Home iHerb Int Antiaging Sys LEF at Amazon LEF at LEF Amazon.com Contact
 Newsletter Archive
 Newsletter via RSS Feed
 Research on Supplements
 Health Conditions
 Anti-aging Recommendations
 Insulin and Aging
 QualityCounts.com in Time
 Longevity Affiliates:
 Int. Anti-aging Systems
 Puritan's Pride
 Vitamin Shoppe
 The Karaoke Channel
 Vital Choice Seafood
Please support this website by purchasing via the links on the website.

Recent Longevity News for the seven days ending 11/20/13.  You should consult your doctor if you are taking any medications.

Bitter Melon Extract May Have Potential to Fight Head, Neck Cancer - Science Daily, 11/18/13 - "In this study, the bitter melon extract treatment suppressed the head and neck cancer cell growth in the mouse model, reducing the growth of the tumor ... bitter melon extract regulated several pathways that helped reduce the head and neck cancer cell growth in the animal model. After a period of four weeks, Ray found that the growth and volume of the tumor had reduced ... Ray's initial research found that treatment with this natural substance halted the breast and prostate cancer cell growth, eventually stopping them from spreading" - See bitter melon extracts at iHerb.

Long-term oral contraceptive users twice as likely to have serious eye disease - Science Daily, 11/18/13 - "females who had used oral contraceptives, no matter which kind, for longer than three years are 2.05 times more likely to also report that they have the diagnosis of glaucoma"

Low-fat fish oil changes cancer tissue in prostate cancer, study shows - Science Daily, 11/18/13 - "Men with prostate cancer who ate a low-fat diet and took fish oil supplements had lower levels of pro-inflammatory substances in their blood and a lower cell cycle progression score, a measure used to predict cancer recurrence ... lowering the cell cycle progression (CCP) score may help prevent prostate cancers from becoming more aggressive ... The Western diet consisted of 40 percent of calories from fat, generally equivalent to what many Americans consume today ... The low-fat diet consisted of 15 percent of calories from fat. Additionally, the men on this diet took five grams of fish oil per day in five capsules, three with breakfast and two with dinner, to provide omega-3 fatty acids" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Is hand sanitizer toxic? - CNN, 11/16/13 - "the main concern with hand sanitizers is triclosan, which is the main antibacterial ingredient in nonalcoholic hand sanitizers ... Triclosan-containing products don't provide any disease protection beyond what you get from washing with soap and water ... Research has shown that triclosan can disrupt the endocrine system, amplifying testosterone. In animal studies, it reduced muscle strength. It may also harm the immune system ... When you expose bacteria to triclosan, it can elicit antibiotic resistance ... The main concern with triclosan, however, is that it doesn't protect against viruses or fungi ... Colds are caused by viruses, not bacteria ... Hand sanitizers that are 60% alcohol are good at killing bacterial pathogens ... They can also kill some viruses, but not all of them -- such as the noroviruses that can cause cruise-ship outbreaks"

Glucose Levels Linked to Dementia - Medscape, 11/14/13 - "This elegantly conducted study demonstrated that an increased risk for dementia was associated with higher glucose levels in populations with and without diabetes"

Are probiotics a promising treatment strategy for depression? - Science Daily, 11/14/13 - "Human studies are still largely lacking, but a few have shown promising results. In one, healthy volunteers received either a probiotic combination (L.. helveticus R0052 and B. longum) or placebo for 30 days. Those who received the probiotics reported lower stress levels. In a separate study, volunteers who consumed a yogurt containing probiotics reported improved mood" - See probiotic products at Amazon.com.

Ask Well: Table Salt vs. Sea Salt - NYTimes.com, 11/14/13 - "While sea salt proponents claim the trace minerals found in sea salts confer added health benefits, nutritionists say the amounts of added minerals are too small to offer a meaningful benefit"

Gut Microbiota Disturbance During Antibiotic Therapy - Medscape, 11/14/13 - "Antibiotic (AB) usage ... The results demonstrate that ABs targeting specific pathogenic infections and diseases may alter gut microbial ecology and interactions with host metabolism at a much higher level than previously assumed"

Aerobic Exercise Improves Memory, Brain Function, Physical Fitness - Science Daily, 11/12/13 - "sedentary adults ages 57-75 were randomized into a physical training or a wait-list control group. The physical training group participated in supervised aerobic exercise on a stationary bike or treadmill for one hour, three times a week for 12 weeks ... By measuring brain blood flow non-invasively using arterial spin labeling (ASL) MRI, we can now begin to detect brain changes much earlier than before ... One key region where we saw increase in brain blood flow was the anterior cingulate, indicating higher neuronal activity and metabolic rate. The anterior cingulate has been linked to superior cognition in late life ... Exercisers who improved their memory performance also showed greater increase in brain blood flow to the hippocampus, the key brain region affected by Alzheimer's disease"

New Cholesterol Guidelines Abandon LDL Targets - Medscape, 11/13/13 - "Gone are the recommended LDL- and non-HDL–cholesterol targets, specifically those that ask physicians to treat patients with cardiovascular disease to less than 100 mg/dL or the optional goal of less than 70 mg/dL. According to the expert panel, there is simply no evidence from randomized, controlled clinical trials to support treatment to a specific target. As a result, the new guidelines make no recommendations for specific LDL-cholesterol or non-HDL targets for the primary and secondary prevention of atherosclerotic cardiovascular disease ... The four major primary- and secondary-prevention patient groups who should be treated with statins were identified ...  Individuals with clinical atherosclerotic cardiovascular disease ... Individuals with LDL-cholesterol levels >190 mg/dL, such as those with familial hypercholesterolemia ... Individuals with diabetes aged 40 to 75 years old with LDL-cholesterol levels between 70 and 189 mg/dL and without evidence of atherosclerotic cardiovascular disease ... Individuals without evidence of cardiovascular disease or diabetes but who have LDL-cholesterol levels between 70 and 189 mg/dL and a 10-year risk of atherosclerotic cardiovascular disease >7.5%"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Efficacy of Holmium Laser Enucleation of the Prostate in Patients With Non-neurogenic Impaired Bladder Contractility: Results of a Prospective Trial - Urology. 2013 Nov 12 - "Fourteen patients with detrusor hypocontractility and 19 patients with acontractility and evidence of BPO underwent HoLEP during the study period. Median age was 71.5 and 75 years, respectively ... Individuals with hypocontratile bladders had statistically significant improvements in American Urological Association Symptom Index (21.5 vs 3; P = .014), maximum urine flow (Qmax, 10 vs 21 mL/s; P = .001), and postvoid residual (250 vs 53 mL; P = .007) from baseline to postoperative assessments"

Blood lipids profile in hyperlipidemic children undergoing different dietary long chain polyunsaturated supplementations: a preliminary clinical trial - Int J Food Sci Nutr. 2013 Nov 14 - "Thirty-six children (8-13 years) were recruited. After an 8-week stabilization period on the Step I diet, they were randomized to additionally receive for a 16-week period one capsule (500 mg) daily of docosahexaenoic acid (DHA) alone or a DHA plus eicosapentaenoic acid (EPA) mixture (45.6% DHA; 41.6% EPA) or wheat germ oil (control). An effect size (as percentage change from baseline) of +8%, -12% and -16% for high-density lipoprotein cholesterol (HDL-C), total cholesterol/HDL-C ratio and triglycerides was observed in children supplemented with DHA, compared to +2%, -8% and -12%, respectively, in children supplemented with DHA plus EPA" - See Jarrow Max DHA at Amazon.com.  Here it is in table form which is easier to see:

DHA 500mg daily 46% DHA + 42% EPA
HDL +8% +2
Total cholesterol/HDL -12% -8%
Triglycerides -16% -12%

Effects of potassium chloride and potassium bicarbonate in the diet on urinary pH and mineral excretion of adult cats - Br J Nutr. 2013 Nov 14:1-13 - "Low dietary K levels have been associated with increasing renal Ca excretion in humans, indicating a higher risk of calcium oxalate (CaOx) urolith formation. Therefore, the present study aimed to investigate whether dietary K also affects the urine composition of cats ... Fasting urine pH increased with higher dietary K levels (P= 0.022), reaching values of 6.38 (1.00 % KCl) and 7.65 (1.00 % KHCO3) ... In conclusion, the dietary inclusion of KHCO3 instead of KCl as K source could be beneficial for the prevention of CaOx urolith formation in cats, since there is an association between a lower renal Ca excretion and a generally higher urine pH. The utilisation of K is distinctly influenced by the K salt, which may be especially practically relevant when using diets with low K levels" - Note:  I mentioned in the past about yogurt having a pH of about 4.3 and how that might effect urine pH and that potassium supplements might bring that closer to a neutral pH of 7.0.  This study seems to support it.

Pulse pressure is associated with Alzheimer biomarkers in cognitively normal older adults - Neurology. 2013 Nov 13 - "One hundred seventy-seven cognitively normal, stroke-free older adult participants (aged 55-100 years) underwent blood pressure assessment for determination of PP (systolic - diastolic blood pressure) ... PP elevation is associated with increased CSF P-tau and decreased Aβ1-42 in cognitively normal older adults, suggesting that pulsatile hemodynamics may be related to amyloidosis and tau-related neurodegeneration. The relationship between PP and CSF biomarkers is age-dependent and observed only in participants in the fifth and sixth decades of life" - Note:  See my pulse pressure page for things that reduce it.

High dietary phosphorus intake is associated with all-cause mortality: results from NHANES III - Am J Clin Nutr. 2013 Nov 13 - "a prospective cohort of healthy US adults (NHANES III; 1998-1994) ... higher phosphorus intake was associated with higher all-cause mortality in individuals who consumed >1400 mg/d [adjusted HR (95% CI): 2.23 (1.09, 4.5) per 1-unit increase in ln(phosphorus intake); P = 0.03]. At <1400 mg/d, there was no association. A similar association was seen between higher phosphorus density and all-cause mortality at a phosphorus density amount >0.35 mg/kcal [adjusted HR (95% CI): 2.27 (1.19, 4.33) per 0.1-mg/kcal increase in phosphorus density; P = 0.01]. At <0.35 mg/kcal (approximately the fifth percentile), lower phosphorus density was associated with increased mortality risk. Phosphorus density was associated with cardiovascular mortality [adjusted HR (95% CI): 3.39 (1.43, 8.02) per 0.1 mg/kcal at >0.35 mg/kcal; P = 0.01], whereas no association was shown in analyses with phosphorus intake"

Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies - Am J Clin Nutr. 2013 Nov 13 - "Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used ... A higher hip fracture rate was observed with lower intakes of α-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06). The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). α-Tocopherol-containing supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95% CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with the highest quintile of α-tocopherol intake in ULSAM (follow-up: 12 y), lower intakes (quintiles 1-4) were associated with a higher rate of hip fracture (HR: 3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The HR for hip fracture in men for each 1-SD decrease in serum α-tocopherol was 1.58 (95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48)" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Carnosine mitigates apoptosis and protects testicular seminiferous tubules from gamma-radiation-induced injury in mice - Andrologia. 2013 Nov 12 - "Carnosine was administered (10, 50 and 100 mg kg-1 body weight) to male mice via intraperitoneal injection for 4 days prior to gamma irradiation (2 Gy) ... These results indicate that carnosine prevents testicular dysfunction induced by gamma-irradiation via an anti-apoptotic effect; this restoration of proper testicular function ultimately leads to the recovery of spermatogenesis" - See carnosine products at iHerb.

Neat Tech Stuff / "How To's":

WD My Cloud EX4 review: Four-bay NAS wins on features, not speed - PCWorld, 11/12/13 - "The My Cloud EX4 has all the features you want in a four-bay NAS [Network-attached storage] and is priced right, provided that you accept its performance deficiencies" - See Western Digital My Cloud EX4 16TB Reliable, High-Performance Personal Cloud Storage NAS (WDBWWD0160KBK-NESN) at Amazon.

Health Focus (C-reactive protein):

Alternative News:

  • Associations of Dietary Fiber Intake With Long-Term Predicted Cardiovascular Disease Risk and C-Reactive Protein Levels (from the National Health and Nutrition Examination Survey Data [2005-2010]) - Am J Cardiol. 2013 Oct 3 - "A total of 11,113 subjects, aged 20 to 79 years with no history of CVD, from the 2005 to 2010 National Health and Nutrition Examination Survey were included in the present study to examine associations of dietary fiber intake with predicted lifetime CVD risk and C-reactive protein levels. Dietary fiber intake showed a significant gradient association with the likelihood of having a low or an intermediate predicted lifetime CVD risk among young and middle-age adults. In fully adjusted multinomial logistic models, dietary fiber intake was related to a low lifetime CVD risk with an odds ratio of 2.71 (95% confidence interval 2.05 to 3.59) in the young adults and 2.13 (95% confidence interval 1.42 to 3.20) in the middle-age adults and was related to an intermediate lifetime risk of 2.65 (95% confidence interval 1.79 to 3.92) in the young and 1.98 (95% confidence interval 1.32 to 2.98) in the middle-age adults compared with a high lifetime risk. A significant inverse linear association was seen between dietary fiber intake and log-transformed C-reactive protein levels with a regression coefficient +/- standard error of -0.18 +/- 0.04 in the highest quartile of fiber intake compared with the lowest fiber intake" - See Garden of Life, RAW Fiber at Amazon.com.
  • Are Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice? Evidence from a Meta-Analysis - Phytother Res. 2013 Aug 7 - "Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and cardiovascular disease (CVD). In this context, C-reactive protein (CRP) has been identified as a strong predictor and independent risk factor of CVD. Curcuminoids are multifunctional natural product with promising cardioprotective and anti-inflammatory properties ... PubMed/MEDLINE and SCOPUS databases were searched ... Compared with placebo, supplementation with curcuminoids was associated with a significant reduction in circulating CRP levels (weighed mean difference: -6.44 mg/L; 95% CI: -10.77 - -2.11; p = 0.004). This significant effect was maintained in subgroups of trials that used bioavailability-improved preparations of curcuminoids and had supplementation duration of ≥4 weeks, but not in the subgroups without these characteristics ... effect appears to depend on the bioavailability of curcuminoids preparations and also duration of supplementation" - See curcumin products at Amazon.com.
  • Habitual Dietary Isoflavone Intake Is Associated with Decreased C-Reactive Protein Concentrations among Healthy Premenopausal Women - J Nutr. 2013 Apr 24 - "Between 2005 and 2007, 259 healthy, regularly menstruating women were enrolled in the BioCycle Study, and followed for up to 2 menstrual cycles ... Diet was assessed up to 4 times per cycle by using 24-h recalls ... Compared with the lowest quartile of total isoflavone intake, women in the highest quartile had, on average, 27% lower serum CRP concentrations"
  • Lutein supplementation reduces plasma lipid peroxidation and C-reactive protein in healthy nonsmokers - Atherosclerosis. 2013 Jan 29 - "117 eligible subjects were randomly assigned to receive 10 or 20 mg/d of lutein or placebo for 12 weeks ... total antioxidant capacity (TAOC) ... A significant reduction was found in malondialdehyde in the 20 mg lutein group. CRP concentration decreased in a dose-dependent manner for lutein supplementation, and there was a significant between-group difference in CRP between the 20 mg lutein and the placebo group. Serum CRP was directly related to the change in plasma lutein and TAOC for both active treatment groups" - See Jarrow Formulas, CarotenALL at Amazon.com.
  • Association Between use of Specialty Dietary Supplements and C-Reactive Protein Concentrations - Medscape, 12/28/12 - "In summary, this study adds support to laboratory research and to some human studies which suggest that glucosamine, chondroitin, and fish oil may reduce systemic inflammation. In doing so, this study adds biologic plausibility to previous studies which have shown beneficial effects of these supplements on chronic diseases. Given the number of diseases with which inflammation is associated, such as cancer and cardiovascular disease, there is a need to find safe and effective ways to reduce inflammation. Research suggests that these 3 supplements have excellent safety profiles, [88–92] supporting their potential role in disease prevention" - See glucosamine products at Amazon.com, chondroitin sulfate at Amazon.com, Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation - Medscape, 11/27/12 - "Inflammation is now recognized as a factor in cancer and cardiovascular disease as well as many rheumatoid diseases ... the researchers found hs-CRP reductions of 17% (95% confidence interval [CI], 7% - 26%) with glucosamine, 22% (95% CI, 8% - 33%) with chondroitin, and 16% (95% CI, 0.3% - 29%) with fish oil compared with participants who did not take the supplements"
  • One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease - Am J Cardiol. 2012 Apr 19 - "In contrast to placebo and conventional grape supplement, the resveratrol-rich grape supplement significantly decreased high-sensitivity C-reactive protein (-26%, p = 0.03), tumor necrosis factor-α (-19.8%, p = 0.01), plasminogen activator inhibitor type 1 (-16.8%, p = 0.03), and interleukin-6/interleukin-10 ratio (-24%, p = 0.04) and increased anti-inflammatory interleukin-10 (19.8%, p = 0.00). Adiponectin (6.5%, p = 0.07) and soluble intercellular adhesion molecule-1 (-5.7%, p = 0.06) tended to increase and decrease, respectively. No adverse effects were observed in any patient. In conclusion, 1-year consumption of a resveratrol-rich grape supplement improved the inflammatory and fibrinolytic status in patients who were on statins for primary prevention of CVD and at high CVD risk (i.e., with diabetes or hypercholesterolemia plus ≥1 other CV risk factor). Our results show for the first time that a dietary intervention with grape resveratrol could complement the gold standard therapy in the primary prevention of CVD" - See resveratrol products at Amazon.com.
  • Fish Oil Supplement Alters Markers of Inflammatory and Nutritional Status in Colorectal Cancer Patients - Nutr Cancer. 2012 Feb 1 - "The supplemented group (SG) consumed 2 g of fish oil containing 600 milligrams of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) for 9 wk ... Patients supplemented with fish oil (SG) showed a clinically relevant decrease in the C-reactive protein/albumin relation (P = 0.005). Low doses of fish oil supplement can positively modulate the nutritional status and the C-reative protein/albumin ratio" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • A diet rich in slowly digested carbs reduces markers of inflammation in overweight and obese adults - Science Daily, 1/11/12 - "Among overweight and obese adults, a diet rich in slowly digested carbohydrates, such as whole grains, legumes and other high-fiber foods, significantly reduces markers of inflammation associated with chronic disease ... a low-glycemic-load diet reduced a biomarker of inflammation called C-reactive protein by about 22 percent ... C-reactive protein is associated with an increased risk for many cancers as well as cardiovascular disease ... a low-glycemic-load diet modestly increased -- by about 5 percent -- blood levels of a protein hormone called adiponectin ... a low-glycemic-load diet modestly increased -- by about 5 percent -- blood levels of a protein hormone called adiponectin. This hormone plays a key role in protecting against several cancers, including breast cancer, as well as metabolic disorders such as type-2 diabetes, nonalcoholic fatty liver disease and hardening of the arteries"
  • Omega-3 again linked to lower inflammation: Study - Nutra USA, 11/28/11 - "the researchers analyzed blood levels of omega-3 fatty acids, CRP, as well as methylmercury levels in the hair of Finnish men aged between 42 and 60 ... Results showed that as omega-3 levels increased, CRP levels decreased, with “statistically significant inverse associations were also observed with the total serum long-chain n-3 PUFA concentration and with the individual long-chain n-3 PUFAs docosapentaenoic acid and docosahexaenoic acid, but not with eicosapentaenoic acid or with the intermediate-chain n-3 PUFA alpha-linolenic acid” ... the anti-inflammatory properties of omega-3 may be linked to the compounds' unsaturated double bonds" - [Abstract] - See Jarrow Max DHA at Amazon.com.
  • Dietary Omega-3 Fatty Acid, Ratio of Omega-6 to Omega-3 Intake, Inflammation, and Survival in Long-term Hemodialysis Patients - Am J Kidney Dis. 2011 Jun 7 - "each 1-unit higher ratio of omega-6 to omega-3 intake was associated with a 0.55-mg/L increase in serum CRP level (P = 0.03). In the fully adjusted model, death HRs for the first (1.7-<7.6), second (7.6-<9.3), third (9.3-<11.3), and fourth (11.3-17.4) quartiles of dietary omega-6 to omega-3 ratio were 0.39 (95% CI, 0.14-1.18), 0.30 (95% CI, 0.09-0.99), 0.67 (95% CI, 0.25-1.79), and 1.00 (reference), respectively (P for trend = 0.06) ... Higher dietary omega-6 to omega-3 ratio appears to be associated with both worsening inflammation over time and a trend toward higher death risk in hemodialysis patients"
  • Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models - Atherosclerosis. 2011 May 5 - "In cultured human endothelial cells, quercetin protected against H(2)O(2)-induced lipid peroxidation and reduced the cytokine-induced cell-surface expression of VCAM-1 and E-selectin. Quercetin also reduced the transcriptional activity of NFκB in human hepatocytes. In human CRP transgenic mice (quercetin plasma concentration: 12.9+/-1.3μM), quercetin quenched IL1β-induced CRP expression, as did sodium salicylate. In ApoE*3Leiden mice, quercetin (plasma concentration: 19.3+/-8.3μM) significantly attenuated atherosclerosis by 40% (sodium salicylate by 86%). Quercetin did not affect atherogenic plasma lipids or lipoproteins but it significantly lowered the circulating inflammatory risk factors SAA and fibrinogen. Combined histological and microarray analysis of aortas revealed that quercetin affected vascular cell proliferation thereby reducing atherosclerotic lesion growth. Quercetin also reduced the gene expression of specific factors implicated in local vascular inflammation including IL-1R, Ccl8, IKK, and STAT3 ...Quercetin reduces the expression of human CRP and cardiovascular risk factors (SAA, fibrinogen) in mice in vivo. These systemic effects together with local anti-proliferative and anti-inflammatory effects in the aorta may contribute to the attenuation of atherosclerosis" - See quercetin at Amazon.com.
  • Dietary Supplementation of Grape Skin Extract Improves Glycemia and Inflammation in Diet-Induced Obese Mice Fed a Western High Fat Diet - J Agric Food Chem. 2011 Mar 9 - "Dietary antioxidants may provide a cost-effective strategy to promote health in obesity by targeting oxidative stress and inflammation. We recently found that the antioxidant-rich grape skin extract (GSE) also exerts a novel anti-hyperglycemic activity. This study investigated whether 3-month GSE supplementation can improve oxidative stress, inflammation, and hyperglycemia associated with a Western diet-induced obesity. Young diet-induced obese (DIO) mice were randomly divided to three treatment groups (n = 12): a standard diet (S group), a Western high fat diet (W group), and the Western diet plus GSE (2.4 g GSE/kg diet, WGSE group). By week 12, DIO mice in the WGSE group gained significantly more weight (24.6 g) than the W (20.2 g) and S groups (11.2 g); the high fat diet groups gained 80% more weight than the standard diet group. Eight of 12 mice in the W group, compared to only 1 of 12 mice in the WGSE group, had fasting blood glucose levels above 140 mg/dL. Mice in the WGSE group also had 21% lower fasting blood glucose and 17.1% lower C-reactive protein levels than mice in the W group (P < 0.05). However, the GSE supplementation did not affect oxidative stress in diet-induced obesity as determined by plasma oxygen radical absorbance capacity, glutathione peroxidase, and liver lipid peroxidation. Collectively, the results indicated a beneficial role of GSE supplementation for improving glycemic control and inflammation in diet-induced obesity" - See grape seed extract at Amazon.com.
  • Whole Grains Are Associated with Serum Concentrations of High Sensitivity C-Reactive Protein among Premenopausal Women - J Nutr. 2010 Jul 28 - "Whole grain intake was inversely associated with hs-CRP concentrations after adjusting for age, race, BMI, illness, and antiinflammatory drug use. Consumers of between 0 and 1 serving/d of whole grains had, on average, 11.5% lower hs-CRP concentrations (P = 0.02) and consumers of >/=1 serving/d had 12.3% lower hs-CRP concentrations (P = 0.02) compared with nonconsumers"
  • Brushing Teeth May Keep Away Heart Disease - WebMD, 5/27/10 - "people who admitted to brushing their teeth less frequently had a 70% extra risk of heart disease ... People who reported poor oral hygiene also tested positive for bloodstream inflammatory markers such as fibrinogen and C-reactive protein"
  • Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent - Am J Clin Nutr. 2010 Apr 28 - "One group was given an oral dose of 45 mg zinc/d as a gluconate for 6 mo ... These findings suggest that zinc may have a protective effect in atherosclerosis because of its antiinflammatory and antioxidant functions" - See Jarrow Zinc Balance at Amazon.com (zinc decreases copper).
  • Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants--a controlled study - J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6 - "evaluated the effects of Pycnogenol as an adjunct to angiotensin-converting enzyme (ACE)-inhibitor ramipril treatment of hypertensive patients presenting with early signs of renal function problems. One group of 26 patients was medicated with 10 mg ramipril per day only; a second group of 29 patients took Pycnogenol in addition to the ACE inhibitor over a period of 6 months ... In both groups, CRP levels decreased from 2.1 to 1.8 with ramipril and from 2.2 to 1.1 with the ramipril-Pycnogenol combination; the latter reached statistical significance" - See Pycnogenol at Amazon.com.
  • Serum vitamin C concentration and hs-CRP level in middle-aged Japanese men and women - Atherosclerosis. 2009 Aug 7 - "Inverse associations between serum vitamin C concentrations and hs-CRP levels were established for both men and women. Multivariable-adjusted mean values of hs-CRP for the lowest to highest quintiles of vitamin C levels were 0.75, 0.65, 0.61, 0.61 and 0.47mg/L (P for trend <0.001) for men, and 0.56, 0.51, 0.49, 0.41 and 0.41mg/L (P for trend <0.001) for women. The inverse association between vitamin C and hs-CRP was stronger for non-smoking men and women, non-overweight women and postmenopausal women ... Serum vitamin C concentrations were found to be inversely associated with hs-CRP levels in both men and women, primarily among non-smokers, non-overweight women and postmenopausal women"
  • Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity - Acta Cardiol. 2009 Jun;64(3):321-7 - "were given 1 gram of fish oil as a single capsule, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid daily for 6 months. Control subjects did not receive any supplementation over the same period. RESULTS: The study was completed by 47 subjects in the intervention group and 42 subjects in the control group. Treatment with omega 3 supplements was associated with a significant fall in body weight (P < 0.05), systolic blood pressures (P < 0.05), serum low density lipoprotein cholesterol (P < 0.05), and total cholesterol (P < 0.05), triglycerides (P < 0.05), high-sensitivity C-reactive protein (hs-CRP) (P < 0.01), and Hsp27 antibody titres (P < 0.05). No significant changes were observed in the control group. CONCLUSION: It appears that omega 3 improves the cardiovascular risk profile of subjects with metabolic syndrome, having effects on weight, systolic blood pressure, lipid profile and markers of inflammation and autoimmunity" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • An inverse relationship between plasma n-3 fatty acids and C-reactive protein in healthy individuals - Eur J Clin Nutr. 2009 Apr 8 - "The highest hs-CRP tertile (>3.0 mg/l) had significantly lower concentrations of total n-3 fatty acids, EPA and DPA, when compared with the other tertiles (P<0.05). This study provides evidence that in healthy individuals, plasma n-3 fatty acid concentration is inversely related to hs-CRP concentration, a surrogate marker of CVD risk" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Omega-3 DHA boost for heart health in high-risk men: Study - Nutra USA, 3/6/09 - "supplementation with DHA for 45 days resulted in decreased levels of the number of circulating white blood cells (neutrophils) by 11.7 per cent, and these reductions were maintained until the end of the 90-day study (10.5 per cent reduction) ... levels of C-reactive protein (CRP) had decreased by 15 per cent, and IL-6 had decreased by 23 per cent ... Furthermore, levels of the anti-inflammatory matrix metalloproteinase-2 rose by 7 per cent ... In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition" - [Abstract] - See Jarrow Max DHA at Amazon.com.
  • DHA Supplementation Decreases Serum C-Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men - J Nutr. 2009 Jan 21 - "DHA supplementation for 45 and 91 d decreased the number of circulating neutrophils by 11.7 and 10.5%, respectively (P < 0.05). It did not alter the circulating concentrations of other inflammatory markers tested within 45 d, but at 91 d it reduced (P < 0.05) concentrations of C-reactive protein (CRP) by 15%, interleukin-6 by 23%, and granulocyte monocyte-colony stimulating factor by 21% and DHA increased the concentration of antiinflammatory matrix metalloproteinase-2 by 7%. The number of circulating neutrophils was positively associated with the weight percent (wt %) of 20:4(n-6) in RBC lipids, and negatively to the wt % of 20:5(n-3) and 22:6(n-3). Concentrations of CRP and serum amyloid A were positively associated with the sum of SFA and negatively with the wt % of 18:1(n-9) and 17:0 in RBC lipids; CRP was also positively associated with the wt % of 20:2(n-6). The mean size of VLDL particles was positively associated with plasma concentrations of neutrophils and CRP. In conclusion, DHA may lessen the inflammatory response by altering blood lipids and their fatty acid composition" - See Jarrow Max DHA at Amazon.com.
  • Inflamed Gums Linked To Heart Disease - Science Daily, 12/20/08 - "a protein associated with inflammation (called CRP) is elevated in people who are at risk for heart disease. But where's the inflammation coming from? ... infected gums may be one place ... something as simple as taking good care of your teeth and gums can greatly reduce your risk of developing serious diseases"
  • Pine bark extract may help joints and hearts: Study - Nutra USA, 12/11/08 - "The decrease of systemic inflammatory markers, particularly CRP, suggests Pycnogenol properties may be potent enough to arrest the spread of inflammation from osteoarthritic joints to the whole organisms ... subjects received either two daily doses of 50 mg Pycnogenol or placebo for three months ... people receiving the pine bark extract experienced significant reductions in CRP levels from an average of 3.9 mg/L at the start of the study to 1.1 mg/L after three months. This is equivalent to a 71 per cent reduction ... Moreover, a reduction in the blood levels of reactive oxygen species (ROS) of 30 per cent was recorded" - See Pycnogenol at Amazon.com.
  • Vitamin C Lowers Levels Of Inflammation Biomarker Considered Predictor Of Heart Disease - Science Daily, 11/14/08 - "for people with elevated CRP levels, the amount of CRP reduction achieved by taking vitamin C supplements in this study is comparable to that in many other studies of cholesterol-lowering drugs called statins. They noted that several larger statin trials lowered CRP levels by about 0.2 milligrams per liter; in this latest study, vitamin C lowered CRP by 0.25 milligrams per liter" - See vitamin C products at Amazon.com.
  • Vitamin C-lipid metabolites: Uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers - Med Sci Monit. 2008 Nov;14(11):CR547-551 - "ascorbic acid (AA), calcium ascorbate (CaA) ... PureWay-C(R) supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C(R). PureWay-C(R) provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C(R) shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C(R) also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C(R) is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C(R)" - See vitamin C products at Amazon.com.
  • Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals - Atherosclerosis. 2008 Sep 27 - "The combination of n-3 PUFA and plant sterols reduced several inflammatory markers. High sensitivity C-reactive protein (hs-CRP) was reduced by 39% (P=0.009), tumor necrosis factor-alpha (TNF-alpha) by 10% (P=0.02), interleukin-6 (IL-6) by 10.7% (P=0.009), leukotriene B(4) (LTB(4)) by 29.5% (P=0.01) and adiponectin was increased by 29.5% (P=0.05). Overall cardiovascular risk was reduced by 22.6% (P=0.006) in the combination group. CONCLUSION: We have demonstrated, for the first time that dietary intervention with n-3 PUFA and plant sterols reduces systemic inflammation in hyperlipidemic individuals. Furthermore, our results suggest that reducing inflammation provides a potential mechanism by which the combination of n-3 PUFA and plant sterols are cardioprotective" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • What Else May Probiotics Do In Adults? - Science Daily, 5/20/08 - "It was found that probiotics have an anti-inflammatory potential seen as a decrease in serum CRP levels and as a reduction in bacteria-induced production of proinflammatory cytokines in peripheral blood mononuclear cells"
  • Whole Grains Shrink Belly Fat? - Dr. Weil, 3/31/08 - "the whole grains may have helped by stabilizing the dieters' blood sugar, which in turn may have had a beneficial effect on CRP levels"
  • Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in u.s. Adults - J Nutr. 2008 Apr;138(4):753-60 - "Among the flavonoid compounds investigated, quercetin, kaempferol, malvidin, peonidin, daidzein, and genistein had inverse associations with serum CRP concentration"
  • Dietary intake of n-3 polyunsaturated fatty acids is inversely associated with CRP levels, especially among male smokers - Atherosclerosis. 2008 Mar 14 - "Sufficient dietary intake of n-3PUFA may attenuate inflammatory reaction and this effect is more evident among high-risk populations such as male smokers although the small numbers of female ex-smokers and nonsmokers limited statistical power to draw strong conclusions about these groups" - See Mega Twin EPA at Amazon.com.
  • Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study - Am J Clin Nutr. 2008 Feb;87(2):424-30 - "Compared with the lowest tertile of choline intake (<250 mg/d), participants who consumed >310 mg/d had, on average, 22% lower concentrations of C-reactive protein (P < 0.05), 26% lower concentrations of interleukin-6 (P < 0.05), and 6% lower concentrations of tumor necrosis factor-alpha" - See citicholine at Amazon.com.
  • The effects of a whole grain enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome - J Clin Nutr. 2008 Jan;87(1):79-90 - "Both hypocaloric diets were effective means of improving CVD risk factors with moderate weight loss. There were significantly (P < 0.05) greater decreases in CRP and percentage body fat in the abdominal region in participants consuming whole grains than in those consuming refined grains"
  • More support for whole grains for healthy hearts - Nutra USA< 1/7/08 - "25 women and 25 men (average age 46, average BMI 35.8 kg per sq. m) were assigned to consume a reduced calorie diet (reduced by 500 kcal/d) with half of the subjects then randomly assigned to obtain all of their grain servings from whole grains or to avoid wholegrain foods for 12 weeks ... CRP levels fell by 38 per cent in the whole-grain"
  • The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome - Int J Clin Pract. 2007 Nov;61(11):1942-8 - "After 52 weeks of treatment, there was a change of carotid IMT of +0.009 +/- 0.003 mm in the placebo group and -0.005 +/- 0.002 mm in the niacin group (p = 0.021 between groups). Endothelial function improved by 22% in the group treated with niacin (p < 0.001), whereas no significant changes were seen in the placebo group. High sensitivity C-reactive protein decreased by 20% in the group treated with niacin for 52 weeks (p = 0.013). Niacin increased HDL-C (p < 0.001) and decreased low-density lipoprotein cholesterol and triglycerides (p < 0.001) significantly, and there were no adverse effects on fasting glucose levels after 52 weeks of treatment" - See niacin at Amazon.com or niacin at Amazon.com.
  • Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients - Curr Med Res Opin. 2007 Jun 29 - "Folic acid and vitamin B complex co-administration effectively lowers tHcy and hs-CRP levels and increases albumin levels in stable hemodialysis subjects, underscoring their potential benefit to attenuate the state of inflammation and possibly improve the nutritional status in patients on hemodialysis"
  • Effect of a High-Fiber Diet vs a Fiber-Supplemented Diet on C-Reactive Protein Level - Arch Intern Med. 2007 Mar 12;167(5):502-6 - "Overall, the mean C-reactive protein (CRP) level changed from 4.4 to 3.8 mg/L (-13.7%; P = .046) in the high-fiber DASH diet group and to 3.6 mg/L (-18.1%) in the fiber-supplemented diet group ... fiber intake of about 30 g/d) from a diet naturally rich in fiber or from a supplement can reduce levels of CRP"
  • High-Fiber Diets, Fiber Supplements Reduce CRP Levels - Medscape, 3/14/07 - "The participants were then randomized to either the DASH (Dietary Approaches to Stop Hypertension), high-fiber diet (mean intake, nearly 28 g of fiber per day), or to a fiber supplement (psyllium) on top of their regular diet (mean intake, totaling 27 g/day). After 3 weeks on one diet, participants crossed over to the other fiber diet ... Overall, the mean CRP level changed from 4.4 to 3.8 mg/L (-13.7%; P = .046) in the high-fiber DASH diet group and to 3.6 mg/L (-18.1%) in the fiber-supplemented diet group (P = .02)"
  • Dietary long-chain n-3 fatty acids of marine origin and serum C-reactive protein concentrations are associated in a population with a diet rich in marine products - Am J Clin Nutr. 2006 Jul;84(1):223-9 - "Greater intake of n-3 PUFAs derived from marine products, as measured with a self-administered questionnaire, was independently related to a lower prevalence of high CRP concentrations in this older Japanese population with a diet rich in marine products. Our findings suggest that even very high intakes of n-3 PUFAs may lower serum CRP concentrations"
  • Fiber Good, and Not Just for Your Gut - WebMD, 4/13/06 - "Compared with those who ate the least fiber, those who ate the most were 63% less likely to have high levels of C-reactive protein (CRP)"
  • Vitamin C could reduce inflammation - Nutra USA, 3/8/06 - "High blood levels of vitamin C were associated with a 45 per cent reduced risk of inflammation (with respect to CRP levels)"
  • Fish Help the Heart by Fighting Inflammation - WebMD, 7/5/05 - "compared with those who said they didn't eat fish, those who ate at least 10.5 ounces of fish per week had 33% lower C-reactive protein and 33% lower tumor necrosis factor-alpha (another indicator of inflammation) levels as well as much lower levels of other signs of inflammation"
  • Total antioxidant capacity of the diet is inversely and independently related to plasma concentration of high-sensitivity C-reactive protein in adult Italian subjects - Br J Nutr. 2005 May;93(5):619-25 - "dietary TAC is inversely and independently correlated with plasma concentrations of hs-CRP and this could be one of the mechanisms explaining the protective effects against CVD of antioxidant-rich foods such as fruits, whole cereals and red wine"
  • Study links good carbs to healthier hearts - MSNBC, 5/2/05 - "the CRP levels of women whose diets consisted primarily of refined grains were 10 percent higher than women who consumed a lot of good carbs such as fiber-rich whole grains, fruits and vegetables"
  • Exercise May Reduce Metabolic Syndrome Risks - WebMD, 11/15/04 - "physical fitness was associated with lower levels of an inflammation marker associated with heart disease, known as C-reactive protein"
  • New Research: What is Your Optimal TSH Level? - About.com, 9/30/04 - "normalizing the TSH with a target TSH level of less than 2 mIU/mL is advisable to lower CRP levels and homocysteine levels, and possibly the cholesterol levels"
  • Red Wine Beats Gin for Heart Health - WebMD, 8/13/04 - "those who drunk red wine also had lower levels of C-reactive protein and two other inflammatory markers"
  • Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk - Am J Clin Nutr. 2004 Jun;79(6):992-8 - "Low concentrations of pyridoxal-5'-phosphate (PLP), the active metabolite of vitamin B-6, are associated with high C-reactive protein (CRP) concentrations"
  • Vitamin C supplement to beat diabetes and heart disease - Nutra USA, 4/14/04 - "Researchers at the University of California say that participants who took about 500 milligrams of vitamin C supplements per day saw a 24 per cent drop in plasma C-reactive protein (CRP) levels after two months" - See iHerb vitamin C products.
  • Reduction of C-reactive protein levels through use of a multivitamin - Am J Med. 2003 Dec 15;115(9):702-7 - "multivitamin use was associated with lower C-reactive protein levels"
  • Mediterranean Diet Lowers C-reactive Protein Levels - Medscape, 11/11/03 - "For each 10-point increase in diet score, there was a corresponding 0.22 mg/dL reduction in C-reactive protein levels, a 0.21 pg/ml reduction in interleukin-6, a 12.5 mg/dL decrease in fibrinogen, and a 0.87 mmol/L decrease in homocysteine levels (P < .05), he said. Also, white blood cell count decreased significantly"
  • Dietary Changes Can Reduce Cholesterol and C-Reactive Protein as Much as Medication - New Hope Natural Media, 9/18/03 - "One group was treated with a statin medication (20 mg of lovastatin per day) and another received placebo. A third group ate a modified daily diet that included an additional 2 grams of plant sterols provided in a margarine, 20 grams of insoluble fiber from psyllium, oats and barley, 43 grams of soy protein from soy milk and soy meat-substitutes, and 1 ounce of whole almonds. At the end of the study, total cholesterol levels had decreased 6% in the placebo group, 23% in the statin group and 22% in the modified-diet group. Levels of LDL-cholesterol dropped 8% in the placebo group, 31% in the statin group and 29% in the modified-diet group. CRP levels decreased 10% in the placebo group, 33% in the statin group and 28% in the modified-diet group"
  • Inflammation Syndrome a Red-Hot Topic - Natural Foods Merchandiser, 9/03 - "What are some of the key anti-inflammatory supplements? ... At the top of the list are omega-3 fish oils, gamma-linolenic acid (GLA, an omega-6 fat that behaves more like an omega-3) and vitamin E. Several studies have shown that natural vitamin E supplements lower CRP levels by 30 percent to 50 percent"
  • Weight Loss Eases Harmful Inflammation - WebMD, 2/4/02 - "They measured levels of a blood chemical called "C-reactive protein," or CRP. This chemical goes up when inflammation in the body rises. Then, 25 of the women were put on a weight-loss program ... On average, CRP levels fell by 32% after a weight loss of about 33 pounds over 14 months"
  • Inflammation and Heart Disease - Life Extension Magazine, 1/01
  • Diet and Exercise Alone Shown to Lower C-Reactive Protein - Doctor's Guide, 11/14/01 - "Hs-CRP, a marker of low level inflammation, has been found to be a strong predictor of myocardial infarction and stroke in men and women, as well as subsequent clinical events in patients following major cardiac events ... a structured program involving a low-fat, Mediterranean diet and a supervised, three-times weekly exercise program for three months ... Values of hs-CRP dropped 31 percent after the three months ... body fat was reduced by 5 percent ... exercise capacity improved 36 percent"
  • A Prescription for Alarm - Nutrition Science News, 9/01 - "Taking natural vitamin E supplements to reduce levels of C-reactive protein, an inflammatory compound that increases the risk of heart disease by 4.5 times.  Heart disease is increasingly viewed as a disease of blood-vessel inflammation"
  • Enzymes Can Hasten Pain Relief - Nutrition Science News, 2/01 - "Enzymes work not by stopping or blocking inflammation, but by supporting and quickening the process . . . By the third day after the operation, levels of C-reactive protein—a measure of inflammation - were threefold higher in the control group"

Other News:


  QualityCounts.com Anti-aging Newsletter
Newsletter Sign-up
Add to Netvibes

Netvibes basic (free)

Join QualityCounts.com on Facebook