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Recent Longevity News for the week ending 1/23/19

High Fiber, Whole Grains Linked to CVD, Diabetes, Cancer Risk - Medscape, 1/15/29 - "those in the highest quartile of egg intake (about 1 egg/day) had a 38% lower risk of type 2 diabetes than men in the lowest quartile (about 1 egg/week) ... For every 8 g increase in dietary fiber consumed daily, total deaths and incidents of CHD, type 2 diabetes, and colorectal cancer decreased by 5% to 17% ... The greatest benefits in fiber consumption were observed in individuals consuming 25 g to 29 g per day (improvement in six of seven critical outcomes), which was higher than in individuals consuming 15 g to 19 g per day (improvement in three of the seven critical outcomes), or 20 g to 24 g per day (improvement in four of seven critical outcomes)"

Up to an Egg a Day May Ward Off Diabetes: Metabolomic Study - Medscape, 1/15/19 - "those in the highest quartile of egg intake (about 1 egg/day) had a 38% lower risk of type 2 diabetes than men in the lowest quartile (about 1 egg/week)"

Teen brain volume changes with small amount of cannabis use, study finds - Science Daily, 1/14/19 - "this research is the first to find evidence that an increase in gray matter volume in certain parts of the adolescent brain is a likely consequence of low-level marijuana use ... Consuming just one or two joints seems to change gray matter volumes in these young adolescents ... The biggest differences in gray matter were in the amygdala, which is involved in fear and other emotion-related processes, and in the hippocampus, involved in memory development and spatial abilities"

Common Heart, Diabetes Meds May Aid Mental Illness - WebMD, 1/10/19 - "Specifically, the benefit was seen when patients were taking: statins, which lower cholesterol; calcium channel blockers, a group of blood pressure drugs; or the oral diabetes drug metformin, the study findings showed ... The findings do not prove that the medications had a direct effect on mental health symptoms, said lead researcher Dr. Joseph Hayes, of the University College London ... But, he said, they do argue for further research"

Excessive body fat around the middle linked to smaller brain size, study finds - Science Daily, 1/9/19 - "After adjusting for other factors that may affect brain volume, such as age, physical activity, smoking and high blood pressure, researchers found that while a high BMI alone was linked to slightly lower brain volumes, those with high BMI and waist-to-hip ratios had lower gray matter brain volumes than participants who did not have a high waist-to-hip ratio. Specifically, researchers found that 1,291 people who had a high BMI and a high waist-to-hip ratio had the lowest average gray matter brain volume of 786 cubic centimeters, compared to 3,025 people of healthy weight who had an average gray matter brain volume of 798 cubic centimeters and 514 people with a high BMI but without high waist-to-hip ratio who had an average gray matter brain volume of 793 cubic centimeters. They found no significant differences in white matter brain volume."

Scientists Say This Popular Bathroom Accessory Really Does Help You Poop Better - Time, 1/10/19 - "Products like the Squatty Potty (which are known scientifically as “defecation postural modification devices,” or DPMDs) have in recent years gained a cult following for purportedly helping people relieve themselves in the most natural position: squatting. People can mimic a squat by simply placing their feet on a stool while using the toilet, raising their knees above their hips ... 90% of people who used a Squatty Potty strained less, and 71% had faster bowel movements. Fewer users also reported feeling like they still had to go after using the bathroom" - [WebMD] - See the Squatty Potty at Amazon.com.

Sodium Restriction in HF: Take It With a Grain of Salt? - Medscape, 1/10/19 - "There was a beautiful paper in JAMA Internal Medicine by Mahtani and colleagues[1] out of Oxford that went deeply into the literature to figure out why we are so insistent on low-sodium diets. It is in every guideline. I have been cantankering patients for years, having them look at everything that they eat, read the labels, add up the sodium, and never exceed that famous [threshold of] 2 g sodium. I think we probably extrapolated it from the hypertension literature, as we know that there are salt-sensitive individuals who have significant hypertension ... They reviewed every paper and found 2700 articles that dealt with sodium. However, when it came down to having good data and good analysis, they came down to fewer than 30.—therefore, less than 100 patients per study. Most of them did not have accurate or very thorough measurements of the diet and what the recommendations have been. Some studies showed benefits, some did not. Some were neutral ... The bottom of this is that we really have no good evidence, yet we are so evidence-driven"

Abstracts from this week:

Inactive matrix Gla protein is a novel circulating biomarker predicting retinal arteriolar narrowing in humans - Scientific Reportsvolume 8, Article number: 15088 (2018) - "Our observations highlight the possibility that vitamin K supplementation might promote retinal health" - [Nutra USA] - See MK-7 at Amazon.com.

Aortic Stiffness is Associated with Increased Risk of Incident Dementia in Older Adults - Alzheimers Dis. 2018; 66(1): 297–306 - "The Cardiovascular Health Study Cognition Study followed 532 non-demented older adults with annual cognitive exams from 1998–99 through 2013. CfPWV was measured on 356 (mean age = 78, 59% women) between 1996–2000. Over 15 years, 212 (59.6%) developed dementia (median time from cfPWV measurement = 4 years). In age and sex-adjusted Cox models, cfPWV was significantly associated with increased risk of dementia, but systolic blood pressure, mean arterial pressure and pulse pressure were not. CfPWV (transformed as –1/cfPWV) remained significantly associated with dementia risk when further adjusted for education, race, APOE4, diabetes, body mass index, mean arterial pressure, and anti-hypertensive medication (hazard ratio = 1.60, 95%CI = 1.02, 2.51). Results were similar when further adjusted for baseline global cognition, subclinical brain measures, and coronary artery calcification. Finally, higher cfPWV was related to lower physical activity intensity and higher systolic blood pressure, heart rate, and waist circumference measured 5 years prior. An important unanswered question is whether interventions to slow arterial stiffening can reduce the risk of dementia" - [Nutra USA] - Note: Some studies support vitamin K for aortic stiffness:

  • Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women - Thromb Haemost 2015; 113(05): 1135-1144 - "Indices of local carotid stiffness (intimamedia thickness IMT, Diameter end-diastole and Distension) were measured by echotracking. Regional aortic stiffness (carotid-femoral and carotid-radial Pulse Wave Velocity, cfPWV and crPWV, respectively) was measured using mechanotransducers. Circulating desphospho-uncarboxylated matrix Gla-protein (dp-ucMGP) as well as acute phase markers Interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP), tumour necrosis factor-α (TNF-α) and markers for endothelial dysfunction Vascular Cell Adhesion Molecule (VCAM), E-selectin, and Advanced Glycation Endproducts (AGEs) were measured. At baseline dp-ucMGP was associated with IMT, Diameter, cfPWV and with the mean z-scores of acute phase markers (APMscore) and of markers for endothelial dysfunction (EDFscore). After three year MK-7 supplementation cfPWV and the Stiffness Index β significantly decreased in the total group, whereas distension, compliance, distensibility, Young’s Modulus, and the local carotid PWV (cPWV) improved in women having a baseline Stiffness Index β above the median of 10.8. MK-7 decreased dp-ucMGP by 50 % compared to placebo, but did not influence the markers for acute phase and endothelial dysfunction. In conclusion, long-term use of MK-7 supplements improves arterial stiffness in healthy postmenopausal women, especially in women having a high arterial stiffness" - [Nutra USA] - See MK-7 at Amazon.com.
  • Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus - American Journal of Hypertension, Volume 30, Issue 2, 1 February 2017 - "In our cross-sectional analysis, circulating dp-ucMGP was independently associated with CF-PWV in type 2 diabetes. This suggests that deficient vitamin K-dependent activation of MGP may lead to large artery stiffening and could be targeted with vitamin K supplementation in the patients with diabetes" - [Nutra USA]

Quercetin phytosome® in triathlon athletes: a pilot registry study - Minerva Med. 2018 Aug;109(4):285-289 - "In total, 23 subjects used the supplement and 25 did not. No side effects were reported. The improvement of time to complete the run was greater in subjects on quercetin supplementation compared with the control group (-11.3% vs. -3.9%; P<0.05). Training was considered more valuable in the quercetin group compared with controls (P<0.05). Similarly, post-run muscular pain, cramps, localized pain and the post-exercise recovery time were all considered better with the supplementation (P<0.05). Oxidative stress was also reduced (P<0.05)" - [Nutra USA] - See Quercetin Phytosome® at Amazon.com.

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