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Recent Longevity News for the week ending 10/5/16

Note: I was going to hold off a week on this newsletter due to lack of any significant news but then things picked up so I'm a couple days late.

Early marijuana use associated with abnormal brain function, lower IQ - Science Daily, 10/5/16 - "The study found no evidence that marijuana use improved depressive symptoms ... those participants who used marijuana from a young age had highly abnormal brain function in areas related to visuo-spatial processing, memory, self-referential activity and reward processing. The study found that early marijuana use was also associated with lower IQ scores"

Cannabis reduces creativity, but user generally not aware - Science Daily, 10/4/16 - "Regular users of cannabis are less aware of their own mistakes, and they are not good at creative thinking ... The research also indicated clear long-term effects: cannabis disrupts the activity of dopamine in the brain. With chronic users a significant reduction was seen in the frequency of spontaneous eye blinking, an indication of a reduction in dopamine production"

This pill could make your dog (and maybe you) live longer - CNN, 10/6/16 - "We knew we could go to Mexico and get rapamycin or order it online, but we wanted to be guided by a veterinarian, by a professional ... a month after his stroke, Sherman was so weak, he had to be fed by hand and carried everywhere ... rapamycin changed all that ... The third day after taking rapamycin, he could eat on his own. By the seventh day, he was walking on his own ... Sixteen months later, the dog who had been given two months to live is still alive, and while clearly old, he's still active and able to run around the yard ... The list of things that can go wrong is long and horrifying: cancer, diabetes, infections and more ... Of the 53 patients on the lowest dose of rapamycin, 22 suffered some side effect, most commonly mouth sores ... he prefers to think in terms of treatments that will delay the onset of diseases of aging, such as dementia or heart disease. In mice, rapamycin has been shown to slow these two types of declines, as well as several others" - Note: I search to purchase it online.  It's expensive.

Do you need to eat more protein? - CNN, 10/4/16 - "While studies are mixed about whether consuming more protein leads to weight loss, research is pretty clear that protein can help you retain more of your lean muscle as you lose fat. One 2011 study suggests amping up protein to as much as 1.8 to 2 grams per kilogram (roughly 0.8 to 0.9 grams per pound) of body weight per day to stave off muscle loss when restricting calories ... Eating more protein as you get older may help you maintain muscle and ward off osteoporosis, "so you can stay stronger and more functional," says Rodriguez. In a 2015 study, adults over the age of 50 who roughly doubled the RDA (eating 1.5 grams of protein per kilogram, or 0.68 grams per pound, of body weight) were better able to rebuild and retain muscle after only four days, compared with control groups eating the RDA ... Eating more protein as you get older may help you maintain muscle and ward off osteoporosis, "so you can stay stronger and more functional," says Rodriguez. In a 2015 study, adults over the age of 50 who roughly doubled the RDA (eating 1.5 grams of protein per kilogram, or 0.68 grams per pound, of body weight) were better able to rebuild and retain muscle after only four days, compared with control groups eating the RDA"

Pot Use Linked to Relapse in Psychosis Patients - WebMD, 9/28/16 - "the risk that patients would relapse was 13 percent higher when they used pot than when they didn't. And the odds appeared to go up when the patients used more pot"

Abstracts from this week:

The effects of synbiotic supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes: a randomised, double-blind, placebo-controlled trial - Br J Nutr. 2016 Sep 29:1-8 - "Patients in the synbiotic group received a daily capsule that contained three viable and freeze-dried strains: Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum (2×109 colony-forming units/g each) plus 800 mg inulin for 6 weeks ... After 6 weeks of intervention, compared with the placebo, synbiotic supplementation led to a significant decrease in serum insulin levels (-1·5 (sd 5·9) v. +4·8 (sd 11·5) µIU/ml, P=0·005), homoeostatic model assessment for insulin resistance (-0·4 (sd 1·3) v. +1·1 (sd 2·7), P=0·003) and homoeostatic model assessment for β cell function (-5·1 (sd 24·2) v. +18·9 (sd 45·6), P=0·008) and a significant increase in quantitative insulin sensitivity check index (+0·01 (sd 0·01) v. -0·007 (sd 0·02), P=0·02). In addition, synbiotic intake significantly decreased serum TAG (-14·8 (sd 56·5) v. +30·4 (sd 37·8) mg/dl, P<0·001) and VLDL-cholesterol concentrations (-3·0 (sd 11·3) v. +6·1 (sd 7·6) mg/dl, P<0·001) compared with the placebo" - [Nutra USA] - See synbiotic products at Amazon.com, probiotic products at Amazon.com and inulin at Amazon.com.

Impact of Chlorhexidine Pretreatment Followed by Probiotic Streptococcus salivarius Strain K12 on Halitosis in Children: A Randomised Controlled Clinical Trial - Oral Health Prev Dent. 2016;14(4):305-13 - "Probiotic therapy following oral disinfection with chlorhexidine may reduce the severity of halitosis over longer periods" - [Nutra USA] - See probiotic products at Amazon.com.

Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis - Crit Care. 2016 Aug 19;19:262 - "Thirty trials that enrolled 2972 patients were identified for analysis. Probiotics were associated with a significant reduction in infections (risk ratio 0.80, 95 % confidence interval (CI) 0.68, 0.95, P = 0.009; heterogeneity I (2) = 36 %, P = 0.09). Further, a significant reduction in the incidence of ventilator-associated pneumonia (VAP) was found (risk ratio 0.74" - See probiotic products at Amazon.com.

Statin Use Significantly Improves Overall Survival in High-Grade Endometrial Cancer - Int J Gynecol Cancer. 2016 Sep 19 - "Overall survival (OS) and progression-free survival (PFS) ... Hyperlipidemic patients who used statins had improved OS compared with hyperlipidemic patients not using statins (hazard ratio, 0.42; 95% confidence interval, 0.20-0.87; P = 0.02). Statin use was also associated with improved PFS (hazard ratio, 0.47; 95% confidence interval, 0.23-0.95; P = 0.04) on multivariate analysis"

A Dietary Supply of Docosahexaenoic Acid Early in Life Is Essential for Immune Development and the Establishment of Oral Tolerance in Female Rat Offspring - J Nutr. 2016 Sep 28 - "Feeding additional DHA during suckling had a beneficial programming effect on the ability of immune cells to produce IFN-γ and IL-10, and feeding DHA during weaning resulted in a lower inflammatory response" - See docosahexaenoic acid at Amazon.com and docosahexaenoic acid at iHerb.

Consumption of a flavonoid-rich açai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men - Am J Clin Nutr. 2016 Sep 28 - "The acute consumption of an AS containing 694 mg total phenolics improved vascular function, with postprandial increases in FMD from baseline of 1.4% at 2 h compared with 0.4% after consumption of the PS" - Note:  The Nutra USA article says a 1% improvement in FMD is reported to reduce the risk of a cardiovascular even by 13%.  See acai berry products at Amazon.com.

Preservation of muscular mass and strength in aged subjects with Pycnogenol® supplementation - Minerva Ortopedica E Traumatologica, Oct 16 - "Supplementation with Pycnogenol® improved muscular strength and the general fitness level (also decreasing oxidative stress) in otherwise healthy, older subjects with symptoms of fatigue and signs of muscle mass loss" - [Nutra USA] - See Pycnogenol at Amazon.com and grape seed extract at Amazon.com (some claim grape seed extract is basically the same thing without the patent mark-up). 

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