Recent Longevity News for the seven days ending 9/15/10.  You should consult your doctor if you are taking any medications.

Science strengthens for olive extract’s bone benefits - Nutra USA, 9/14/10 - “Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis" - [Abstract] - See olive leaf extract at Amazon.com.

Blueberries show anti-diabetic potential: Study - Science Daily, 9/13/10 - "Obese, non-diabetic, and insulin-resistant participants who consumed a blueberry smoothie daily for six weeks experienced a 22 percent change in insulin sensitivity, compared to only 4.9 percent in the placebo group ... The United States Highbush Blueberry Council (USHBC) prepared the freeze-dried whole blueberry powder used in this study" - [Abstract] (the full abstract was already in a previous newsletter) - See blueberry extract at Amazon.com.

Early prostate cancer detection, screening: No benefit for men with low baseline PSA value, study finds - Science Daily, 9/13/10 - "The greatest benefits of early detection programs may be when men, aged 55-74 years, are diagnosed and treated when their serum PSA is in the range 4.0-9.9 ng/ml or 10.0-19.9 ng/ml. Furthermore, following research efforts that recommend more intensive PSA based screening by lowering the PSA cut-off may greatly increase the number of men that need additional investigations and treatment, whilst having little effect on the reduction of prostate cancer mortality"

Consumption of 'good salt' can reduce population blood pressure levels, research finds - Science Daily, 9/13/10 - "the average potassium intake in 21 countries including the US, China, New Zealand, Germany and the Netherlands varies between 1.7 and 3.7 g a day. This is considerably lower than the 4.7 g a day, which has been recommended based on the positive health effects observed at this level of intake ... A hypothetical increase in the potassium intake to the recommended level would reduce the systolic blood pressure in the populations of these countries by between 1.7 and 3.2 mm Hg ... Earlier studies have shown that salt reduction of 3 g per day in food could reduce blood pressure and prevent 2500 deaths per year due to cardiovascular diseases in the Netherlands. In Western countries, salt consumption can be as high as 9-12 g a day whereas 5 g is the recommended amount according to WHO standards"

Chemicals in indoor swimming pools may increase cancer risk - Science Daily, 9/13/10 - "Swimming in indoor chlorinated pools may induce genotoxicity (DNA damage that may lead to cancer) as well as respiratory effects, but the positive health effects of swimming can be maintained by reducing pool levels of the chemicals behind these potential health risks"

B vitamins slow brain atrophy in people with memory problems - Science Daily, 9/12/10 - "on average the brains of those taking the folic acid, vitamin B6 and B12 treatment shrank at a rate of 0.76% a year, while those in the placebo group had a mean brain shrinkage rate of 1.08%. People with the highest levels of homocysteine benefited most, showing atrophy rates on treatment that were half of those on placebo"

Vitamin B is revolutionary new weapon against Alzheimer's Disease - telegraph.co.uk, 9/9/10 - "Mild Cognitive Impairment (MCI) – a kind of memory loss and forgetfulness – and Alzheimer's ... On average, taking B vitamins slowed the rate of brain atrophy by 30 per cent, and in many cases reductions was as high as 53 per cent were seen"

Omega-3, vitamins C and E may boost pancreatic health - Nutra USA, 9/9/10 - "consuming at least 850 milligrams of omega-3 fatty acids per day was associated with a 53 percent reduction in the risk of pancreatic cancer, compared to intakes of between 330 and 580 milligrams per day ... According to findings published in the International Journal of Cancer, benefits were also observed for intakes of vitamin C and E, the highest average intakes associated with 31 and 33 percent reductions, respectively, compared with the lowest average intakes" - [Abstract] - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com and Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

High stress hormone levels linked to increased cardiovascular mortality - Science Daily, 9/9/10 - "urinary cortisol did not increase the risk of non-cardiovascular mortality but did increase cardiovascular mortality risk. The third of the subjects with the highest urinary cortisol had a five-fold increased risk of dying of cardiovascular disease"

Use of medication for insomnia or anxiety may increase mortality risk, study suggests - Science Daily, 9/9/10 - "results through analysis of 12 years of data on over 14,000 Canadians ... A number of hypotheses have been put forward to explain the link between use of these medications and increased mortality. Sleeping pills and anxiolytics affect reaction time, alertness, and coordination and are thus conducive to falls and other accidents. They may also have an inhibiting effect on the respiratory system, which could aggravate certain breathing problems during sleep. These medications are also central nervous system inhibitors that may affect judgment and thus increase the risk of suicide"

Massachusetts health reform fails the disadvantaged, study finds - Science Daily, 9/9/10 - "it has not increased people's access to a personal physician or improved their self-rated health. Neither has it reduced healthcare inequalities between ethnic or income groups ... The research by Jane Zhu from Harvard Medical School and team ... study is published online in the Journal of General Internal Medicine ... In 2006, Massachusetts passed comprehensive health reform legislation to expand health coverage to all its residents and has achieved near-universal coverage ... Although there were improvements in both coverage and cost barriers in Massachusetts for some disadvantaged groups compared to trends in New England, overall this did not reduce healthcare inequalities between ethnic or socioeconomic groups, largely because of comparable or larger improvements among whites and those on higher incomes"

NSAID use associated with future stroke in healthy population - theheart.org, 9/8/10 - "NSAID use was associated with an increased risk of stroke. This increased risk ranged from about 30% with ibuprofen and naproxen to 86% with diclofenac ... there was also a dose-relationship found, with the increased risk of stroke reaching 90% (HR 1.90) with doses of ibuprofen over 200 mg and 100% (HR 2.0) with diclofenac doses over 100 mg. He pointed out that the results were particularly striking, given that this study was conducted in healthy individuals"

Can a new supplement boost immunity, slow aging? - USA Today, 9/8/10 - "The research, published in the scientific journal Rejuvenation Research, reports on a year-long study on a dietary supplement called Telomerase Activator TA-65, which researchers believe may help reverse the aging process by lengthening telomeres — the caps on the ends of chromosomes that keep DNA intact as cells divide. Shortened telomeres are linked with aging and a lowered immune response"

• Patton Protocol - tasciences.com - "Version 1: “A La Carte” Options for products and bloodwork ... 1.6 months supply of TA-65, product only: $4,000 ... initial tests cost $2,890 ... If you choose to begin the full Patton Protocol, it consists of 6 month segments. Each segment costs $6,225"

Animal-Based Low-Carbohydrate Diet Linked to Higher All-Cause Mortality - Medscape, 9/7/10 - "In a pooled analysis comparing the lowest vs the highest deciles, overall low-carbohydrate score was associated with a slight increase in overall mortality rates (hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.01 - 1.24; P for trend = .136). Higher animal-based low-carbohydrate score was associated with higher all-cause mortality rates (pooled HR, 1.23; 95% CI, 1.11 - 1.37; P for trend = .051), cardiovascular deaths (HR, 1.14; 95% CI, 1.01 - 1.29; P for trend = .029), and cancer-related deaths (corresponding HR, 1.28; 95% CI, 1.02 - 1.60; P for trend = .089) ... In contrast, higher vegetable-based low-carbohydrate score was linked to reduced all-cause mortality rates (HR, 0.80; 95% CI, 0.75 - 0.85; P for trend ≤ .001) and cardiovascular deaths (HR, 0.77; 95% CI, 0.68 - 0.87; P for trend < .001)"

Regular statin use is associated with a reduced risk of developing rheumatoid arthritis - Science Daily, 9/7/10 - "After adjusting for other possible confounders, patients who persistently took statins had a lower risk (risk ratio of 0.58) of developing rheumatoid arthritis compared with patients who did not persistently take statins. There was only a small short term decrease in risk ratio in patients taking statins and the development of osteoarthritis. (hazard ratio of 0.85)"

Chronic drinking increases levels of stress hormones, leading to neurotoxicity - Science Daily, 9/7/10 - "Both drinking and withdrawal from chronic drinking can raise circulating glucocorticoid levels, known as cortisol in humans and corticosterone in rodents. Prolonged and high concentrations of glucocorticoids can have damaging effects on neuronal function and cognition"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Hypoadiponectinemia is strongly associated with metabolic syndrome in korean type 2 diabetes patients - J Am Coll Nutr. 2010 Jun;29(3):171-8 - "Our findings show that hypoadiponectinemia is strongly associated with MetS in type 2 DM patients. Dietary intake may be indirectly associated with adiponectin levels through factors such as BMI, waist circumference, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, HDL-cholesterol, and blood pressure. Therefore, our results suggest that manipulation of the level of adiponectin may prevent MetS and reduce the risk of cardiovascular disease in type 2 DM patients"

Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow - Osteoporos Int. 2010 May 21 - "Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis" - See olive leaf extract at Amazon.com.

Hair loss in long-term or home parenteral nutrition: are micronutrient deficiencies to blame? - Curr Opin Clin Nutr Metab Care. 2010 Sep 4 - "A serum ferritin level of 70 mug/l should be targeted when hair loss is unexplained" - See Slow Fe Slow Release Iron Tablets 90-Count Box at Amazon.com.

Resveratrol: a relevant pharmacological approach for the treatment of metabolic syndrome? - Curr Opin Clin Nutr Metab Care. 2010 Sep 4 - "Through its regulatory action of both AMP kinase and the sirtuin sirtuin-1, resveratrol is a natural sirtuin activator that certainly will be the head of a new pharmacological family of drugs targeted on sirtuin-1 activity exacerbation in order to treat/protect from obesity and diabetes, and thus metabolic syndrome" - See resveratrol products at Amazon.com.

Curcuminoids Suppress the Growth and Induce Apoptosis through Caspase-3-Dependent Pathways in Glioblastoma Multiforme (GBM) 8401 Cells - J Agric Food Chem. 2010 Sep 7 - "The results observed with proliferation inhibition (y = 94.694e(-0.025x), R(2) = 0.9901, and n = 6) and apoptosis (y = 0.9789e(-0.0102x), R(2) = 0.99854, and n = 3) depend upon the amount of curcuminoid treatment in the cancer cells" - See curcumin products at Amazon.com.

Serum 25(OH) Vitamin D and Risk of Breast Cancer: A Nested Case-Control Study from the French E3N Cohort - Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2341-50 - "We found a decreased risk of breast cancer with increasing 25(OH) vitamin D(3) serum concentrations (odds ratio, 0.73; 95% confidence interval, 0.55-0.96; P trend = 0.02) among women in the highest tertile. We also observed a significant inverse association restricted to women under 53 years of age at blood sampling [odds ratio (T(3) versus T(1)), 0.60; 95% confidence interval, 0.37-0.98; P trend = 0.04]. In premenopausal women, the risk was also decreased, although not significantly" - See vitamin D at Amazon.com.

Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study - Am Heart J. 2010 Sep;160(3):464-70 - "sudden cardiac death (SCD) ... Individuals in the highest quartile of serum Mg were at significantly lower risk of SCD in all models. This association persisted after adjustment for potential confounding variables, with an almost 40% reduced risk of SCD (hazard ratio 0.62, 95% CI 0.42-0.93) in quartile 4 versus 1 of serum Mg observed in the fully adjusted model ... This study suggests that low levels of serum Mg may be an important predictor of SCD" - See magnesium supplements at Amazon.com.

Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area - Int J Cancer. 2010 Oct 15;127(8):1893-904 - "Positive associations were observed for high levels of the 8 individual saturated fatty acids (4th vs. 1st quartile: ORs ranged from 1.6 to 2.6; all p(trend) < 0.01), monounsaturated palmitoleic and oleic fatty acids [OR = 1.6 (95% CI: 1.2-2.1) and 1.4 (95% CI: 1.1-1.9); both p(trend) < 0.01], and polyunsaturated linolenic acid [OR = 1.5 (95% CI: 1.1-2.0); p(trend) = 0.02]. Inverse associations were observed for high levels of gadolic acid [4th vs. 1st quartile: OR = 0.68 (95% CI: 0.50-0.92); p(trend) = 0.007] and omega-3 fatty acids [>or=0.85 g/day vs. 1st quartile: OR = 0.47 (95% CI: 0.25-0.90)]. An inverse association was also observed for high total intake of vitamin C [4th vs. 1st quartile: OR = 0.69 (95% CI: 0.51-0.94); p(trend) = 0.004] and of vitamin E [OR = 0.67 (95% CI: 0.49-0.92); p(trend) = 0.01]" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com and Mega Twin EPA at Amazon.com and Jarrow Max DHA at iHerb.

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis - Int J Cancer. 2010 Sep 7 - "Cholangiocarcinoma (CCA) is a highly metastatic tumor linked to liver fluke infection and consumption of nitrosamine-contaminated foods, and is a major health problem especially in South-Eastern Asia ... Our results suggest that curcumin exhibits an anticarcinogenic potential via suppression of various events involved in multiple steps of carcinogenesis, which is accounted for by its ability to suppress proinflammatory pathways" - See curcumin products at Amazon.com.

Neat Tech Stuff / "How To's" (I've got both of these and they are great.  Both don't work in daylight plus I feel they save because you don't need to leave or turn as many lights on):

Supplement Focus (Vitamin C):

News & Research:

• vitamin C products at Amazon.com
• Citrus surprise: Vitamin C boosts the reprogramming of adult cells into stem cells - Science Daily, 12/29/09 - "The researchers found that adding vitamin C, an essential nutrient that is abundant in citrus fruits, enhanced iPSC generation from both mouse and human cells. Vitamin C accelerated gene expression changes and promoted a more efficient transition to the fully reprogrammed state. Somewhat to their surprise, they found that other antioxidants do not have the same effect, but vitamin C does seem to act at least in part through slowing cell senescence ... It is also of interest that a vitamin with long-suspected anti-aging effects has such a potent influence on reprogramming, which can be considered a reversal of the aging process at the cellular level"
• Antioxidant compound reduced incidence of colorectal metachronous adenomas - Science Daily, 12/7/09 - "The researchers randomized 411 participants to the placebo group or to receive an antioxidant compound -- specifically selenomethionnine 200 μg, zinc 30 mg, vitamin A 6,000 IU, vitamin C 180 mg and vitamin E 30 mg ... individuals who consumed antioxidants had a 40 percent reduction in the incidence of metachronous adenomas of the large bowel ... It is noteworthy that the benefit observed after the conclusion of the trial persisted through 13 years of follow up"
• New Role Of Vitamin C In Skin Protection; Relevance To The Cosmetics Industry - Science Daily, 9/8/09 - "a form of Vitamin C helped to promote wound healing and also helped protect the DNA damage of skin cells ... Previously, the group has published evidence that DNA repair is upregulated in people consuming vitamin C supplements ... The results demonstrated that vitamin C may improve wound healing by stimulating quiescent fibroblasts to divide and by promoting their migration into the wounded area. Vitamin C could also protect the skin by increasing the capacity of fibroblasts to repair potentially mutagenic DNA lesions ... Free radicals are associated with premature skin aging, and antioxidants, such as vitamin C, are known to counter these highly damaging compounds. This new evidence suggest that, in addition to ‘mopping up’ free radicals, vitamin C can help remove the DNA damage they form, if they get past the cell’s defences"
• Vitamin C Deficiency Impairs Early Brain Development, Guinea Pig Study Finds - 9/4/09 - "guinea pigs subjected to moderate vitamin C deficiency have 30 per cent less hippocampal neurones and markedly worse spatial memory than guinea pigs given a normal diet. Like guinea pigs, human beings are dependent on getting vitamin C through their diet, and Jens Lykkesfeldt therefore speculate that vitamin C deficiency in pregnant and breast-feeding women may also lead to impaired development in foetuses and new-born babies"
• Stopping Diabetes Damage With Vitamin C - Science Daily, 6/10/09 - "While neither therapy produced desired results when used alone, the combination of insulin to control blood sugar together with the use of Vitamin C, stopped blood vessel damage caused by the disease in patients with poor glucose control"
• Antioxidant vitamins may protect against female cancer - Nutra USA, 6/3/09 - "for every 1,000 microgram increase per 1,000 kcal of diet of beta-carotene was associated with a 12 per cent reduction in the risk of endometrial cancer ... Similarly, for every 50 milligram increase per 1,000 kcal of vitamin C the risk of endometrial cancer was reduced by 15 per cent, and for every 5 milligram increase per 1,000 kcal of vitamin E the risk of endometrial cancer was reduced by 9 per cent" - [Abstract]
• Vitamin C May Help Prevent Gout - WebMD, 3/9/09 - "men who had the highest vitamin C intake from supplements and food were up to 45% less likely to develop the painful condition than those who had the lowest ... the results suggest that taking vitamin C supplements at the levels in the study (less than 2,000 milligrams per day) may be a safe and effective way to prevent gout"
• Support For Adjunctive Vitamin C Treatment In Cancer - Science Daily, 3/5/09 - "Challem points out two main problems with the study: the oxidized form of vitamin C (dehydroascorbic acid) and not actual vitamin C (ascorbic acid) was used; and in the mouse experiments, the animals were given toxic doses of dehydroascorbic acid, a compound that is not used as a dietary supplement in humans ... This study and the subsequent headlines [it generated] were a grievous disservice to physicians and patients with cancer ... considerable positive research…has shown striking benefits from high-dose vitamin C (ascorbic acid) in cancer cells and animals—and in actual human beings"
• Vitamin C Production: Molecular Gatekeeper In Enzyme Discovered - Science Daily, 2/26/09
• Vitamin C and BP - Medscape, 1/6/09 - "plasma vitamin-C concentrations were inversely associated with blood pressure in young women [1]. The results suggest that this nutrient may favorably influence blood pressure in healthy young adults ... plasma ascorbic acid at year 10 was inversely associated with systolic and diastolic BP. Those in the highest quartile of plasma vitamin C had 4.66-mm-Hg lower systolic BP and 6.04-mm-Hg lower diastolic BP (p=0.0002) than those in the lowest quartile ... Block says she has recently authored two papers detailing possible mechanisms by which vitamin C could lower BP. These show that vitamin C significantly lowers F2-isprostane, a marker of oxidative stress, and CRP, a marker of inflammation [2,3]. "Both inflammation and oxidative stress are pretty well established as having a role in hypertension ... Vitamin C is a powerful antioxidant in vitro, and in some animal studies it has been shown to act as a vasodilator, possibly by enhancing the bioavailability of nitric oxide"
• Vitamin C Lowers Levels Of Inflammation Biomarker Considered Predictor Of Heart Disease - Science Daily, 11/14/08 - "for people with elevated CRP levels, the amount of CRP reduction achieved by taking vitamin C supplements in this study is comparable to that in many other studies of cholesterol-lowering drugs called statins. They noted that several larger statin trials lowered CRP levels by about 0.2 milligrams per liter; in this latest study, vitamin C lowered CRP by 0.25 milligrams per liter" - See vitamin C products at Amazon.com.
• Vitamin C, Chemotherapy: Bad Combo? - WebMD, 10/1/08 - "What vitamin C does is protect the cancer cells from the chemotherapy mainly by protecting their mitochondria [the cell's power sources]"
• Vitamin C May Prevent Hyperuricemia, Gout - Medscape, 9/26/08 - "Hyperuricemia is considered a precursor of gout, which is the most common inflammatory arthritis in adult men ... An association was observed between greater vitamin C intake and lower prevalence of hyperuricemia defined as > 6 mg/dL. The multivariable odds ratio for hyperuricemia for the highest intake of vitamin C (>1000 mg/d) compared to the lowest (<90 mg/d) was 0.34 ... These findings support a potential role of vitamin C in the prevention of hyperuricemia and gout"
• Vitamin C linked to Reduced Bone Loss in Older Men - WebMD, 9/19/08 - "If you don't have enough vitamin C, you don't make bones right. Collagen is the principal protein of bones, accounting for nearly half the volume. What the collagen does is prevent bones from coming apart"
• Vitamin C Intake May Reduce Fracture Risk - Medscape, 9/15/08 - "Basically, people who had higher levels of vitamin C intake had half the rate of hip fractures as people who had the lowest vitamin C [levels]"
• Vitamin C may help lower diabetes risk - MSNBC, 8/7/08 - "the likelihood of developing diabetes was 62 percent lower in men and women with the highest circulating vitamin C levels, relative to men and women with the lowest vitamin C levels" - See vitamin C products at Amazon.com.
• Vitamin C Injections Slow Tumor Growth In Mice - Science Daily, 8/4/08 - "high concentrations of ascorbate had anticancer effects in 75 percent of cancer cell lines tested, while sparing normal cells. In their paper, the researchers also showed that these high ascorbate concentrations could be achieved in people" - Note:  I was taking about 8 grams of vitamin C per day when I had neck cancer.  Maybe that's what saved me.
• Vitamin C-rich diet may slash diabetes risk - Nutra USA, 7/29/08 - "Increased blood levels of vitamin C may reduce the risk of developing diabetes by 62 per cent ... Correlating blood levels of vitamin C and diabetes, the researchers found that men and women with the highest blood levels (at least 1.10 and 1.29 mg/dL, respectively) had a 62 per cent reduction in their risk of developing type-2 diabetes, compared to men and women with the lowest blood levels (less than 0.56 and 0.77 mg/dL, respectively)"
• How Humans Make Up For An 'Inborn' Vitamin C Deficiency - Science Daily, 3/20/08
• Vitamin C can keep you healthy, looking younger - CNN.com, 2/27/08 - "people who ate foods rich in vitamin C had fewer wrinkles and less age-related dry skin than those whose diets contained only small amounts of the vitamin. C helps form collagen, which smooths fine lines and wrinkles ... Farris recommends La Roche-Posay Active C facial moisturizer or SkinCeuticals C E Ferulic topical antioxidant treatment ... taking more than 700 milligrams of C supplements daily reduced the risk of cardiovascular disease by 25 percent. And a recent study from Harvard University researchers hints that women who take a combo of 500 milligrams of vitamin C daily and 600 IU of vitamin E (another antioxidant) can cut their risk of stroke by 30 percent ... Pairing vitamins C and E is smart for another reason: It may lessen your Alzheimer's risks by as much as 64 percent ..." - See La Roche-Posay Active C facial moisturizer or SkinCeuticals C E Ferulic at Amazon.com and vitamin C products at Amazon.com.
• Fruit, Vegetable Eaters Have Fewer Strokes - WebMD, 1/9/08 - "Specifically, vitamin C levels may prove to be a good predictive indicator of stroke risk, independent of known risk factors such as age, smoking history, blood pressure, and cholesterol, they write"
• Vitamin C, Surgery, Arnica Montana - Dr. Weil, 1/4/08
• Vitamin C linked to lower stroke risk: study - WebMD, 1/7/08 - "The highest average blood levels of vitamin C (greater than 66 micromoles per litre) were associated with a 42 per cent lower risk of stroke, compared to the lowest average blood levels (less than 41 micromoles per litre)"
• Vitamin C and dairy linked to less abdominal weight - Nutra USA, 11/16/07 - "low vitamin C intake was associated with a 131 per cent increase in probability of central fat accumulation, while low calcium increased the probability by 30 per cent" - [Abstract]
• Vitamin C May Slow Skin Wrinkling - WebMD, 10/8/07 - "After adjusting for other factors likely to influence skin aging, such as sun exposure and smoking, vitamin C and linoleic acid were independently associated with skin aging ... After digestion, linoleic acid is converted to DHA and EPA -- two fatty acids" - See vitamin C products at Amazon.com and Mega Twin EPA at Amazon.com. - Note:  I'm not sure that is correct.  Linoleic acid is an omega-6, which is not converted to DHA and EPA.  Most Americans get about ten time too much omega-6 already.
• How Vitamin C Stops Cancer - Science Daily, 9/10/07 - "Both of these cancers produce high levels of free radicals that can be suppressed by feeding the mice supplements of antioxidants, either vitamin C or N-acetylcysteine (NAC) ... Some rapidly growing tumors consume enough energy to easily suck out the available oxygen in their vicinity, making HIF-1 absolutely critical for their continued survival. But HIF-1 can only operate if it has a supply of free radicals. Antioxidants remove these free radicals and stop HIF-1, and the tumor, in its tracks"
• Fat Transforms Vitamin C From 'Good Cop' Into 'Bad Cop' - Science Daily, 9/4/07 - "Nitrites, which are present in human saliva, and in certain preserved foodstuffs, may be converted to cancer causing compounds called nitrosamines. Nitrosamines are formed in acidic conditions, such as those afforded by stomach acid, but vitamin C inhibits their formation, by converting nitrite to nitric oxide ... Without fat, vitamin C curbed the levels of two nitrosamines by a factor of between five and 1000. And it completely eliminated the production of the other two ... But when 10% fat was added, vitamin C actually boosted the production of nitrosamines between 8 and 140-fold"
• Is there anything that I can do to aid recovery and reduce soreness [from exercise]? - Dr. Murray - "Take 3,000-8,000 mg of vitamin C and 400-800 IU of vitamin E in divided doses daily"
• Vitamin C 'benefits diabetics' - BBC News, 6/28/07 - "Vitamin C neutralises free radicals, while Telmisarten stimulates the natural removal of the molecules by cells"
• An Antioxidant Update? - Dr. Weil, 10/9/06
• Ester-C gets tolerability boost - Nutra USA, 5/5/06
• Vitamin C could lower body fat levels - Nutra USA, 4/6/06 - "As vitamin C blood concentrations fell, so did the participants' ability to oxidize fat (an 11 per cent reduction)"
• Vitamin C could reduce inflammation - Nutra USA, 3/8/06 - "High blood levels of vitamin C were associated with a 45 per cent reduced risk of inflammation (with respect to CRP levels)"
• Cortisol, Stress, and Health - Life Extension Magazine, 12/05 - "Supplements to reduce high cortisol levels secondary to stress ... Vitamin C: 1000-3000 mg/day ... Fish oil (omega-3 fatty acids):1-4 gm/day ... Phosphatidylserine: 300-800 mg/day ... Rhodiola rosea: 100-200 mg/day, standardized extract ... Ginseng: 100-300 mg/day, standardized extract ... Ginkgo biloba: 100-200 mg/day, standardized extract ... DHEA: 25-50 mg/day (any hormone supplementation should be monitored by your physician)"
• Study: Vitamin C May Fight Cancer - WebMD, 9/12/05 - "Vitamin C appeared to boost production of hydrogen peroxide, which killed cancer cells and left healthy cells unharmed ... The levels of vitamin C were so high that they could only be achieved through IV infusions"
• Vitamins E and C Confirmed Safe At High Doses - NPI Center, 4/29/05
• Discovery Shows New Vitamin C Health Benefits - Science Daily, 1/12/05 - "the new discovery indicates it has a complex protective role against toxic compounds formed from oxidized lipids, preventing the genetic damage or inflammation they can cause"
• Alternative Medicine: Vitamin C - The Epoch Times, 11/28/04 - "Guinea pigs and primates are the only mammals known that do not manufacture vitamin C in their gut. Other mammals not only manufacture vitamin C (ascorbic acid), but do it on an as-needed basis. For daily maintenance they manufacture what would be equivalent to a 150-pound man taking 5 to 50 grams a day"
• Study Shows Vitamins C And E Can Prevent Metabolic Damaage In Extreme Exercise - Science Daily, 7/15/04 - "ultramarathon runners who used supplements of vitamins C and E for six weeks prior to their races totally prevented the increase in lipid oxidation that is otherwise associated with extreme exercise"
• Vitamin C May Fight Rheumatoid Arthritis - WebMD, 6/9/04 - "people who ate the least amount of fruits and vegetables had double the risk of developing inflammatory arthritis ... People who got the least vitamin C in their diet had three times the risk of developing inflammatory arthritis than those who got the most"
• Excess Vitamin C May Worsen Osteoarthritis - WebMD, 6/3/04
• Vitamin C supplement to beat diabetes and heart disease - Nutra USA, 4/14/04 - "Researchers at the University of California say that participants who took about 500 milligrams of vitamin C supplements per day saw a 24 per cent drop in plasma C-reactive protein (CRP) levels after two months"
• A Preferred Source of Vitamin C? - Dr. Weil, 3/9/04
• Vitamins C and E May Lower Alzheimer's Risk - WebMD, 1/20/04
• Vitamin Supplement Use May Reduce Effects Of Alzheimer's Disease - Doctor's Guide, 1/20/04
• Ulcer Agent Lowered in Vitamin C Study - Natural Foods Merchandiser, 11/03
• Diet Rich in Vitamin C Decreases Stroke Risk - Medscape, 11/10/03
• Low Blood Levels of Vitamin C Linked to Mortality - Medscape, 11/6/03 - "Individuals in the lowest quintile for ascorbate concentration (<17 µmol/L) had the highest mortality, whereas those in the highest quintile (>66 µmol/L) had the lowest mortality ... After excluding subjects with cardiovascular disease or cancer at baseline, mortality for those in the highest quintile was still about half of that in the lowest quintile"
• Vitamin C Cream Reverses Skin Damage from Sun Exposure - Healthwell Exchange Daily News, 10/16/03
• The Chromium Connection - Natural Foods Merchandiser, 9/03 - "The body requires certain nutrients to control glucose metabolism, especially chromium, zinc and vitamins B and C" - See Vitacost chromium products.
• Vitamin Supplements Improve Blood Vessel Function - Physician's Weekly, 9/8/03 - "In a study where children with hyperlipidemia were given doses of the antioxidants vitamins C and E, researchers have found that the supplements can significantly improve blood vessel function ... the test group received 500 mg of vitamin C and 400 IU of vitamin E daily. Both groups saw an 8% decline in LDL cholesterol and the test group had significant improvement in endothelial function comparable to the levels of normal healthy children"
• Vitamins E and C Lower Kids' Heart Risks - WebMD, 8/11/03
• E and C May Give Older Women a Mental Edge - Natural Foods Merchandiser, 8/03 - "The women who had taken vitamin C and E supplements for more than 10 years scored an average of 1.5 years younger in cognitive function than those not taking vitamins. The results were even more marked for those with low dietary vitamin E intake: Women with the lowest 30 percent of dietary vitamin E intake who did not take supplements tested two years older in mental function than women who compensated for low dietary intake with antioxidant supplements"
• Low Vitamin C Tied to Ulcer Bug - WebMD, 8/4/03
• Vitamin C May Protect Against Ulcer-Causing Bacteria - Doctor's Guide, 8/1/03 - "the lower the level of vitamin C in the blood the more likely a person will become infected by Helicobacter pylori, the bacteria that can cause peptic ulcers and stomach cancer ... The bottom line is that higher levels of vitamin C may have the potential to prevent peptic ulcers and stomach cancer"
• Vitamin C Lowers Heart Disease Risk - WebMD, 7/15/03
• Vitamin C Reduces Oxidant Stress In Renal Failure - Doctor's Guide, 3/26/03 - "The acute administration of vitamin C reduces oxidant stress in renal failure, and improves nitric oxide-mediated resistance-vessel dilatation ... In addition, vitamin C was found to increase the dilator response to acetylcholine in resistance vessels"
• Vitamin C May Fight Colds After All - WebMD, 3/12/03 - "12 healthy subjects who took one gram of vitamin C a day for two weeks showed a boosted immune system response during that time ... in two of them, the response to vitamin C took place within five hours ... this might mean that taking a vitamin C tablet at the first sign of a cold could achieve an effect quickly enough to ward off that cold"
• Vitamin C May Aid People with Diabetes - New Hope Natural Media, 2/13/03 - "randomly assigned to receive 500 mg of vitamin C per day or a placebo. After four weeks of treatment, the average blood pressure decreased significantly in the group taking vitamin C, whereas no change was seen in the placebo group. The systolic blood pressure (the higher number) decreased by an average of 9.8 mm Hg, while the diastolic blood pressure (the lower number) decreased by 4.4 mm Hg. These changes in blood pressure are nearly as great as one might expect from taking a prescription blood pressure-lowering medication. In addition, the stiffness of the arteries decreased significantly in the vitamin C group ... Vitamin C inhibits all three of the biochemical reactions that are believed to contribute to the development of these complications: (1) the production of oxygen-derived free radicals, (2) the accumulation of sorbitol within cells, and (3) a tissue-damaging reaction called glycosylation"
• Vitamins C and E may enhance effectiveness of insulin for diabetes - University of California at Irvine, 1/29/03 - "Boosting insulin with vitamins C and E may improve the drug's effectiveness for treating diabetes ... the popular antioxidant supplements not only enhance insulin's ability to reduce blood sugar, but also lower the risks of organ damage that can occur despite insulin treatments"
• Vitamins C and E Improve Outcome in Critically Ill Surgical Patients - New Hope Natural Media, 1/9/03 - "The incidence of multiple organ failure was significantly lower (by 57%) in the group receiving antioxidants than in the control group (2.7% vs. 6.1%). In addition, the average length of stay in the ICU was significantly lower (by 17%) in the antioxidant group.  After 28 days, the mortality rate was 44% lower in the antioxidant group than in the control group (1.3% vs. 2.4%), but this difference was not statistically significant"
• Vitamin C, Fish, And A Gout Drug Target Artery Damage From Smoking - Intelihealth, 1/7/03 - "vitamin C and taurine, an amino acid in fish, reversed abnormal blood vessel response associated with cigarette smoking - a discovery that may provide insight into how smoking contributes to "hardening of the arteries,""
• Antioxidant Vitamins Improve Surgical Outcomes - Medscape, 12/20/02 - "Compared with patients receiving standard care, those who received antioxidant supplementation with alpha-tocopherol and ascorbate had a shorter duration of mechanical ventilation and length of ICU stay, and lower relative risk (RR) of pulmonary morbidity (RR, 0.81; 95% confidence interval [CI], 0.60 - 1.1) and of multiple organ failure (RR, 0.43; 95% CI, 0.19 - 0.96)"
• Antioxidants May Reduce Alzheimer's Disease Risk - Clinical Psychiatry News, 10/02 - "Use of vitamins E and C together—which is what most subjects did—was associated with an eightfold reduction in prevalence and a fivefold lower incidence of Alzheimer's disease"
• Vitamins C And E Support Breathing Following An Operation - Intelihealth, 9/12/02 - "Patients who have recently undergone an operation experience less breathing problems after being given a cocktail of vitamins C and E"
• Vitamins C, E May Prevent Artery Damage - Vitacost, 9/11/02
• Low Vitamin C Increases Stroke Risk - WebMD, 6/7/02
• Vitamin C May Prevent Platelet Aggregation - Doctor's Guide, 5/28/02 - "Vitamin C may inhibit collagen-induced platelet aggregation. This may add to the protection that vitamin C is already known to give against coronary heart disease ... In smokers who received vitamin C, there were significant decreases in platelet aggregation after six hours with both collagen concentrations compared to placebo. In non-smokers, there were significant decreases of platelet aggregation after three and six hours for both collagen concentrations"
• Vitamin C Beneficial In Heart Disease - Doctor's Guide, 5/27/02 - "These two groups were split into subgroups: those who received 2 g of vitamin C and those who did not after eating high-fat meal ... Although the postprandial flow-mediated dilatation was significantly aggravated in people not taking vitamin C (both with and without heart disease), this parameter in patients and subjects taking vitamin C showed no significant change"
• Proton Pump Inhibitor Therapy Reduces Bioavailability of Dietary Vitamin C - Doctor's Guide, 5/20/02 - "The mean pre-treatment plasma vitamin C concentration in H. pylori -negative subjects was 25.1 mg/mL (range 16.1-33) and 17.4 mg/mL (6.7-29) in H. pylori-positive subjects (p<0.001). Mean daily dietary intake of vitamin C was 44 mg/day (range 10-130) in H. pylori positive subjects compared to 141 mg/day (range 23-282) negative subjects (p<0.001) ... Four week of omeprazole [Prilosec - the purple pill] treatment achieved reductions in mean plasma vitamin C concentrations of 15 percent (p=0.005) in H. pylori-positive and -negative subjects"
• Vitamins Help After Heart Transplant - WebMD, 3/28/02 - "The plaque-fighting benefits of the antioxidant supplements were even greater than those found using statin medications, which have already been shown to slow hardening of the arteries after transplants. Previous research has shown that antioxidants, such as vitamin C and E, can promote heart health by reducing blood clots and keeping the blood vessels flexible"
• Few Vitamins Effectively Prevent or Reverse Skin Damage - Medscape, 3/02 - "Even minimal UV exposure can decrease the vitamin C levels in the skin by 30%, while exposure from the ozone of city pollution can decrease the level by 55%"
• Vitamin C Reduces The Odds Of Developing Early-Onset Cataract - Doctor's Guide, 2/22/02 - "A significant interaction was observed between age, vitamin C intake, and the prevalence of cataracts. For women younger than 60 years, the consumption of vitamin C >/= 362 mg/day was associated with a 57 percent lower risk of developing cortical opacities, and the use of vitamin C supplements for at least 10 years was associated with a 60 percent reduction in the risk of cataracts, when compared to no supplement use ... the incidence of posterior subcapsulary cataracts was considerably lower in women who had never smoked and who had high intakes of folate and carotenoids"
• Vitamin C May Improve Alzheimer's Treatments - WebMD, 1/14/02 - "When ascorbic acid -- better known as vitamin C -- is chemically attached to certain drugs, it allows them to penetrate the [blood brain] barrier, reaching more of its target cells within the brain ... they tested one of the modified drugs in mice with induced convulsions. They injected some of the animals with the normal version of the drug and others with the modified version. Only animals that received the drug with attached vitamin C had delayed convulsions -- indicating that the drug was more effective"
• Antioxidants, At Certain Levels, May Reduce Blood Pressure - Doctor's Guide, 11/14/01 - "increasing levels of serum beta- carotene were associated with significant reductions in systolic blood pressure, while increasing levels of serum vitamin C were associated with significant reductions in diastolic pressure ... In contrast, serum levels of vitamin E were associated with significant increases in diastolic blood pressure"
• Vitamin C Inhibits Cell Death In Congestive Heart Failure Patients - Intelihealth, 10/30/01
• Zinc, Antioxidants Prevent Some Forms of Vision Loss - WebMD, 10/12/01 - "people at risk of losing more sight due to a condition called "age-related macular degeneration" (AMD) could prevent further vision loss by taking a combination of zinc and antioxidants, including vitamins C and E and beta-carotene ... The antioxidants were taken once a day at a dose of 500 mg of vitamin C, 400 IU of vitamin E, and 15 mg of beta-carotene. Zinc was given as 80 mg of zinc oxide along with 2 mg of copper in the form of cupric oxide to prevent anemia, which can occur from too much zinc ... the high levels of dietary supplements that were taken in this study are very difficult to achieve from diet alone"
• Antioxidants Resolve Radiation Side Effects - Nutrition Science News, 9/01
• Parkinson's Defense - Nutrition Science News, 5/01
• Arterial Disease Depletes Body of Vitamin C - WebMD, 4/9/01 - "In atherosclerosis, arteries and other blood vessels are lined with fat deposits and buildup of cellular materials, including inflammatory cells, which release unstable molecules called free radicals. The free radicals do additional damage to the delicate vessels, says Langlois. Antioxidants such as vitamin C seek out and destroy free radicals, but in the process the antioxidants are themselves destroyed ... PAD appears to kick the body's inflammatory process into high gear, which then releases a free radical bombardment, that can "deplete the supply of vitamin C""
• The Prediabetic Epidemic - Nutrition Science News, 3/01 - "Supplements to Regulate Glucose and Insulin ... Alpha-Lipoic Acid ... Vitamin E ... Vitamin C ... Some research has found that 2,000 mg/day vitamin C daily lowers both glucose and glycosylated hemoglobin levels, the latter a standard marker of diabetic control ... Chromium ... Silymarin"
• Vitamin C May Help Ward Off Osteoporosis - WebMD, 2/8/01 - "Researchers have found that postmenopausal women who took vitamin C supplements had a higher bone density than those who didn't. The highest bone densities were also found in the women who were taking more than 1,000 mg/d."
• Antioxidant Vitamins Block Homocysteine's Acute Toxic Effects - Nutrition Science News, 12/00
• Vitamins and Vision, Lots of "C" May Help You See Later in Life - WebMD, 12/11/00 - "Risk of cataracts was 60% lower among people who took multivitamins or any supplement containing vitamin C or E for more than 10 years."
• Ulcer Therapy, Vitamins May Team Up to Prevent Stomach Cancer, Drugs Halted, Healed Abnormalities With Cancer Potential - WebMD, 12/8/00 - "people who took the three-drug combination alone or in combination with vitamin C and/or beta carotene were three to five times more likely than people who received no treatment to have a reduction in the size of precancerous stomach abnormalities."
• Vitamins C and E May Reduce Risk, Complications of Diabetes - WebMD, 11/15/00
• Study Says Vitamin C Helps Prevent Strokes - Intelihealth, 10/27/00
• Low Stroke Rates Associated With Vitamin C Level In Bloodstream - Doctor's Guide, 10/6/00
• Vitamin C May Help a Smoker's Heart, Study Shows - WebMD, 9/11/00
• The Vitamin C Controversy - Life Extension Magazine, 5/5/00
• Lower Vitamin C Means Higher Cancer Risk for Men - WebMD, 7/18/00
• Some Drugs May Protect Against Alzheimer's, Others Might Increase Risk - Doctor's Guide, 4/12/00
• Low Vitamin C Levels Linked to Increase in Gallbladder Disease - Doctor's Guide, 4/10/00
• Study: Vitamin C Pills Linked To Artery Clogging - Intelihealth, 3/2/00 - Note: There is a big problem with taking vitamin C without bioflavonoids but if this is true, my suggestion is to ad statins or red yeast rice as I do.  I'm 50 years old and my blood pressure is 118/68 and I've been taking about 4 grams/day of vitamin C for decades.  Linus Pauling took 18 grams/day of vitamin C for 30 years and died at 93 1/2 of prostate cancer, not heart disease.  I feel that you are not going to slow aging without large doses of vitamin C combined with bioflavonoids.  If we had not lost our ability to produce our own vitamin C as other mammals do, we would be producing 2 to 12 grams/day.
• Bad studies may be more dangerous than vitamins... Does Vitamin C Really Damage DNA? - Jack Challem
• Vitamin C: A possible treatment for high blood pressure - CNN, 12/20/99
• Stressed out? Vitamin C is possibly the perfect chill pill - CNN, 8/23/99
• Cancer Prevention Diet - Nutrition Science News, 8/99
• Oxidation-Resistant Version of Vitamin C Slows Age-Dependent Telomere Shortening - Life Enhancement Magazine, 7/99
• Second Sight - Nutrition Science News, 4/99
• Breathe Easy with Vitamin C - Nutrition Science News, 3/99
• High C Linked to Fewer Gallstones - Nutrition Science News, 1/99
• High blood pressure: Newest research explores prevention, treatment - CNN, 9/21/98
• Low Dietary Calcium, Low Vitamin C Linked To Increased Risk Of Gum Disease - Doctor's Guide, 6/29/98
• Paleolithic Nutrition: Your Future Is In Your Dietary Past - The Nutrition Reporter - "This theory regarding how our evolutionary ancestors lost their ability to produce vitamin C is generally accepted by scientists, Stone's other theory is more controversial. He contended that people never lost the need for large amounts of vitamin C, even though they lost the ability to make it. Based on animal data, he estimated that people might require 1.8-13 grams of vitamin C daily."
• Antioxidants May Reduce Harmful Complications Of Diabetes - Doctor's Guide, 4/20/98
• Vitamin C Removes Lead From Blood Stream In Men - Doctor's Guide, 4/3/98
• Vitamin C Shown To Cross The Blood Brain Barrier - Doctor's Guide, 12/1/97
• Vitamins C And E Temporarily Block Some Harmful Effects Of High-Fat Meal - Doctor's Guide, 11/25/97
• Long-Term Vitamin C Use Cuts Cataract Risk In Older Women - Doctor's Guide, 10/9/97 - "taking vitamin C supplements for more than 10 years lowers the risk of lens opacities that can lead to cataract surgery in older women"
• Vitamin C Deficit Linked To Skin Disease - Doctor's Guide, 8/14/97
• Vitamin C May Play Role In Protecting Heart, Lungs From Disease - Doctor's Guide, 6/13/97
• Vitamin Supplements May Help Asthmatics Cope With Air Pollution - Doctor's Guide, 5/20/97

Abstracts:

• The effects of vitamin C supplementation on incident and progressive knee osteoarthritis: a longitudinal study - Public Health Nutr. 2010 Aug 16:1-7 - "In the present prospective cohort study, we found no evidence to support a protective role of vitamin C in the progression of knee OA. However, after controlling for confounding variables, these data suggest that vitamin C supplementation may indeed be beneficial in preventing incident knee OA. Given the massive public health burden of OA, the use of a simple, widely available and inexpensive supplement to potentially reduce the impact of this disease merits further consideration"
• Vitamin C requirement in surgical patients - Curr Opin Clin Nutr Metab Care. 2010 Aug 4 - "Blood vitamin C concentration falls after uncomplicated surgery and further decreases in surgical intensive care unit patients. The decline may be owing to increased demand caused by increased oxidative stress. To normalize plasma vitamin C concentration, much higher doses than the recommended daily allowance or doses recommended in parenteral nutrition guidelines are needed in these patients. In uncomplicated surgical patients, more than 500 mg/day of vitamin C may be required, with much higher doses in surgical intensive care unit patients. In uncomplicated gastrointestinal surgery, continuous parenteral administration of 500 mg/day of vitamin C reduced postoperative oxidative stress as manifested by reduced urinary excretion of isoprostane. In some studies, postoperative atrial fibrillation was prevented after cardiac surgery by perioperative vitamin C supplementation. In critically ill patients, some prospective randomized controlled trials support parenteral supplementation of high doses of vitamin C, E and trace elements"
• High dose of ascorbic acid induces cell death in mesothelioma cells - Biochem Biophys Res Commun. 2010 Feb 18 - "High dose of ascorbic acid induced cell death of all mesothelioma cell lines in a dose-dependent manner ... These data suggest that ascorbic acid may have benefits for patients with mesothelioma"
• Ascorbic Acid for Anemia Management in Hemodialysis Patients: A Systematic Review and Meta-analysis - Am J Kidney Dis. 2009 Sep 22 - "Combining the 3 randomized clinical trials involving patients with baseline hemoglobin levels <11 g/dL, change in hemoglobin level was greater for ascorbic acid use compared with standard care (WMD, 0.9 g/dL; 95% CI, 0.5-1.2 g/dL). Compared with standard care, ascorbic acid use also was associated with a statistically significant decrease in rHuEPO dose (WMD, -17.1 U/kg/wk; 95% CI, -26.0 to -8.2 U/kg/wk) and improvement in transferrin saturation (WMD, 7.9%; 95% CI, 5.2-10.5%), with no change in ferritin concentration"
• Serum vitamin C concentration and hs-CRP level in middle-aged Japanese men and women - Atherosclerosis. 2009 Aug 7 - "Inverse associations between serum vitamin C concentrations and hs-CRP levels were established for both men and women. Multivariable-adjusted mean values of hs-CRP for the lowest to highest quintiles of vitamin C levels were 0.75, 0.65, 0.61, 0.61 and 0.47mg/L (P for trend <0.001) for men, and 0.56, 0.51, 0.49, 0.41 and 0.41mg/L (P for trend <0.001) for women. The inverse association between vitamin C and hs-CRP was stronger for non-smoking men and women, non-overweight women and postmenopausal women ... Serum vitamin C concentrations were found to be inversely associated with hs-CRP levels in both men and women, primarily among non-smokers, non-overweight women and postmenopausal women"
• Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs - Am J Clin Nutr. 2009 Jul 29 - "Our data show that vitamin C deficiency in early postnatal life results in impaired neuronal development and a functional decrease in spatial memory in guinea pigs. We speculate that this unrecognized effect of vitamin C deficiency may have clinical implications for high-risk individuals, such as in children born from vitamin C-deficient mothers"
• Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis - Cancer Causes Control. 2009 Jul;20(5):699-711 - "Based on case-control data, the random-effects summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98) per 1,000 mcg/1,000 kcal (I2: 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI: 0.73-0.98) per 50 mg/1,000 kcal (I2: 66.1%; p < 0.01); and, for vitamin E: 0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I2: 0.0%; p: 0.45)"
• Multivitamin use and telomere length in women - Am J Clin Nutr. 2009 Jun;89(6):1857-63 - "After age and other potential confounders were adjusted for, multivitamin use was associated with longer telomeres. Compared with nonusers, the relative telomere length of leukocyte DNA was on average 5.1% longer among daily multivitamin users (P for trend = 0.002). In the analysis of micronutrients, higher intakes of vitamins C and E from foods were each associated with longer telomeres, even after adjustment for multivitamin use. Furthermore, intakes of both nutrients were associated with telomere length among women who did not take multivitamins"
• Intake of plant foods and associated nutrients in prostate cancer risk - Nutr Cancer. 2009;61(2):216-24 - "Plant foods and associated nutrients may impact prostate cancer (PC) risk and survival ... Reduced PC risk was associated with the highest tertile of cryptoxanthin (OR = 0.51; 95% CI = 0.35-0.75), fiber (OR = 0.56; 95% CI = 0.35-0.89), vitamin C (OR = 0.60; 95% CI = 0.41-0.88), and fruits and/or fruit juices (OR = 0.46; 95% CI = 0.31-0.68), with significant linear trends. Increased risk of PC was associated with the highest tertile of protein (OR = 1.99; 95% CI = 1.05-3.79) and daily servings of grains (OR = 1.99; 95% CI = 1.23-3.22) with significant linear trends"
• Vitamin C-rich foods may boost artery health - Nutra USA, 2/17/09 - "increased intakes of vitamin C and fruit and berries were associated with less thickening of the carotid artery ... one mg per decilitre increase in blood vitamin C levels was linked to a 4.1 and 4.0 mmHg in systolic and diastolic blood pressures" - [Abstract]
• Vitamin C consumption is associated with less progression in carotid intima media thickness in elderly men: A 3-year intervention study - Nutr Metab Cardiovasc Dis. 2009 Jan;19(1):8-14 - "Vitamin C containing foods may protect against the progression of carotid atherosclerosis in elderly men"
• Vitamin C: Is Supplementation Necessary for Optimal Health? - J Altern Complement Med. 2008 Nov 25 - "Consumption of vitamin C is essential for life in humans because the body does not synthesize it. Numerous studies have demonstrated that supplementation with vitamin C enhances the immune system, avoids DNA damage, and significantly decreases the risk of a wide range of pathologies, such as cancers, and degenerative and chronic diseases. Moreover, it has been demonstrated that modern crop production, transport, and food storage severely impair the quality of food and provoke a loss in micronutrients, such as vitamin C ... In this paper, we report that the Recommended Daily Allowance (RDA) in vitamin C is lower than the bodily needs. In fact, it does not seem to ensure true health protection and it appears difficult to reach an effective dose of vitamin C only through food consumption. Furthermore, the literature shows that vitamin C intake higher than the RDA is safe. Therefore, in order to achieve optimal health and avoid a number of diseases, we suggest that, in the present situation, vitamin C supplementation is required ... According to the current literature, we would like to emphasize that to ensure an optimal allowance of vitamin C, we advise 1 g daily intake of vitamin C supplementation, accompanied by a diet rich in fruits and vegetables"
• Vitamin C-lipid metabolites: Uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers - Med Sci Monit. 2008 Nov;14(11):CR547-551 - "ascorbic acid (AA), calcium ascorbate (CaA) ... PureWay-C(R) supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C(R). PureWay-C(R) provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C(R) shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C(R) also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C(R) is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C(R)" - See vitamin C products at Amazon.com.
• Vitamin C consumption is associated with less progression in carotid intima media thickness in elderly men: A 3-year intervention study - Nutr Metab Cardiovasc Dis. 2008 May 7 - "Vitamin C containing foods may protect against the progression of carotid atherosclerosis in elderly men"
• Vitamin C Intake and Serum Uric Acid Concentration in Men - J Rheumatol. 2008 May 1 - "An inverse dose-response association was observed through vitamin C intake of 400-500 mg/day, and then reached a plateau ... Greater vitamin C intake was associated with lower prevalence of hyperuricemia (serum uric acid > 6 mg/dl). Multivariate odds ratios for hyperuricemia across total vitamin C intake categories were 1 (reference), 0.58, 0.57, 0.38, and 0.34 (95% CI 0.20-0.58; P for trend < 0.001). When we used dietary data, which were assessed 4-8 years before blood collection, as predictors, we observed similar inverse associations between vitamin C intake and uric acid ... These population-based data indicate that vitamin C intake in men is inversely associated with serum uric acid concentrations. These findings support a potential role of vitamin C in the prevention of hyperuricemia and gout"
• A 12 week, open label, phase I/IIa study using apatone for the treatment of prostate cancer patients who have failed standard therapy - Int J Med Sci. 2008 Mar 24;5(2):62-7 - "oral Apatone (Vitamin C and Vitamin K3) administration in the treatment of prostate cancer ... 5,000 mg of VC and 50 mg of VK3 each day ... At the conclusion of the 12 week treatment period, PSAV decreased and PSADT increased in 13 of 17 patients (p < or = 0.05). There were no dose-limiting adverse effects. Of the 15 patients who continued on Apatone after 12 weeks, only 1 death occurred after 14 months of treatment"
• Dehydroascorbic acid as an anti-cancer agent - Cancer Lett. 2008 Mar 28 - "dehydroascorbic acid has the remarkable ability to eliminate the aggressive mouse tumours, L1210, P388, Krebs sarcoma, and Ehrlich carcinoma"
  • Dehydroascorbic acid - Wikipedia - "Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid"
• Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study - Am J Clin Nutr. 2008 Jan;87(1):64-9 - "persons in the top quartiles of baseline plasma vitamin C concentrations had a 42% lower risk (relative risk: 0.58; 95% CI: 0.43, 0.78) than did those in the bottom quartile"
• Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance - Am J Clin Nutr. 2008 Jan;87(1):142-9 - "The administration of vitamin C significantly (P = 0.014) hampered endurance capacity"
• Ascorbic Acid Decreases the Binding Affinity of the AT(1) Receptor for Angiotensin II - Am J Hypertens. 2008 Jan;21(1):67-71 - "Ascorbic acid decreases the binding affinity of the AT(1) receptor. These results offer a mechanistic explanation for the reported blood pressure lowering effect of ascorbic acid"
• Dietary and non-dietary determinants of central adiposity among Tehrani women - Public Health Nutr. 2007 Sep 3;:1-7 - "Marriage (1.31; 1.10-1.82), menopause (1.22; 1.02-1.61), low vitamin C intake (2.31; 1.25-4.25) and low calcium intake (1.30; 1.07-3.78) were associated with central fat accumulation"
• Dietary nutrient intakes and skin-aging appearance among middle-aged American women - Am J Clin Nutr. 2007 Oct;86(4):1225-1231 - "Higher intakes of vitamin C and linoleic acid and lower intakes of fats and carbohydrates are associated with better skin-aging appearance. Promoting healthy dietary behaviors may have additional benefit for skin appearance in addition to other health outcomes in the population"
• Supplementation with vitamins C and e improves arterial stiffness and endothelial function in essential hypertensive patients - Am J Hypertens. 2007 Apr;20(4):392-7 - "Combined treatment with vitamins C and E has beneficial effects on endothelium-dependent vasodilation and arterial stiffness in untreated, essential hypertensive patients"
• Intravenously administered vitamin C as cancer therapy: three cases - CMAJ. 2006 Mar 28;174(7):937-942 - "We found 3 well-documented cases of advanced cancers, confirmed by histopathologic review, where patients had unexpectedly long survival times after receiving high-dose intravenous vitamin C therapy"
• Associations of vitamin C status, fruit and vegetable intakes, and markers of inflammation and hemostasis - Am J Clin Nutr. 2006 Mar;83(3):567-574 - "The findings suggest that vitamin C has antiinflammatory effects and is associated with lower endothelial dysfunction in men with no history of cardiovascular disease or diabetes"
• Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical Conditions - Annals of Nutrition and Metabolism 2006;50:85-94 - "These trials document that adequate intakes of vitamin C and zinc ameliorate symptoms and shorten the duration of respiratory tract infections including the common cold"
• Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina - Heart. 2005 Oct;91(10):1319-23 - "L-arginine dependent coronary segment vasodilatation was augmented by the antioxidant vitamin C in patients with coronary artery disease. Thus, vitamin C may have beneficial effects on nitric oxide bioavailability induced by L-arginine"
• Vitamins E and C are safe across a broad range of intakes - Am J Clin Nutr. 2005 Apr;81(4):736-45 - "vitamin E supplements appear safe for most adults in amounts </=1600 IU (1073 mg RRR-alpha-tocopherol or the molar equivalent of its esters) and that vitamin C supplements of </=2000 mg/d are safe for most adults"
• Antioxidant vitamins and mortality in older persons - Am J Clin Nutr. 2003 Nov;78(5):999-1010 - "We found strong inverse trends for blood ascorbate concentrations with all-cause and cardiovascular disease mortality ... Low blood vitamin C concentrations in the older British population are strongly predictive of mortality"
• Vitamin C Inhibits Lipid Oxidation in Human HDL - J Nutr. 2003 Oct;133(10):3047-51 - "In the absence of vitamin C, lipid oxidation in HDL began immediately and proceeded rapidly ... Vitamin C (50-200 micro mol/L) retarded initiation of lipid oxidation for at least 4 h under the same conditions ... Our results demonstrate that vitamin C inhibits lipid oxidation in HDL and preserves the antioxidant activity associated with this lipoprotein fraction"
• Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial - Circulation. 2003 Sep 2;108(9):1059-63. Epub 2003 Aug 11
• Oral Antioxidant Therapy Improves Endothelial Function in Type 1 but not Type 2 Diabetes Mellitus - Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2392-8 - "subjects were randomized to oral vitamin C 1000 mg and vitamin E 800 IU daily or matching placebo for six months ... Oral antioxidant therapy improves EDV in T1 but not T2 diabetes" - The measurement of Vitamin E in IUs shows that they are still using d-alpha-tocopherol or worse, the dl-alpha-tocopherol instead of mixed tocopherols including the tocotrienols in studies.  Just for starters, the d-alpha lowers gamma.
• Effect of Ascorbic Acid Consumption On Urinary Stone Risk Factors - J Urol. 2003 Aug;170(2):397-401
• Influence of Vitamin C on Baroreflex Sensitivity in Chronic Heart Failure - Hypertension 2003 May 12 - "Chronic heart failure (CHF) reduces baroreflex sensitivity. Low baroreflex sensitivity, a risk factor for sudden death, could arise partly from CHF-dependent endothelial dysfunction. Vitamin C at high doses has a protective role against CHF-related endothelial damage ... In subjects with CHF, baroreflex sensitivity was significantly higher after vitamin C than after placebo infusion ... Acute administration of vitamin C at high doses improves baroreflex sensitivity and vagal sinus modulation in patients with CHF"
• Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people - Neurosci Lett 2003 May 8;341(3):173-6 - "We found that lower grey matter volume was associated with lower plasma vitamin C and higher homocysteine, cholesterol and LDL. Lower blood cell folate was also associated with lower grey matter volume ... These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration"
• High-dose antioxidant supplements and cognitive function in community-dwelling elderly women - Am. J. of Clin. Nutr., 4/03 - "Long-term, current users of vitamin E with vitamin C had significantly better mean performance, as judged by a global score that combined individual test scores, than did women who had never used vitamin E or C (P = 0.03); there was a trend for increasingly higher mean scores with increasing durations of use (P = 0.04). These associations were strongest among women with low dietary intakes of alpha-tocopherol. Benefits were less consistent for women taking vitamin E alone, with no evidence of higher scores with longer durations of use. Use of specific vitamin C supplements alone had little relation to performance on our cognitive tests"
• No contribution of ascorbic acid to renal calcium oxalate stones - Ann Nutr Metab 1997;41(5):269-82

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