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Home >
Anti-aging Research > Statins > Lescol
(fluvastatin)
Lescol (fluvastatin)
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Alternative News:
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Lycopene as effective as statins for artery health: rabbit study
- Nutra USA, 7/3/08 - "The results of our
experiment in the high-fat diet rabbit model showed that lycopene
and fluvastatin lowered serum levels of total cholesterol and
LDL-cholesterol, improved lipid metabolism, and reduced the amount
of triacylglycerols ... Lycopene intervention reduced the increase
in ox-LDL levels in rabbits on the high-fat diet, whereas
fluvastatin did not show such an effect. The cause of this
difference is at present not known, although the result speaks in
favour of lycopene ... These findings provide a theoretical
rationale for the use of lycopene as a preventive in
atherosclerosis" - [Abstract]
- See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com
 .
-
Comparison of
lycopene and fluvastatin effects on atherosclerosis induced by a
high-fat diet in rabbits - Nutrition. 2008 Jun 26 -
"Compared with the control, levels of total
cholesterol, total triacylglycerol, low-density lipoprotein
cholesterol, malonaldehyde, oxidized low-density lipoprotein, and
interleukin-1 were increased and total antioxidant capacity and
nitric oxide were decreased in the animals with a high-fat diet (P <
0.05). Intragastric administration of lycopene counteracted the
change in these parameters (P < 0.05). In this case, the data showed
that lycopene in the used dose was better than the fluvastatin
intervention. Morphologic analysis revealed that lycopene and
fluvastatin markedly reduced the formation of atherosclerotic
plaques in the aorta compared with the situation in rabbits on a
high-fat diet alone ... Lycopene, like fluvastatin, significantly
attenuated atherogenesis in rabbits fed a high-fat diet" -
See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
News & Research:
-
Fluvastatin inhibits HMG-CoA
reductase and prevents non-small cell lung carcinogenesis - Cancer Prev Res
(Phila). 2019 Sep 25 - "Lung cancer is the leading cause
of cancer death worldwide ... our findings suggest that fluvastatin might be
promising chemopreventive or potential therapeutic drug against NSCLC
tumorigenesis, providing hope for rapid clinical translation"
-
Long-term use of statins reduces the risk of hospitalization for dementia
- Atherosclerosis. 2013 Oct;230(2):171-6 - "A
population-based, nested case-control study was carried out by including the
cohort of 152,729 patients from Lombardy (Italy) aged 40 years or older who
were newly treated with statins between 2003 and 2004. Cases were the 1380
patients who experienced hospitalization for dementia disease from initial
prescription until 2010 ... Compared with patients who had very short
statins coverage (less than 6 months), those on 7-24, 25-48, and >48 months
of coverage respectively had risk reductions of 15% (OR: 0.85; 95% CI: 0.74
to 0.98), 28% (OR: 0.72; 95% CI: 0.61 to 0.85), and 25% (OR: 0.75; 95% CI:
0.61 to 0.94). Simvastatin and atorvastatin were both associated with a
reduced risk of dementia, while no similar evidence was observed for
fluvastatin and pravastatin"
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Fluvastatin (Lescol) Reduces Angiotensin II Sensitivity in Patients With
Familial Hypercholesterolaemia - Doctor's Guide, 6/21/05
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Daily Fluvastatin Increases High-Density Lipoprotein Levels in Diabetics
With Low Levels - Doctor's Guide, 10/26/04
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Combined Fluvastatin-Fibrate Therapy Improves Lipid Profile of
Hypercholesterolaemic Patients - Doctor's Guide, 10/1/03
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Fluvastatin Reduces Myocardial Ischemia in Patients With Coronary Heart
Disease - Doctor's Guide, 9/30/03
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Statins Decrease Aortic Stiffness in Hypertensives With High Cholesterol
- Doctor's Guide, 9/30/03 -
"Most significantly, while the PWV remained
unchanged in the pravastatin and non-statin group, it was moderately
decreased in the simvastatin group and remarkably reduced in the fluvastatin
group ... Dr. Ichihara theorized that lipophilic statins, such as
fluvastatin, reduce aortic
stiffness via three mechanisms -- decreasing serum total cholesterol
levels without reducing serum high-density lipoprotein levels, providing
powerful scavenging reactive oxygen species, as well as reducing serum
levels of low-density lipoprotein and C-reactive protein" - See
Zocor (simvastatin)
 ,
Pravachol (pravastatin)
and
Lescol (fluvastatin)
at drugstore.com.
-
Fluvastatin Improves Hyperlipidaemia in Nephrotic Syndrome - Doctor's
Guide, 6/11/03
- Lescol/LescolXL
(Fluvastatin) Maintains Favorable Efficacy/Safety Profile in Lipid
Management - Doctor's Guide, 1/18/02
- Combined Analysis
Underscores Safety, Efficacy of Lescol (Fluvastatin)/Lescol XL For
Cholesterol Reduction - Doctor's Guide, 9/10/01
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