary protein stimulates the production of insulin-like growth factor-1 (IGF-1), a factor that promotes osteoblast-mediated bone formation. Protein also increases urinary calcium losses, by several proposed mechanisms. Increasing calcium intake may offset the negative impact of dietary protein on urinary calcium losses, allowing the favorable effect of protein on the IGF-1 axis to dominate"
• Vitamin D Can Prevent Fractures In Older People - Intelihealth, 2/28/03
• Vitamin D Helps Elderly Avoid Fractures - WebMD, 2/27/03
• Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women - Am J Clin Nutr. 2003 Feb;77(2):504-11 - "Women consuming 12.5 µg vitamin D/d from food plus supplements had a 37% lower risk of hip fracture (RR = 0.63; 95% CI: 0.42, 0.94) than did women consuming < 3.5 µg/d. Total calcium intake was not associated with hip fracture risk (RR = 0.96; 95% CI: 0.68, 1.34 for 1200 compared with < 600 mg/d). Milk consumption was also not associated with a lower risk of hip fracture (P for trend = 0.21)"
• Vitamin K intake and bone mineral density in women and men - Am J Clin Nutr. 2003 Feb;77(2):512-6 - "Low dietary vitamin K intake was associated with low BMD in women ... In contrast, there was no association between dietary vitamin K intake and BMD in men"
• Walking Your Way to Better Bones - WebMD, 11/13/02
• Low Vitamin D Levels Not Restricted To High-risk Groups - Doctor's Guide, 9/23/02 - "Vitamin D insufficiency is far more common than is generally assumed and is not necessarily restricted to high-risk groups such as the elderly ... Low vitamin D levels were found across diagnostic categories and were identified in 88 percent of patients with hip fractures; 67 percent of patients with wrist fractures; 50 percent of patients with vertebral fractures, and 52 percent of patients with other fractures ... This study demonstrates the high frequency of hypovitaminosis D in a UK specialist bone clinic setting and the clear need for vitamin D therapy may not [be] appreciated without [taking] vitamin D measurements"
• Low Bone Mineral Density and Quantitative Ultrasound in Men Associated with Low Vitamin K Status - Doctor's Guide, 9/23/02 - "Low vitamin K status is associated with low quantitative ultrasound (QUS) and low bone mineral density (BMD) of the femoral neck and trochanter ... What we did was measure the amount of vitamin K in circulation and use the more sensitive measures of vitamin K status which was % undercarboxylated osteocalcin ... We corrected for triglycerides because vitamin K is transported in the blood by triglyceride-rich lipoproteins ... What we found was that the higher the amounts of vitamin K in the plasma, the higher the BMD" - So does that mean that if your triglycerides are in check you may need extra vitamin K?  See iHerb and Vitacost vitamin K products. - Ben
• Treating & Preventing Osteoporosis - Life Extension Magazine, 9/02 - "From systematic research the best external evidence is available for a supplementation with calcium and vitamin D and a therapy with the bisphosphonates alendronate or risedronate, as well as the selective estrogen receptor modulator raloxifene (Evista)."
• People Living In Higher Latitudes Require Fall, Winter Vitamin D Supplements - Doctor's Guide, 6/10/02 - "Given that almost every person in our sample had serum 25-hydroxyvitamin D [25(OH)D] levels below 80 nmol/L at one point in the year, and that more than one-third of subjects had levels below the most conservative definition of vitamin D insufficiency, our findings support a recommendation for more aggressive vitamin D supplementation, particularly for elderly people and especially during the fall and winter months ... Low levels of vitamin D metabolites are associated with malabsorption of calcium, which results in bone loss"
• Soy Isoflavone May Improve Bone Metabolism in Perimenopausal Women - Doctor's Guide, 5/27/02 - "The isoflavone group (n=12) received daily capsules of soy isoflavone extract (61.8 mg of isoflavones) ... Excretion of bone resorption markers was reduced significantly in the isoflavone group"
• Getting Calcium On Young Girls' Radar - Intelihealth, 5/23/02 - "Ninety percent of girls ages 9 to 12 don't get enough calcium in their diets ... Ninety to 98 percent of your skeletal system is developed by age 20, so it's important that these bone-healthy activities are done early. After that, you're either going to maintain the bone density or you're going to lose it"
• Long-Time Tea Drinking Builds Strong Bones - WebMD, 5/14/02
• Calcium and Vitamin D3 Effective and Cost-Saving in Preventing Hip Fracture in Elderly European Women - Doctor's Guide, 5/13/02 - "simple dietary supplementation with calcium and vitamin D not only helps prevent hip fracture in institutionalized elderly women, it also saves up to 711,000 Euros (some US $640,000) per 1000 treated ... One group received elemental 1200 mg/day calcium plus 800 IU/day vitamin D3, while the other received a placebo. After three years, 25 percent fewer hip fractures were found among members of the supplemented group ... The savings may even be greater than this: remember, this study only takes into account hip fractures, but supplementation could prevent many other types of fracture as well"
• Tea May Strengthen Bones - Intelihealth, 5/13/02
• Aging Bone Mineral Density Better With High Protein Diet Plus Extra Calcium, Vitamin D - WebMD, 4/1/02
• High-Protein Diet Could Repair Bone Loss - WebMD, 3/25/02 - "The supplement group -- particularly those who ate a diet high in protein -- had significantly better bone mass density -- an accurate measure of bone loss. Those who took the placebo, however, had less calcium absorbed into their bloodstream when they consumed more protein"
• Does High Intake of Vitamin A Pose a Risk for Osteoporotic Fracture? - JAMA. 2002 Mar 20;287(11):1396-7 - "the evidence relating to a possible relationship between moderately high retinol intake and possible adverse effects on bone health remains inconclusive"
• Curbing Caffeine May Benefit Bones - HealthandAge, 1/11/02
• Kids Plagued by 'Calcium Crisis' - WebMD, 12/14/01 - "Only 14% of girls and 36% of boys age 12 to 19 in the U.S. are getting the recommended amounts of calcium, according to the U.S. Department of Agriculture ... Close to 90% of adult bone is established by the end of the teen years. So if kids are off to a bad start in getting enough calcium, says the National Institute of Child Health and Human Development (NICHD), down the road, they are at serious risk of developing the brittle-bone disease osteoporosis as well as other bone diseases"
• Calcium, Keep What You Take - Life Extension Magazine, 3/99
• Vitamin K Deficiency Linked to Low Bone Mineral Density in Women - Doctor's Guide, 10/15/01
• Vitamin K Cuts Hip Fractures - Nutrition Science News, 9/01
• Vitamin E May Help Prevent Menopause Bone Loss - WebMD, 6/28/01 - "Treating these rats with vitamin E at a dose comparable to 400 IU in humans was just as good as estrogen treatment in restoring bone density and weight"
• Study Relates Jogging And Strong Bones - Intelihealth, 6/28/01 - "Young men who jog regularly build strong bones and may be less likely to develop the brittle bone disease osteoporosis ... For couch potatoes, men who do little or no exercise, the bone density of joggers was almost 8 percent better"
• Not for Ladies Only: Soy May Also Help Men at Risk for Osteoporosis - WebMD, 4/2/01 - "research suggests that a diet enriched with soy protein, which some research has shown can help preserve women's bones, may be able to do the same thing for men ... The group consuming soy protein had significantly more of this growth factor"
• PUFAs (omega-3 polyunsaturated fatty acids) for Bone Growth and Repair - Nutrition Science News, 3/01
• Vitamin C May Help Ward Off Osteoporosis - WebMD, 2/8/01 - "Researchers have found that postmenopausal women who took vitamin C supplements had a higher bone density than those who didn't. The highest bone densities were also found in the women who were taking more than 1,000 mg/d."

Other News:

• Facial Wrinkles Linked to Lower Bone Density - WebMD, 6/7/11 - "Researchers measured the number and depth of facial wrinkles and the skin firmness of 114 women who were within three years of their last menstrual period ... Women who had worse wrinkles also had lesser bone density ... Pal thinks the connection may be a protein called type 1 collagen, a building block of skin and bone tissue, which is lost with age. It is thought that this loss may be accelerated during menopause, when hormone levels drop ... The strongest association of the facial wrinkles with the bone was between the eyebrows ... When we looked at the effects of sun exposure on skin, we did not see that women who had more sun exposure had worse skin wrinkles"
• Higher bone mineral density is associated with a decreased risk of colorectal adenomas - Int J Cancer. 2010 Oct 14 - "patients in the highest tertile of total body BMD (>1.294 g/cm(2)) and in the middle tertile (≥1.167 to ≤1.294 g/cm(2)) compared to those with a total body BMD in the lowest tertile (<1.167 g/cm(2)) had a lower risk of colorectal adenomas (highest vs. lowest tertile: OR=0.29 (0.10-0.84); middle vs. lowest tertile: OR=0.26 (0.08-0.80); p-trend=0.02)"
• Long term use of oral bisphosphonates may double risk of esophageal cancer, study finds - Science Daily, 9/2/10 - "Typically, oesophageal cancer develops in one per 1000 people at age 60-79 over five years. Based on their findings, the authors estimate that with five years' use of oral bisphosphonates this would increase to two cases per 1000 people taking bisphosphonates over five years"
• High-protein diets may cause bone loss in older women, study - Nutra USA, 7/8/10 - "Study 1 ... on average, all women lost around 19 pounds, but those who ate the higher-protein, meat-containing diet also lost bone mineral density by about 1.4 percent ... Study 2 ... All women lost weight, but the groups that consumed the higher-protein meat-containing diets again also lost bone mineral density by up to 1.4 percent compared to the control group ... In the first study, all the participants con&shy;sumed calcium supplements to achieve calcium intakes of 2,000mg per day. In the second study, about half of the participants con&shy;sumed calcium supplements ... However, in neither case were the supplements found to impact the loss of bone density"
• Many Psychotropic Medications May Be Bad for Bones - Medscape, 5/27/10 - "osteoporosis was found to be associated with the use of selective serotonin reuptake inhibitors (SSRIs), mood stabilizers other than lithium, and benzodiazepines. Use of tricyclic antidepressants was protective"
• Diabetes Weakens Your Bones - Science Daily, 9/28/09 - "They observed increased levels of inflammatory molecules, including TNF-α during fracture healing. The diabetic animals had rapid loss of cartilage in the healing bones, which was due to increased numbers of osteoclasts, cells that remove bone and cartilage. Factors that stimulate osteoclast formation were regulated by both TNF-α and a downstream mediator, FOXO1. These results suggest that diabetes-mediated increases in TNF-α and FOXO1 may underlie the impaired healing of diabetic fractures"
• Sex Hormones Associated With Broken Bones In Older Men - Science Daily, 8/3/09 - "Low levels of estradiol or high levels of sex hormone binding globulin (SHBG) are associated with an increased risk of osteoporotic fracture in older men"
• Popular Class Of Diabetes Drugs Doubles Risk Of Fractures In Women - Science Daily, 12/10/08 - "We knew going into this study that there was an association between thiazolidinediones and fracture risk ... these agents double the risk of fractures in women with type 2 diabetes"
• Adiponectin Is A Metabolic Link Between Obesity And Bone Mineral Density - Science Daily, 11/25/08 - "adiponectin, a protein secreted from adipocytes, is a metabolic link that can explain, in part, the known positive relationship between obesity and both bone mineral density and reduced susceptibility to fractures ... In summary, elevated circulating adiponectin was associated with lower bone mass and weaker bones in growing mice compared to control animals" - See my adiponectin page for ways to increase it. - Ben
• Angiotensin II type 2 receptor blockade increases bone mass - J Biol Chem. 2008 Nov 11 - "Treatment with AT2 receptor blocker significantly enhanced the levels of bone mass and this effect was based on the enhancement of osteoblastic activity as well as the suppression of osteoclastic activity in vivo" - That might be another good reason for telmisartan as a first line treatment for hypertension.  See telmisartan at OffshoreRx1.com.
• Too Much Body Fat Bad for Bones? - WebMD, 10/31/08 - "postmenopausal women with a higher proportion of body fat tend to have lower bone mineral content"
• Guidelines for Osteoporosis Treatment - WebMD, 9/15/08
• New Test for Osteoporosis Fracture Risk - WebMD, 6/24/08
• Testosterone Replacement Theraphy Beneficial In Men 60 And Older, Study Suggests - Science Daily, 4/7/08 - "These preliminary data show beneficial effects of testosterone therapy on bone turnover markers in older men with low-to-normal testosterone concentrations using both continuous and monthly cycled testosterone replacement"
• Low Testosterone Levels Associated With Risk Of Fracture In Men Over 60 - Science Daily, 1/14/08 - "Although low levels of estradiol and testosterone were associated with a higher risk of fracture in men over 60, only the effect of testosterone was independent of other risk factors, the authors conclude"
• Chocolate consumption and bone density in older women - Am J Clin Nutr. 2008 Jan;87(1):175-80 - "Higher frequency of chocolate consumption was linearly related to lower bone density and strength (P < 0.05). Daily (>/=1 times/d) consumption of chocolate, in comparison to <1 time/wk, was associated with a 3.1% lower whole-body bone density; with similarly lower bone density of the total hip, femoral neck, tibia, and heel; and with lower bone strength in the tibia and the heel"
• Many Osteoporosis Medications Prevent Fractures, but None Is Proven Best - Doctor's Guide, 12/18/07
• Depression Associated With Low Bone Mineral Density - Medscape, 12/3/07 - "The novelty of this study is the fact that these women were not severely depressed ... Depression is considered a disease of chronic stress, Dr. Cizza said, with attendant increases in the stress hormone cortisol, and cytokines produced by the immune system. "Those substances are helpful to fight stress, but if there is too much cortisol or cytokines, there are side effects," he said. "One of the side effects is bone loss, so it was obvious to ask the question, 'do women with depression have low bone mass?'""
• New Diabetes Drugs Bad for Bones - WebMD, 12/3/07 - "The diabetes drug Avandia promotes osteoporosis not only by slowing bone growth but also by speeding up bone loss. Actos, the only other drug in the same class, likely does this as well"
• Depression Linked To Bone-thinning In Premenopausal Women - Science Daily, 11/26/07 - "The researchers found that 17 percent of the depressed women had thinner bone in a vulnerable part of the hip called the femoral neck, compared with 2 percent of those who were not depressed"
• Just Being Naturally Thin May Raise Risk of Osteoporosis in Women - Doctor's Guide, 11/8/07
• The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women - Clin Endocrinol (Oxf). 2007 Jun 6 - "oestradiol (E2) and testosterone (T) ... Low levels of bioE2 and bioT were found to be associated with high bone turnover, low QUS and BMD and high risk of osteoporotic fractures in both men and women"
• Antidepressant Use May Boost Fracture Risk - Science Daily, 5/29/07 - "people ages 50 and over who regularly took antidepressants called selective serotonin reuptake inhibitors (SSRIs) had double the rate of fractures as people not using such medications"
• Once-a-year Drug Reduces Fractures From Osteoporosis - Doctor's Guide, 5/4/07
• Relation of Cortisol Levels and Bone Mineral Density Among Premenopausal Women With Major Depression - Medscape, 5/4/07 - "a lower BMD and increased bone resorption were found in women with mild depression. Major depression had important effects on BMD and bone turnover markers. Depression should be considered among risk factors for osteoporosis in premenopausal women, therefore it may be useful to assess BMD values of MDD patients, and to treat them in cases of lower BMD values"
• Men Warned Of Osteoporosis Problems - Science Daily, 1/31/07 - "Statistically, one in three men die following a fracture, compared to one in five women, possibly because of underlying health problems such as heart disease which make it difficult for them to cope with a fracture that could involve hip surgery, prolonged bed rest and rehabilitation"
• Study Says Depression May Weaken Bones - WebMD, 10/30/06 - "After four weeks, the depressed mice had lost bone density, the study shows. The problem: They had a drop in bone-building cells called osteoblasts ... When the depressed mice drank water laced with imipramine, their depression eased and their bone loss stopped"
• Study Links Cola to Bone Loss in Women - WebMD, 10/6/06 - "drinking cola soft drinks on a regular basis was associated with lower bone mineral density in the hip"
• Low Bone Density May Predict Cognitive Impairment - Doctor's Guide, 5/5/06 - "Low bone mineral density (BMD) in postmenopausal women may be associated with cognitive impairment, and estrogen metabolism may be the cause"
• Elderly Men Who Fall Should Be Screened for Osteoporosis - Doctor's Guide, 5/5/06
• Low Estrogen May Up Men’s Hip Fracture - WebMD, 5/3/06
• Lack of Estrogen Linked to Hip Fractures in Men - Intelihealth, 5/1/06 - "men who have lost bone mass should take calcium and vitamin D supplements to help reverse bone loss and reduce the risk of hip fractures ... This is an interesting paper and tends to confirm that among men, estradiol (estrogen) levels may be more important to bone strength than is testosterone"
• FDA Approves Once-a-Week Osteoporosis Hormone Therapy Patch Climara Pro (Estradiol/Levonorgestrel) - Doctor's Guide, 1/4/06 - "the FDA has approved the hormone therapy patch, Climara Pro® (estradiol/levonorgestrel transdermal system), for the prevention of postmenopausal osteoporosis"
• Women Over 50 Likely to Have Both Low Bone Mineral Density and Elevated Cholesterol - Doctor's Guide, 10/4/05 - "17.3 million (43%) of women over 50 years had osteopenia, and 4.8 million (12%) had osteoporosis, while 18.2 million (45%) had normal BMD"
• Treating Osteoporosis: What Works Best? - WebMD, 8/10/05 - "Treatment with parathyroid hormone increases bone density. But women who took parathyroid hormone for a year progressively lost bone density afterward unless they took Fosamax"
• What's Best for Bones? - Dr. Weil, 5/13/05
• Bone Fracture Rates Significantly Reduced Over Just Two Years in Patients Who Consistently Stayed on Bisphosphonate Therapy for Osteoporosis - Doctor's Guide, 4/7/05 - "We found that women with postmenopausal osteoporosis who faithfully continued to take their prescribed bisphosphonate medication reduced their risk for fractures substantially more - about 25% - than women who did not"
• Newer Antiepileptics May Increase Risk of Osteoporosis - Clinical Psychiatry News, 4/05
• Few Patients Exposed to High-Dose Corticosteroids Receive Osteoporosis Education - Doctor's Guide, 3/28/05
• More Osteoporosis Seen With Raw Foods Diet - WebMD, 3/28/05
• Osteoporosis and Bone Health - Physician's Weekly, 3/21/05 - "half of all Americans older than 50 will be at risk for fractures from osteoporosis and low bone mass by 2020 if no immediate actions are taken ... Calcium and vitamin D intakes are far below recommended levels for all ages, sexes, and races in the United States"
• Dental X-Rays Could Be First Step in Osteoporosis Screening - Doctor's Guide, 12/1/04
• Osteoporosis Drugs May Prevent Knee Arthritis - WebMD, 11/4/04
• Four Osteoporosis Drugs Show No Difference in Impact on Endothelial Function - Doctor's Guide, 10/11/04
• Ultra-Low Dose Estradiol Good for Bone Health, and Appears to Have No Impact on Endometrium - Doctor's Guide, 10/11/04 - "14 mcg of estradiol patch ... By the end of 2 years, there was a 2.6% increase in bone mineral density of the lumbar spine over baseline, and a 0.4% increase in BMD at the hip. By comparison in the placebo group, the increase in BMD of the spine was 0.6% and there was a loss in BMD at the hip of 0.8% ... These ultra-low doses of estradiol should be sufficient to preserve bone health in women over the age of 60 years"
• Declining Estradiol Levels More Predictive of Fracture Risk Than Low Testosterone in Aging Men - Doctor's Guide, 10/8/04 - "While low levels of free testosterone are a predictor of hip-bone loss, declines in estradiol levels play a stronger role than testosterone"
• Exercise More Critical Than Calcium For Adolescent Bones - Doctor's Guide, 6/9/04 - "Exercise is more influential than calcium intake in determining bone strength in young women ... attaining optimal bone mass and bone strength in adolescence may offer the best protection possible against osteoporosis - bone loss in post-menopausal women and the elderly"
• New Fracture Risk: High Homocysteine - WebMD, 5/12/04
• Postmenopausal Women Show Significantly Reduced Incident Fracture Risk While on Hormone Therapy - Doctor's Guide, 5/12/04 - "We found a significantly reduced risk of fracture a year or so after women had started using hormone therapy, with the risk decreasing further with increasing duration of use"
• Ultra-Low Dose Estrogen Patch Helps Bones - WebMD, 5/4/04
• Ultra-Low-Dose Estradiol Patch Stops Bone Turnover, Increases Bone Density - Medscape, 5/4/04 - "The patch dose is "roughly one fourth of the standard 0.625-mg dose usually prescribed for menopause symptoms ... That minimal increase translated into a "3% increase in BMD at the spine compared to placebo and a 1.5% increase at the hip compared to placebo ... All women received 800 mg calcium and 400 IU vitamin D daily"
• Peak Bone Mass, Size Appear Almost Fully Attained by Late Adolescence - Doctor's Guide, 4/6/04
• Few Treated for Osteoporosis; Many at Risk - WebMD, 3/26/04 - "Researchers say recent advances in the prevention and treatment of osteoporosis not only slow the bone-thinning disease, but they can also help rebuild your bones ... The problem is, only a fraction of those at risk for the disease are ever screened for osteoporosis"
• Inhaled Steroids: More Evidence of Bone Loss - WebMD, 3/26/04
• Inverse Relationship Observed Between Statin Treatment and Risk of Hip Fracture - Doctor's Guide, 3/12/04 - "The risk of hip fracture decreased as the number of statin prescriptions increased ... 0.72 ... for subjects who redeemed more than 3 statin prescriptions"
• Statins May Help Prevent Bone Fractures - WebMD, 1/26/04 - "statin users had a 38%-81% lower risk of hip bone fractures and a 5%-51% lower risk of nonspinal fractures ... statin use was associated with a 57% reduction in the number of hip fractures reported and a 31% reduction in nonspinal fractures"
• Human Parathyroid Hormone Appears Effective, Safe in Increasing Bone Mineral Density in Postmenopausal Osteoporosis - Doctor's Guide, 11/20/03
• Is Low Bone Mass in Men an Underdiagnosed Disease State? - Doctor's Guide, 10/31/03 - "The leading three risk factors from the questionnaire for predicting bone loss were history of smoking, no calcium supplementation, and difficulty maintaining an erection ... 62.5% showed evidence of either osteopenia (> -1.0 SD of bone mass density [BMD]) or osteoporosis"
• More Awareness of Guidelines to Prevent Corticosteroid-Induced Osteoporosis - Medscape, 10/27/03
• Few Get Osteoporosis Drugs After Falls - WebMD, 10/2/03 - "only 22% of elderly men and women who had a major bone fracture filled a prescription for an osteoporosis drug within six months after their injury ... that's despite the fact that people who have suffered one fracture from osteoporosis are up to five times more likely so suffer another one, and use of osteoporosis drugs can reduce that risk of by as much as 60%"
• Statins Used to Treat High Cholesterol and Osteoporosis - Doctor's Guide, 9/30/03 - "simvastatin acts as a double therapeutic weapon by blocking the conversion of HMG-CoA to mevalonate. Not only does this action increase new bone formation via the stimulation of osteoblasts, but it also prevents the production of cholesterol"
• Men Present With More Severe Osteoporosis Than Women - Medscape, 9/25/03
• Most Postmenopausal Women With Fractures Not Prescribed Osteoporosis Medications - Doctor's Guide, 9/26/03
• Postmenopausal Women with Fracture are Under-Treated - Doctor's Guide, 9/24/03 - "The majority of postmenopausal women with low trauma fracture are not being treated with osteoporosis medications"
• Regular Cola Consumption Linked to Lower Bone Density in Women - Medscape, 9/22/03 - "Among the female subjects, regular cola drinkers had decreased BMD compared with the infrequent drinkers. BMD was 2.3% lower in the trochanter, 3.3% lower in the femoral neck, and 5.1% lower in Ward's area ... When phosphoric acid comes packaged with other nutrients, it's absorbed normally and everything is in balance. We think the problem with cola is that you're getting those doses of phosphoric acid without any calcium. It's not balanced, and that extra phosphorus binds with calcium and prevents it from being absorbed"
• Cessation of Hormone Replacement Results in Rapid Increase in Bone Turnover, Bone Loss - Doctor's Guide, 9/2/03 - "HRT withdrawal was followed by significant bone loss, with an annual rate ranging from -0.7 to -1.6% ... These findings have important implications for women who are given HRT for preventing the risk of osteoporosis"
• Peak Bone Mineral Density Has Greatest Influence on Onset of Osteoporosis - Doctor's Guide, 8/27/03
• Low-Dose Oestrogen Increased Bone Density in Older Women Without Increasing Oestrogen-Associated Adverse Effects - Doctor's Guide, 8/26/03 - "They randomised 167 women, older than 65 years of age, to receive either 0.25 mg/day micronized 17beta-estradiol or placebo for 3 years ... patients treated with low-dose estradiol showed bone mineral density increases of 2.6% at the femoral neck, 3.6% of the total hip, 2.8% at the spine, and 1.2% in total body measurements. Similar bone mineral density changes were seen between those who received and did not receive progesterone"
• Male Master Cyclists at Potential High-Risk for Developing Osteoporosis - Doctor's Guide, 7/24/03 - "Of the master cyclists, 15% met the World Health Organisation's criteria for having osteoporosis and 52% for having osteopaenia at either the spine or hip or both. This compares to 0% of the non-athletes who met the criteria for osteoporosis and 42% who met the criteria for osteopaenia ... The authors recommend that cyclists supplement their training with weight-bearing exercise, receive periodic BMD screening, and include adequate levels of dietary calcium and vitamin D" - See OS-Cal Plus at drugstore.com.
• Osteoporosis Linked to Joint Destruction in Postmenopausal Rheumatoid Arthritis - Doctor's Guide, 7/21/03 - "Up to 56% of postmenopausal women with rheumatoid arthritis (RA) who are not treated with hormone replacement therapy (HRT) or bisphosphonates develop osteoporosis"
• Low Bone Mineral Density Is Associated With Future Dementia - Clinical Psychiatry News, 7/03
• Menopausal Estrogen-Related Bone Loss Much Greater than Age-Related Bone Loss - Doctor's Guide, 6/25/03 - "In middle-aged women, age-related bone loss has a minor impact on the metabolic activity of bone compared to the impact of estrogen loss that accompanies menopause, which affects metabolic activity and bone density to a larger degree"
• Too Much or Too Little Vitamin A Raises Hip-Fracture Risk in Post-Menopausal Women - Doctor's Guide, 6/24/03 - "the highest and lowest quintiles were at twice the risk of hip fracture compared to the middle quintile ... without knowing the vitamin A status of an individual, eliminating vitamin A supplements could actually increase the number of vitamin A-deficient individuals, which would put them at risk not only of hip fractures, but also for other health risks associated with low vitamin A"
• Children on Frequent Oral Corticosteroids Should Maintain a Lifestyle that Wards Off Osteoporosis - Doctor's Guide, 6/20/03
• Ulnohumeral Arthroplasty Improves Pain and Function in Elbow Osteoarthritis - Doctor's Guide, 5/26/03
• Anti-hip Fracture Efficacy Lost with Estrogen Cessation - Doctor's Guide, 4/29/03 - "We found a statistically significant correlation between ending estrogen and increased risk of hip fracture ... Among this sub-group, the current users showed a statistically significant reduced tendency toward hip fracture over never-users (0.10% of 67,973 vs. 0.28% of 53,737"
• Stronium Ranelate Potential New Option for Postmenopausal Osteoporosis - Doctor's Guide, 4/28/03
• Simvastatin Enhances Bone Formation And Augments Bone Mineral Density - Doctor's Guide, 4/24/03 - "After a year's treatment with simvastatin the increases in bone mineral density at the lumbar spine, femoral neck and femur were 2.8, 1.0 and 0.8% respectively. In contrast, lumbar spine, femoral neck and femur bone mineral density declined by 1.6, 1.4, and 1.2% in the control group" - Note: Red yeast rice is a non-prescription statin but you should still check with your physician.  See iHerb or Vitacost red yeast rice products.
• Boosting Bone Mineral Density Without Hormones - WebMD, 3/25/03 - "experts urge women who discontinued their hormones to get a bone mineral density test and discuss new treatments for osteoporosis with their doctor ... The statistics are staggering. One in two postmenopausal women has osteoporosis, 25% will sufferer a spine fracture, and 15% will sustain a hip fracture as a result ... Depending on the results of the test, your doctor can prescribe one of several drugs including Fosamax, Actonel, Evista, the nasal spray Miacalcin, and the newest drug on the block, Forteo, an injectable form of human parathyroid hormone"
• Growth Hormone Increase Bone Content In Osteoporotic Postmenopausal Women - Doctor's Guide, 3/12/03 - "80 osteoporotic postmenopausal women, aged between 50 and 70, who were using oestrogen therapy (HRT), were randomised to receive either recombinant human growth hormone (GH), 1.0 U or 2.5 U/day, subcutaneous, or placebo. Calcium (750 mg) and vitamin D (400 U) were given to all patients as well ... At 3 years, when GH was discontinued, total body and femoral neck bone mineral content had increased in both GH-treated groups, and differences were not significant ... At the fourth year of follow-up, total body boner mineral content had increased 5% and lumbar spine bone mineral content increased 14% among women who received GH 2.5 U, and compared with placebo. Femoral neck bone mineral density increased 5% and bone mineral content 13% for women taking GH 2.5 U compared with those taking GH 1.0 U"
• Parathyroid Hormone [hPTH] May Increase Vertebral Bone Strength In Some Postmenopausal Women - Doctor's Guide, 2/14/03
• PTHrP Leads To Significant Increase In Bone Mineral Density - Doctor's Guide, 2/5/03
• Long-Distance Runners Risk Bone Loss - WebMD, 1/27/03
• News - Inhaled Corticosteroids Do Not Affect Bone Density - Doctor's Guide, 1/24/03
• Daily Clodronate Prevents Early Postmenopausal Bone Loss - Doctor's Guide, 1/8/03
• Oral Contraceptive Use May Preserve Bone Density in Some Women - Doctor's Guide, 12/24/02
• Bone Loss Accelerated After Solo Estrogen Withdrawal For Some Postmenopausal Women - Doctor's Guide, 12/10/02 - "An acceleration of bone loss is seen after withdrawal of oestrogen therapy but not after withdrawal of alendronate alone or combination therapy with oestrogen"
• Several Bone Metabolism Factors Affect Hip Fracture Risk in Postmenopausal Women - Doctor's Guide, 12/5/02
• Micro-CT Scans Provide 3-D Proof of Estrogen's Bone Benefit - Medscape, 12/3/02 - "A three-dimensional glimpse of bone micro-architecture suggests that estrogen replacement is an effective treatment for osteoporosis because it "protects and retains bone structure, rather than laying down new bone,""
• Bone Loss in Men with Steroid Induced Osteoporosis May Be Due to Low Oesetradiol Levels - Doctor's Guide, 11/18/02
• Men With Hip Fracture Seldom Osteoporosis Therapy - Doctor's Guide, 11/13/02
• Light Exercise Won't Make Bones Strong - WebMD, 11/1/02 - "The fittest people were at just the same risk for brittle bones as those who gasped for breath after a short time on the treadmill"
• Osteoporosis Not Just for Women - WebMD, 10/28/02
• Fracture Treatment Differs - Intelihealth, 10/28/02 - "Thirty-two percent of the men died within a year of their fractures. Many deaths were likely from ailments linked to the weakened condition of being immobilized by the fractures, which may have been preventable with treatment for osteoporosis or underlying conditions that can cause it ... In men, low testosterone levels, alcoholism and excessive use of steroid medicines can cause low bone density and can often be treated"
• Hormone Therapy Plus Alendronate Better for Bone Density than Hormone Therapy Alone - Doctor's Guide, 10/8/02
• Testosterone supplementation provides additional BMD gains in hypogonadal men following cardiac transplantation - Doctor's Guide, 9/23/02 - "hypogonadal men who received additional testosterone supplementation showed the largest increases in BMD [bone mineral density]"
• Height Loss Good Index for Ruling Fracture Risk Out in General Practice Setting - Doctor's Guide, 9/23/02
• Secondary Causes of Osteoporosis Higher in Fracture Patients - Doctor's Guide, 9/23/02 - "The most common cause of secondary osteoporosis is corticosteroid excess, whereas others include malignancy, gastric surgery, alcoholism, and anticonvulsant therapy use. Prior studies have shown that as many as 30 percent of postmenopausal women exposed to corticosteroids demonstrate causes of secondary osteoporosis"
• Bisphosphonates Safe in Renally Impaired Osteoporosis Patients - Doctor's Guide, 9/23/02
• Osteoporosis Under-Recognized at Time of Admission to Nursing Home - Doctor's Guide, 9/23/02 - "New data confirm that few patients in nursing homes are on osteoporosis-related treatments despite the known high prevalence of osteoporosis in this population"
• Low Bone Mineral Density Common in Elderly Black Women - Doctor's Guide, 9/23/02 - "New findings document that 60 percent of elderly African-American women have a low bone mineral density (BMD)"
• Primary Care Residents Don't Screen for Osteoporosis - Doctor's Guide, 9/23/02 - "Primary care residents assess women who are at risk for postmenopausal osteoporosis at a rate far below that for other common health conditions ... She also pointed out that the results are regrettable since osteoporosis is a prevalent chronic health problem with associated morbidity and mortality outcomes on a par with other chronic illnesses such as hypertension, hypercholesterolemia, and diabetes. Also, the disease is preventable"
• Secondary Causes of Osteoporosis Higher in Fracture Patients - Doctor's Guide, 9/23/02 - "The most common cause of secondary osteoporosis is corticosteroid excess, whereas others include malignancy, gastric surgery, alcoholism, and anticonvulsant therapy use. Prior studies have shown that as many as 30 percent of postmenopausal women exposed to corticosteroids demonstrate causes of secondary osteoporosis"
• Low-Carbohydrate, High-Protein Diets Increase Risk Of Kidney Stones And May Raise Bone Loss Risk - Doctor's Guide, 8/1/02 - "acid excretion - a marker for the acid load in the blood - increased as much as 90 percent while subjects were on diets that severely restricted carbohydrates. Levels of urinary citrate, which inhibits kidney stones, fell by almost 25 percent in the group during the six-week study ... People may lose weight on this diet, but this study shows that this is not a healthy way to lose weight ... there was an increased risk of developing kidney stones and a possible increase in the risk of bone loss"
• Relation of Statin Use and Bone Loss: A Prospective Population-Based Cohort Study in Early Postmenopausal Women - Doctor's Guide, 7/15/02
• Osteoporosis in Elderly Men Underestimated - Doctor's Guide, 6/24/02 - "As many as 30 percent of men over 65 years old may have osteoporosis ... The serum thyroid-stimulating hormone (TSH), although normal, was slightly lower in men with osteoporosis, an average of 1.57+/-0.74 in comparison to an average of 2.34+/-1.93 in men with no osteoporosis ... Because both groups of men have low-normal 25-OH vitamin D, and low urinary calcium, the investigators suggest that patients in their situation, could benefit from enhancing their nutritional status"
• Epilepsy Drugs Are Risk Factors For Osteoporosis - Doctor's Guide, 6/20/02 - "Epilepsy and its therapies - older or modern - are both risk factors for low bone density, irrespective of vitamin D levels"
• Daily Oral Pamidronate Effective, Safe In Established Osteoporosis - Doctor's Guide, 6/17/02
• Triple Combination Incorporating Hormone Replacement May Protect Against Osteoporotic Fractures - Doctor's Guide, 6/7/02
• Irregular Periods In Young Women Could Be Warning Sign For Later Osteoporosis - Doctor's Guide, 5/29/02 - "Irregular menstrual periods in young women may be a warning sign of a hormonal shortage that could lead to osteoporosis"
• Effect of Lower Doses of Conjugated Equine Estrogens With and Without Medroxyprogesterone Acetate on Bone in Early Postmenopausal Women - JAMA. 2002 May 22-29;287(20):2668-76
• Vivelle-Dot (Estradiol Transdermal System) Now Approved In New, Low Dose For Postmenopausal Osteoporosis Prevention - Doctor's Guide, 5/21/02 - "Vivelle-Dot is now approved in the 0.025 mg/day dosage strength, providing among the lowest effective ERT dosage strengths available in the U.S. for the prevention of postmenopausal osteoporosis"
• Nandrolone Decanoate Increases Bone Mineral Density in Elderly Patients with Osteoporosis - Doctor's Guide, 5/15/02
• Strontium Ranelate Reduces Vertebral Fracture Risk in Postmenopausal Osteoporosis - Doctor's Guide, 5/15/02
• Teriparatide (Parathyroid Hormone) Increases Vertebral Bone Mineral Density in Men Irrespective of Osteoporosis Secondary Cause Factors - Doctor's Guide, 5/15/02
• Strontium Ranelate Reduces Vertebral Fracture Risk in Postmenopausal Osteoporosis - Doctor's Guide, 5/14/02
• Intermittent Oral Ibandronate Reduces Fracture Risk in Postmenopausal Women - Doctor's Guide, 5/14/02
• Reduction in Bone Turnover Markers Convenient, Practical Way to Monitor Osteoporosis Therapy - Doctor's Guide, 5/14/02
• FDA Approves New Indication, Strength of Alora (Estradiol Transdermal System) for Prevention of Postmenopausal Osteoporosis - Doctor's Guide, 4/9/02 - "These approvals add a new indication, prevention of postmenopausal osteoporosis, and a new strength, 0.025mg/day, to the Alora label"
• Protein [Runx or core binding factor A] May Help Bone Growth - Intelihealth, 4/8/02
• Investigation Of Bone Loss After Discontinuation Of Hormone Replacement - Doctor's Guide, 4/5/02
• Bone Mass Response to Discontinuation of Long-term Hormone Replacement Therapy: Results From the Postmenopausal Estrogen/Progestin Interventions (PEPI) Safety Follow-up Study - Arch Intern Med. 2002 Mar 25;162(6):665-72 - "Rates of BMD loss among women who stopped HRT during or after the PEPI-RCT [Postmenopausal Estrogen/Progestin Interventions randomized controlled trial] did not differ significantly from those of women who did not undergo HRT, who lost bone at a rate of approximately 1% yearly during the first year of the PEPI-RCT and about half that rate afterward. Women who continued HRT after the PEPI-RCT did not show additional BMD gains"
• Bone Loss Resumes at Normal Rate When Hormone Replacement Therapy is Stopped - Doctor's Guide, 3/25/02
• Risk of Fracture Reduced in Women Using Statins - Doctor's Guide, 3/19/02 - "Fracture risk is reduced by 60 percent in women using 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) ... This substantial risk reduction is greater than might be anticipated from increases in bone mineral density (BMD) alone"
• Estradiol Via Matrix Patch Reverses Bone Loss - Doctor's Guide, 3/12/02 - "Transdermal estradiol delivered by matrix patch reversed bone loss in hysterectomized, post-menopausal women and produced few side effects"
• Statin Use, Bone Mineral Density, and Fracture Risk: Geelong Osteoporosis Study - Arch Intern Med. 2002 Mar 11;162(5):537-40 - "The substantial 60% reduction in fracture risk associated with statin use is greater than would be expected from increases in BMD alone"

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