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Recent Longevity News for the week ending 4/8/15

Pomegranate-date cocktail a day keeps the doctor away - Science Daily, 4/6/15 - "Prof. Aviram had a hunch that since dates and pomegranate juice are composed of different phenolic antioxidants, the combination could thus prove more beneficial than the sum of its parts ... In a trial performed on arterial cells in culture, as well as in atherosclerotic mice, the Technion team found that the triple combination of pomegranate juice, date fruits and date pits did indeed provide maximum protection against the development of atherosclerosis because the combination reduced oxidative stress in the arterial wall by 33% and decreased arterial cholesterol content by 28%"

Regular, Vigorous Exercise May Lengthen Your Life: Study - WebMD, 4/6/15 - "Researchers compared those who engaged in only moderate activities -- like gentle swimming, social tennis or household chores -- with people who got some amount of vigorous activity -- such as jogging, aerobics or competitive tennis ... The death rate for those who said up to 30 percent of their physical activity was vigorous was 9 percent lower than those who reported no vigorous activity. The risk of death dropped 13 percent for those who said that more than 30 percent of their exercise was vigorous, the study authors reported" - Note:  The studies keep going back and forth on this.  I'm sticking with my seven miles per day plus dancing three times per week.

High-fat dairy products linked to reduced type 2 diabetes risk - Science Daily, 4/2/15 - "are in line with previous studies of eating habits that indicated a link between high consumption of dairy products and a reduced risk of type 2 diabetes ... the new study indicates that it is high-fat dairy products specifically that are associated with reduced risk ... Those who ate the most high-fat dairy products had a 23 per cent lower risk of developing type 2 diabetes than those who ate the least. High meat consumption was linked to an increased risk of type 2 diabetes regardless of the fat content of the meat"

Eating eggs reduces risk of type 2 diabetes, study indicates - Science Daily, 4/2/15 - "The dietary habits of 2,332 men aged between 42 and 60 years were assessed at the baseline of the Kuopio Ischaemic Heart Disease Risk Factor Study, KIHD, at the University of Eastern Finland in 1984-1989 ... follow-up of 19.3 years ... egg consumption was associated with a lower risk of type 2 diabetes as well as with lower blood glucose levels. Men who ate approximately four eggs per week had a 37 per cent lower risk of type 2 diabetes than men who only ate approximately one egg per week ... The consumption of more than four eggs did not bring any significant additional benefits" - [Abstract]

Common cholesterol drug stimulates the same receptors as marijuana - Science Daily, 4/1/15 - "If you want the benefits of medical marijuana without the "unwanted side effects" of cannabis, new research should leave you on a high note ... fenofibrate, also known by the brand name Tricor®, may benefit a wide range of health issues, such as pain, appetite stimulation, nausea, as well as immune and various psychiatric and neurological conditions. This suggests that fenofibrate may be the starting point for a new class of cannabis-like drugs to treat these types of conditions ... It may be difficult to persuade people in Colorado, Washington, and the District of Columbia that there are people who want the beneficial effects of marijuana without actually getting high ... but there are people who do not want to get stoned just to get the relief that marijuana brings. This new work suggests that possibility"

Treating a common gum condition could reduce risk of heart attacks in kidney disease patients - Science Daily, 4/1/16 - "more than 85% of people with CKD have inflammatory gum problems, caused by inadequate removal of dental plaque from between the tooth and gum margin and made worse by impaired immunity and wound healing. Experts have identified that bacteria in the mouth can enter the bloodstream through periodontal conditions, causing blood cells to malfunction and leading to clots and narrowing of the arteries" - Note:  Here's a cut and paste from my dental page with my solution to periodontal disease in addition to dental cleaning and good hygiene:

ActiveGuard mattress liners reduce bed bugs' ability to lay eggs, study finds - Science Daily, 4/1/15 - "out of 52 females tested, only one laid a single egg" - See ActiveGuard mattress liners at Amazon.com.

Blueberries show promise as treatment for post-traumatic stress disorder - Science Daily, 3/31/15 - "Ebenezer et al. have previously demonstrated that SSRIs increase levels of serotonin (5-HT) and the neurotransmitter norepinephrine (NE) and that the increased NE may reduce the effectiveness of SSRI therapy. In the new study, the research team looked at the ability of blueberries to modulate neurotransmitter levels in a rat model of PTSD ... PTSD rats who did not receive blueberries demonstrated a predictable increase in NE and 5-HT when compared with the control group. However, the PTSD rats that received blueberries showed a beneficial increase in 5-HT with no effect on NE levels, suggesting that blueberries can effectively modulate neurotransmitters in PTSD" - Note:  That's probably another one that's a better alternative to pot for people who claim pot helps their PTSD when there's no evidence to support it and it's probably just a con-game to get high.  See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.

Abstracts from this week:

Dietary intakes of glutamic Acid and glycine are associated with stroke mortality in Japanese adults - J Nutr. 2015 Apr;145(4):720-8 - "Their diets were assessed by a validated food frequency questionnaire. Deaths from stroke were ascertained over 16 yr ... A high intake of glutamic acid in terms of a percentage of total protein was significantly associated with a decreased risk of mortality from total stroke in women after controlling for covariates; the HR (95% CI) for the highest vs. lowest quartile was 0.72 (0.53, 0.98; P-trend: 0.03). Glycine intake was significantly associated with an increased risk of mortality from total and ischemic stroke in men without history of hypertension at baseline; the HRs (95% CIs) for the highest vs. lowest tertile were 1.60 (0.97, 2.51; P-trend: 0.03) and 1.88 (1.01, 3.52; P-trend: 0.02), respectively" - See glutamic acid at Amazon.com.

Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients - J Nutr. 2015 Apr;145(4):742-8 - "A total of 58 diabetic patients were given 160 mg of anthocyanins twice daily or placebo (n = 29/group) for 24 wk ... Anthocyanin supplementation significantly decreased serum LDL cholesterol (by 7.9%; P < 0.05), triglycerides (by 23.0%; P < 0.01), apolipoprotein (apo) B-48 (by 16.5%; P < 0.05), and apo C-III (by 11.0%; P < 0.01) and increased HDL cholesterol (by 19.4%; P < 0.05) compared with placebo after the 24-wk intervention ... Furthermore, supplementation with anthocyanin lowered fasting plasma glucose (by 8.5%; P < 0.05) and homeostasis model assessment for insulin resistance index (by 13%; P < 0.05), and elevated serum adiponectin (by 23.4%; P < 0.01) and β-hydroxybutyrate (by 42.4%; P = 0.01) concentrations compared with placebo supplementation" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com, anthocyanin at Amazon.com and Jarrow Formulas OPCs + 95 100mg, Grape Seed Extract, 100 Capsules at Amazon.com.

  • Anthocyanin  - Wikipedia - "They belong to a parent class of molecules called flavonoids ... Plants rich in anthocyanins are Vaccinium species, such as blueberry, cranberry, and bilberry; Rubus berries, including black raspberry, red raspberry, and blackberry; blackcurrant, cherry, eggplant peel, black rice, Concord grape, muscadine grape, red cabbage, and violet petals"
  • Anthocyanin Pigments and Polyphenolics - oregonstate.edu - "Anthocyanins are one class of flavonoid compounds, which are widely distributed plant polyphenols"

Flavonoid intake and all-cause mortality - Am J Clin Nutr. 2015 Apr 1 - "to explore the association between flavonoid intake and risk of 5-y mortality from all causes by using 2 comprehensive food composition databases to assess flavonoid intake ... Participants with high total flavonoid intake were at lower risk [multivariate-adjusted HR (95% CI)] of 5-y all-cause mortality than those with low levels of total flavonoid consumption [total flavonoidUSDA: 0.37 (0.22, 0.58); total flavonoidPE: 0.36 (0.22, 0.60)]. Similar beneficial relationships were observed for both cardiovascular disease mortality [total flavonoidUSDA: 0.34 (0.17, 0.69); flavonoidPE: 0.32 (0.16, 0.61)] and cancer mortality [total flavonoidUSDA: 0.25 (0.10, 0.62); flavonoidPE: 0.26 (0.11, 0.62)]" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.

The effect of a high-egg diet on cardiovascular risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) study-a 3-mo randomized controlled trial - Am J Clin Nutr. 2015 Apr;101(4):705-13 - "we aimed to determine whether a high-egg diet (2 eggs/d for 6 d/wk) compared with a low-egg diet (<2 eggs/wk) affected circulating lipid profiles, in particular high-density lipoprotein (HDL) cholesterol, in overweight or obese people with prediabetes or T2D ... There was no significant difference in the change in HDL cholesterol from screening to 3 mo between groups; the mean difference (95% CI) between high- and low-egg groups was +0.02 mmol/L (-0.03, 0.08 mmol/L; P = 0.38). No between-group differences were shown for total cholesterol, low-density lipoprotein cholesterol, triglycerides, or glycemic control. Both groups were matched for protein intake, but the high-egg group reported less hunger and greater satiety postbreakfast. Polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid (MUFA) intakes significantly increased from baseline in both groups"

Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension? - Age (Dordr). 2015 Apr;37(2):9769 - "Both drugs significantly increased survivorship and maximal life span. Maximal longevity was 136 days for controls, 188 days (138 % of controls) for metformin, and 194 days (143 % of controls) for aspirin. Metformin and aspirin in combination extended longevity to a lesser degree (163 days, 120 % of controls)" - See metformin at IAS.

Supplementation of n-3 Polyunsaturated Fatty Acids for Major Depressive Disorder: A Randomized, Double-Blind, 12-Week, Placebo-Controlled Trial in Korea - Ann Nutr Metab. 2015 Mar 24;66(2-3):141-148 - "n-3 PUFAs demonstrated an advantage over placebo that did not reach clinical significance, although CGI-I score was significantly decreased in the n-3 PUFA group as compared with the placebo group" - See fish oil supplements at Amazon.com.

Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins - Int J Food Sci Nutr. 2015 Mar 30:1-5 - "The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory properties" - Note:  It's probably another one in addition to cherry juice that's a better alternative for pain than pot where I feel most people are just claiming the pain as an excuse to get high.  See pomegranate extract at Amazon.com.

The Prescription Pattern of Chinese Herbal Products Containing Ginseng among Tamoxifen-Treated Female Breast Cancer Survivors in Taiwan: A Population-Based Study - Evid Based Complement Alternat Med. 2015 - "Chinese herbal products (CHPs) ... tamoxifen (TMX) ... The HR for the development of endometrial cancer among breast cancer survivors who had ever taken Ginseng after TXM treatment was significantly decreased compared to those who never used CHP" - See ginseng at Amazon.com.

The Synergistic Beneficial Effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a Mouse Model of Dementia - Evid Based Complement Alternat Med. 2015 - "This study reports the combination of Ginkgo flavonoid (GF) and Coriolus versicolor polysaccharide (CVP) in the prevention and treatment of a mouse model of Alzheimer's disease (AD). GF is a traditional health product, and CVP is the main active ingredient of the medicinal fungus Coriolus versicolor. The Morris water maze test, the Y maze, and the step-through test showed that the combinational use of CVP and GF synergistically improved memory in a mouse model of AD" - See Ginkgo biloba at Amazon.com and Coriolus versicolor at Amazon.com.

Metformin reduces ovarian cancer risk in Taiwanese women with type 2 diabetes mellitus - Diabetes Metab Res Rev. 2015 Mar 28 - "The overall fully adjusted hazard ratio (95% confidence intervals) for ever- versus never-users was 0.658 (0.593-0.730). The fully adjusted hazard ratios for the first, second, and third tertiles of cumulative duration of metformin therapy were 1.169 (1.019-1.341), 0.761 (0.644-0.898) and 0.276 (0.225-0.340), respectively (P-trend <0.01); and 1.220 (1.067-1.395), 0.610 (0.513-0.725) and 0.305 (0.248-0.374), respectively (P-trend <0.01), for cumulative dose of metformin" - See metformin at IAS.

The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats - Clin Nutr. 2015 Mar 17 - "These results indicated that lycopene might have a protective effect against indomethacin-induced gastric ulcer and oxidative stress in rats" - See lycopene at Amazon.com.

Serum 25-hydroxyvitamin D is associated with major cardiovascular risk factors and cardiac structure and function in patients with coronary artery disease - Nutr Metab Cardiovasc Dis. 2015 Feb 25 - "Low levels of Vitamin D were associated with high BMI (p < 0.001), high total and LDL cholesterol and triglyceride levels (p < 0.001 for all) in both diabetics and non-diabetics. Among non-diabetic patients, low Vitamin D was also associated independently with elevated systolic and diastolic blood pressure (p < 0.005). Low Vitamin D levels were independently associated with reduced left ventricular (LV) ejection fraction (p < 0.005) and increased left atrial diameter (p < 0.03) measured by cardiac ultrasound by 2-dimensional echo. In the non-diabetic group, low Vitamin D levels were associated with impaired LV filling (high E/E') (p < 0.03) and low E/A mitral flow pattern measured by Doppler echocardiography (p < 0.05). Among diabetics, low Vitamin D levels were also related to increased LV end-systolic diameter (p < 0.05) and right ventricular diameter (p < 0.005). The association between LV diastolic filling (E/E') and Vitamin D levels was significant (p < 0.01) after adjustment for the commonly recognized risk factors of diastolic dysfunction in linear regression analysis" - See vitamin D at Amazon.com.

Circulating Vitamin D Levels and Risk of Colorectal Cancer in Women - Cancer Prev Res (Phila). 2015 Mar 26 - "a nested case-control study using 274 colorectal cases and 274 controls ... plasma 25(OH)D was significantly and inversely associated with odds of colorectal cancer (quartile 4 [Q4] versus quartile 1 [Q1]: OR (95% CI): 0.45 (0.25-0.81) ... In this cohort of healthy women, we found a significant inverse association between prediagnostic 25(OH)D levels and risk of incident colorectal cancer, and a borderline significant inverse association between prediagnostic 25(OH)D levels and colorectal cancer mortality" - See vitamin D at Amazon.com.

Neat Tech Stuff / "How To's":

Intel's PC on a stick is now available for pre-order - engadget.com, 4/6/15 - "Like the idea of Intel's Compute Stick turning your TV into a full-fledged Linux or Windows PC? You can finally plunk down some cash to get one. Online stores (including Amazon and Newegg) have started taking pre-orders for the HDMI dongle, which is now expected to ship by late April rather than the originally planned March release" - [CNET] - See Intel computer sticks at Amazon.com.

I hate spelling like cheap cologne or perfume and I’m surprised at how difficult it is to find soaps and shampoos that are fragrance free plus some studies show that those chemical fragrances get into your bloodstream. After a lot of surfing on Amazon, this was my solution.

These are good to add to Chinese chicken recipes (three different brands):

 Health Focus (Aromatization/Gynecomastia):

 

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