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Recent Longevity News for the seven days ending 10/27/10.  You should consult your doctor if you are taking any medications.

High resting heart linked to shorter life expectancy in stable heart disease patients, study suggests - Science Daily, 10/26/10 - "Compared to heart disease patients with the lowest heart rate (58 beats per minute or less), those who had heart rates greater than 78 had a 39 per cent increased risk of suffering a major vascular event, a 77 per cent increased risk of cardiovascular disease death, and a 65 per cent increased risk of all-cause deaths"

Consuming polyunsaturated fatty acids may lower the incidence of gum disease - Science Daily, 10/26/10 - "There was an approximately 20% reduction in periodontitis prevalence in those subjects who consumed the highest amount of dietary DHA. The reduction correlated with EPA was smaller, while the correlation to LNA was not statistically significant" - See Jarrow Max DHA at Amazon.com.

Active ingredient levels vary among red yeast rice supplements - Science Daily, 10/25/10 - "Across the 12 products, levels of total monacolins ranged from 0.31 milligrams to 11.15 milligrams per capsule and levels of monacolin K or lovastatin ranged from 0.10 milligrams to 10.09 milligrams per capsule. Four of the formulations had elevated levels of citrinin"

Improved outcomes for HPV-positive head and neck cancer with cetuximab and IMRT, study suggests - Science Daily, 10/25/10 - "Two year progression free survival rates were 60 percent for those with HPV compared to 23 percent for those with HPV negative tumors (p=0.05)"

Vitamin E in front line of prostate cancer fight - Science Daily, 10/23/10 - "the research team have discovered a particular form of T3, called gamma-tocotrienol (γ-T3), can successfully kill off the prostate cancer CSCs ... Other research has found γ-T3 is also effective in suppressing other types of cancer, including breast, colon, liver and gastric ... not all vitamin E preparations had the active constituent" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Diabetes may affect as many as 1 in 3 Americans by 2050 - USA Today, 10/21/10 - "one in 10 U.S. adults have diabetes now. The prevalence is expected to rise sharply over the next 40 years with as many as one in three having the disease, primarily type 2 diabetes, according to the report" - Note:  I believe that's the main reason life expectancy in the U.S. isn't that impressive.  Americans do not get enough exercise and they overeat. The portion size at restaurants is three times that of some countries I've been to.  Exercise also slows the rate of loss of telomere shortening.  Longer telomeres is associated with longevity.  Even if it's not full blown diabetes, even insulin resistance is associated will multiple problems of aging and cancer.  See my Insulin and Aging page.

Vitamin D Deficiency Associated With Diabetic Retinopathy - Medscape, 10/22/10 - "People with diabetes had significantly lower mean 25-hydroxyvitamin D levels than people without diabetes (22.9 vs 30.3 ng/mL; P < .001), according to the poster. People with no eye disease had the highest serum vitamin D levels (mean, 31.9 ng/mL), and those with proliferative retinopathy had the lowest levels (mean, 21.1 ng/mL) ... People who took a daily multivitamin that included vitamin D (n = 102) had a mean serum vitamin D level of 31.1 ng/mL; those who did not take a multivitamin (n = 119) had vitamin D levels averaging only 22.0 ng/mL (P < .001), according to the poster. Dr. Payne noted that even those who took daily multivitamins had a 44% incidence of vitamin D insufficiency" - See vitamin D at Amazon.com.

Cholesterol-lowering drug shrinks enlarged prostates in hamster model - Science Daily, 10/21/10 - "Ezetimibe reduced prostatic enlargement in aged hamsters as effectively as finasteride and combining the two drugs worked better than either one alone ... finasteride caused atrophy of the hamster prostate while ezetimibe did not"

Olive oil compounds may boost cardiac fat oxidation: Study - Nutra USA, 10/21/10 - "Obese rats supplemented with olive oil, oleuropein, and cafeic acid had higher oxygen consumption, increased fat-oxidation, and lower carbon dioxide production than non supplemented obese rats" - [Abstract] - See olive leaf extract at Amazon.com.

Professional athletes should drink more water, Spanish research finds - Science Daily, 10/21/10 - "91% of professional basketball, volleyball, handball and football players are dehydrated when they begin their training sessions"

HPV Oral Cancers on Rise as Oral Sex Becomes More Popular, May Spread Human Papilloma Virus - ABC News, 10/20/10 - "Cure rates are higher than for smoking-related throat cancers, but still only 50 percent" - The video claims that they can't rule out the the virus can be transmitted via sharing a spoon or a drink.  They claim that if it spreads to the lymph nodes, your chances are 25%.  See Cancerous Growths: Mouth Growths - "if the cancer has spread to lymph nodes, the 5-year survival rate is only 25%"

Eating mostly whole grains, few refined grains linked to lower body fat - Science Daily, 10/20/10 - "People who consume several servings of whole grains per day while limiting daily intake of refined grains appear to have less of a type of fat tissue thought to play a key role in triggering cardiovascular disease and type 2 diabetes ... Visceral Adipose Tissue ... VAT volume was approximately 10 % lower in adults who reported eating three or more daily servings of whole grains and who limited their intake of refined grains to less than one serving per day ... Visceral fat surrounds the intra-abdominal organs while subcutaneous fat is found just beneath the skin ... visceral fat is more closely tied to the development of metabolic syndrome ... participants who consumed, on average, three daily servings of whole grains but continued to eat many refined grains did not demonstrate lower VAT volume"

Burn injuries rapidly deplete vitamin E, study finds - Science Daily, 10/20/10 - "An analysis of eight children with third-degree burns over much of their body found they lost almost half of their stored vitamin E in three weeks, even though they were being given about 150 percent of the recommended daily allowance of vitamin E and other nutrients in a high-calorie diet ... "the depletion of vitamin E may be a very significant problem in patients with burn injury" and other forms of severe trauma"

Low testosterone linked to heightened risk of early death - Science Daily, 10/19/10 - "tracked for around 7 years ... One in four of the men was classified as having low testosterone, using measurements of either bioavailable testosterone (bio-T) -- available for tissues to use -- of under 2.6 mmol/l or total testosterone (TT) of under 8.1 mmol/l ... During the monitoring period almost twice as many men with low testosterone died as did those with normal levels"

Genetic predisposition to certain skin cancers may be associated with vitamin D deficiency - Science Daily, 10/18/10 - "Patients with basal cell nevus syndrome, which predisposes them to develop non-melanoma skin cancers, appear to be at increased risk for vitamin D deficiency if they take steps to protect themselves from sunlight ... When compared with the general population, patients with basal cell nevus syndrome had lower average vitamin D levels and were three times more likely to be deficient" - See vitamin D at Amazon.com.

High-Protein Diet Limits Bone Resorption - Doctor's Guide, 10/19/10 - "The clinical takeaway message is that if you are a postmenopausal woman and dieting, if you can take 24% of your total calories as protein, and have adequate calcium and vitamin D, you can prevent the bone loss that is typically associated with weight loss"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

High-cocoa polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients - Diabet Med. 2010 Nov;27(11):1318-21 - "Subjects were randomized to 45 g chocolate with or without a high polyphenol content for 8 weeks and then crossed over after a 4-week washout period ... HDL cholesterol increased significantly with high polyphenol chocolate (1.16 +/- 0.08 vs. 1.26 +/- 0.08 mmol/l, P = 0.05) with a decrease in the total cholesterol: HDL ratio (4.4 +/- 0.4 vs. 4.1 +/- 0.4 mmol/l, P = 0.04). No changes were seen with the low polyphenol chocolate in any parameters. Over the course of 16 weeks of daily chocolate consumption neither weight nor glycaemic control altered from baseline" - The Lindt - Excellence 90% Cocoa Bar are 3.5 ounces or 99 grams or about 90 grams of chocolate.  So 45 grams would be half a bar per day.

Coffee consumption but not green tea consumption is associated with adiponectin levels in Japanese males - Eur J Nutr. 2010 Oct 16 - "We not only revealed that habitual coffee consumption is associated with higher adiponectin levels in Japanese males but also found a dose-dependent association between coffee consumption and adiponectin levels. Therefore, our study suggested that coffee components might play an important role in the elevation of adiponectin level" - See my adiponectin page.  A higher adiponectin is a good thing.

Metabolic syndrome in 25% of older people with intellectual disability - Fam Pract. 2010 Oct 11 - "intellectual disabilities (IDs) ... The prevalence of the metabolic syndrome in the population with ID is significantly higher than that in the general Dutch population aged ≥50 years"

Effects of olive oil and its minor phenolic constituents on obesity-induced cardiac metabolic changes Nutr J. 2010 Oct 19;9(1):46 - "The present study demonstrated for the first time that olive-oil, oleuropein and cafeic-acid enhanced fat-oxidation and optimized cardiac energy metabolism in obesity conditions. Olive oil and its phenolic compounds improved myocardial oxidative stress in standard-fed conditions" - See olive leaf extract at Amazon.com.

Vitamin D deficiency prevalence and cardiovascular risk in Israel - Eur J Clin Invest. 2010 Oct 18 - "The prevalence of vitamin D deficiency or insufficiency (vitamin D levels <30 ng mL(-1) ) for the entire study population was surprisingly high for men and women (79.2% and 77.5%, respectively) ... Vitamin D deficiency is associated with CVD and other risk factors in this Israeli study population. The prevalence of the deficiency in Israel is similar to the prevalence found in less sunny regions" - See vitamin D at Amazon.com.

Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study - Neurology. 2010 Oct 19;75(16):1408-14 - "homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12 ... The odds ratios (ORs) (95% confidence interval [CI]) for AD were 1.16 (1.04-1.31) per increase of 1 μmol/L of tHcy at baseline and 0.980 (0.965-0.995) for each increase of 1 pmol/L baseline holoTC ... This study suggests that both tHcy and holoTC may be involved in the development of AD. The tHcy-AD link may be partly explained by serum holoTC. The role of holoTC in AD should be further investigated"

Acetaminophen Increases Blood Pressure in Patients With Coronary Artery Disease - Circulation. 2010 Oct 18 - "Treatment with acetaminophen resulted in a significant increase in mean systolic (from 122.4+/-11.9 to 125.3+/-12.0 mm Hg P=0.02 versus placebo) and diastolic (from 73.2+/-6.9 to 75.4+/-7.9 mm Hg P=0.02 versus placebo) ambulatory blood pressures. On the other hand, heart rate, endothelial function, early endothelial progenitor cells, and platelet function did not change"

Association between red meat consumption and metabolic syndrome in a Mediterranean population at high cardiovascular risk: Cross-sectional and 1-year follow-up assessment - Nutr Metab Cardiovasc Dis. 2010 Sep 26 - "Subjects in the upper quartile of RM consumption were more likely to meet the criteria for the MetS at baseline (OR, 2.3; 95% CI, 1.4-3.9; P-trend = 0.001) and after 1-year follow-up (OR, 2.2; 95% CI, 1.3-3.7; P-trend = 0.034) compared with those in the quartile of reference, even after adjusting for potential confounders. The longitudinal analyses showed that individuals in the fourth quartile of RM consumption had an increased risk of MetS (OR, 2.7; 95% CI, 1.1-6.8; P-trend = 0.009) or central obesity incidence (OR, 8.1; 95% CI, 1.4-46.0; P-trend = 0.077) at the end of the follow-up compared to the lowest quartile"

Racial disparity in death from colorectal cancer: does vitamin D deficiency contribute? - Cancer. 2010 Oct 13 - "vitamin D deficiency was associated significantly with CRC mortality (HR, 2.11; 95% CI, 1.11-4.00), and the effect of race was decreased (HR, 1.60" - See vitamin D at Amazon.com.

AMACR polymorphisms, dietary intake of red meat and dairy and prostate cancer risk - Prostate. 2010 Oct 13 - "Red meat consumption was positively associated with PCa risk, and the association was stronger for more aggressive disease (lowest vs. highest tertile OR = 1.55"

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