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Recent Longevity News for the week ending 2/4/15:

Expert panel recommends new sleep durations - Science Daily, 2/2/15 - "Younger adults (18-25): Sleep range is 7-9 hours (new age category) ... Adults (26-64): Sleep range did not change and remains 7-9 hours ... Older adults (65+): Sleep range is 7-8 hours (new age category)"

Ways to Age-Proof Your Brain - ABC News, 2/2/15 - "Take dance lessons ... Play an instrument ... Learn a foreign language ... Play chess ... Read more of less ... Change your font ... Write about your stress"

Older adults: Double your protein to build more muscle - Science Daily, 1/30/15 - "Current US recommendations for daily dietary protein intake are 0.8 grams/kilogram of body weight (roughly 62 g of protein per day for a 170-pound person). Previous research has shown that older adults need a protein intake of at least 0.40 g/kg of body weight at each meal (roughly 31 g of protein per meal or 93 g per day for a 170-pound person) to encourage maximum protein synthesis. This represents a significantly higher amount of protein than the recommended dietary allowance (RDA) suggests ... The research team studied 20 healthy adults between 52-75 years of age, randomly assigning them to one of four groups over a four-day test period ... while the distribution of protein across meals did not make a significant impact, total amount of protein consumed"

Totality of trials data confirm Tamiflu reduces length of symptoms, complications, and hospital admissions from influenza - Science Daily, 1/30/15 - "oseltamivir significantly reduces the risk of influenza complications requiring antibiotics (such as pneumonia) and hospitalisations in adults infected with influenza ... treating adults with laboratory-confirmed influenza with oseltamivir reduced the duration of symptoms by 21% compared with placebo (from 123 hours to 98 hours) ... oseltamivir reduced the risk of lower respiratory tract infections requiring antibiotics more than 48 hours after study entry by 44% compared with placebo (4.9% vs 8.7%), and hospital admission for any cause by 63% (0.6% vs 1.7%) in adults with laboratory-confirmed influenza"

Chondroitin/Glucosamine Reduced Pain in Knee Arthritis in RCT - Medscape, 1/30/15 - "a combination glucosamine/chondroitin sulfate product produced a 50.1% decrease in Western Ontario and McMaster OA index (WOMAC) pain, which is comparable to the 50.2% decrease seen in patients randomly assigned to receive celecoxib ... Patients received either chondroitin sulfate 400 mg plus glucosamine hydrochloride 500 mg (CS+GH; Droglican, Bioibérica SA) three times a day or celecoxib 200 mg every day for 6 months" - See glucosamine chondroitin formulas at Amazon.com.

Pharmacological Potential of Tocotrienols: A Review - Medscape, 1/29/15 - "In contrast to αT, despite no evidence that deficiency of other vitamin E forms would result in obvious clinical symptoms, accumulating evidence suggests that γT, δT, and tocotrienols seem to have unique properties that are superior to αT and relevant to prevention and therapy against chronic diseases even under conditions with adequate αT status. It is noteworthy that these bioactivities of tocopherols and tocotrienols including anti-inflammatory properties have been identified by mechanistic studies and subsequently substantiated in some preclinical models as well as clinical studies ... Hence, tocotrienols possess neuroprotective, antioxidant, anti-cancer and cholesterol lowering properties. Tocotrienols are thought to have more potent antioxidant and free radical scavenging properties due to their better distribution in the lipid layers of the cell membrane. In spite of the promising potential, the experimental analysis of tocotrienols accounts for only a small portion of vitamin E research" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Saying No to Cannabis Improves Bipolar Outcomes - Medscape, 1/19/15 - "quitting cannabis during acute treatment for manic/mixed bipolar episodes and refraining from use during a maintenance treatment period significantly improved function and lowered the risk for recurrence ... Our results also showed that patients who continued to use cannabis had worse outcomes than those who either stopped using cannabis or had never used it ... patients that continued using cannabis had more suicide attempts than those that quit or those who never used cannabis"

Researchers find hormone that increases the sex drive of mice - Science Daily, 1/27/15 - "when mice receive a supplement of ghrelin, they increase their sexual activity and their efforts to find a partner" - Note:  It doesn't sound like a cure to me.  Ghrelin is the hunger hormone.  So you pack on the pounds, plugging up your arteries and you're back where you started.  Plus it may have just been the increase in calories that caused the increase in sexual activity in the first place.

Many U.S. consumers do not use a food thermometer when cooking poultry, despite hazardous risks - Science Daily, 1/16/15 - "fewer than two-thirds of consumers own a food thermometer, and less than 10 percent of food thermometer owners actually use it to check for doneness of all types of poultry ... Pathogens, such as Salmonella and Campylobacter, may be present on raw poultry. Using a food thermometer is the only reliable way to ensure food is cooked to a safe internal temperature to destroy any harmful bacteria that may present. USDA recommends that consumers cook all poultry to a safe minimum internal temperature of 165°F" - Note:  I was surprise that the number that use them is so few.  Here's my favorite.  It's simple and easy to read: MeasuPro DCT250 Ultra-Fast Instant Read Digital Cooking Thermometer with Timer, Silver

Abstracts from this week:

Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis - J Physiol. 2015 Jan 13 - "A compromised cardiac function is often seen in elderly cancer patients receiving doxorubicin therapy ... resveratrol ameliorates doxorubicin-induced cardiotoxicity in the aged hearts through the restoration of SIRT1 activity to attenuate USP7-related catabolic/pro-apoptotic signalling" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.

Omega-3 fatty acids protect from diet-induced obesity, glucose intolerance and adipose tissue inflammation through PPARγ dependent and independent actions - Mol Nutr Food Res. 2015 Jan 31 - "high-fat diet (HFD) ... High endogenous n-3 fatty acid levels protect from HFD obesity, glucose intolerance, and adipose tissue inflammation" - See fish oil supplements at Amazon.com.

Resveratrol restores the circadian rhythmic disorder of lipid metabolism induced by high-fat-diet in Mice - Biochem Biophys Res Commun. 2015 Jan 29 - "resveratrol reduced lipogenesis and ultimately normalized rhythmic expression of plasma lipids, possibly via its action on clock machinery" - See ReserveAge Resveratrol Vegetarian Capsules, 500 Mg, 60-Count at Amazon.com.

Glycemic load and coronary heart disease in a Mediterranean population: The EPIC Greek cohort study - Nutr Metab Cardiovasc Dis. 2014 Dec 11 - "High adherence to MD with low/moderate GL was associated with lower risk of CHD incidence (HR = 0.61, CI: 0.39-0.95) and mortality (HR = 0.47, 95% CI: 0.23-96)"

Vitamin C supplementation in the critically ill patient - Curr Opin Clin Nutr Metab Care. 2015 Jan 29 - "Restoration of normal plasma levels in inflammatory patients requires the administration of 3 g/day for several days ... The recent research on the modulation of oxidative stress and endothelial protection offer interesting therapeutic perspectives, based on the biochemical evidence, with limited or even absent side-effects" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.

Vitamin D supplementation in the ICU patient - Curr Opin Clin Nutr Metab Care. 2015 Jan 29 - "Both biological and observational studies support the role of vitamin D deficiency in adverse critical illness outcomes. Interventional trials of critically ill patients show that to improve vitamin D status, high-dose vitamin D3 is required. Critically ill patients have a relatively blunted response to vitamin D supplementation compared to the general outpatient population" - See vitamin D at Amazon.com.

Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium - Int J Cancer. 2014 Dec 8 - "Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend<0.001) and laryngeal cancers (OR = 0.52, 95% CI: 0.40-0.68, p for trend = 0.006), although in the presence of heterogeneity among studies for both sites. Inverse associations were consistently observed for the anatomical subsites of oral and pharyngeal cancer, and across strata of age, sex, education, body mass index, tobacco, and alcohol, for both cancer sites" - See American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com.

Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects - Br J Nutr. 2015 Jan 29:1-7 - "The purpose of the present study was to determine whether probiotic supplementation (Lactobacillus casei Shirota (LcS)) prevents diet-induced insulin resistance in human subjects. A total of seventeen healthy subjects were randomised to either a probiotic (n 8) or a control (n 9) group ... Glucose AUC values increased by 10 % (from 817 (se 45) to 899 (se 39) mmol/l per 120 min, P< 0.05) and whole-body insulin sensitivity decreased by 27 % (from 5.3 (se 1.4) to 3.9 (se 0.9), P< 0.05) in the control group, whereas normal insulin sensitivity was maintained in the probiotic group (4.4 (se 0.8) and 4.5 (se 0.9) before and after overeating, respectively (P>0.05). These results suggest that probiotic supplementation may be useful in the prevention of diet-induced metabolic diseases such as type 2 diabetes" - See probiotic products at Amazon.com.

Green tea changes serum and liver metabolomic profiles in mice with high-fat diet-induced obesity - Mol Nutr Food Res. 2015 Jan 28 - "Green tea (GT) consumption helps to prevent and control obesity by stimulating hepatic lipid metabolism ... HFD-induced abnormal mitochondrial β-oxidation was moderated by the consumption of caffeine- and theanine-enriched GT ... Results of LC/MS-based metabolomic analysis of obese mice showed changes associated with abnormal lipid and energy metabolism, which were alleviated by GT intake, indicating the mechanism underlying the anti-obesity effects of GT" - See green tea extract at Amazon.com.

Immune-mediated antitumor effect by type 2 diabetes drug, metformin - Proc Natl Acad Sci U S A. 2015 Jan 26 - "Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer effects; however, the underlying mechanism is poorly understood. Here we show that this mechanism may be immune-mediated. Metformin enabled normal but not T-cell-deficient SCID mice to reject solid tumors. In addition, it increased the number of CD8+ tumor-infiltrating lymphocytes (TILs) and protected them from apoptosis and exhaustion characterized by decreased production of IL-2, TNFα, and IFNγ. CD8+ TILs capable of producing multiple cytokines were mainly PD-1-Tim-3+, an effector memory subset responsible for tumor rejection" - See metformin at IAS.

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