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Recent Longevity News for the week ending 2/20/19

Why Do South Asians Have Such High Rates of Heart Disease? - NYT, 2/12/19 - "Cardiovascular risks tended to be highest in two groups: those who maintained very strong ties to traditional South Asian religious, cultural and dietary customs, and those who vigorously — embraced a Western lifestyle. Those with lower risk are what the researchers call bicultural, maintaining some aspects of traditional South Asian culture while also adopting some healthy Western habits."

Gut Bacteria Tied to Depression - Medscape, 2/11/19 - "In analyzing data from 1054 individuals enrolled in the Flemish Gut Flora Project (FGFP), investigators found two groups of bacteria — Coprococcus and Dialister — were consistently depleted in people diagnosed with depression, regardless of antidepressant treatment ... They validated the results in an independent cohort of 1063 individuals from the Dutch LifeLines DEEP cohort and in a group of patients with treatment-resistant major depressive disorder ... They also found that Faecalibacterium and Coprococcus bacteria were consistently associated with higher quality of life indicators. Both bacteria produce butyrate, a short-chain fatty acid that strengthens the epithelial defense barrier and reduces intestinal inflammation, and both have been reported to be depleted in association with inflammatory bowel disease and depression" - See probiotic products at Amazon.com.

Could omega-3 fatty acids help prevent miscarriages? - Science Daily, 2/7/19 - "Approximately one in 10 U.S. infants are born before term. Between 10 and 30 percent of preterm births have been attributed to uterine infections with a type of bacteria commonly found in the mouth, F. nucleatum ... Bleeding gums create an entryway for bacteria to leak into the bloodstream. Once in the circulatory system, the bacteria can migrate to the placenta and cause inflammation there, sometimes triggering miscarriage or stillbirth ... We knew from our previous work that uterine inflammation due to infection with this bacteria is associated with adverse pregnancy outcomes, but in order to prevent those outcomes, we needed to determine exactly how these infections trigger inflammation ... We were looking for an anti-inflammatory agent that's safe for pregnant women to use ... The experiments showed that supplements containing omega-3 fatty acids also inhibited inflammation and bacterial growth in pregnant mice, and reduced preterm births, miscarriages, and stillbirths" - See omega-3 supplements at Amazon.com.

The 1 Exceptional Magnesium that Corrects Many Neurological Problems - Dr Alan Mandell, DC - YouTube

What is The Best Magnesium Supplement? - YouTube/Dr. David Jockers


How exercise may protect against Alzheimer's - Science Daily, 2/8/19 - "A few years ago, exercise researchers discovered a hormone called irisin that is released into the circulation during physical activity. Initial studies suggested that irisin mainly played a role in energy metabolism. But newer research found that the hormone may also promote neuronal growth in the brain's hippocampus, a region critical for learning and memory ... irisin is present in the human hippocampus and that hippocampal levels of the hormone are reduced in individuals with Alzheimer's ... irisin, in mice, protects the brain's synapses and the animals' memory: When irisin was disabled in the hippocampus of healthy mice, synapses and memory weakened. Similarly, boosting brain levels of irisin improved both measures of brain health ... mice who swam nearly every day for five weeks did not develop memory impairment despite getting infusions of beta amyloid -- the neuron-clogging, memory-robbing protein implicated in Alzheimer's ... Blocking irisin with a drug completely eliminated the benefits of swimming, the researchers also found"

Does Sunlight Through Glass Provide Vitamin D? - NYT, 2/8/19 - "And you can’t get adequate UVB exposure sitting indoors or in a car. Virtually all commercial and automobile glass blocks UVB rays. As a result, you will not be able to increase your vitamin D levels by sitting in front of a sunny window, though much of the UVA radiation will penetrate the glass and may be harmful ... “It doesn’t matter if it’s winter or summer, you will make no vitamin D sitting in front of a window — zip,” said Dr. Michael Holick, a professor of medicine, physiology and biophysics at Boston University School of Medicine ... Those concerned about low vitamin D levels can get more of the vitamin through foods. The best dietary source for vitamin D is old-fashioned cod liver oil."

The involvement of the gut in Parkinson's disease: hype or hope? - Science Daily, 2/7/19 - "The gut has emerged as one of the new frontiers in PD research," commented Patrik Brundin, MD, PhD, Van Andel Research Institute, Grand Rapids, MI, USA, and J. William Langston, MD, Stanford Udall Center, Department of Pathology, Stanford University, Palo Alto, CA, USA, Editors-in-Chief of the Journal of Parkinson's Disease. "We predict there will be several advances regarding the gut in the coming 20 years. Changes in the gut might be utilized to diagnose PD earlier; new therapies targeting these changes might slow disease progression, reduce constipation, and improve gut function in patients who have already been diagnosed."

Flaxseed fiber ferments in gut to improve health, reduce obesity - Science Daily, 2/5/19 - "The breakdown of dietary fiber in the gut -- a process called fermentation -- can produce favorable changes in the digestive system, such as an increase in beneficial fatty acids, which may reduce the production of fat tissue in the body and improve immune function. Flaxseed is a fiber-rich plant that has been shown to improve cholesterol levels and inflammation in the colon ... The flaxseed group was more physically active and had less weight gain than the other high-fat diet groups. The mice that received flaxseed supplements also had better glucose control and levels of beneficial fatty acids that were comparable to the healthy control group. When examining the cecal contents, the research team found evidence that the bacteria present ferment fibers from the thick, glue-like layer of the flaxseed shell. The bacteria that perform fermentation then produce more beneficial fatty acids ... Our data suggest that flaxseed fiber supplementation affects host metabolism by increasing energy expenditure and reducing obesity as well as by improving glucose tolerance" - See ground flaxseed at Amazon.com.

Abstracts from this week:

The Bone—Vasculature Axis: Calcium Supplementation and the Role of Vitamin K - Front. Cardiovasc. Med., 05 February 2019 - "Data suggest that supplementing post-menopausal women with high doses of calcium has a detrimental impact on cardiovascular morbidity and mortality. Chronic kidney disease (CKD) patients are prone to vascular calcification in part due to impaired phosphate excretion. Calcium-based phosphate binders further increase risk of vascular calcification progression. In both bone and vascular tissue, vitamin K-dependent processes play an important role in calcium homeostasis and it is tempting to speculate that vitamin K supplementation might protect from the potentially untoward effects of calcium supplementation. This review provides an update on current literature on calcium supplementation among post-menopausal women and CKD patients and discusses underlying molecular mechanisms of vascular calcification. We propose therapeutic strategies with vitamin K2 treatment to prevent or hold progression of vascular calcification as a consequence of excessive calcium intake" - [Nutra USA] - See vitamin K2 at amazon.com.

Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development - Biomedicine & Pharmacotherapy, February 2019 - "Wuzhi (WZ) capsule contains an ethanol extract of Schisandra sphenanthera ... Liver histology revealed significantly less steatosis, inflammation, and necrosis, which was confirmed by decreased intrahepatic triglycerides and serum ALT in WZ-treated mice. WZ also reduced the liver mRNA expression of IL-1β, IL-6, and TNF-α and the serum levels of IL-1β and IL-6. Sensitivity to steatohepatitis due to WZ administration correlated significantly with alterations in the expression of PPAR-α/γ, as well as the NF-κB signalling pathway ... WZ plays a protective role against MCD-induced steatohepatitis. The underlying mechanism likely involves the upregulation of PPAR-α/γ and downregulation of the NF-κB signalling pathway. Based on its beneficial effects on the liver, WZ is a promising therapeutic for NAFLD patients" - [Nutra USA] - See schizandra at Amazon.com.

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