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Recent Longevity News for the seven days ending 7/14/10. You should consult your doctor if you are taking any medications. Medications found to cause long term cognitive impairment of aging brain, study finds - Science Daily,7/13/10 - "They are sold over the counter under various brand names such as Benadryl®, Dramamine®, Excedrin PM®, Nytol®, Sominex®, Tylenol PM®, and Unisom®. Other anticholinergic drugs, such as Paxil®, Detrol®, Demerol® and Elavil® are available only by prescription ... taking one anticholinergic significantly increased an individual's risk of developing mild cognitive impairment and taking two of these drugs doubled this risk"
Anti-cancer effects of broccoli ingredient explained - Science Daily,
7/12/10 - "sulforaphane,
a chemical found in broccoli, interacts with cells lacking a gene called PTEN to
reduce the chances of prostate cancer
developing"
- See
sulforaphane at Amazon.com
Eating foods rich in vitamin E associated with lower dementia risk - Science
Daily, 7/12/10 - "the one-third of individuals who
consumed the most
vitamin E
(a median or midpoint of 18.5 milligrams per day) were 25 percent less likely to
develop dementia than the one-third of
participants who consumed the least (a median of 9 milligrams per day)" -
See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com Moderate Physical Activity Linked to Lower Dementia Risk - Medscape, 7/12/10 - "Compared with those with lower levels of activity, participants reporting moderate to heavy physical activity had a 45% lower risk for dementia over time"
Regular Tea Consumption May Slow Cognitive Decline - Medscape, 7/12/10 -
"Participants who drank
tea 5 to 10 times per year, 1 to 3 times per
month, 1 to 4 times per week, or 5 or more times per week had average annual
rates of
cognitive decline that were 17%, 32%, 37%, and
26% lower, respectively, than those of non-tea-drinkers" - See
green tea extract at Amazon.com
Low
vitamin D levels associated with cognitive decline - Science Daily, 7/12/10
- "An estimated 40 percent to 100 percent of older
adults in the United States and Europe are deficient in
vitamin D ... Participants who were severely deficient in vitamin D (having
blood levels of 25-hydroxyvitamin D of less than 25 nanomoles per liter) were 60
percent more likely to have substantial
cognitive decline in general over the six-year
period and 31 percent more likely to experience declines on the test measuring
executive function than those with sufficient vitamin D levels" - See
vitamin D at Amazon.com
Vitamin D levels associated with Parkinson's disease risk - Science Daily,
7/12/10 - "Over a 29-year follow-up, through 2007, 50 of
the participants developed Parkinson's disease.
After adjusting for potentially related factors, including physical activity and
body mass index, individuals in the highest quartile (one-fourth of the study
population) of serum
vitamin D levels had a 67 percent lower risk of
developing Parkinson's disease than those in the lowest quartile of vitamin D
levels" - See
vitamin D at Amazon.com
Sirtuin1
may boost memory and learning ability; Discovery could lead to new drugs to
fight Alzheimer's, other neurological diseases - Science Daily, 7/11/10 -
"Resveratrol,
found in wine, has been touted as a life-span enhancer because it activates a
group of enzymes known as sirtuins, which have gained fame in recent years for
their ability to slow the aging process. Now MIT researchers report that
Sirtuin1 -- a protein that in humans is encoded by the SIRT1 gene -- also
promotes memory and brain flexibility ... We have now found that SIRT1 activity
also promotes plasticity and memory" - See
resveratrol products at Amazon.com Plant extract may be effective against inflammatory bowel disease - Science Daily, 7/7/10 - "PEITC is found in the Brassica genus of plants, which includes cabbage, cauliflower, watercress and broccoli ... it not only alleviates several clinical signs of ulcerative colitis -- for example, it attenuates the damage that occurs in the colon tissues and colon epithelium, as well as the clinical signs like diarrhea and blood in stool. The weight loss is a major sign in colitis and that was alleviated, too" Short Telomeres Tied to Cancer Risk - Medscape, 7/9/10 - "short telomere length was associated with a 60% increased risk for subsequent cancer" High-protein diets may cause bone loss in older women, study - Nutra USA, 7/8/10 - "Study 1 ... on average, all women lost around 19 pounds, but those who ate the higher-protein, meat-containing diet also lost bone mineral density by about 1.4 percent ... Study 2 ... All women lost weight, but the groups that consumed the higher-protein meat-containing diets again also lost bone mineral density by up to 1.4 percent compared to the control group ... In the first study, all the participants con­sumed calcium supplements to achieve calcium intakes of 2,000mg per day. In the second study, about half of the participants con­sumed calcium supplements ... However, in neither case were the supplements found to impact the loss of bone density"
Fish oil
may reduce risk of breast cancer - Science Daily, 7/8/10 -
"asked 35,016 postmenopausal women who did not have a
history of breast cancer to complete a 24-page
questionnaire about their use of non-vitamin, non-mineral "specialty"
supplements in the Vitamins and Lifestyle (VITAL) cohort study ... Regular use
of fish oil supplements, which contain high
levels of the omega-3 fatty acids, EPA and DHA, was linked with a 32 percent
reduced risk of breast cancer. The reduction in risk appeared to be restricted
to invasive ductal breast cancer, the most common type of the disease" -
See
Mega Twin EPA at Amazon.com
High
blood levels of vitamin E reduces risk of Alzheimer's, Swedish study finds -
Science Daily, 7/7/10 - "High levels of several
vitamin E components in the blood are
associated with a decreased risk for Alzheimer's
disease (AD) in advanced age, suggesting that vitamin E may help prevent
cognitive deterioration in elderly people. This is the conclusion reached in a
Swedish study ... Vitamin E is a family of eight natural components, but most
studies related to Alzheimer's disease investigate only one of these components,
+/--tocopherol ... We hypothesized that all the vitamin E family members could
be important in protecting against AD ... subjects with higher blood levels of
all the vitamin E family forms had a reduced risk of developing AD, compared to
subjects with lower levels. After adjusting for various confounders, the risk
was reduced by 45-54%, depending on the vitamin E component" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top): Independent and joint effects of serum 25-hydroxyvitamin D and calcium on ovarian cancer risk: A prospective nested case-control study - Eur J Cancer. 2010 Jun 18 - "We observed a significant inverse association between calcium and ovarian cancer risk. Relative risk (estimated as odds ratio, OR) comparing the highest quartile to the lowest quartile was significantly decreased; 0.41 [95% confidence interval (CI) 0.19-0.85, P-trend 0.004]. Even though a comparable association between 25-OHD and ovarian cancer did not reach statistical significance (OR 0.57, 95% CI 0.26-1.24, P-trend 0.07), having sufficient (>75nmol/L) serum 25-OHD levels compared to insufficient serum 25-OHD was associated with a significantly decreased risk of ovarian cancer (OR 0.32; 95% CI 0.12-0.91, p-value 0.03)"
Gamma-tocotrienol as an effective agent in targeting prostate cancer stem
cell-like population - Int J Cancer. 2010 Jul 8 -
"Emerging evidence supports that prostate cancer originates from a rare
sub-population of cells, namely prostate cancer
stem cells (CSCs). Conventional therapies for prostate cancer are believed to
mainly target the majority of differentiated tumor cells but spare CSCs, which
may account for the subsequent disease relapse after treatment. Therefore,
successful elimination of CSCs may be an effective strategy to achieve complete
remission from this disease.
Gamma-tocotrienols
(gamma-T3) is one of the vitamin-E constituents which have been shown to have
anticancer effects against a wide-range of human cancers. Recently, we have
reported that gamma-T3 treatment not only inhibits prostate cancer cell invasion
but also sensitizes the cells to docetaxel-induced apoptosis, suggesting that
gamma-T3 may be an effective therapeutic agent against advanced stage prostate
cancer. Here, we demonstrate for the first time that gamma-T3 can down-regulate
the expression of prostate CSC markers (CD133/CD44) in androgen independent (AI)
prostate cancer cell lines (PC-3 & DU145), as evident from western blotting
analysis. Meanwhile, the spheroid formation ability of the prostate cancer cells
was significantly hampered by gamma-T3 treatment. In addition, pre-treatment of
PC-3 cells with gamma-T3 was found to suppress tumor initiation ability of the
cells. More importantly, while CD133-enriched PC-3 cells were highly resistant
to docetaxel treatment, these cells were as sensitive to gamma-T3 treatment as
the CD133-depleted population. Our data suggest that gamma-T3 may be an
effective agent in targeting prostate CSCs, which may account for its anticancer
and chemosensitizing effects reported in previous studies" - See
Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com
Low Serum
Levels of Dehydroepiandrosterone Sulfate Predict All-Cause and Cardiovascular
Mortality in Elderly Swedish Men - J Clin Endocrinol Metab. 2010 Jul 7 -
"During a mean 4.5-yr follow-up, 328 deaths occurred.
Low levels of DHEA-S (quartile 1 vs. quartiles 2-4), predicted death from all
causes [hazard ratio (HR) 1.54, 95% confidence interval (CI) 1.21-1.96; adjusted
for traditional cardiovascular risk factors], from CVD (n = 123 deaths; HR 1.61,
95% CI 1.10-2.37) and ischemic heart disease (n = 73; HR 1.67, 95% CI 1.02-2.74)
but not cancer. Analyses with DHEA gave similar results. The association between
low DHEA-S and CVD death remained after adjustment for C-reactive protein and
circulating estradiol and testosterone levels. When stratified by the median age
of 75.4 yr, the mortality prediction by low DHEA-S was more pronounced among
younger (age adjusted HR for CVD death 2.64, 95% CI 1.37-5.09) than older men
(HR 1.30, 95% CI 0.83-2.04). Conclusions: Low serum levels of DHEA(-S) predict
death from all causes, CVD, and ischemic heart disease in older men" -
See
DHEA at Amazon.com
Aged garlic
extract lowers blood pressure in patients with treated but uncontrolled
hypertension: A randomised controlled trial - Maturitas. 2010 Jun 29 -
"In patients with uncontrolled hypertension
(SBP>/=140mmHg at baseline), systolic blood
pressure was on average 10.2+/-4.3mmHg (p=0.03) lower in the
garlic group compared with controls over the
12-week treatment period. Changes in blood pressure between the groups were not
significant in patients with SBP<140mmHg at baseline. Aged garlic extract was
generally well tolerated and acceptability of trial treatment was high (92%).
CONCLUSION: Our trial suggests that aged garlic extract is superior to placebo
in lowering systolic blood pressure similarly to current first line medications
in patients with treated but uncontrolled hypertension" - See
garlic supplements at Amazon.com Telomere length and risk of incident cancer and cancer mortality - JAMA. 2010 Jul 7;304(1):69-75 - "Short telomere length at baseline was associated with incident cancer independently of standard cancer risk factors (multivariable hazard ratio [HR] per 1-SD decrease in log(e)-transformed telomere length, 1.60; 95% confidence interval [CI], 1.30-1.98; P < .001). Compared with participants in the longest telomere length group, the multivariable HR for incident cancer was 2.15 (95% CI, 1.12-4.14) in the middle length group and 3.11 (95% CI, 1.65-5.84) in the shortest length group (P < .001). Incidence rates were 5.1 (95% CI, 2.9-8.7) per 1000 person-years in the longest telomere length group, 14.2 (95% CI, 10.0-20.1) per 1000 person-years in the middle length group, and 22.5 (95% CI, 16.9-29.9) per 1000 person-years in the shortest length group. The association equally applied to men and women and emerged as robust under a variety of circumstances. Furthermore, short telomere length was associated with cancer mortality (multivariable HR per 1-SD decrease in log(e)-transformed telomere length, 2.13; 95% CI, 1.58-2.86; P < .001) and individual cancer subtypes with a high fatality rate. CONCLUSION: In this study population, there was a statistically significant inverse relationship between telomere length and both cancer incidence and mortality"
Vitamin D
levels and mortality in type 2 diabetes - Diabetes Care. 2010 Jul 6 -
"All-cause mortality
was increased in patients with severe
vitamin D deficiency; HR [95% CI] 1.96
[1.29-2.98] ... Severe vitamin D deficiency was associated with increased
cardiovascular mortality; HR 1.95 [1.11-3.44]" - See
vitamin D at Amazon.com Health Focus (Hearing Loss): Alternative News:
Other News:
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