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Recent Longevity News for the seven days ending 3/3/10. You should consult your doctor if you are taking any medications. Insulin used to treat diabetes may be linked to increased cancer risk, review suggests - Science Daily, 3/2/10 - "Research suggests that metformin, which is used to treat some patients with diabetes, may provide a protective effect, while insulin and/or certain insulin analogues may promote tumour growth ... Diabetic patients were 30 per cent more likely to develop colorectal cancer ... Women with diabetes had a 20 per cent greater risk of developing breast cancer ... People with diabetes had an 82 per cent higher risk of developing pancreatic cancer" - Note: See my Insulin and Aging page. I think it's like what came first the chicken or the egg. I don't believe they know whether it's the insulin or the high blood sugar. This seems to support that it's the high insulin. Combination therapy more effective for enlarged prostate - Science Daily, 3/2/10 - "On the strengths of both dutasteride and tamsulosin, participants reported fewer symptoms, and we observed a 25 percent reduction in prostate volume ... subjects who received the combination therapy also showed a 50 percent reduction of prostate-specific antigen (PSA), a protein produced by both cancerous and noncancerous prostate tissue ... Compared with tamsulosin alone, the combination of drugs reduced the incidence of acute urinary retention by 67 percent and reduced the need for BPH-related surgery by 70 percent" - See - See dutasteride at OffshoreRx1.com. Regular analgesic use increases hearing loss in men, study finds - Science Daily, 3/1/10 - "For aspirin, regular users under 50 and those aged 50-59 years were 33% more likely to have hearing loss than were nonregular users, but there was no association among men aged 60 years and older. For NSAIDs, regular users aged under 50 were 61% more likely, those aged 50-59 were 32% more likely, and those aged 60 and older were 16% more likely to develop hearing loss than nonregular users of NSAIDs. For acetaminophen, regular users aged under 50 were 99% more likely, regular users aged 50-59 were 38% more likely, and those aged 60 and older were 16% more likely to have hearing loss than nonregular users of acetaminophen"
Researchers fishing for cancer cure discover active DHA derivatives -
Science Daily, 3/1/10 - "Results showed that
DHA killed the cancer cells, but that the toxic
derivatives produced by DHA were even more effective at killing the
cancer cells. This suggests that DHA could become a new agent for treating
neuroblastoma and possibly many other cancers" - See
Jarrow Max DHA at Amazon.com Vitamin combo may delay ageing: Mouse study - Nutra USA, 3/1/10 - "Results showed maintenance of youthful levels of locomotor activity into old age in the supplemented animals, whereas old non-supplemented mice showed a 50 per cent loss in daily movement, said the researchers. This was accompanied by a loss of mitochondria activity, and declines in brain signalling chemicals relevant to locomotion, such as striatal neuropeptide Y. This chemical is associated with a range of functions, including maintaining energy balance, as well as effects in memory and learning ... No such declines were observed in supplemented animals ... The supplement was composed of vitamins B1, B3 (niacin), B6, B12, C, D, E, folic acid, beta-carotene, CoQ10, rutin, bioflavonoids, ginko biloba, ginseng, green tea extract, ginger root extract, garlic, L-Glutathione, magnesium, selenium, potassium, manganese, chromium picolinate, acetyl L-carnitine, melatonin, alpha-lipoic acid, N-acetyl cysteine, acetylsalicylic acid, cod liver oil, and flax seed oil"
DHA brain benefits may extend to middle age - Nutra USA, 3/1/10 -
"Higher
DHA was related to better performance on tests of
nonverbal reasoning and mental flexibility, working memory, and vocabulary ...
increasing levels of DHA were associated with improved
mental function in a “generally linear" - [Abstract]
- See
Jarrow Max DHA at Amazon.com Why BPA leached from 'safe' plastics may damage health of female offspring - Science Daily, 2/25/10 - "Here's more evidence that "safe" plastics are not as safe as once presumed: New research published online in The FASEB Journal suggests that exposure to Bisphenol A (BPA) during pregnancy leads to epigenetic changes that may cause permanent reproduction problems for female offspring. BPA, a common component of plastics used to contain food, is a type of estrogen that is ubiquitous in the environment" High calcium intakes may improve male survival: Study - Nutra USA, 2/25/10 - "The highest average intakes, almost double the recommended levels, were associated with a 25 per cent reduction in so-called all-cause mortality, compared with the lowest average intakes" - [Abstract]
Vitamin
B3 shows early promise in treatment of stroke - Science Daily, 2/24/10 -
"An early study suggests that vitamin B3 or
niacin, a common water-soluble vitamin, may help improve neurological
function after stroke ... Niacin is known to be
the most effective medicine in current clinical use for increasing high-density
lipoprotein cholesterol (HDL-C), which helps those
fatty deposits ... Niacin essentially re-wires the brain which has very exciting
potential for use in humans" - See
niacin at Amazon.com
Omega-3 may boost brain function in boys: Study - Nutra USA, 2/24/10 -
"The “main finding” from the fMRI data was an indication
of significant increases in the activation of the dorsolateral prefrontal cortex
part of the brain in the
DHA groups – an area of the brain associated with
working memory. Changes in other parts of the brain, including the occipital
cortex (the visual processing centre) and the cerebellar cortex (plays a role in
motor control) were observed ... These findings suggest that this imaging
paradigm could be useful for elucidating neurobiological mechanisms underlying
deficits in cortical activity in psychiatric disorders associated with DHA
deficiencies, including ADHD and major depression" - [Abstract]
- See
Jarrow Max DHA at Amazon.com Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):
Low serum
25-hydroxyvitamin D levels are associated with increased all-cause mortality
risk in a general population. The Tromso study - Eur J Endocrinol. 2010 Feb
25 - "During a mean 11.7 years of follow up 1359 (19.0
%) participants died. In multivariate regression models there was a
significantly increased risk of all-cause mortality
(hazard ratio (HR) 1.32, confidence interval (CI) 1.07-1.62), among non-smoking
participants in the lowest
25(OH)D quartile when compared to participants
in the highest quartile" - See
vitamin D at Amazon.com
Lipid-Lowering Efficacy of Red Yeast Rice in a Population Intolerant to Statins
- Am J Cardiol. 2010 Mar 1;105(5):664-666 - "The total
cholesterol decreased 15% (-37 +/- 26 mg/dl,
p <0.001) and LDL cholesterol decreased 21% (-35 +/- 25 mg/dl, p <0.001) during
74 +/- 39 days of treatment. Most (92%) patients tolerated the treatment, and
many (56%) achieved their LDL cholesterol goal. In patients unable to tolerate
daily statin use, the total cholesterol level decreased 13% (-33 +/- 10 mg/dl, p
<0.001) and LDL cholesterol decreased 19% (-31 +/- 4 mg/dl, p <0.001). In
conclusion, red yeast rice modestly decreased
total and LDL cholesterol, was well-tolerated, and was an acceptable alternative
in patients intolerant of other lipid-lowering medications" - See
red yeast rice at Amazon.com Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial - Am J Clin Nutr. 2010 Feb 24 - "Significant changes were also observed for serum concentrations of interleukin-18, 8-isoprostane, and adiponectin (medians: -8%, -16%, and 6%, respectively; consumption of 8 compared with 0 cups coffee/d). Serum concentrations of total cholesterol, HDL cholesterol, and apolipoprotein A-I increased significantly by 12%, 7%, and 4%, respectively, whereas the ratios of LDL to HDL cholesterol and of apolipoprotein B to apolipoprotein A-I decreased significantly by 8% and 9%, respectively (8 compared with 0 cups coffee/d)"
DHA May
Prevent Age-Related Dementia - J Nutr. 2010 Feb 24 -
"DHA is pleiotropic, acting at multiple steps to reduce the production of the
beta-amyloid peptide, widely believed to initiate AD. DHA moderates some of the
kinases that hyperphosphorylate the tau-protein, a component of the
neurofibrillary tangle. DHA may help suppress insulin/neurotrophic factor
signaling deficits, neuroinflammation, and oxidative damage that contribute to
synaptic loss and neuronal dysfunction in dementia. Finally, DHA increases brain
levels of neuroprotective brain-derived neurotrophic factor and reduces the
(n-6) fatty acid arachidonate and its prostaglandin metabolites that have been
implicated in promoting AD. Clinical trials suggest that DHA or fish oil alone
can slow early stages of progression, but these effects may be apolipoprotein E
genotype specific, and larger trials with very early stages are required to
prove efficacy. We advocate early intervention in a prodromal period with
nutrigenomically defined subjects with an appropriately designed nutritional
supplement, including DHA and antioxidants" - See
Jarrow Max DHA at Amazon.com
Serum
Phospholipid Docosahexaenonic Acid Is Associated with Cognitive Functioning
during Middle Adulthood - J Nutr. 2010 Feb 24 -
"higher
DHA (mol %) was related to better performance on
tests of nonverbal reasoning and mental flexibility, working memory, and
vocabulary (P </= 0.05). These associations were generally linear. Associations
between DHA and nonverbal reasoning and working memory persisted with additional
adjustment for participant education and vocabulary scores ... Among the 3 key
(n-3) PUFA, only DHA is associated with major aspects of
cognitive performance in nonpatient adults <55 y old. These findings suggest
that DHA is related to brain health throughout the lifespan and may have
implications for clinical trials of neuropsychiatric disorders" - See
Jarrow Max DHA at Amazon.com Dietary Calcium and Magnesium Intake and Mortality: A Prospective Study of Men - Am J Epidemiol. 2010 Feb 19 - "Dietary calcium was associated with a statistically significant lower rate of all-cause mortality (hazard ratio (HR) = 0.75, 95% confidence interval (CI): 0.63, 0.88; P(trend) < 0.001) and a nonsignificantly lower rate of CVD (HR = 0.77, 95% CI: 0.58, 1.01; P(trend) = 0.064) but not cancer mortality (HR = 0.87, 95% CI: 0.65, 1.17; P(trend) = 0.362) when the highest intake tertile (mean = 1,953 mg/day; standard deviation (SD), 334) was compared with the lowest (990 mg/day; SD, 187)"
Docosahexaenoic acid
supplementation increases prefrontal cortex activation during sustained
attention in healthy boys: a placebo-controlled, dose-ranging, functional
magnetic resonance imaging study - Am J Clin Nutr. 2010 Feb 3 -
"During sustained attention, both
DHA dose groups had significantly greater changes from baseline in
activation of the dorsolateral prefrontal cortex than did the placebo group, and
the low-dose and high-dose DHA groups had greater decreases in the occipital
cortex and cerebellar cortex, respectively. Relative to low-dose DHA, high-dose
DHA resulted in greater decreases in activation of bilateral cerebellum. The
erythrocyte DHA composition was positively correlated with dorsolateral
prefrontal cortex activation and was inversely correlated with reaction time, at
baseline and endpoint" - See
Jarrow Max DHA at Amazon.com Telmisartan Prevents Weight Gain and Obesity Through Activation of Peroxisome Proliferator-Activated Receptor-{delta}-Dependent Pathways - Hypertension. 2010 Feb 22 - "long-term administration of telmisartan significantly reduced visceral fat and prevented high-fat diet-induced obesity in wild-type mice and hypertensive rats but not in PPAR-delta knockout mice. Administration of telmisartan did not influence food intake in mice ... We conclude that telmisartan prevents adipogenesis and weight gain through activation of PPAR-delta-dependent lipolytic pathways and energy uncoupling in several tissues" - See telmisartan at OffshoreRx1.com.
Supplement Focus (Silica): Specific Recommendations: News & Research:
Abstracts:
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