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Recent Longevity News for the week ending 6/27/18

Daily fasting works for weight loss, finds report on 16:8 diet - Science Daily, 6/18/18 - "Between the hours of 10 a.m. and 6 p.m. the dieters could eat any type and quantity of food they desired, but for the remaining 16 hours they could only drink water or calorie-free beverages. The study followed the participants for 12 weeks ... those who followed the time-restricted eating diet consumed fewer calories, lost weight and had improvements in blood pressure. On average, participants consumed about 350 fewer calories, lost about 3 percent of their body weight and saw their systolic blood pressure decreased by about 7 millimeters of mercury (mm Hg), the standard measure of blood pressure. All other measures, including fat mass, insulin resistance and cholesterol, were similar to the control group" - Note:  It sounds good on paper but some people can't sleep when their stomach is on empty.

Congress May Soon Make CBD From Hemp Legal - WebMD, 6/18/18 - "Although it’s a type of cannabis plant like marijuana, hemp does not produce the ''high" of THC. It’s often used in industrial products and also contains cannabidiol, or CBD; much more, in fact, than cannabis or marijuana. CBD is used in products that claim to relieve pain, ease stress, help you sleep, improve skin, and pump up mascara's lash-thickening power" - Note: I'm betting that all those people that claim they need pot for their condition won't use it because they really want the high and use their condition as an excuse.  The studies I've read show the THC that gives the high does nothing for the conditions.

Young Marijuana Users Face Psychosis Risk - WebMD, 6/18/18 - "The effect was seen for everyone in the study, says Conrod, not just teens with a family history of schizophrenia or something biological that makes them more likely to be affected by it"

New research shows marathoners have less arthritis than non-runners - Washington Post, 6/13/18 - "veteran American marathoners had only half as much arthritis as non-runners"

Greater levels of vitamin D associated with decreasing risk of breast cancer - Science Daily, 6/15/18 - "We found that participants with blood levels of 25(OH)D that were above 60 ng/ml had one-fifth the risk of breast cancer compared to those with less than 20 ng/ml ... To reach 25(OH)D levels of 60 ng/ml, said Garland, would generally require dietary supplements of 4,000 to 6,000 international units (IU) per day" - See vitamin D at Amazon.com.

All Young Cannabis Users Face Psychosis Risk - Medscape, 6/15/18 - "The effect was observed for the entire cohort. This finding, said Conrod, means that all young cannabis users face psychosis risk, not just those with a family history of schizophrenia or a biological factor that increases their susceptibility to the effects of cannabis ... The first time point occurred at a mean age of 12.8 years. Twelve months separated each assessment. In total, 86.7% and 94.4% of participants had a minimum of two time points out of four on psychosis symptoms and cannabis use, respectively ... Cannabis use, in any given year, predicted an increase in psychosis symptoms a year later" - Note: I don’t know where Dr. Sanjay Gupta on CNN finds his positive studies but it burns me up that he ignores the overwhelming number of negative stories.  At a minimum he's not the totality of all the studies into account.  Those positive studies aren't showing up in the abstracts I read and I go through about 200 per day.  Too many reporters have an agenda and I think Gupta's agenda is ratings.

Omega-3 Fatty Acids Reduce Pain From AIs -- When BMI Is 30 or More - Medscape,6/14/18 - "among patients with a BMI of 30 or greater, once-a-day omega-3 fatty acid use was associated with a 2.89-point decrease in the Brief Pain Inventory (BPI) worst pain score at 24 weeks, which was the study's primary endpoint, compared with only a 1.49-point decrease with placebo use (P = .02). In other words, among the heavier women, the treatment significantly reduced pain vs placebo" - See fish oil supplements at Amazon.com.

Higher vitamin D levels linked to lower colorectal cancer risk, study finds - Washington Post, 6/14/18 - "The researchers found that people who had lower levels of vitamin D than recommended by the National Academies for bone health had a 31 percent higher risk of colorectal cancer during a follow-up period that averaged five-and-a-half years. Those with levels above the recommended concentrations had a 22 percent lower risk, they said" - See vitamin D at Amazon.com.

Common Drugs May Be Contributing to Depression - NYT, 6/13/18 - "About 200 prescription drugs can cause depression, and the list includes common medications like proton pump inhibitors (P.P.I.s) used to treat acid reflux, beta-blockers used to treat high blood pressure, birth control pills and emergency contraceptives, anticonvulsants like gabapentin, corticosteroids like prednisone and even prescription-strength ibuprofen ... For some drugs, like beta-blockers and interferon, the side effect of depression is well known"

Dementia risk increased in 50-year-olds with blood pressure below hypertension threshold - Science Daily, 6/13/18 - "Those who had a systolic blood pressure of 130 mmHg or more at the age of 50 had a 45% greater risk of developing dementia than those with a lower systolic blood pressure at the same age. This association was not seen at the ages of 60 and 70, and diastolic blood pressure was not linked to dementia.* ... Our analysis suggests that the importance of mid-life hypertension on brain health is due to the duration of exposure. So we see an increased risk for people with raised blood pressure at age 50, but not 60 or 70, because those with hypertension at age 50 are likely to be 'exposed' to this risk for longer ... Possible reasons for the link between raised blood pressure and dementia include the fact that high blood pressure is linked to silent or mini strokes (where symptoms often are not noticeable), damage to the white matter in the brain, which contains many of the brain's nerve fibres, and restricted blood supply to the brain. This damage may underlie the resulting decline in the brain's processes"

Better physical fitness and lower aortic stiffness key to slower brain aging - Science Daily, 6/12/18 - "The results of this study indicate that remaining as physically fit as possible, and monitoring central arterial health, may well be an important, cost effective way to maintain our memory and other brain functions in older age"

As CBD Oil Flirts with Mainstream, Questions Mount - Medscape, 6/11/18 - "Yet evidence for most benefits is lacking, experts warn. The industry has set no standards. As with other products, a CBD product may not deliver what it promises on the label. Despite Internet marketing implying anyone can buy CBD products, that's not the case legally"

Abstracts from this week:

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency - Proc Natl Acad Sci U S A. 2018 Feb 20 - "NR-treated 3xTgAD/Polβ+/- mice exhibited reduced DNA damage, neuroinflammation, and apoptosis of hippocampal neurons and increased activity of SIRT3 in the brain. NR improved cognitive function in multiple behavioral tests and restored hippocampal synaptic plasticity in 3xTgAD mice and 3xTgAD/Polβ+/- mice. In general, the deficits between genotypes and the benefits of NR were greater in 3xTgAD/Polβ+/- mice than in 3xTgAD mice. Our findings suggest a pivotal role for cellular NAD+ depletion upstream of neuroinflammation, pTau, DNA damage, synaptic dysfunction, and neuronal degeneration in AD. Interventions that bolster neuronal NAD+ levels therefore have therapeutic potential for AD" - [Nutra USA] - See nicotinomide riboside at Amazon.com.

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