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Recent Longevity News for the week ending 8/17/16

Pioglitazone Diabetes Prevention Data Now Published - Medscape, 8/12/16 - "The now-generic glucose-lowering drug pioglitazone cuts the risk of developing diabetes in half among people with insulin resistance and cerebrovascular disease"

Oral Carnitine Supplementation Reduces Body Weight and Insulin Resistance in Women With Polycystic Ovary Syndrome - Medscape, 8/10/16 - "Overall, 12 weeks of carnitine administration in PCOS women resulted in reductions in weight, BMI, WC and HC, and beneficial effects on glycaemic control; however, it did not affect lipid profiles or free testosterone" - See L-carnitine at Amazon.com.

Marijuana Tied to Persistent Subclinical Psychotic Symptoms in Teens - Medscape, 8/15/16 - "for each year the teens engaged in weekly marijuana use, their level of subsequent subclinical psychotic symptoms rose by 21%. The increase was greatest for paranoia (133%) and hallucinations (92%)"

Abstracts from this week:

Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials - Nutrients. 2016 Aug 6;8(8) - "It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder ... Probiotics had an effect on both the healthy population (MD = -0.25, 95% CI (-0.47--0.03), p = 0.03) and patients with major depressive disorder (MDD) (MD = -0.73, 95% CI (-1.37--0.09), p = 0.03) ... probiotics were associated with a significant reduction in depression" - See probiotic products at Amazon.com.

Tocotrienols and Whey Protein Isolates Substantially Increase Exercise Endurance Capacity in Diet -Induced Obese Male Sprague-Dawley Rats - PLoS One. 2016 Apr 8;11(4):e0152562 - "whey protein isolates (WPIs) and vitamin E tocotrienols (TCTs) ... Ten weeks of both TCTs and WPIs increased exercise endurance by 50% in sedentary, diet-induced obese rats" - [Nutra USA] - See whey protein at Amazon.com and Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

A randomized, double blind, placebo controlled study of spirulina supplementation on indices of mental and physical fatigue in men - Int J Food Sci Nutr. 2016;67(2):203-6 - "After 1 week, a 3 g/day dose of spirulina produced a small, but statistically significant increase in exercise output (Kcals consumed in 30 min exercise on a cross trainer machine). A mathematical based mental fatigue test showed improved performance 4 h after the first time of supplementation as well as 8 weeks later. Similarly, a subjective survey for a sense of physical and mental fatigue showed improvement within 4 h of the first supplementation as well as 8 weeks later. These results show that spirulina intake can affect fatigue in men" - [Nutra USA] - See spirulina at Amazon.com

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