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Anti-aging Research > Statins >
Pravachol (pravastatin)
Pravachol (pravastatin)
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News & Research:
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Long-term use of statins reduces the risk of hospitalization for dementia
- Atherosclerosis. 2013 Oct;230(2):171-6 - "A
population-based, nested case-control study was carried out by including the
cohort of 152,729 patients from Lombardy (Italy) aged 40 years or older who
were newly treated with statins between 2003 and 2004. Cases were the 1380
patients who experienced hospitalization for dementia disease from initial
prescription until 2010 ... Compared with patients who had very short
statins coverage (less than 6 months), those on 7-24, 25-48, and >48 months
of coverage respectively had risk reductions of 15% (OR: 0.85; 95% CI: 0.74
to 0.98), 28% (OR: 0.72; 95% CI: 0.61 to 0.85), and 25% (OR: 0.75; 95% CI:
0.61 to 0.94). Simvastatin and atorvastatin were both associated with a
reduced risk of dementia, while no similar evidence was observed for
fluvastatin and pravastatin"
-
Red Yeast Rice Comparable to Pravastatin for Statin-Intolerant Patients
- Medscape, 1/21/10 - "After 12 weeks of treatment,
red yeast rice reduced LDL-cholesterol levels 30% from baseline, from 181
mg/dL to 126 mg/dL, while pravastatin reduced LDL-cholesterol levels 27%, a
nonstatistical difference between treatments. Similarly, there were no
significant differences observed in changes in total cholesterol,
triglycerides, or HDL-cholesterol levels ... Regarding the primary end
point, the incidence of treatment discontinuation because of myalgia, both
red yeast rice and pravastatin were equivalent. In the red-yeast-rice arm,
one patient of 21 (5%) withdrew because of muscle pain, while two patients
of 22 (9%) withdrew in the pravastatin arm. Also, there were no reported
differences in the mean pain severity scores with the two treatments"
- See
red yeast rice at Amazon.com
 .
-
Low-dose statin therapy reduces risk of CHD in Japanese subjects by 33%
- Medscape, 9/28/06 - "the addition of pravastatin
10 mg to a low-fat diet rich in omega-3 fatty acids reduces the risk of CHD
in Japanese individuals with moderately elevated cholesterol levels by 33%,
approximately the same reduction observed in US and European
primary-prevention trials that have used larger statin dose"
-
FDA OKs Generic Version of Pravachol - WebMD, 4/25/06 -
"Bristol-Myers Squibb's patent for the drug expired
on April 20. Generic pravastatin tablets (10 milligrams, 20 milligrams, and
40 milligrams) are manufactured by TEVA Pharmaceuticals in Kfar Sava,
Israel"
-
Statins May Lower Blood Pressure - Doctor's Guide, 11/20/04 -
"simvastatin was associated with a 2.79-mm Hg
decrease in systolic blood pressure and a 2.67-mm Hg drop in diastolic blood
pressure, while pravastatin led to a 2.47-mm Hg decline in systolic blood
pressure and a 2.47-drop in diastolic blood pressure"
-
Pravastatin Can Significantly Decrease Systolic Blood Pressure in Moderately
Hypertensive Patients With Hyperlipidaemia - Doctor's Guide, 6/17/04 -
"Pravastatin 10 mg/day and probucol 500 mg/day were
used during each treatment period ... Systolic blood pressure (BP) decreased
significantly by 4.7 mm Hg after pravastatin treatment"
- Statins Effectively
Lower Cholesterol, But Experts Debate First Choice - Medscape, 3/15/04 -
"HDL cholesterol levels were increased more than 10%
with
rosuvastatin 40 mg, nearly 5% with
atorvastatin 80 mg, 10% with 40 mg
simvastatin, and 6.4% with 40 mg pravastatin"
-
Pravastatin Therapy May Produce Anti-Inflammatory and Anticoagulant Effects
in Patients with Type 2 Diabetes - Doctor's Guide, 2/10/04
-
High Dose Atorvastatin Stops Progression of Disease in Patients With
Symptomatic Coronary Artery Disease - Doctor's Guide, 11/12/03 -
"After 18 months of treatment, intravascular
ultrasound analysis found zero progression in the group treated with
atorvastatin, compared with 2.7% progression in the group treated with
pravastatin ... atorvastatin stopped plaque progression in each of 22
pre-determined subgroups, while "we were unable to stop progression in any
of the subgroups in the pravastatin arm" - Yeah but the way I read
the following, Zocor (simvastatin) not only stopped but reversed
progression:
-
Pravastatin Treatment Reduces Risk Of Cardiovascular Events For Patients
With Diabetes Or Impaired Fasting Glucose - Doctor's Guide, 10/10/03
-
Rosuvastatin Improves Plasma Lipid Ratios - Doctor's Guide, 10/1/03 -
"Rosuvastatin
significantly more effective than
atorvastatin, simvastatin, and
pravastatin in improving the ratios of total cholesterol to high-density
lipoprotein cholesterol" - See
Crestor (rosuvastatin)
at drugstore.com.
-
Statins Decrease Aortic Stiffness in Hypertensives With High Cholesterol
- Doctor's Guide, 9/30/03 -
"Most significantly, while the PWV remained
unchanged in the pravastatin and non-statin group, it was moderately
decreased in the simvastatin group and remarkably reduced in the fluvastatin
group ... Dr. Ichihara theorized that lipophilic statins, such as
fluvastatin, reduce aortic
stiffness via three mechanisms -- decreasing serum total cholesterol
levels without reducing serum high-density lipoprotein levels, providing
powerful scavenging reactive oxygen species, as well as reducing serum
levels of low-density lipoprotein and C-reactive protein" - See
Zocor (simvastatin)
 ,
Pravachol (pravastatin)
and
Lescol (fluvastatin)
at drugstore.com.
-
FDA Approves Pravigard PAC (Buffered Aspirin and Pravastatin Sodium) Tablets
For Those At Risk Of Heart Disease, Heart Attack, Or Stroke - Doctor's
Guide, 6/25/03
-
Pravastatin Plays Significant Role in Preventing Progression of Coronary
Atherosclerosis - Doctor's Guide, 3/28/03
-
Pravastatin Reduces Left Ventricular Mass Independently of Lipid Lowering
Effect - Doctor's Guide, 12/30/02
-
Results in Hypertensives with Elevated Cholesterol Similar with Pravastatin,
Usual Care - Doctor's Guide, 12/18/02
-
Pravastatin Therapy May Help Protect Kidney Function In Patients With
Well-Controlled Hypertension - Doctor's Guide, 7/25/02
-
Eight Year Follow-Up Shows Safety/Efficacy of Cholesterol-Lowering
Pravastatin - Doctor's Guide, 4/22/02
-
Pravastatin Mortality Benefit In Patients With And Without Heart Disease
- Doctor's Guide, 2/14/02
-
FDA Approves Pravachol (Pravastatin) 80 mg for Heart Disease - Doctor's
Guide, 2/11/02
- Pravastatin Therapy
Decreases the Risk of Stroke - Medscape, 8/3/00
- Pravastatin Appears To
Reduce Incidence Of Stroke - Doctor's Guide, 11/9/99
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