Recent Longevity News for the seven days ending 4/28/10.  You should consult your doctor if you are taking any medications.

Low Testosterone Tied to Frailty in Older Men - Medscape, 4/26/10 - "In general, men with total testosterone levels below the median were more likely to be frail. Moreover, lower levels of free testosterone were tied to a greater risk of becoming frail over the next four to seven years"

Regular aerobic exercise is good for the brain - Science Daily, 4/26/10 - "Regular exercise speeds learning and improves blood flow to the brain ... monkeys who exercised regularly at an intensity that would improve fitness in middle-aged people learned to do tests of cognitive function faster and had greater blood volume in the brain's motor cortex than their sedentary counterparts ... This suggests people who exercise are getting similar benefits ... When the researchers examined tissue samples from the brain's motor cortex, they found that mature monkeys that ran had greater vascular volume than middle-aged runners or sedentary animals. But those blood flow changes reversed in monkeys that were sedentary after exercising for five months"

Brown rice and cardiovascular protection -Science Daily, 4/26/10 - "brown rice might have an advantage over white rice by offering protection from high blood pressure and atherosclerosis ("hardening of the arteries") ... a component in a layer of tissue surrounding grains of brown rice may work against angiotensin II. Angiotensin II is an endocrine protein and a known culprit in the development of high blood pressure and atherosclerosis"

Phosphorous in sodas and processed foods accelerates signs of aging, study suggests - Science Daily, 4/26/10 - "high levels of phosphates may add more "pop" to sodas and processed foods than once thought. That's because researchers found that the high levels of phosphates accelerate signs of aging. High phosphate levels may also increase the prevalence and severity of age-related complications, such as chronic kidney disease and cardiovascular calcification, and can also induce severe muscle and skin atrophy"

Erectile dysfunction and increased dangers of cardiovascular disease - Science Daily, 4/25/10 - "men with erectile dysfunction and low testosterone have a higher than normal risk of dying from cardiovascular disease. Further work from the same research group shows that obesity is also associated with an impairment of blood flow to the penis, which in turn is also associated with cardiovascular disease in men with erectile dysfunction ... Low testosterone itself was not associated with major cardiac events, but those patients with the lowest testosterone who had a major cardiac event were significantly more likely to die than those with higher levels of testosterone (P<0.001; the risk is increased by a factor of seven ... In a second study (but using the same group of patients as above), the group showed that the degree of obesity, along with erectile dysfunction, were significantly and independently associated with cardiac events"

Better vitamin D status could mean better quality of life for seniors - Science Daily, 4/25/10 - "When the results were tabulated, participants with the highest levels of 25-hydroxyvitamin D had better physical function. And, although physical function declined over the course of the study, it remained significantly higher among those with the highest vitamin D levels at the beginning of the study compared to those with the lowest vitamin D levels. The scientists were not surprised to learn that, in general, vitamin D consumption was very low in this group of otherwise healthy seniors. In fact, more than 90% of them consumed less vitamin D than currently recommended, and many were relying on dietary supplements" - See vitamin D at Amazon.com.

To learn better, take a nap (and don't forget to dream) - Science Daily, 4/22/10 - "What's got us really excited, is that after nearly 100 years of debate about the function of dreams, this study tells us that dreams are the brain's way of processing, integrating and really understanding new information ... Dreams are a clear indication that the sleeping brain is working on memories at multiple levels, including ways that will directly improve performance"

A1c Levels: Is Lower Always Better? - Medscape, 4/23/10 - "A1c values in the lowest decile (median, 6.4%) were associated with an increased risk for mortality for all patients (hazard ratio [HR], 1.52; 95% confidence interval [CI], 1.40-1.64). This finding was stronger in the INS cohort (HR, 1.79; 95% CI, 1.45-1.22) than in the SUMET cohort (HR, 1.30; 95% CI, 1.07-1.58). Only the 10th decile (median, 10.4%) was also associated with increased mortality risk in the SUMET cohort (HR, 1.93; 95% CI, 1.55-2.42); but in the INS cohort, deciles 2 (median, 6.95%; HR,1.45; 95% CI, 1.17-1.80), 3 (median, 7.3%; HR, 1.35; 95% CI, 1.09-1.67), 9 (median, 9.4%; HR, 1.46; 95% CI, 1.21-1.77), and 10 (median, 10.6%; HR, 1.80; 95% CI, 1.49-2.17) were all associated with greater risk. The combined model yielded results similar to the INS cohort, and the inclusion of a variable for membership in the INS cohort was significantly associated with increased mortality (HR, 1.49; 95% CI, 1.39-1.59). The adjusted risk for progression to large-vessel disease had the same general U-shaped association as for all-cause mortality, and insulin treatment was associated with an increased risk for a first large-vessel disease event"

Study: Too Much Sugar Increases Heart Risks - Time Magazine, 4/21/10 - "Compared with people consuming less than 5% of their daily calories in added sugar, those in the highest consumption group — who got 25% or more of their daily calories in added sugar — were twice as likely to have low levels of HDL cholesterol, the beneficial lipid that mops up artery-clogging LDL cholesterol. According to government health guidelines, HDL levels below 50 mg/dL for women and 40 mg/dL for men are considered low; 43% of the highest sugar consumers recorded low HDL, while only 22% of the lowest sugar consumers did ... People eating the most added sugar also recorded the highest triglyceride levels ... Low HDL and high triglyceride levels are two of the primary risk factors for heart disease"

Excessive alcohol consumption may lead to increased cancer risk - Science Daily, 4/21/10 - "Researchers have detected a link between alcohol consumption, cancer and aging that starts at the cellular level with telomere shortening ... Telomeres are found at the region of DNA sequences at the end of a chromosome, and are important for the genetic stability of cells. As people age, telomere length shortens progressively ... Since telomere shortening is thought to increase cancer risk, the researchers speculated that those with shorter telomeres due to heavy alcohol consumption would have an increased risk of cancer ... telomere length was dramatically shortened in those who consumed heavy amounts of alcohol; telomere length was nearly half as long as telomere length in the non-abusers (0.41 vs. 0.79 relative units)"

How red wine may shield brain from stroke damage: researchers discover pathway in mice for resveratrol's apparent protective effect - Science Daily, 4/21/10 - "Two hours after feeding mice a single modest dose of resveratrol, a compound found in the skins and seeds of red grapes, the scientists induced an ischemic stroke by essentially cutting off blood supply to the animals' brains. They found that the animals that had preventively ingested the resveratrol suffered significantly less brain damage than the ones that had not been given the compound ... his study suggests that resveratrol increases levels of an enzyme (heme oxygenase) already known to shield nerve cells in the brain from damage. When the stroke hits, the brain is ready to protect itself because of elevated enzyme levels. In mice that lacked the enzyme, the study found, resveratrol had no significant protective effect and their brain cells died after a stroke" - See resveratrol products at Amazon.com.

Lung Cancer Risk in Painters: A Meta-Analysis - Medscape, 4/21/10 - "Although there was not enough information in the studies provided to assess the association of lung cancer with specific chemical agents encountered in painting, the robustness of the estimates in the subgroup analyses (by sex, region, study design, and controlling for smoking and other occupational exposures) and the stronger associations seen in specific subgroups (by duration of exposure) support the conclusion that occupational exposures in painters are causally associated with the risk of lung cancer. Because several million people are employed as painters worldwide and because lung cancer is the most common cancer in painters, even a modest increase in the relative risk is remarkable"

Does a man's estrogen level impact his risk of prostate cancer? - Science Daily, 4/19/10 - "The relative amounts of the 15 estrogens and estrogen metabolites in the urine of prostate cancer cases were similar to that of non-cancer patients with the exception of the estrogen metabolite 4-OHE1 ... This particular estrogen metabolite appeared to be more abundant among men diagnosed with prostate cancer"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression - Lipids Health Dis. 2010 Apr 19;9(1):40 - "Curcumin inhibits cholesterol uptake through suppression of NPC1L1 expression in the intestinal cells"

Effects of phenylethyl isothiocyanate and its metabolite on cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells - Int J Food Sci Nutr. 2010 May;11(7):324-36 - "Cruciferous vegetable consumption is associated with decreased risk of several cancers, including prostate cancer. Gluconasturtiin, one of the predominant glucosinolates in cruciferous vegetables, is hydrolyzed to yield phenylethyl isothiocyanate (PEITC). PEITC absorption and metabolism in humans involves glutathione conjugation followed by conversion via the mercapturic acid pathway to an N-acetylcysteine (NAC) conjugate that is excreted in the urine. We observed an inhibitory effect of PEITC and its metabolite, NAC-PEITC, on cancer cell proliferation, cell-cycle progression, and apoptosis in LNCaP human prostate cancer cells. PEITC and NAC-PEITC suppressed LNCaP cell proliferation in a dose-dependent manner, and exposure to 5 microM PEITC or NAC-PEITC reduced cell proliferation by 25% and 30%, respectively. Cell-cycle analysis revealed that cells treated with 5 microM PEITC or NAC-PEITC arrested at the G(2)/M phase. In addition, the percentage of cells in the S phase decreased from 46% to 25% following 48 h of incubation with PEITC or NAC-PEITC. The G(2)/M-phase cell-cycle arrest of LNCaP cells grown in the presence of PEITC or NAC-PEITC is correlated with the downregulation of Cdk1 and cyclin B(1) protein expression. Apoptosis was observed at the later stages of 24-h and 48-h treatments with 5 microM PEITC and NAC-PEITC. In conclusion, PEITC and NAC-PEITC are potential chemopreventive/chemotherapeutic agents against LNCaP human prostate cancer cells"

Lowering Midlife Levels of Systolic Blood Pressure as a Public Health Strategy to Reduce Late-Life Dementia. Perspective From the Honolulu Heart Program/Honolulu Asia Aging Study - Hypertension. 2010 Apr 19 - "Compared with those with SBP <120 mm Hg, untreated, and <50 years of age at baseline, 17.7% (95% CI: 4.6% to 29.1%) of the cases were attributable to prehypertensive levels (SBP: 120 to <140 mm Hg) of SBP, translating into 11 excess cases per 1000. Among those who did not report taking antihypertensive medication in midlife, 27% (95% CI: 8.9% to 42.1%) of dementia cases can be attributed to systolic BP >/=120 mm Hg, translating into 17 excess cases per 1000. Although population-attributable risk estimates for population subgroups may differ by relative risk for dementia or prevalence of elevated levels of blood pressure, these data suggest that reducing midlife systolic BP is an effective prevention strategy to reduce risk for late-life dementia"

Health Focus (Liver Disease):

Related Topics:

• liver cancer / cirrhosis / hepatitis

Popular Supplements:

• SAM-e / Milk Thistle / artichoke extract / B-complex / vitamin C / vitamin E / selenium / fatty acids / choline / carnitine / glutathione / vitamin K

Alternative News:

• Liver Degenerative Disease - Life Extension Foundation
• I have seen artichoke extract and milk thistle extract being promoted as liver remedies. Which one is better? - Dr. Murray
• Liver Health - Powerful Support for Liver Function & Hepatitis C - Dr. Murray (.pdf)
• Indian spice may delay liver damage and cirrhosis, study suggests - Science Daily, 3/24/10 - "The findings showed that the curcumin diet significantly reduced bile duct blockage and curbed liver cell (hepatocyte) damage and scarring (fibrosis) by interfering with several chemical signalling pathways involved in the inflammatory process" - See curcumin products at Amazon.com.
• High fructose corn syrup linked to liver scarring, research suggests - Science Daily, 3/22/10 - "The researchers found only 19 percent of adults with NAFLD reported no intake of fructose-containing beverages, while 52 percent consumed between one and six servings a week and 29 percent consumed fructose-containing beverages on a daily basis"
• Pomegranate oil-seaweed mix may improve liver health and waist size - Nutra USA, 1/25/10 - "Results showed that body weight was significantly reduced by an average of 5.5 kg in people in the NAFLD group and 4.9 kg in the normal liver function group. Women in the placebo group lost an average of 1.4 kilos. In addition, women with NAFLD experienced improvements in waist circumference, body and liver fat content, liver enzymes, and serum triglycerides" - [Abstract] - 5.5 kg is 12.1 pounds - See FucoThin at Amazon.com
• The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat - Diabetes Obes Metab. 2010 Jan;12(1):72-81 - "Xanthigen-600/2.4 mg (300 mg PSO + 300 mg brown seaweed extract containing 2.4 mg fucoxanthin) resulted in statistically significant reduction of body weight (5.5 +/- 1.4 kg NAFLD group and 4.9 +/- 1.2 kg NLF group, p < 0.05), waist circumference (NAFLD group only), body (3.5 +/- 1.9 kg NAFLD group, p < 0.001; 3.6 +/- 0.7 kg NLF group, p < 0.05) and liver fat content, liver enzymes (NAFLD group only), serum triglycerides and C-reactive protein. Weight loss and reduction in body and liver fat content occurred earlier in patients with NLF than in patients with NAFLD. Fucoxanthin (> 2.4 mg) and Xanthigen-400/1.6 mg (200 mg PSO + 200 mg brown seaweed extract containing 1.6 mg fucoxanthin) significantly increased REE in NAFLD subjects compared to placebo. CONCLUSIONS: Xanthigen promoted weight loss, reduced body and liver fat content, and improved liver function tests in obese non-diabetic women. Xanthigen and Fucoxanthin also increased REE. This product may be considered a promising food supplement in the management of obesity" - See FucoThin at Amazon.com
• Review article: omega-3 fatty acids - a promising novel therapy for non-alcoholic fatty liver disease - Aliment Pharmacol Ther. 2009 Dec 30 - "Non-alcoholic fatty liver disease (NAFLD) affects 10-35% of the adult population worldwide; there is no consensus on its treatment ... Omega-3 fatty acids are important regulators of hepatic gene transcription. Animal studies demonstrate they reduce hepatic steatosis, improve insulin sensitivity and reduce markers of inflammation. Clinical trials in human subjects generally confirm these findings but have significant design inadequacies. Conclusions Omega-3 fatty acids are a promising treatment for NAFLD which require to be tested in randomised placebo controlled trials" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Review supports omega-3 for liver health - Nutra USA, 1/6/10 - "A review of four human studies found that the fatty acids could improve liver health and function, and increase insulin sensitivity in people suffering from fatty liver, a condition that is usually symptomless but said to increase the risk for liver inflammation, and ultimately results in liver failure" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Milk thistle herb protects cancer patients from chemotherapy-associated liver toxicity - Science Daily, 12/27/09 - "Fifty children with ALL were enrolled in the study and were randomized to receive milk thistle or placebo for 28 days. At the start of the study, all of the children had evidence of liver inflammation as measured by elevations in blood levels of the liver enzymes, aspartate amino transferase (AST) and amino alanine transferase (ALT). When the investigators performed liver function tests on the children at day 56 (28 days after receiving the herb or placebo), children receiving milk thistle had improvements in their liver enzymes compared with children receiving a placebo. Specifically, the group that took milk thistle had significantly lower levels of AST and a trend towards significantly lower levels of ALT. Taking milk thistle also seemed to help keep fewer patients from having to lower the dose of their medications: chemotherapy doses were reduced in 61 percent of the group receiving milk thistle, compared with 72 percent of the placebo group. In addition, milk thistle appeared to be safe for consumption" - See silymarin (milk thistle) products at iHerb.
• Herb May Treat Chemotherapy Liver Damage - WebMD, 12/14/09 - "The youths who took milk thistle had significantly lower levels of AST and a trend toward significant lower levels of ALT, the researchers say ... Milk thistle also seemed to help keep fewer patients from having to lower the dose of their chemotherapy drugs ... Chemotherapy doses were reduced in 61% of those on milk thistle, compared to 72% in the placebo group. Milk thistle appeared to be safe for consumption, the researchers write" - See silymarin (milk thistle) products at iHerb.
• Antifibrotic effects of green tea - Science Daily, 11/18/09 - "The researchers drew a conclusion that green tea may protect liver cells and reduce the deposition of collagen fibers in the liver. Green tea provides a safe and effective strategy for improving hepatic fibrosis" - See green tea extract at Amazon.com.
• Medication Effective For Acute Liver Failure In Early Stages Of Disease, Study Suggests - Science Daily, 10/8/09 - "Researchers found that 52 percent of acute liver failure patients in mild to moderate comas survived when treated with NAC, compared to just 30 percent of those treated with only a placebo. In patients experiencing more severe coma, treatment with NAC did not result in a significant difference in survival rates" - See n-acetyl cysteine at Amazon.com.
• Regular Aerobic Exercise Reduces Health Concerns Associated With Fatty Liver - Science Daily, 9/9/09
• Liver Carbohydrate and Lipid Metabolism of Insulin-Deficient Mice Is Altered by trans-10, cis-12 Conjugated Linoleic Acid - J Nutr. 2009 Aug 19 - "Feeding mice the trans-10, cis-12 (t10c12) conjugated linoleic acid (CLA) isomer is associated with lipodystrophy, insulin resistance, hyperinsulinemia, and liver steatosis. It has been hypothesized that CLA-induced liver steatosis is the result of increased hepatic lipogenesis stimulated by high insulin levels. We studied the effects of a 12-d t10c12CLA treatment (1 g/100 g diet) on liver carbohydrate and lipid metabolism in control and streptozotocin (STZ)-injected mice. STZ mice were characterized by insulin deficiency, hypertriglyceridemia, and depletion of liver triglyceride and glycogen. Remarkably, feeding t10c12CLA to diabetic mice (STZ-CLA) normalized these variables. Reconstitution of fat stores in the livers of STZ-CLA mice was associated with lower fatty acid (FA) oxidation rates and greater malonyl-CoA concentration than in STZ mice. FA translocase and VLDL receptor mRNA levels were greater in STZ-CLA than in STZ mice, suggesting that t10c12CLA increased liver lipid uptake. Phosphoenolpyruvate carboxykinase mRNA levels and AMP kinase phosphorylation were lower in STZ-CLA than in STZ mice, indicating that t10c12CLA may reduce glucogenic activity and promote glycogenesis in diabetic mice. Because glycemia and glucokinase expression were not modified by t10c12CLA treatment, we postulated that glycogen accumulation is likely not the result of an effect of t10c12CLA on plasma glucose utilization, but rather is due to the contribution of lactate, the concentration of which was higher in muscle of STZ-CLA mice. The results demonstrate that t10c12CLA stimulates liver lipid accumulation in the absence of insulin and, thus, suggest that t10c12CLA can improve liver carbohydrate and lipid metabolism in type I diabetic mice" - See conjugated linoleic acid at Amazon.com.
• Nutritional Supplement, SAMe, Effective In Preventing Formation Of Primary Liver Cancer In Rats - Science Daily, 7/30/09 - "A new study investigated the effectiveness of S-adenosylmethionine (SAMe) in the prevention and treatment of hepatocellular carcinoma (HCC) or primary liver cancer. SAMe, a widely available nutritional supplement, with little known side effects, was found to be effective in preventing the formation of HCC in rats" - [Abstract] - See SAM-e at Amazon.com.
• S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model - Hepatology. 2009 Apr 6 - "SAMe is effective in preventing HCC establishment but ineffective in treating established HCC because of induction of hepatic methyltransferases, which prevents SAMe level to reach high enough to kill liver cancer cells. SAMe's chemopreventive effect may be related to its proapoptotic action and its ability to inhibit angiogenes" - See SAM-e at Amazon.com.
• Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells - Br J Pharmacol. 2009 Jul 7 - "This curcumin, a constituent of turmeric, may be useful in preventing hypercholesterolemia-associated hepatic fibrogenesis" - See curcumin products at Amazon.com.
• Fish Oil-Based Lipid Emulsions Prevent and Reverse Parenteral Nutrition-Associated Liver Disease: The Boston Experience - JPEN J Parenter Enteral Nutr. 2009 Jul 1 - "Parenteral nutrition-associated liver disease (PNALD) is the most prevalent and most severe complication of long-term parenteral nutrition. Its underlying pathophysiology, however, largely remains to be elucidated. The currently approved parenteral lipid emulsions in the United States contain safflower or soybean oils, both rich in omega-6 polyunsaturated fatty acids (PUFAs). Mounting evidence indicates that the omega-6 PUFAs originating from plant oils in these lipid emulsions may play a role in the onset of liver injury. Fish oil-based lipid emulsions, in contrast, are primarily composed of omega-3 PUFAs, thus providing a promising alternative. The authors review the literature on the role of lipid emulsions in the onset of PNALD and discuss prevention and treatment strategies using a fish oil- based lipid emulsion. They conclude that a fish oil-based emulsion is hepatoprotective in a murine model of PNALD, and it appears to be safe and efficacious for the treatment of this type of liver disease in children" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cells - Eur J Clin Invest. 2009 Jun 8 - "In hepatocytes from normal rats, the quercetin-induced decrease in both de novo fatty acid and TAG synthesis, with a consequent reduction in VLDL-TAG formation, may represent a potential mechanism contributing to the reported hypotriacylglycerolemic effect of quercetin" - See quercetin at Amazon.com.
• Combination of vitamin K(2) and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma - J Hepatol. 2009 May 15 - "A 48-month follow-up revealed that the combination treatment with VK and ACE-I markedly inhibited the cumulative recurrence of HCC in association with suppression of the serum level of the vascular endothelial growth factor (VEGF); a central angiogenic factor. The serum level of lectin-reactive alpha-fetoprotein was also suppressed almost in parallel with VEGF. These beneficial effects were not observed with single treatment using VK or ACE-I" - See vitamin K at Amazon.com.
• Two Glasses Of Wine A Day Helps To Reduce Quantity Of Fat In Liver - Science Daily, 5/12/09 - "Alter four weeks, samples of liver and blood were taken from individuals of the three different groups for their subsequent analysis. It was shown that in the third group - the one treated with resveratrol -, infiltration of liver fat dropped in comparison with group two. After this and a number of other analyses, the researcher concluded that resveratrol reduces the severity of ESNA in models with rats because, in the animals treated with resveratrol, the percentage of the cells of affected liver cells was notably less in non-treated animals" - See resveratrol products at Amazon.com.
• Fatty Liver Disease: The Next Big Thing - Science Daily, 4/19/09 - "New research in The Journal of Physiology connects low aerobic capacity to another serious condition – non-alcoholic fatty liver disease (NAFLD) – and suggests that the resulting liver problems play a crucial step developing obesity-related illnesses ... Sufferers of NAFLD accumulate fat in their livers and have high levels of fat in their blood, amplifying the risk-factors of obesity. The disease leads to a form of liver damage called fibrosis, similar to the results of alcohol abuse"
• Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway - Biochem Biophys Res Commun. 2009 Mar 13;380(3):644-9 - "Our results suggest that resveratrol may attenuate fat deposition by inhibiting SREBP1 expression via Sirt1-FOXO1 pathway and thus may have application for the treatment of NAFLD" - See resveratrol products at Amazon.com.
• Why Diets High In High-fructose Corn Syrup (found In Soda And Processed Foods) Can Lead To Insulin Resistance - Science Daily, 3/3/09 - "mice on a high-fructose diet were protected from insulin resistance when a gene known as transcriptional coactivator PPARg coactivator-1b (PGC-1b) was "knocked down" in the animals' liver and fat tissue ... Fructose is much more readily metabolized to fat in the liver than glucose is and in the process can lead to nonalcoholic fatty liver disease ... NAFLD in turn leads to hepatic insulin resistance and type II diabetes"
• Fat-free Diet Reduces Liver Fat In Fat-free Mice, Researchers Report - Science Daily, 2/13/09
• Omega-3 Fatty Acids Prevent Medical Complications Of Obesity, Study Suggests - Science Daily, 2/12/09 - "Our study shows for the first time that lipids called protectins and resolvins derived from omega-3 fatty acids can actually reduce the instance of liver complications, such as hepatic steatosis and insulin resistance, in obese people" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Aspirin May Prevent Liver Damage That Afflicts Millions, Study Finds - Science Daily, 1/26/09 - "Simple aspirin may prevent liver damage in millions of people suffering from side effects of common drugs, alcohol abuse, and obesity-related liver disease"
• New Therapeutic Properties Of N-acetyl-L-cysteine Discovered - Science Daily, 1/19/09 - "N-acetyl-L-cysteine (NAC) combined with mesalamine produces a significant improvement in patients suffering from ulcerative colitis ... N-acetyl-L-cysteine, is a drug normally used for the treatment of chronic obstructive pulmonary disease (COPD) and to minimize the effects of cold and flu. Its hepatic protective properties also make this drug a useful tool in paracetamol intoxications ... N-acetyl-L-cysteine reduced the negative effects caused by azathioprine, a immunosuppressant of clinical use, on the liver" - See n-acetyl cysteine at Amazon.com.
• How Did Glycine Significantly Decrease Liver Injury? - Science Daily, 10/31/08 - "Recent studies demonstrated that dietary glycine protected both the lung and liver against lethal doses of endotoxin in rat or other animals and improved graft survival after liver transplantation" - See L-glycine products at iHerb.
• Bilberry extract may ease the damages of stress: study - Nutra USA, 10/28/08 - "Mice supplemented with an anthocyanin-rich bilberry extract (Mirtoselect, Indena) at doses of 50, 100, and 200 milligrams per kilograms per day experienced lower ALT levels than non-supplemented restrained animals (17.23 versus 107.68 units per litre, respectively)"
• Low-carb Diets Alter Glucose Formation By The Liver - Science Daily, 10/20/08 - "a low-carbohydrate diet changes hepatic energy metabolism. When carbohydrates are restricted, the liver relies more on substances like lactate and amino acids to form glucose, instead of glycerol ... They suggest that the shift in glucose metabolism associated with a low carbohydrate diet could be beneficial in individuals with non-alcoholic fatty liver disease (NAFLD) due to improved disposal of hepatic fat"
• Resveratrol Prevents Fat Accumulation In Livers Of 'Alcoholic' Mice - Science Daily, 10/14/08 - "The accumulation of fat in the liver as a result of chronic alcohol consumption could be prevented by consuming resveratrol, according to a new study with mice. The research found that resveratrol reduced the amount of fat produced in the liver of mice fed alcohol and, at the same time, increased the rate at which fat within the liver is broken down" - [WebMD] - See resveratrol products at Amazon.com.
• Vitamin D Deficiency Common In Patients With IBD, Chronic Liver Disease - Science Daily, 10/13/08 - "analyzed vitamin D levels of 504 inflammatory bowel disease patients ... almost 50 percent of the patients were Vitamin D deficient at some point, with 11 percent being severely deficient ... 92.4 percent of chronic liver patients had some degree of vitamin D deficiency and at least one third were severely deficient. Severe vitamin D deficiency was more common among cirrhotics" - See vitamin D at Amazon.com.
• Patients With IBD, Chronic Liver Disease at Increased Risk of Vitamin D Deficiencies - Doctor's Guide, 10/7/08 - "conducted analysed vitamin D levels of 504 patients with IBD ... researchers found almost 50% of the patients were vitamin D deficient at some point, with 11% being severely deficient ... with hepatitis C virus (HCV) ... 92.4% of the patients had some degree of vitamin D deficiency and at least one-third was severely deficient" - See vitamin D at Amazon.com.
• Can Taurine Be A Potent Antioxidant Drug In The Future? - Science Daily, 9/19/08 - "Taurine is a potent antioxidant with hepatoprotective effects. Organelle based changes in hepatocytes after taurine treatment in experimental liver fibrosis were searched systematically and organelle injury scores decreased were found to decrease significantly" - See taurine at Amazon.com.
• Protective Effects of Bilberry (Vaccinium myrtillus L.) Extract on Restraint Stress-Induced Liver Damage in Mice - J Agric Food Chem. 2008 Aug 9 - "Bilberry extract (containing 42.04% anthocyanins) was oral administrated to mice at 50, 100, and 200 mg/(kg.day) for five days, which remarkably decreased plasma ALT level to 17.23 +/- 2.49 U/L at the dose of 200 mg/(kg.day) and thus alleviated stress-induced liver damage. In addition, bilberry extracts increased glutathione (GSH) and vitamin C levels and significantly decreased MDA and nitric oxide (NO) levels in the liver tissues. These results suggest that bilberry extract plays an important role in protecting against restraint stress-induced liver damage by both scavenging free radicals activity and lipid peroxidation inhibitory effect. This study showed the beneficial health effects of bilberry extract through its antioxidative action" - See bilberry at Amazon.com.
• Red wine keeps liver healthy, suggests new study - Nutra USA, 5/22/08 - "People who drank up to one glass of wine a day saw the risk of liver disease due to Non-Alcoholic Fatty Liver Disease (NAFLD) cut in half ... In contrast, compared with wine drinkers, people who reported modest consumption of beer or spirits had over four times the odds of having suspected NAFLD"
• Fast-Food Liver Damage Can Be Reversed, Experts Say - Science Daily, 4/30/08 - "Diets high in fast food can be highly toxic to the liver and other internal organs, but that damage can be reversed ... You can likely reverse the damage to your liver and other vital organs if you simply give up the unhealthy lifestyle"
• Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles - Breast Cancer Res Treat. 2008 Apr 22 - "Tamoxifen (TAM) ... TAM also has estrogenic activity on liver and endometrium causing severe oxidative stress with various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN) are well-known potent antioxidants and protective agents against many diseases including cancer ... A statistically significant alteration in various blood chemistry parameters, such as serum total bilirubin (S. BIL), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid (UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases (LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group, was favorably reverted back to near normal levels on combinatorial therapy with CoRN" - See ubiquinol products at Amazon.com.
• Hepatoprotective effect of vitamin b(12) on dimethylnitrosamine-induced liver injury - Biol Pharm Bull. 2008 Feb;31(2):309-11 - "Vitamin B(12) decreased the blood levels of aspartate aminotransferase and alanine aminotransferase, and clearly inhibited the overaccumulation of collagen fibrils ... vitamin B(12) could be an effective hepatoprotective agent" - Note:  Aspartate aminotransferase is the AST reading on blood tests and alanine aminotransferase is the ALT.  See vitamin B12 at Amazon.com.
• Green Tea Extract Protects Leptin-Deficient, Spontaneously Obese Mice from Hepatic Steatosis and Injury - J Nutr. 2008 Feb;138(2):323-331 - "Histologic evaluation showed a significant reduction in hepatic steatosis in GTE-fed obese mice only and histologic scores were correlated with hepatic lipid concentration (r = 0.84; P < 0.05), which was reduced dose dependently by GTE. GTE protected against hepatic injury as suggested by 30-41% and 22-33% lower serum alanine aminotransferase and aspartate aminotransferase activities, respectively" - Note:  Alanine aminotransferase is the "ALT" you see on blood tests and aspartate aminotransferase is the "AST" you see on blood tests.  See green tea extract at Amazon.com.
• Green tea shows benefits against fatty liver - Nutra USA, 1/22/08 - "the obese mice fed the GTE-supplemented diets had 23 to 25 per cent less body than the obese mice fed the non-supplemented diet. Moreover, the lean mice fed the GTE-supplemented diets had 11 to 20 per cent less body than their lean counterpart on the non-supplemented diet ... Measurements of the blood enzymes alanine aminotransferase and aspartate aminotransferase, used as markers of liver damage, showed that GTE-supplementation was associated with 30 to 41 per cent and 22 to 33 per cent lower activities, respectively" - [Abstract] - Note:  Alanine aminotransferase is the "ALT" you see on blood tests and aspartate aminotransferase is the "AST" you see on blood tests.  See green tea extract at Amazon.com.
• Treatment With NAC Is Associated With Better Outcomes For Children With Liver Failure, Study Suggests - Science Daily, 1/3/08 - "The children who received NAC spent fewer days in intensive care, and in the hospital overall. 43 percent survived with their native liver, compared to 22 percent of children who did not receive NAC. And death rates while awaiting transplant, after transplant, and after ten years were notably lower in children who had received NAC" - See n-acetyl cysteine at Amazon.com.
• Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats - Br J Nutr. 2007 Dec 7;:1-9 - "Lipoic acid profoundly decreased serum and liver concentrations of TAG, and also lowered serum concentrations of phospholipid and NEFA, and the concentration of cholesterol in the liver. A hypoglycaemic effect of this compound was also observed. Lipoic acid dose-dependently decreased the activity and mRNA levels of fatty acid synthase, ATP-citrate lyase, glucose 6-phosphate dehydrogenase, malic enzyme and pyruvate kinase in the liver despite that reductions were considerably attenuated in the NADPH-producing enzymes. This compound also dose-dependently lowered the mRNA levels of spot 14, adiponutrin, stearoyl-CoA desaturase 1, and Delta5- and Delta6-desaturases. In addition, lipoic acid dose-dependently lowered serum concentrations of insulin and leptin, but increased those of adiponectin. Lipoic acid appeared to reduce hepatic lipogenesis and hence decreases serum and liver lipid levels. Alterations in serum concentrations of insulin and (or) adiponectin may trigger this consequence" - See alpha lipoic acid at Amazon.com.
• Quick-burning Carbs May Cause Fatty Liver: Low-glycemic Diet Protected Mice - Science Daily, 9/21/07 - "After six months, the mice weighed the same. However, mice on the low-glycemic index diet were lean, with normal amounts of fat in throughout their bodies. Mice on the high-glycemic index diet had twice the normal amount of fat in their bodies, blood and livers"
• Starchy diet 'may damage liver' - BBC News, 9/21/07 - ""High-glycaemic" foods - rapidly digested by the body - could be causing "fatty liver", increasing the risk of serious illness ... After six months on the diet, the mice weighed the same, but those on the high GI diet had twice the normal amount of fat in their bodies, blood and livers"
• The Effect of a Silybin-Vitamin E-Phospholipid Complex on Nonalcoholic Fatty Liver Disease: A Pilot Study - Dig Dis Sci. 2007 Apr 5 - "silybin conjugated with vitamin E and phospholipids could be used as a complementary approach to the treatment of patients with chronic liver damage"
• Zinc and the Liver: An Active Interaction - Dig Dis Sci. 2007 Apr 6 - "zinc could protect against liver diseases"
• Sugar intake may hurt liver - Reuters, 10/31/06 - "fatty liver disease was more common in the group given sugar water, especially when exposed to a type of sugar called fructose ... These data support the hypothesis that high fructose consumption may not only (damage) the liver through over-feeding, but may be directly" toxic"
  • Obesity and Fatty Liver disease - MedicineNet.com - "Doctors also are using medications to treat non alcoholic fatty liver disease. For example, insulin-sensitizing agents, such as the thiazolidinediones, pioglitazone (Actos) and rosiglitazone (Avandia), and metformin (Glucophage) not only help to control blood glucose in patients with diabetes, but they also improve enzyme levels in patients with non alcoholic fatty liver disease" - See pioglitazone or rosiglitazone at OffshoreRx1.com, XlPharmacy or SuperSaverMeds.com.
  • Avandia Positively Impacts On Factors Linked With Insulin Resistance - Doctor's Guide, 9/18/00 - "Increased deposits of fat around the internal organs and in the liver are commonly associated with insulin resistance and are found in many type 2 diabetes patients ... Avandia helps prevent accumulation of fat around the internal organs and significantly reduces hepatic fat"
  Is Coffee or Tea Good for Your Liver? - Medscape, 10/2/06 - "The consumption of coffee and tea is associated with a reduced risk of CLD"
• Nutritional Support in Chronic Liver Disease - Doctor's Guide, 4/21/06
• Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study - Aliment Pharmacol Ther. 2006 Apr 15;23(8):1143-51 - "non-alcoholic fatty liver disease (NAFLD) ... Supplementation with n-3 PUFA improves biochemical, ultrasonographic and haemodynamic features of liver steatosis. Our study supports the efficacy of n-3 PUFA as a new therapeutic approach in the treatment of NAFLD"
• Coffee and Tea Can Reduce Risk of Chronic Liver Disease - Doctor's Guide, 12/2/05 - "people at high risk for liver injury may be able to reduce their risk for developing chronic liver disease significantly by drinking more than two cups of coffee or tea daily. This preventative effect was only seen in people at higher risk for liver disease due to heavy alcohol intake, being overweight or having diabetes or iron overload"
• Component Of Green Tea Protects Injured Livers In Mice - Science Daily, 3/9/05
• Food Can Have Powerful Effect on Health - WebMD, 5/17/04 - "people who drank more than two cups of coffee a day were about half as likely to have elevated liver enzyme blood tests compared with those who consumed less than a cup a day. And when divided into five groups according to the total amount of caffeine consumed, people in the highest group had about one-third the risk of liver damage than those in the lowest group"
• Looking for a Liver Cure? - Dr. Weil, 5/13/04
• Weight Loss Helpful in Chronic Liver Disease - Medscape, 2/20/04
• A New Era for SAMe - Life Extension Magazine, 6/03
• SAMe Beneficial in Treating Osteoarthritis, Depression, and Liver Disease - New Hope Natural Media, 12/12/02
• Milk Thistle's Liver-Protective Properties - Nutrition Science News, 10/99
• Can Cirrhosis be Prevented? - Nutrition Science News, 1/99
• SAMe - Part 3: The Liver Super- Nutrient - Life Extension Magazine, 6/97

Other News:

• Non-alcoholic fatty liver disease associated with high mortality rates - Science Daily, 2/1/10
• Drinking Coffee Slows Progression Of Liver Disease In Chronic Hepatitis C Sufferers, Study Suggests - Science Daily, 10/24/09 - "Patients with chronic hepatitis C and advanced liver disease who drink three or more cups of coffee per day have a 53% lower risk of liver disease progression than non-coffee drinkers"
• Second-hand Smoking Results In Liver Disease, Study Finds - Science Daily, 9/10/09
• Fat In The Liver -- Not The Belly -- May Be A Better Marker For Disease Risk - Science Daily, 8/25/09 - "Having too much liver fat is known as nonalcoholic fatty liver disease ... when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body's ability to metabolize sugar. They also have increases in production of fat particles in the liver that are secreted into the bloodstream and increase the level of triglycerides"
• Liver Disease 'Shrunk' By Blood-pressure Drug - Science Daily, 6/2/09 - "analysed a small clinical trial of losartan, a drug normally prescribed for hypertension, on 14 patients in Spain, who had Hepatitis C ... Half of the patients in the trial saw the scars in their liver shrink allowing the organ to repair itself ... Researchers believe that the drug blocks the signalling pathway so that the liver myofibroblasts die, removing the source of scar tissue. As the scar tissue breaks up, the damaged area of the liver is repaired by the body"
• Environmental Pollution Increases Risk Of Liver Disease, Study Finds - Science Daily, 5/29/09
• Statin Drugs May Protect Against Cancer And Also Result in Fewer Gallbladder Removals - Science Daily, 5/5/09 - "The research team found a significant inverse association between having statin prescriptions filled and the risk of developing HCC. There was a trend toward stronger risk reduction with longer and more frequent statin prescriptions"
• Daily Drinking Rather Than Binge Drinking Is Biggest Risk Factor In Serious Liver Disease, New Study Finds - Science Daily, 3/20/09
• Iron Overload: An Important Co-factor In The Development Of Liver Disease In Alcoholics - Science Daily, 2/24/09 - "A high prevalence of iron overload was found in alcoholics, which appeared to be related to the development of liver disease [odds ration for having liver disease in alcoholics with transferrin saturation greater than 45% was 2.2 (95% CI 1.37-3.54)]"
• Hepatitis C Is Killing Liver Cells - Science Daily, 2/5/09
• Tobacco Smoke And Alcohol Harm Liver Worse As Combo - Science Daily, 2/3/09
• Fat-free Diet Reduces Liver Fat In Fat-free Mice, Researchers Report - Science Daily, 2/3/09
• Fatty Liver Disease Medication May Have No Effect - Science Daily, 1/13/09
• Antibiotics: Single Largest Class Of Drugs Causing Liver Injury - Science Daily, 12/8/08 - "Antibiotics are the single largest class of agents that cause idiosyncratic drug-induced liver injury (DILI) ... DILI is the most common cause of death from acute liver failure and accounts for approximately 13 percent of cases of acute liver failure in the U.S"
• Pioglitazone Improves Fatty Liver Disease in Nondiabetics - Medscape, 11/5/08
• New Imaging Technology Accurately Identifies A Broad Spectrum Of Liver Disease - Science Daily, 11/1/08
• Angiotensin receptor blockers in the treatment of NASH/NAFLD: Could they be a first-class option? - Adv Ther. 2008 Oct 29 - "Nonalcoholic fatty liver disease (NAFLD) ... nonalcoholic steatohepatitis (NASH) ... In our opinion there are two major advantages of ARBs that make them a possible therapeutic option for treating NASH and MS: their specific antihypertensive effect, and their impact on liver fibrosis. In light of this, and based on the current evidence (including existent human studies), we can speculate that some ARBs like telmisartan, candesartan, and losartan can be beneficial in treating NASH/NAFLD and its consequences, and further larger controlled clinical trials will bring consistent data into this field"
• Cortisol And Fatty Liver: Researchers Find Cause Of Severe Metabolic Disorders - Science Daily, 9/11/08 - "The researchers in Herzig's team specifically switched off the cortisol receptor in the livers of mice, thus blocking the hormone's effect. As a result, the triglyceride level in the livers of the experimental animals dropped considerably"
• Normal ALT Levels May Mask Advanced Fibrosis In Liver Disease Patients - Science Daily, 9/4/08
• The effects of 8 months of metformin on circulating GGT and ALT levels in obese women with polycystic ovarian syndrome - Int J Clin Pract. 2008 Jun 19 - "treated with metformin 1500 or 2550 mg/day for 8 months ... Mean weight, serum ALT and GGT decreased from 100.3 to 96.6 kg (p < 0.0001), 29.7 to 25.8 U/l (p = 0.012) and 21.4 to 16.9 U/l (p < 0.0001) respectively ... In women with baseline ALT > 29.7 U/l (median), ALT reduction was highly significant (p = 0.005); however in those with baseline ALT < 29.7 U/l, ALT did not change despite similar weight reduction. There was no difference in reductions in ALT and GGT when the two metformin doses were compared"
• Belly Fat May Affect Liver Function - Science Daily, 6/10/08 - "It has been shown that people who store body fat in their abdomens are at greater risk to develop diabetes and other chronic illnesses, but why this happens has remained unclear ... Our study found lipid release from abdominal fat was substantially elevated during the night, which may be a primary mechanism leading to insulin resistance, a strong risk factor for type 2 diabetes"
• Elevated Liver Enzymes Linked to Development of Diabetes - Medscape, 6/9/08 - "Compared with individuals in the lowest quintile of GGT, the adjusted hazard ratios (HRs) for incident diabetes were 1.13 for quintile 2, 1.67 for quintile 3, 2.77 for quintile 4, and 2.67 for quintile 5 (p for linear trend < 0.001). For ALT, the corresponding HRs were 0.93, 1.28, 1.35, and 1.93, respectively"
• Fatty Liver Linked To Increased Risk Of Diabetic Kidney Disease - Science Daily, 5/29/08 - "For patients with type 2 diabetes, a condition called non-alcoholic fatty liver disease (NAFLD) may be an important risk factor for diabetes-related chronic kidney disease (CKD)"
• Elevated AST, ALT Linked to Higher Future Mortality Rate - Medscape, 4/1/08 - "An abnormal AST up to 2 times ULN was associated with a 32% increased risk of death, and more than 2 times ULN was linked to a 78% increase in risk ... An abnormal ALT up to 2 times ULN was associated with a 21% increase in mortality risk, and more than 2 times ULN was associated with a 59% increase in risk ... patients with normal AST or ALT had a lower than expected risk of death (SMR 0.95 for AST and 0.61 for ALT)"
• Elevated Liver Enzymes Associated With Higher Future Mortality - Science Daily, 3/4/08 - "Liver enzymes include aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and high concentrations in the blood tend to indicate liver disease ... elevated AST was associated with a significantly increased standardized mortality rate (SMR). Elevated ALT was also associated with a higher SMR. The SMRs ranged between 1.21 and 1.78 ... elevated serum AST and ALT may be markers of cardiovascular diseases (nearly 34 percent of the deaths in the study population were due to cardiovascular causes)"
• Fatty Fast Food, Idleness May Vex Liver - WebMD, 2/13/08 - "The students were asked to gain 5% to 15% of their body weight in a month by eating at least two daily meals at fast-food restaurants and adopting a sedentary lifestyle ... On average, the students gained 14 pounds, added 2.6 inches to their waistline, and padded their body fat percentage by 3.7% during the study ... Blood samples provided by the students throughout the study show a spike in levels of the liver enzyme alanine aminotransferase (ALT). ALT levels rose quickly -- typically within a week -- after the students started the fast-food diet"
• Liver damage 'could be reversed' - BBC News, 12/27/07
• Association between serum TSH, free T4 and serum liver enzyme activities in a large cohort of unselected outpatients - Clin Endocrinol (Oxf). 2007 Oct 17 - "GGT and ALT concentrations increased steadily across the increasing TSH categories (P < 0.0001 for trends), ranging from mean values of 36 to 62 U/l for GGT and from 29 to 41 U/l for ALT, respectively. Similarly, there was a negative, graded, relationship between serum GGT and ALT concentrations and free T4 categories"
• Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin - Acta Paediatr. 2007 Sep;96(9):1326-32 - "In obese adolescents fed ad libitum, metformin (a) prevented the rise in ALT concentrations that were observed in placebo-treated subjects at the 3 to 5 month time-points (p < 0.05); (b) reduced (p < 0.01) the percentage of all ALT values exceeding 40 U/L; and (c) caused a modest (10%) but statistically significant (p < 0.05) reduction in serum ALT in Caucasian subjects. Metformin had no effect on ALT levels or the ALT to AST ratio in the five African American adolescents enrolled in the study ... metformin might reduce the rates or severity of liver dysfunction in selected high-risk adolescents"
• Fatty Liver and the Metabolic Syndrome - Medscape, 3/1/07
• The association between non-alcoholic fatty liver disease and insulin resistance in 20 obese children and adolescents - Acta Paediatr. 2007 Jan;96(1):109-12 - "The high prevalence of insulin resistance we found in children with NAFLD confirms the suggestion that there may be an association between insulin resistance and NAFLD in obese children"
• Elevated ALT Levels Predict Risk of Death From Liver Cancer - Medscape, 11/2/06 - "Upper limits of normal range from 30 IU/L to 60 IU/L, depending on the laboratory. "We want to reset it southward of 30 IU/L," ... ALT levels are a reflection of the general vascular condition ... If the level is above 30, then that person probably has a problem — fatty liver or some vascular disease, including occlusive coronary artery disease"
• Drug 'may reverse liver disease' - BBC News, 9/26/06
• Combating Fatigue Associated with Liver Disease - Doctor's Guide, 5/25/05
• New Ways To Ease Liver Disease - Science Daily, 3/21/05
• Chronic Liver Failure To Be Treated Using Stem Cell Therapy - Science Daily, 11/15/04
• Stem Cells Can Convert to Liver Tissue, Help Restore Damaged Organ - Doctor's Guide, 6/2/04
• Intra-Arterial Folinic Acid and 5-Flurouracil Effective in Locally Advanced Hepatocarcinoma - Doctor's Guide, 5/19/04
• Obesity Epidemic Invades the Liver - Doctor's Guide, 5/14/04
• Chronic Liver Disease Patients May Have Impaired Driving Skills - Doctor's Guide, 10/31/03
• High-Fat Diet May Protect Liver in Morbidly Obese Patients - Doctor's Guide, 10/30/03
• Liver Function Test Correlates with Histologic Stage and Clinical Status in Patients with Hepatitis C-Related Chronic Liver Disease - Doctor's Guide, 2/20/03
• Hepatitis E Vaccine Recommended For Patients With Chronic Liver Disease - Doctor's Guide, 8/5/02
• Living Liver Donors Report High Satisfaction - Doctor's Guide, 6/24/02
• Recombinant Human Factor VIIa Enables Coagulation in Patients with Advanced Liver Disease - Doctor's Guide, 5/23/02
• Elevated Liver Enzymes in Obese Children - Doctor's Guide, 5/21/02 - "Childhood obesity may set the stage for liver damage, with elevated liver enzymes a warning sign ... Of the 90 percent of obese children who did not show elevated enzymes, "all probably had fatty liver" and were at risk for liver damage"
• Pulsatility Index May Help Predict Outcome in Liver Disease Patients - Doctor's Guide, 4/17/02
• New Diabetes Drugs Still Pose Liver Risks - WebMD, 3/19/02
• Steroid Withdrawal Accelerates Bone Mass Recovery After Successful Liver Transplantation - Doctor's Guide, 3/12/02
• Doctors Aware of Acetaminophen-Related Liver Risk, Must Educate Public - Doctor's Guide, 6/18/01
• FDA Probes New Acetaminophen Worry - Intelihealth, 3/27/01 - "There are warnings not to take it if you consume more than three alcoholic drinks ... acetaminophen overdoses could be a bigger cause of liver failure than some prescription drugs recently banned for liver poisoning, such as the diabetes medicine Rezulin ... He tracked more than 300 acute liver failure cases at 22 hospitals and linked 38 percent to acetaminophen ... In a second database tracking 307 adults suffering severe liver injury - not full-fledged failure - at six hospitals, Lee linked acetaminophen to 35 percent of cases ... initial symptoms are flu-like and doctors may not promptly test for acetaminophen's hallmark sky-high liver enzymes"
• Scanty Truncal Hair Distribution Occurs in Patients With Alcoholic Liver Disease - Doctor's Guide, 10/18/00
• Women More Likely To Develop Alcohol-Related Liver Disease - Doctor's Guide, 12/9/97
• CFC Alternative Causes Liver Disease - Doctor's Guide, 8/22/97

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