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Recent Longevity News for the seven days ending 10/6/10.  You should consult your doctor if you are taking any medications.

Low testosterone linked to Alzheimer's disease - Science Daily, 10/5/10 - "Low levels of the male sex hormone, testosterone, in older men is associated with the onset of Alzheimer's disease"

Amino acid supplement makes mice live longer - Science Daily, 10/5/10 - "leucine, isoleucine, and valine extend the life span of single-celled yeast ... Animals that were given the extra amino acids over a period of months lived longer, with a median life span of 869 days compared to 774 days for untreated control animals, the researchers report. That's an increase of 12 percent ... The findings in older mice suggest that the supplementary mixture may be specifically beneficial for those who are elderly or ill" - See Now Foods, Branched Chain Amino Acids, 240 Capsules at iHerb, it contains the three of these.

Sleep loss limits fat loss - Science Daily, 10/4/10 - "When dieters got adequate sleep, however, more than half of the weight they lost was fat. When they cut back on their sleep, only one-fourth of their weight loss came from fat"

Here's a fun way to get more exercise.  See YouTube - West Coast Swing Flash Mob 2010—Houston, TX—1080p HD!.  The choreography for it is at YouTube - Choreography.  It might look complicated at first but it’s only eight West Coast Swing moves totally about 50 seconds then it repeats itself. You could teach a monkey to do something in sequence for 50 seconds. Two of the eight moves are the underhand turn and the whip, both basic West Coast Swing maneuvers so you only need to learn the other six.  The music for it is called "DJ Got Us Falling In Love".  See #6 at http://ax.itunes.apple.com/us/album/uk-chart-hits-volume-eight/id393505575#ls=1.  I you download the videos, I made a DVD label.  Click here.

Garlic oil may reverse diabetes linked heart disease - Nutra USA, 9/30/10 - "garlic oil supplementation for diabetic rats leads to several alterations at multiple levels in hearts including cardiac contractile functions and structures, myosin chain gene expressions, oxidative stress, and apoptosis and related signaling activities" - [Abstract] - See garlic oil products at iHerb.

Women's study finds longevity means getting just enough sleep - Science Daily, 9/30/10 - "the secret to a long life may come with just enough sleep. Less than five hours a night is probably not enough; eight hours is probably too much ... sleeping 6.5 to 7.5 hours per night was associated with best survival ... when sleep was measured objectively, the best survival was observed among women who slept 5 to 6.5 hours ... Women who slept less than five hours a night or more than 6.5 hours were less likely to be alive at the 14-year follow-up"

Vitamin D Treatment for the Prevention of Falls in Older Adults - Medscape, 9/30/10 - "In summary, vitamin D supplementation is an effective strategy for reducing falls in older adults and should probably be incorporated into the clinical practice of providers caring for older adults, especially those at risk for falling. Although the effect appears to be modest, possibly because of inadequate dosing, vitamin D is inexpensive and well tolerated; a slight reduction in falls with vitamin D supplementation might lead to a significant decrease in the costs associated with fall morbidity and mortality" - See vitamin D at Amazon.com.

Garlic oil shows protective effect against heart disease in diabetes - Science Daily, 9/29/10 - "Garlic has "significant" potential for preventing cardiomyopathy, a form of heart disease that is a leading cause of death in people with diabetes ... people with diabetes have at least twice the risk of death from heart disease as others ... The scientists fed either garlic oil or corn oil to laboratory rats with diabetes. Animals given garlic oil experienced beneficial changes associated with protection against heart damage" - See garlic supplements at Amazon.com.

Blueberries help fight artery hardening, lab animal study indicates - Science Daily, 9/29/10 - "Atherosclerosis is the leading cause of two forms of cardiovascular disease--heart attacks and strokes. Cardiovascular disease is the number one killer of Americans ... Lesion size, measured at two sites on aorta (arteries leading from the heart), was 39 and 58 percent less than that of lesions in mice whose diet did not contain blueberry powder ... The blueberry-spiked diet contained 1 percent blueberry powder, the equivalent of about a half-cup of fresh blueberries" - See blueberry extract at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Oral iron supplementation leads to oxidative imbalance in anemic women: A prospective study - Clin Nutr. 2010 Sep 29 - "the glutathione peroxidase (GSH-Px) and antioxidant vitamins A, C and E were found significantly decreased ... Study found recommended dose of iron effective for improving Hb, but at the cost of increased oxidative stress (mild > moderate > severe). It is suggested that blind iron supplementation should be avoided and shall be provided on need basis"

Once-Daily Extended-Release Niacin Lowers Serum Phosphorus Concentrations in Patients With Metabolic Syndrome Dyslipidemia - Am J Kidney Dis. 2010 Sep 29 - Note:  It doesn't have the abstract, just the title but it's something I didn't know.  Most people get too much phosphorus.

Subclinical Zinc Deficiency in Alzheimer's Disease and Parkinson's Disease - Am J Alzheimers Dis Other Demen. 2010 Sep 14 - "Results showed a significantly lower blood zinc in patients with Alzheimer's and patients with Parkinson's than in controls. Urine zinc excretion, normalized to urine creatinine excretion, was not significantly different in either patient group compared to controls. These patients are probably zinc deficient because of nutritional inadequacy" - Note:  Zinc interferes with copper and too much zinc can cause a deficiency of copper.  See Jarrow Zinc Balance at Amazon.com.

Association of facial skin aging and vitamin D levels in middle-aged white women - Cancer Causes Control. 2010 Sep 30 - "Adjusting for age and season of blood collection, women with lower photodamage scores were associated with a 5-fold increased odds of being vitamin D insufficient (OR 5.0, 95% CI: 1.1, 23). Low scores for specific photodamage parameters including erythema/telangiectasias, hyperpigmentation, and wrinkling were also significantly associated with vitamin D insufficiency. Our results suggest an association between skin aging and 25(OH)D levels" - See vitamin D at Amazon.com.

Dietary protein and risk of ischemic heart disease in middle-aged men - Am J Clin Nutr. 2010 Sep 29 - "The RR of IHD was 1.08 (95% CI: 0.95, 1.23; P for trend = 0.30) comparing the top with the bottom quintile of percentage of energy from total protein. RRs for animal and vegetable protein were 1.11 (95% CI: 0.97, 1.28; P for trend = 0.18) and 0.93 (95% CI: 0.78, 1.12; P for trend = 0.49), respectively. When the population was restricted to "healthy" men (those free of hypertension, hypercholesterolemia, and diabetes at baseline), the RR of IHD was 1.21 (95% CI: 1.01, 1.44; P for trend = 0.02) for total protein, 1.25 (95% CI: 1.04, 1.51; P for trend = 0.02) for animal protein, and 0.93 (95% CI: 0.72, 1.19; P for trend = 0.65) for vegetable protein ... We observed no association between dietary protein and risk of total IHD in this group of men aged 40-75 y. However, higher intake of animal protein may be associated with an increased risk of IHD in "healthy" men"

Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer improves long-term survival - Am J Clin Nutr. 2010 Sep 29 - "Plasma arginine concentrations are lower in patients with cancer, which indicates that arginine metabolism may be disturbed in these patients. Arginine supplementation has been associated with positive effects on antitumor mechanisms and has been shown to reduce tumor growth and to prolong survival. Furthermore, the prognosis of patients with head and neck cancer remains disappointing. Insufficient intake frequently leads to malnutrition, which contributes to high morbidity and mortality rates ... The group receiving arginine-enriched nutrition had a significantly better overall survival (P = 0.019) and better disease-specific survival (P = 0.022). Furthermore, the arginine-supplemented group had a significantly better locoregional recurrence-free survival (P = 0.027). No significant difference in the occurrence of distant metastases or occurrence of a second primary tumor was observed between the groups" - See L-arginine products at Amazon.com.  Maybe that's what saved me, I've been taking that Jarrow brand for ages.  Someone needs to tell Michael Douglas.

Whole- and refined-grain intakes are differentially associated with abdominal visceral and subcutaneous adiposity in healthy adults: the Framingham Heart Study - Am J Clin Nutr. 2010 Sep 29 - "visceral adipose tissue (VAT) ... Increasing whole-grain intake is associated with lower VAT in adults, whereas higher intakes of refined grains are associated with higher VAT" - See brown rice pasta at Amazon.com.

Coffee and acute ischemic stroke onset: The Stroke Onset Study - Neurology. 2010 Sep 29 - "The relative risk (RR) of stroke in the hour after consuming coffee was 2.0 (95% confidence interval [CI], 1.4-2.8; p < 0.001). There was no apparent increase in risk in the hour following consumption of caffeinated tea (RR = 0.9, 95% CI 0.4-2.0; p = 0.85) or cola (RR = 1.0, 95% CI 0.4-2.4; p = 0.95). The association between ischemic stroke in the hour after coffee consumption was only apparent among those consuming ≤1 cup per day but not for patients who consumed coffee more regularly (p for trend = 0.002) ... Coffee consumption transiently increases the risk of ischemic stroke onset, particularly among infrequent drinkers"

Association of Japanese dietary pattern with serum adiponectin concentration in Japanese adult men - Nutr Metab Cardiovasc Dis. 2010 Sep 27 - "Although previous studies suggest that the traditional Japanese dietary pattern is independently associated with a low cardiovascular disease mortality risk, the mechanisms mediating or linking this association are not well understood. Adiponectin has emerged as a valuable biomarker for cardiovascular diseases ... Greater adherence to the "Japanese" dietary pattern was independently associated to a higher serum adiponectin concentration in Japanese adult men. This finding supports the hypothesis that the traditional Japanese diet may have a potentially beneficial effect on adiponectin concentrations"

Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells - Nutr Metab Cardiovasc Dis. 2010 Sep 27 - "Chronic inflammation plays pivotal roles in both cancer and cardiovascular diseases. A large body of evidence suggests that high intake of cruciferous vegetables is closely related with low risk of these disorders ... Taken all together, adhesion molecules are confirmed to be the novel targets of sulphoraphane in preventing inflammatory insult to endothelial cells. Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-кB translocation and the subsequent expression of adhesion molecules. These data suggested a novel inflammatory pathway mediated by sulphoraphane" - See sulforaphane at Amazon.com.

Cardiac Contractile Dysfunction and Apoptosis in Streptozotocin-Induced Diabetic Rats Are Ameliorated by Garlic Oil Supplementation - J Agric Food Chem. 2010 Sep 13 - "these diabetes-related cardiac dysfunctions were almost dose-dependently ameliorated by garlic oil administration. In conclusion, garlic oil possesses significant potential for protecting hearts from diabetes-induced cardiomyopathy" - See garlic oil products at iHerb.

Association between red meat consumption and metabolic syndrome in a Mediterranean population at high cardiovascular risk: Cross-sectional and 1-year follow-up assessment - Nutr Metab Cardiovasc Dis. 2010 Sep 26 - "Subjects in the upper quartile of RM consumption were more likely to meet the criteria for the MetS at baseline (OR, 2.3; 95% CI, 1.4-3.9; P-trend = 0.001) and after 1-year follow-up (OR, 2.2; 95% CI, 1.3-3.7; P-trend = 0.034) compared with those in the quartile of reference, even after adjusting for potential confounders. The longitudinal analyses showed that individuals in the fourth quartile of RM consumption had an increased risk of MetS (OR, 2.7; 95% CI, 1.1-6.8; P-trend = 0.009) or central obesity incidence (OR, 8.1; 95% CI, 1.4-46.0; P-trend = 0.077) at the end of the follow-up compared to the lowest quartile"

Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: A prospective cohort study - Int J Cancer. 2010 Sep 28 - "We found no association of breast cancer risk to dietary intake of linoleic acid, arachidonic acid, α-linolenic acid, or marine-derived n-3 PUFA. We found a statistically significant interaction between n-6 PUFA intake, marine-derived n-3 PUFA intake and breast cancer risk (p = 0.008). Women with lower intake (the lowest tertile) of marine-derived n-3 PUFA and higher intake (the highest tertile) of n-6 PUFA had an increase risk for breast cancer (RR=2.06; 95% CI=1.27-3.34) compared to women with higher intake (the highest tertile) of marine-derived n-3 PUFAs and lower intake (the lowest tertile) of n-6 PUFAs after adjusting for potential confounders. The relative amounts of n-6 PUFA to marine-derived n-3 PUFAs may be more important for breast cancer risk than individual dietary amounts of these fatty acids" -  See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.  Here's a breakdown of the fats:

LA - Linoleic Acid ALA or LNA - Alpha linolenic acid Oleic acid
GLA - Gamma linolenic acid EPA - Eicosapentaenoic acid
DGLA - Dihomo gamma-linolenic Acid DHA - Docosahexaenoic acid  
AA - Arachidonic Acid DPA (omega 3) - Docosapentaenoic acid
DTA - Docosatetraenoic acid    
DPA -  (omega 6) Docosapentaenoic

Prospective randomized comparison between omega-3 fatty acid supplements plus simvastatin versus simvastatin alone in Korean patients with mixed dyslipidemia: lipoprotein profiles and heart rate variability - Eur J Clin Nutr. 2010 Sep 29 - "After 6 weeks of drug treatment, triglyceride levels decreased by 41.0% in the combination treatment group and 13.9% in the simvastatin monotherapy group (from 309.2+/-95 mg per 100 ml to 177.7+/-66 versus 294.6+/-78 mg per 100 ml to 238.3+/-84 mg per 100 ml, respectively" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems - an observational cohort study - Lipids Health Dis. 2010 Sep 24;9(1):105 - "After 12 weeks of consumption of a combination of omega-3 and omega-6 fatty acids as well as magnesium and zinc most subjects showed a considerable reduction in symptoms of attention deficit and hyperactivity/impulsivity assessed by SNAP-IV. Further, the assessment by SDQ revealed fewer emotional problems at the end of the study period compared to baseline and also sleeping disorders. Mainly problems to fall asleep, decreased during the 12 week nutritional therapy" - Note:  If it were me I'd skip the omega-6.  Most people get way too much as it is.  While I was posting this on my ADHD page, I noticed that this was the previous post:

Health Focus (St. John's wort):

Related Topics:

Specific Recommendations:

Ze 117 Extract (Not available in the US, Remotiv brand in Germany):

LI 160 Extract (Kira® Brand LI-160 extract in the US, Jarsin 300 brand in Germany):

WS 5572 Extract (Perika Brand in US, Neuroplant 300 brand in Germany):

WS 5570 Extract (contains at least 4% hyperforin but I don't believe it's available)/(Perika Brand  in US, Neuroplant 300 brand in Germany):

STW3-VI Extract:

Other News:

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