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Recent Longevity News for the seven days ending
8/21/13. You should consult your doctor if you are taking any medications.
One Iron Pill a Day Keeps
Fatigue Away? - Medscape, 8/20/13 - "evidence is
growing that fatigue in non-anaemic, menstruating
women with low ferritin can be influenced positively by
iron supplementation ... the authors randomised 198 menstruating women with
considerable fatigue (>6 on a 1–10 Likert scale), ferritin levels less than 50
μg/l and haemoglobin ≥12 g/dl to have 80 mg oral ferrous sulphate or placebo for
12 weeks ...A total of 47.7% of the patients in the iron group compared with
28.8% in the placebo group reported decreased fatigue.
Quality of life, depression and anxiety were not affected ... As in all oral
iron trials, darkening of stool leads to possible differentiation of verum from
placebo, therefore, blinding was not totally assured; a substantial limitation
considering the huge placebo effect on fatigue reported in studies using
Plastics Chemicals May Boost Kids' Risk for Obesity, Diabetes - WebMD,
8/19/13 - "One study links phthalates to increased
insulin resistance in children, while another associates
bisphenol A (BPA) with high body-mass index (BMI) and expanding waistlines
... The study reviewed data on about 3,300 kids aged 6 to 18, and found that
children with high BPA levels tend to have excessive amounts of body fat and
unusually expanded waistlines ... Trasande recommends that parents avoid using
plastic containers with the recycling numbers 3, 6 or 7, in which phthalates or
BPA are used ... I also advise families not to microwave plastics, hand wash
plastic containers, and throw away plastic containers where there is etching or
other damage to them"
and tea may contribute to a healthy liver - Science Daily, 8/16/13 -
intake may reduce fatty liver in people with
non-alcoholic fatty liver disease (NAFLD) ... caffeine stimulates the
metabolization of lipids stored in liver cells and decreased the fatty liver of
mice that were fed a high-fat diet. These findings suggest that consuming the
equivalent caffeine intake of four cups of coffee or tea a day may be beneficial
in preventing and protecting against the progression of NAFLD in humans"
artichokes contain flavonoids that kill human pancreatic cancer cells -
Science Daily, 8/15/13 - "Apigenin alone induced cell
death in two aggressive human pancreatic
cancer cell lines. But we received the best results when we pre-treated
cancer cells with apigenin for 24 hours, then applied the
chemotherapeutic drug gemcitabine for 36
hours ... our study indicated that taking antioxidant supplements on the same
day as chemotherapeutic drugs may negate the effect of those drugs ... One of
the ways that chemotherapeutic drugs kill cells is based on their pro-oxidant
activity, meaning that flavonoids and
chemotherapeutic drugs may compete with each other when they're introduced at
the same time ... In one of the cancer cell lines, the percentage of cells
undergoing apoptosis went from 8.4 percent in cells that had not been treated
with the flavonoid to 43.8 percent in cells that had been treated with a
50-micromolar dose. In this case, no chemotherapy drug had been added" -
Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
Healthy Eating Might Ward Off Pancreatic Cancer - WebMD, 8/15/13 -
"it is important to focus on eating an overall healthful
diet and not on a single nutrient, supplement or specific food in hopes of
preventing cancer or any other disease ... The effect of eating a variety of
fruits, vegetables and whole grains, and limiting sugar, unhealthy fats and
alcohol, is greater than the sum of its parts when it comes to lowering the risk
of chronic disease ... Arem's group assessed the eating habits of more than
500,000 people, aged 50 to 71, who took part in the U.S. National Institutes of
Health/AARP Diet and Health Study ... those who followed the diet lowered their
chances of pancreatic cancer by 15
percent, compared with those who didn't"
than 28 cups of coffee a week may endanger health in under 55s - Science
Daily, 8/15/13 - "A study of more than 40,000
individuals found a statistically significant 21% increased
mortality in those drinking more than 28 cups
of coffee a week and death from all causes, with
a greater than 50% increased mortality risk in both men and women younger than
55 years of age ... No adverse effects were found in heavy coffee drinkers aged
over 55 ... Between 1979 and 1998, nearly 45,000 individuals aged between 20 and
87 years old participated and returned a medical history questionnaire assessing
lifestyle habits (including coffee consumption) and personal and family medical
history ... Those who consumed higher amounts of coffee (both men and women)
were more likely to smoke and had lower levels of cardiorespiratory fitness"
- Note: It doesn't say whether the results were adjusted for the smoking
so maybe that was the real cause.
18-Year Study Finds Drug Cut Prostate Cancer Risk - WebMD, 8/14/13 -
"an 18-year follow-up on the Prostate Cancer Prevention
Trial, which took place in the late 1990s. Back then, the trial found that
finasteride could reduce
overall risk of prostate cancer by 25 percent
-- but that it increased by 27 percent the risk of high-grade prostate cancer in
those men who did wind up with the disease ... the drug actually worked better
than earlier reported in reducing prostate cancer risk ... You take Proscar for
six months to a year and it halves the size of your prostate, but the cancer
inside your prostate does not shrink .... If I'm performing a biopsy on a
smaller prostate, I'm more likely to hit that cancer than if I am sticking into
a larger prostate. This drug wasn't causing more prostate cancer. It's causing
more prostate cancer to be diagnosed" - [Abstract]
bacteria found in mouth may cause colorectal cancer - Science Daily, 8/14/13
- "gut microbes known as fusobacteria, which are found
in the mouth, stimulate bad immune responses and turn on cancer growth genes to
generate colorectal tumors ... fusobacteria are
prevalent in human adenomas -- benign tumors that can become malignant over time
-- suggesting that these microbes contribute to early stages of tumor formation.
In a mouse model of colorectal cancer, these bacteria accelerated the formation
of tumors by attracting immune cells called myeloid cells, which invade tumors
and stimulate inflammatory responses that can cause cancer" - [WebMD]
- Note: Here's a cut and paste from my dental page on how to combat
Periogard - Needs a prescription but is usually available at you dentist
for around $10.
Sunstar Butler Proxabrush GUM Eez-Lok Handle
Sunstar Butler GUM Proxabrush Refill Ultra Wide (614) - use this wide
brush for the back teeth
Butler 612 Soft Picks or
Butler Ultra-Fine - use these narrower brushes for the front teeth
- Put a few tablespoons of Periogard into a small glass. Soak the brush
in it and run it between your teeth.
DHA-Enriched Formula in Infancy Linked to Positive Cognitive Outcomes in
Childhood - Science Daily, 8/13/13 - "infants
who were fed formula enriched with long-chain
polyunsaturated fatty acids (LCPUFA) from birth to 12 months scored
significantly better than a control group on several measures of intelligence
conducted between the ages of three to six years ... the children showed
accelerated development on detailed tasks involving pattern discrimination,
rule-learning and inhibition between the ages of three to five years of age as
well as better performance on two widely-used standardized tests of
intelligence: the Peabody Picture Vocabulary Test at age five and the Weschler
Primary Preschool Scales of Intelligence at age six" - See
Jarrow Max DHA at Amazon.com.
Abstracts from this week's
Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
meta-analysis of randomized trials of telmisartan versus losartan for reduction
of ambulatory blood pressure - Hypertens Res. 2013 Aug 15 -
"MEDLINE, EMBASE and the Cochrane Central Register of
Controlled Trials were searched through July 2012 ...
telmisartan therapy appears to
reduce ambulatory BP more than losartan therapy in patients with hypertension"
- See my telmisartan as a
first line treatment page.
products and the risk of type 2 diabetes: a systematic review and dose-response
meta-analysis of cohort studies - Am J Clin Nutr. 2013 Aug 14 -
"searched the PubMed database for prospective cohort and
nested case-control studies of dairy product intake
and risk of type 2 diabetes up to 5 June 2013
... the summary RRs (95% CIs) were 0.93 (0.87, 0.99; I2 = 33%) per 400 g total
dairy products/d (n = 12), 0.98 (0.94, 1.03; I2 = 8%) per 200 g high-fat dairy
products/d (n = 9), 0.91 (0.86, 0.96; I2 = 40%) per 200 g low-fat dairy
products/d (n = 9), 0.87 (0.72, 1.04; I2 = 94%) per 200 g milk/d (n = 7), 0.92
(0.86, 0.99; I2 = 0%) per 50 g cheese/d (n = 8), and 0.78 (0.60, 1.02; I2 = 70%)
per 200 g yogurt/d (n = 7) ... This meta-analysis suggests that there is a
significant inverse association between intakes of dairy products, low-fat dairy
products, and cheese and risk of type 2 diabetes" - Note: Yogurt
was the most protective at .78 per 200 grams. 200 grams is 7 ounces.
See my yogurt recipe on my yogurt page.
and Prostate-Specific Antigen in the National Health and Nutrition Examination
Survey - J Natl Cancer Inst. 2013 Aug 13 -
"Shiftwork has been implicated as a risk factor for
prostate cancer. Results from prior studies have been mixed but generally
support an association between circadian disruption and prostate cancer ... We
combined three NHANES surveys (2005-2010) to obtain current work schedule among
employed men aged 40 to 65 years with no prior history of cancer (except
nonmelanoma skin cancer) ... We found a statistically significant, age-adjusted
association between current shiftwork and elevated PSA at the 4.0ng/mL or
greater level (odds ratio = 2.48, 95% confidence interval [CI] = 1.08 to 5.70; P
- Note: Many believe that the increased risk of breast cancer in shift
workers is attributed to melatonin.
Maybe it's the same for prostate cancer.
Coadministration of Erlotinib and Curcumin Augmentatively Reduces Cell Viability
in Lung Cancer Cells - Phytother Res. 2013 Aug 13 -
"Resistance to erlotinib in
cases includes T790M mutant epidermal growth factor receptor and c-Met gene
amplification, but other unknown mechanisms account for about 30% of the
resistance. Activation of the nuclear factor kappa B (NFkappaB)-related pathways
in association with the reduction in ikappaB level may be one of such potential
mechanisms. It is known that curcumin inhibits
the inducible activation of NFkappaB at least in part by sustaining ikappaB
expression level ... We found that erlotinib and curcumin augmentatively reduced
cell viability ... Furthermore, coadministration of erlotinib and/or curcumin
augmentatively attenuated the growth of PC9 tumors in mice" - See
curcumin products at Amazon.com.
apigenin modified gene expression associated with inflammation and cancer and
induced apoptosis in human pancreatic cancer cells through inhibition of
GSK-3β/NF-κB signaling cascade - Mol Nutr Food Res. 2013 Aug 14 -
"Flavonoids have a
protective role in pancreatic cancer
tumorigenesis" - See
Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
D status is associated with reduced muscle mass and impaired physical
performance in frail elderly people - Eur J Clin Nutr. 2013 Aug 14 -
"Serum 25-hydroxyvitamin D
(25(OH)D) status has been associated with muscle mass, strength and physical
performance in healthy elderly people. Yet, in
pre-frail and frail elderly people this association has not been studied ...
study included 127 pre-frail and frail elderly people in The Netherlands ...
appendicular lean mass (ALM) ... In this frail elderly population, 25(OH)D
status is low and suggests a modest association with reduced ALM and impaired
physical performance. In addition, vitamin D intake tended to be associated with
impaired physical performance" - See
vitamin D at Amazon.com.
Human Breast Cell Carcinogenesis by Triclocarban and Intervention by Curcumin
- Biochem Biophys Res Commun. 2013 Aug 10 - "More than
85% of breast cancers are sporadic and
attributable to long-term exposure to environmental
carcinogens and co-carcinogens. To identify co-carcinogens with abilities to
induce cellular pre-malignancy, we studied the activity of triclocarban (TCC),
an antimicrobial agent commonly used in household and personal care products.
Here, we demonstrated, for the first time, that chronic exposure to TCC at
physiologically-achievable nanomolar concentrations resulted in progressive
carcinogenesis of human breast cells from non-cancerous to pre-malignant ...
Using TCC-induced transient and constitutive endpoints as targets will likely
help identify non-cytotoxic preventive agents, such as
curcumin, effective in suppressing TCC-induced
cellular pre-malignancy" - See
curcumin products at Amazon.com.
improves obesity-induced inflammatory responses and modulates the unbalanced
phenotype of adipose tissue macrophages - Mol Nutr Food Res. 2013 Aug 12 -
"It is increasingly accepted that
chronic inflammation is a feature of
obesity. Obesity-induced inflammation triggers enhanced recruitment of
macrophages into the adipose tissue. Depending on their phenotype, macrophages
can be designated either as pro-inflammatory M1 macrophages or anti-inflammatory
M2 macrophages ... Our findings indicate that
taurine treatment attenuates the infiltration of adipose tissue by
macrophages and modulates the phenotype of macrophages, which suggest that
taurine is a valuable food constituent with a potential to attenuate chronic
inflammation in adipose tissue and improve obesity-related
insulin resistance" - See
taurine at Amazon.com.
intake is an independent predictor of endothelial function in patients with
ischemic stroke - J Nutr Health Aging. 2013;17(7):600-4 -
"ischemic stroke (ISS)
... 125 Chinese patients with prior ISS due to athero-thrombotic disease were
recruited from the outpatient clinics during July 2005 to December 2006 ...
validated food frequency questionnaire ... Daily
garlic intake is an independent predictor of endothelial function in
patients with ISS and may play a role in the secondary prevention of
atherosclerotic events" - See
garlic supplements at Amazon.com.
Neat Tech Stuff / "How To's":
AirCast for Android sends local or cloud videos to Chromecast, test it out
now - engadget.com, 8/18/13 - Seems like it would allow you to view on
your TV screen any form of media that's on you hard drive.
AirCast app closes the gap between Chromecast and AirPlay - The
Verge, 8/19/13 - "It seems likely that Google
would try to block apps like AirCast, which could upset its
relationships with content providers by make it easier for users to play
pirated movies on their TVs ... Still, the enthusiastic response to
Dutta's post indicates that the market for apps like AirCast will be
strong. Chromecast's inability to support local video streaming is
currently the glaring difference between it and Apple's AirPlay
standard. The existence of AirCast suggests that gap is about to be
closed, whether Google is ready for it or not"
Google Chromecast HDMI Streaming Media Player
- Amazon started taking orders again. It's saves you $4 shipping over
buying it from Google.
Health Focus (HDL
the Metabolic Syndrome: Results of a Randomized Clinical Trial - J Clin
Endocrinol Metab. 2013 Jul 3 - "Patients included 120
postmenopausal women with MetS ... postmenopausal women with MetS were randomly
assigned to receive placebo (n = 60) or 54 mg genistein daily (n = 60) for 1
year ... At 1 year in genistein recipients, fasting glucose, fasting insulin,
and HOMA-IR (mean from 4.5 to 2.7; P < .001) decreased and were unchanged in
placebo recipients. Genistein statistically increased HDL-C (mean from 46.4 to
56.8 mg/dL) and adiponectin and decreased total cholesterol, LDL-C (mean from
108.8 to 78.7 mg/dL), triglycerides, visfatin, and homocysteine (mean from 14.3
to 11.7) blood levels. Systolic and diastolic blood pressure was also reduced in
genistein recipients. Genistein recipients neither experienced more side adverse
effects than placebo nor discontinued the study" - See
genistein at Amazon.com.
olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1
anti-inflammatory activities - Br J Nutr. 2013 Mar 19:1-13 -
"EVOO consumption increased the anti-inflammatory effect
of HDL and reduced the age-related decrease in anti-atherogenic activity"
olive leaf extract at Amazon.com.
the consumption of a new symbiotic shake on glycemia and cholesterol levels in
elderly people with type 2 diabetes mellitus - Lipids Health Dis. 2012 Feb
22;11:29 - "A randomized, double-blind,
placebo-controlled study was conducted on twenty volunteers (ten for placebo
group and ten for symbiotic group), aged 50 to 60 years ... Over a total test
period of 30 days, 10 individuals (the symbiotic group) consumed a daily dose of
200 mL of a symbiotic shake containing 10(8) UFC/mL Lactobacillus acidophilus,
10(8) UFC/mL Bifidobacterium bifidum and 2 g oligofructose, while 10 other
volunteers (the placebo group) drank daily the same amount of a shake that did
not contain any symbiotic bacteria ... The results of the symbiotic group showed
a non-significant reduction (P > 0.05) in total cholesterol and triglycerides, a
significant increase (P < 0.05) in HDL cholesterol and a significant reduction
(P < 0.05) in fasting glycemia. No significant changes were observed in the
effects of artichoke leaf extract supplementation on increasing HDL-cholesterol
in subjects with primary mild hypercholesterolaemia: a double-blind, randomized,
placebo-controlled trial - Int J Food Sci Nutr. 2012 Jun 29 -
"The aim of this study was to evaluate the effects of
artichoke leaf extract (ALE) supplementation (250 mg, 2 b.i.d.) on the lipid
pattern. A randomized, double-blind, placebo-controlled clinical trial was
performed on 92 overweight subjects with primary mild hypercholesterolaemia for
8 weeks. Forty-six subjects were randomized to supplementation (age: 54.2 +/-
6.6 years, body mass index (BMI): 25.8 +/- 3.9 kg/m(2), male/female: 20/26) and
46 subjects to placebo (age: 53.8 +/- 9.0 years, BMI: 24.8 +/- 1.6 kg/m(2),
male/female: 21/25). Verum supplementation was associated with a significant
increase in mean high-density lipoprotein (HDL)-cholesterol (p < 0.001) and in
mean change in HDL-cholesterol (HDL-C) (p = 0.004). A significantly decreased
difference was also found for the mean change in total cholesterol (p = 0.033),
low-density lipoprotein (LDL)-cholesterol (p < 0.001), total cholesterol/HDL
ratio (p < 0.001) and LDL/HDL ratio (p < 0.001), when verum and placebo
treatment were compared. These results indicate that ALE could play a relevant
role in the management of mild hypercholesterolaemia, favouring in particular
the increase in HDL-C, besides decreasing total cholesterol and LDL-cholesterol"
- See artichoke products
Pomegranate Juice Lowers
Cardiovascular Risk Factors - Medscape, 11/12/11 -
"HDL rose significantly (P = .005) in the juice group" - See
pomegranate at Amazon.com.
soy and milk protein supplementation on serum lipid levels: a randomized
controlled trial - Eur J Clin Nutr. 2011 Sep 28 -
"Previous clinical trials have documented that soy protein reduces low-density
lipoprotein cholesterol and increases high-density lipoprotein (HDL) cholesterol
compared with milk protein ... Compared with carbohydrate, soy protein
supplementation was significantly associated with a net change (95% confidence
interval (CI)) in total cholesterol and total/HDL cholesterol ratio of
-3.97 mg/dl (-7.63 to -0.31, P=0.03) and -0.12 (-0.23 to -0.01, P=0.03),
respectively. Compared with milk protein, soy protein supplementation was
significantly associated with a net change (95% CI) in HDL and total/HDL
cholesterol ratio of 1.54 mg/dl (0.63 to 2.44, P=0.0009) and -0.14 (-0.22 to
-0.05, P=0.001), respectively. Compared with carbohydrate, milk protein
supplementation was significantly associated with a net change (95% CI) in HDL
of -1.13 mg/dl (-2.05 to -0.22, P=0.02). Conclusions: This randomized controlled
trial indicates that soy protein, but not milk protein, supplementation improves
the lipid profile among healthy individuals"
Diet on High-Density Lipoprotein Cholesterol - Curr Atheroscler Rep. 2011
Sep 8 - "Multiple dietary factors have been shown to
increase high-density lipoprotein cholesterol (HDL-C) concentrations, and HDL-C
has been inversely associated with coronary heart disease (CHD) risk.
Replacement of dietary carbohydrate with polyunsaturated, monounsaturated and
saturated fat has been associated with progressively greater increases in HDL-C
(7-12%) in addition to other lipid changes. Added sugars, but not high glycemic
carbohydrates, have been associated with decreased HDL-C. Alcohol consumption
has been associated with increased HDL-C (9.2%) independent of changes in other
measured lipids. Modest effects on HDL-C (~4-5%) among other lipid and non-lipid
CHD risk factors have also been observed with weight loss by dieting, omega-3
fatty acids, and a Mediterranean diet pattern. The CHD benefit of increasing
HDL-C is unclear given the inconsistent evidence from HDL-raising pharmacologic
trials. Furthermore, pleiotropic effects of diet preclude attribution of CHD
benefit specifically to HDL-C"
Vitamin E tocotrienols show cholesterol benefits for healthy adults: Study -
Nutra USA, 6/29/11 - "Daily supplements of a palm
oil-based tocotrienol-rich product increased the ratio of HDL cholesterol to
total cholesterol – reported to be the most specific lipid risk factor for
cardiovascular disease (CVD) – by 14 percent in people over 50, compared to a
decrease of about 5 percent in the placebo group ... HDL cholesterol increases
of the magnitude observed in this study have been associated with a 22.5 percent
reduced risk of cardiovascular events" - [Abstract]
Jarrow FamilE (contains all eight members of the vitamin E family, includes
Tocomin) at Amazon.com.
25-hydroxyvitamin D levels and the metabolic syndrome in older persons. A
population-based study - Clin Endocrinol (Oxf). 2011 May 20 -
"Among the participants, the prevalence of the metabolic
syndrome was 37.0%. The mean 25OHD level was 53.3 nmol/l. 47.8% had 25OHD levels
below 50 nmol/l. There was a significantly increased risk for the metabolic
syndrome in the subjects with serum 25OHD levels below 50 nmol/l, compared to
subjects with levels over 50 nmol/l [odds ratio (OR)=1.54; 95% confidence
interval (CI) 1.23-1.94]. After adjustment for confounders, age, sex, season,
years of education, alcohol use, total activity, smoking and PTH the OR was 1.29
(95% CI 1.00-1.68). The association between vitamin D deficiency and the
metabolic syndrome was mainly determined by the components low HDL and (high)
waist circumference" - See
vitamin D at Amazon.com.
Identification of a mechanism for increased cardiovascular risk among
individuals with low vitamin D concentrations - Menopause. 2011 May 17 -
"Plasma vitamin D3 concentration was positively
associated with high-density lipoprotein cholesterol (HDL-C; P = 0.003). Monkeys
in the high vitamin D3 group had a significantly greater plasma HDL-C
concentration (57.9 mg/dL) than did those in the low vitamin D3 group (47.1
mg/dL; P = 0.001). Although the difference was not significant (P = 0.120), the
monkeys in the high vitamin D3 group had a decreased total plasma
cholesterol-to-HDL-C ratio compared with those in the low vitamin D3 group (5.4
and 6.2, respectively), potentially putting them at lower risk of
atherosclerosis development" - See
vitamin D at Amazon.com.
results in reduced monocyte adhesion in patients with type 2 diabetes mellitus
- Atherosclerosis. 2010 Dec 25 - "Patients with type 2
diabetes have increased expression of cell adhesion molecules (CAMs). CAMs and
monocyte adhesion mediate essential processes in atherogenesis ... Niacin 1500mg
daily raised HDL-cholesterol from 0.8mmol/l (95% CI: 0.7-0.9) to 0.9mmol/l (95%
CI: 0.8-1.1), p=0.10, and significantly reduced PECAM-1 by 24.9% (95% CI:
10.9-39.0; p<0.05), increased adiponectin by 30.5% (95% CI: 14.1-47.0; p<0.05),
with monocyte adhesion reduced by 9.2% (95%CI: 0.7-17.7; p<0.05) in endothelial
cells treated in basal conditions, and 7.8% (95% CI: 3.1-12.5; p<0.05) after
TNF-α stimulation ... Monocytes isolated from patients on niacin had reduced
adhesion to endothelial cells. Our findings suggest niacin has broad range of
effects apart from lipid-modification, and these could be important in
cardiovascular risk reduction" - See
niacin at Amazon.com.
decreases low-density lipoprotein cholesterol in hypercholesterolemic subjects
and improves lipid transfer to high-density lipoprotein in normal and
hypercholesterolemic subjects - Nutr Res. 2010 Oct;30(10):689-94 -
"normolipidemic (NC) and hypercholesterolemic (HCH)
subjects ... consumed 750 mL/day OJ concentrate (1:6 OJ/water) for 60 days ...
Orange juice consumption decreased low-density lipoprotein cholesterol (160 +/-
17 to 141 +/- 26 mg/dL, P < .01) in the HCH group but not in the NC group.
HDL-cholesterol and triglycerides remained unchanged in both groups.
Free-cholesterol transfer to HDL increased (HCH: 4.4 +/- 2 to 5.6 +/- 1%, NC:
3.2 +/- 2 to 6.2 +/- 1%, P< .05) whereas triglyceride (HCH 4.9 +/- 1 to 3.1 +/-
1%, NC 4.4 +/- 1 to 3.4 +/- 1%, P< .05) and phospholipid (HCH 21.6 +/- 2 to 18.6
+/- 3%, NC 20.2 +/- 2 to 18.4 +/- 2%, P < .05) transfers decreased in both
groups. Cholesteryl-ester transfer decreased only in HCH (3.6 +/- 1 to 3.1 +/-
1%, P < .05), but not in NC"
- Note: 750 ml is .79 quarts. Seem like it might be a problem with weight
polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients
- Diabet Med. 2010 Nov;27(11):1318-21 - "Subjects were
randomized to 45 g chocolate with or without a high polyphenol content for 8
weeks and then crossed over after a 4-week washout period ... HDL cholesterol
increased significantly with high polyphenol chocolate (1.16 +/- 0.08 vs. 1.26
+/- 0.08 mmol/l, P = 0.05) with a decrease in the total cholesterol: HDL ratio
(4.4 +/- 0.4 vs. 4.1 +/- 0.4 mmol/l, P = 0.04). No changes were seen with the
low polyphenol chocolate in any parameters. Over the course of 16 weeks of daily
chocolate consumption neither weight nor glycaemic control altered from
baseline" - The
Lindt - Excellence 90% Cocoa Bar are 3.5 ounces or 99 grams or about 90
grams of chocolate. So 45 grams would be half a bar per day.
myo-inositol supplementation in postmenopausal women with metabolic syndrome: a
perspective, randomized, placebo-controlled study - Menopause. 2010 Aug 31 -
"Myo-inositol plus diet improved systolic and diastolic
blood pressure, HOMA index, cholesterol, and triglyceride serum levels with
highly significant differences, compared with the groups treated only with diet
and placebo. In the group treated with myo-inositol, a decrease in diastolic
blood pressure (-11%), HOMA index (-75%), and serum triglycerides (-20%) and an
improvement in high-density lipoprotein cholesterol (22%) were shown ...
CONCLUSIONS: Supplementation with myo-inositol may be considered a reliable
option in the treatment of metabolic syndrome in postmenopausal women" -
http://en.wikipedia.org/wiki/Inositol which claim myo-inositol and inositol
are the same. See
inositol products at iHerb.
Astaxanthin’s heart benefits get human data support - Nutra USA, 8/9/10 -
"Daily supplements of the carotenoid astaxanthin may
improve HDL ‘good’ cholesterol levels in people with mildly abnormal blood lipid
levels ... participants receiving the two highest doses experienced significant
reductions in their triglyceride levels, of 25 and 24 percent, respectively,
compared to baseline. Furthermore, people receiving 6 or 12 mg per day
experienced significant increases in their HDL-cholesterol levels of 10 and 15
percent, respectively ... Additionally, adiponectin levels increased in the two
highest dose groups, with increases over 20 percent in the 12 mg per day group,
and between 15 and 20 percent in the 18 percent group" - See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.comor
astaxanthin products at iHerb.
Administration of natural astaxanthin increases serum HDL-cholesterol and
adiponectin in subjects with mild hyperlipidemia - Atherosclerosis. 2010
Apr;209(2):520-3 - "Multiple comparison tests showed
that 12 and 18 mg/day doses significantly reduced triglyceride, and 6 and 12 mg
doses significantly increased HDL-cholesterol. Serum adiponectin was increased
by astaxanthin (12 and 18 mg/day), and changes of adiponectin correlated
positively with HDL-cholesterol changes independent of age and BMI" - See
Jarrow Formulas, CarotenALL, Mixed Carotenoid Complex at Amazon.comor
astaxanthin products at iHerb.
HDL Cholesterol and Cancer - Medscape, 6/15/10 -
"even after adjustment for multiple variables, there was a 36% lower risk of
cancer for every 10-mg/dL increase in HDL cholesterol" - See
niacin at Amazon.com.
Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are Impaired
in Patients With Type 2 Diabetes Mellitus but Are Improved After
Extended-Release Niacin Therapy - Circulation. 2009 Dec 21 -
"Patients with diabetes were randomized to a 3-month
therapy with ER niacin (1500 mg/d) or placebo ... HDL from healthy subjects
stimulated endothelial nitric oxide production, reduced endothelial oxidant
stress, and improved endothelium-dependent vasodilation and early
endothelial progenitor cell-mediated endothelial repair. In contrast, these
beneficial endothelial effects of HDL were not observed in HDL from diabetic
patients, which suggests markedly impaired endothelial-protective properties
of HDL. ER niacin therapy improved the capacity of HDL to stimulate
endothelial nitric oxide, to reduce superoxide production, and to promote
endothelial progenitor cell-mediated endothelial repair. Further
measurements suggested increased lipid oxidation of HDL in diabetic
patients, and a reduction after ER niacin therapy ... HDL from patients with
type 2 diabetes mellitus and metabolic syndrome has substantially impaired
endothelial-protective effects compared with HDL from healthy subjects. ER
niacin therapy not only increases HDL plasma levels but markedly improves
endothelial-protective functions of HDL in these patients, which is
potentially more important" - See
niacin at Amazon.com.
Niacin Tops Zetia in Cutting Artery Plaque - WebMD, 11/16/09 -
"The question is whether ezetimibe works at all ...
Niacin has been around for 50 years. It's a well-understood drug, and in
this trial it was clearly superior ... Ultrasound images of neck arteries
showed that Niaspan reduced artery plaque by about 2%. Zetia did not slow
plaque buildup, although it did lower cholesterol" - See
niacin at Amazon.com.
ARBITER 6-HALTS: HDL Raising With Niacin Superior to Ezetimibe -
Medscape, 11/16/09 - "Adding extended-release niacin
(Niaspan, Abbott) to statin therapy results in a significant regression of
atherosclerosis as measured by carotid intima-media thickness (IMT), whereas
the addition of ezetimibe (Zetia, Merck/Schering-Plough) to statin therapy
did not, according to an eagerly anticipated study" - See
niacin at Amazon.com.
Raising 'Good' Cholesterol Levels May Benefit Clogged Arteries - Science
Daily, 11/6/09 - "Using MRI scans, we have shown a
reduction in the size of artery walls in patients after a year of treatment
with nicotinic acid ... Nicotinic acid, sometimes known as niacin, is one of
the oldest drugs used for atherosclerosis and only fell out of favour as
statins came to prominence. It is known to raise levels of good cholesterol
in the blood" - See
niacin at Amazon.com.
Low HDL Levels as the Most Common Metabolic Syndrome Risk Factor in Heart
Failure - Int Heart J. 2009 Sep;50(5):571-80 -
"The most prevalent parameters were low HDL-C (69%) and hypertension (69%)
in all participants" - Note: The best way to raise HDL is with
niacin. The no flush form doesn't work and the slow release may cause liver
damage. People complain about the flush but I've been taking it for years
and the longer you take it the less flush. After a while, there is no flush
at all but be sure to take it with food.
http://www.lipidsonline.org/slides/slide01.cfm?tk=25&dpg=34 shows that
with extended release niacin, HDL peaks out at 2,500 mg.
shows immediate release crystalline niacin compared to Niaspan. The numbers
are basically the same. I don't see any point in the prescription other
than that it might have less flushing when you first start taking it. See
niacin at Amazon.com.
Anthocyanin supplementation improves serum LDL- and HDL-cholesterol
concentrations associated with the inhibition of cholesteryl ester transfer
protein in dyslipidemic subjects - Am J Clin Nutr. 2009 Jul 29 -
"Anthocyanin consumption increased HDL-cholesterol
concentrations (13.7% and 2.8% in the anthocyanin and placebo groups,
respectively; P < 0.001) and decreased LDL-cholesterol concentrations (13.6%
and -0.6% in the anthocyanin and placebo groups, respectively; P < 0.001).
The cellular cholesterol efflux to serum increased more in the anthocyanin
group than in the placebo group (20.0% and 0.2%, respectively; P < 0.001).
Anthocyanin supplementation decreased the mass and activity of plasma
cholesteryl ester transfer protein (CETP) (10.4% and 6.3% in the anthocyanin
group and -3.5% and 1.1% in the placebo group, respectively; P < 0.001)"
blueberry extract at Amazon.com
bilberry at Amazon.com.
Biology Of Flushing Could Renew Niacin As Cholesterol Drug - Science
Daily, 4/6/09 - "Niacin, also known as nicotinic
acid or vitamin B3, has long been regarded as one of the most effective
weapons in managing cholesterol. It can lower levels of triglycerides, fatty
acids and to a lesser extent, the "bad" kind of cholesterol (LDL) while at
the same time powerfully increasing the "good" kind (HDL). But there's a
catch – a big one. Patients don't like to take niacin because in most of
them, it causes embarrassing, uncontrollable intense flushing, a rush of
blood to the face and other skin surfaces accompanied by a prickling
sensation ... One particular protein in that group, beta-arrestin1, was
found to trigger the chemical reaction that led to flushing ...
beta-arrestin1 plays no role whatsoever in niacin's ability to lower
cholesterol and fatty acids ... the discovery opens the door to the
possibility of developing a "biased ligand," a drug that would trigger
GP109A, but not the beta-arrestins"
fish diet increases insulin sensitivity compared to a red meat diet in young
iron-deficient women - Br J Nutr. 2009 Feb 12:1-8 -
"Insulin levels significantly decreased and insulin
sensitivity significantly increased with the oily fish diet. HDL-cholesterol
significantly increased with the oily fish diet"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
of cranberry extracts on lipid profiles in subjects with Type 2 diabetes
- Diabet Med. 2008 Dec;25(12):1473-7 - "Changes in
lipid profiles, oxidized low-density lipoprotein (ox-LDL), glycaemic
control, components of the metabolic syndrome, C-reactive protein (CRP) and
urinary albumin excretion (UAE) were assessed after cranberry or placebo
treatment for 12 weeks ... Low-density lipoprotein (LDL) cholesterol
decreased significantly in the cranberry group (from 3.3 +/- 0.2 to 2.9 +/-
0.2 mmol/l, P = 0.005) and the decrease was significantly greater than that
in the placebo group (-0.4 +/- 0.1 vs. 0.2 +/- 0.1 mmol/l, P < 0.001). Total
cholesterol and total : high-density lipoprotein (HDL) cholesterol ratio
also decreased significantly (P = 0.020 and 0.044, respectively) in the
cranberry group and the reductions were significantly different from those
in the placebo group (P < 0.001 and P = 0.032, respectively) ... Cranberry
supplements are effective in reducing atherosclerotic cholesterol profiles,
including LDL cholesterol and total cholesterol levels, as well as total :
HDL cholesterol ratio, and have a neutral effect on glycaemic control in
Type 2 diabetic subjects taking oral glucose-lowering agents" - See
cranberry extract at Amazon.com.
Long-term effects of resveratrol supplementation on suppression of
atherogenic lesion formation and cholesterol synthesis in apo E-deficient
mice - Biochem Biophys Res Commun. 2008 Jul 5 -
"The concentration of total-cholesterol (total-C) and LDL-cholesterol
(LDL-C) in plasma was significantly lower in the resveratrol-supplemented
groups compare to the control group over the entire experimental period. The
plasma HDL-C concentration was significantly elevated, and the ratio of
HDL-C/total-C was significantly higher in the CF and RV groups than in the
control group. Plasma paraoxonase (PON) activity was significantly higher in
the 0.06% resveratrol group. The hepatic HMG-CoA reductase (HMGR) activity
was significantly lower in the clofibrate and resveratrol groups than in the
control group. Resveratrol supplements attenuated the presence of
atherosclerotic lesions and periarterial fat deposition in the apo E(-/-)
mice. The presence of intracellular adhesion molecule-1 (ICAM-1) and
vascular cell adhesion molecule-1 (VCAM-1) in atherosclerotic vessels was
diminished in the resveratrol-supplemented apo E(-/-) mice. These results
provide new insight into the anti-atherogenic and hypocholesterolemic
properties of resveratrol in apo E(-/-) mice that were fed a normal diet"
resveratrol products at Amazon.com.
Niacin's Role In Maintaining Good Cholesterol - Science Daily, 6/5/08
HDL Cholesterol Linked to Lower Extremity Performance in Elderly -
Medscape, 5/2/08 - "HDL-C levels were significantly
associated with all indices of function ... participants with the highest
HDL-C levels having the best physical performance"
Combination Niacin-Laropiprant Plus Simvastatin Reduces Cholesterol by
Almost 50% - Doctor's Guide, 11/6/07 - "When
patients with dyslipidemia added simvastatin to their experimental
combination of extended-release niacin and laropiprant -- a novel
anti-flushing agent -- they reported reductions in low density lipoprotein
cholesterol (LDL-C) of as much as 48% from baseline ... high density
liopoprotein cholesterol (HDL-C) was increased by 28% and triglycerides
decreased by 33%"
The effects of extended-release niacin on carotid intimal media thickness,
endothelial function and inflammatory markers in patients with the metabolic
syndrome - Int J Clin Pract. 2007 Nov;61(11):1942-8 - "After
52 weeks of treatment, there was a change of carotid IMT of +0.009 +/- 0.003
mm in the placebo group and -0.005 +/- 0.002 mm in the niacin group (p =
0.021 between groups). Endothelial function improved by 22% in the group
treated with niacin (p < 0.001), whereas no significant changes were seen in
the placebo group. High sensitivity C-reactive protein decreased by 20% in
the group treated with niacin for 52 weeks (p = 0.013). Niacin increased
HDL-C (p < 0.001) and decreased low-density lipoprotein cholesterol and
triglycerides (p < 0.001) significantly, and there were no adverse effects
on fasting glucose levels after 52 weeks of treatment" - See
niacin at Amazon.com
niacin at Amazon.com.
Dietary glycemic index and glycemic load are associated with
high-density-lipoprotein cholesterol at baseline but not with increased risk
of diabetes in the Whitehall II study - Am J Clin Nutr. 2007
Oct;86(4):988-994 - "At baseline, dietary GI and GL
were associated inversely with HDL cholesterol, and GI was associated
directly with triacylglycerols. Dietary GI and GL were related inversely to
fasting glucose and directly to 2-h postload glucose ... The proposed
protective effect of low-dietary GI and GL diets on diabetes risk could not
be confirmed in this study"
Vitamin E dietary supplementation significantly affects multiple risk
factors for cardiovascular disease in baboons - Am J Clin Nutr. 2007
Sep;86(3):597-603 - "vitamin E caused 2 paradoxical
effects on HDL metabolism: higher apolipoprotein A-I (apo A-I)
concentrations and lower HDL sizes ... They also show 2 apparently
paradoxical effects on HDL metabolism: lower HDL(2), which is mediated by
genes, and higher apo A-I, which is not. These effects have contrasting
associations with CVD risk and may help account for the mixed results from
clinical trials of dietary vitamin E"
Niacin (Nicotinic Acid) -- The Old Drug Is Making a Comeback With A New Act
- Medscape, 6/11/07 - "Niacin (nicotinic acid) is
well known as the most effective drug currently available for raising levels
of high-density lipoprotein (HDL) cholesterol, raising it by 25% to 35% at
the highest doses"
Exercise May Boost 'Good' Cholesterol - WebMD, 5/29/07 -
"Participants who got at least two hours per week of
aerobic exercise had a modest rise in their HDL cholesterol level ... the
gains in HDL cholesterol levels translate to a 5% drop in men's heart
disease risk and more than a 7% drop in women's heart disease risk"
Continuous intake of polyphenolic compounds containing cocoa powder reduces
LDL oxidative susceptibility and has beneficial effects on plasma
HDL-cholesterol concentrations in humans - Am J Clin Nutr. 2007
Mar;85(3):709-17 - "A significantly greater increase
in plasma HDL cholesterol (24%) was observed in the cocoa group than in the
control group (5%)"
An Old Cholesterol Remedy Is New Again - New York Times, 1/23/07 -
"In its therapeutic form, nicotinic acid, niacin can
increase HDL as much as 35 percent when taken in high doses, usually about
2,000 milligrams per day. It also lowers LDL, though not as sharply as
statins do, and it has been shown to reduce serum levels of artery-clogging
triglycerides as much as 50 percent ... There’s a great unfilled need for
something that raises HDL ... Right now, in the wake of the failure of
torcetrapib, niacin is really it. Nothing else available is that effective"
niacin at Amazon.com.
What is the dietary treatment for low HDL cholesterol? - J Fam Pract.
2006 Dec;55(12):1076-8 - "Low-carbohydrate diets
raise high-density lipoprotein (HDL) cholesterol levels by approximately
10%; soy protein with isoflavones raises HDL by 3% ... Dietary Approaches to
Stop Hypertension (DASH) diet and multivitamin supplementation raise HDL 21%
- Research shows benefits
of cranberries -MSNBC, 11/20/06 -
"Drinking cranberry juice daily may increase levels
of HDL, or good cholesterol and reduce levels of LDL, or bad cholesterol"
cranberry supplements at Amazon.com.
Favourable impact of low-calorie cranberry juice consumption on plasma
HDL-cholesterol concentrations in men - Br J Nutr. 2006 Aug;96(2):357-64
- "daily CJC consumption is associated with an
increase in plasma HDL-cholesterol concentrations in abdominally obese men.
We hypothesise that polyphenolic compounds from cranberries may be
responsible for this effect, supporting the notion that the consumption of
flavonoid-rich foods can be cardioprotective"
Comparative Effects on Lipid Levels of Niaspan and Statins - Medscape,
7/28/06 - "Niacin is the best HDL-cholesterol
raising drug right now"
About 5% of Long-term Niacin Users Evolve Into HDL Hyperresponders -
Doctor's Guide, 3/14/06 - "about 5% of patients on
long-term therapy become hyperresponders, increasing their HDL levels by 50%
or more ... Overall, these patients lost 4% of body weight while on niacin
Fiber Supplements May Lower Cardiovascular Risk In Type 2 Diabetics -
Science Daily, 4/30/05 - "Study participants
received 10g to 15g of BiosLife 2, an over-the-counter fiber supplement ...
total cholesterol had dropped from 215 mg/dL to 184 mg/dL, a 14.4 percent
decrease. Triglycerides also improved, dropping from 299 mg/dL to 257 mg/dL,
a 14 percent decrease ... LDL decreased from 129 mg/dL to 92 mg/dL -- a 28.7
percent improvement. HDL rose from 43 mg/dL to 55 mg/dL -- a 21.8 percent
The Effects of Niacin on Lipoprotein Subclass Distribution - Medscape,
"the combination of
niacin and a statin may be among the best
available treatment options for many patients with complex forms of
dyslipidemia ... Niacin effectively modifies all major lipids and
lipoproteins with respect to both their quantity and quality. It is the most
effective agent currently available for raising low levels of HDL
Grape Juice Raises 'Good' Cholesterol Levels - WebMD, 11/19/04 -
"Grape juice drinkers had HDL levels of 50 mg/dL,
compared with almost 45 mg/dL in the placebo group"
- Raising HDL in
Clinical Practice - Medscape, 6/10/04 -
"Niacin increases HDL-C to the greatest extent of
all available monotherapies: by 15% to 35% at higher daily doses on the
order of 3 grams ... Capsules containing omega-3 fatty acids (1.48 g of
docosahexaenoic acid + 1.88 g of eicosapentaenoic acid) have been formulated
and are commercially available in some parts of the world (as Omacor). In a
recent small study in patients with familial combined hyperlipidemia,
treatment with this formulation for 8 weeks increased HDL-C by 8%"
Dietary supplementation with olive oil leads to improved lipoprotein
spectrum and lower n-6 PUFAs in elderly subjects - Med Sci Monit. 2004
Mar 23;10(4):PI49-PI54 - "The supplement was taken
for 6 weeks and involved daily consumption of 2 tablespoons ... There was
also a significant decline in the total-to-HDL and LDL-to-HDL cholesterol
ratios" - I alternate between
Smart Balance Omega-Plus (made with omega-3 fish oil) and
Fleischmann's Olive Oil spread.
HDL: The "Quit" Cholesterol - Physician's Weekly, 2/23/04 -
"for every 1 mg/dL increase in HDL, risk for a CAD
event is reduced by 2% in men and 3% in women ... It hasn't gotten the same
attention as LDL partly because there haven't been good medicines for
raising it ... Niacin is, according to Dr. Rader, “…the best HDL-raising
agent currently available.”"
Scientists Eye Pills To Unclog Arteries - Intelihealth, 2/2/04 -
"HDL scoops up cholesterol from the arteries and
carries it back to the liver for disposal ... men's average HDL is about 45
and women's is 55. HDL under 40 is an especially bad sign, while anything
over 60 is considered good. Those with HDL over 75 may even be blessed with
what's called the "longevity syndrome." ... many specialists recommend more
use of the HDL booster already on the market, the vitamin niacin"
4 Popular Diets Heart Healthy - WebMD, 11/10/03 -
"the heart disease risk score is based on the ratio
between LDL cholesterol and HDL "good" cholesterol ... The
Atkins and Zone
diets increased HDL by 15%, while Weight Watchers posted an 18.5% gain. But
Ornish diet increased HDL by just 2.2%"
Vitamin C Inhibits Lipid Oxidation in Human HDL - J Nutr. 2003
"In the absence of vitamin C, lipid oxidation in HDL
began immediately and proceeded rapidly ... Vitamin C (50-200 micro mol/L)
retarded initiation of lipid oxidation for at least 4 h under the same
conditions ... Our results demonstrate that vitamin C inhibits lipid
oxidation in HDL and preserves the antioxidant activity associated with this
Vitamin B12 Improves Homocysteine Levels and Lipid Profiles in Patients with
End-Stage Renal Disease - Doctor's Guide, 10/6/03 -
"During Phase 1, patients were prescribed oral doses
of folic acid 5 mg/day and vitamin B12
0.6mg/day. Through out Phase 2, participants were given intravenous doses of
vitamin B12 1mg every other day in addition to folic acid 5 mg/day ... By
the completion of the study, patients exhibited significantly lower serum
tHcy (29.4 verses
21.1 mg/dL), total cholesterol (222 verses 196 mg/dL), and low-density
lipoprotein cholesterol levels (139 versus 109 mg/dL). Serum high-density
lipoprotein (HDL) cholesterol levels increased significantly among the
- Does High Cholesterol Harm
Your Kidneys? - Dr. Weil, 8/22/03 -
"apparently healthy men with low HDL (high density
lipoprotein), the “good” cholesterol, and high LDL (low density lipoprotein)
or “bad” cholesterol and triglycerides have twice the normal risk of
reduced kidney function ... You can raise HDL by increasing exercise,
drinking alcohol moderately, and eating only healthy fats (monounsaturates
such as olive oil and omega-3s from sources like salmon and sardines).
Taking prescription statin drugs also will help, although I prefer natural
alternatives such as red rice yeast"
Cholesterol: Finding Right Mix - CBS News, 7/11/03 -
"High-density Lipoprotein (HDL) cholesterol is known
as the "good"
cholesterol. It helps move the bad
cholesterol through the body's system to get rid of excess amounts. With
enough "good" cholesterol, the "bad" cholesterol doesn't get a chance to
build up ... Your total cholesterol should be less than 200. Levels of
"good" cholesterol should be below 40. Levels of "bad" cholesterol should be
less than 130, or less than 100 if you already have heart disease ...
Certain foods such as soy, whole grain oats or fish containing omega-3 fatty
acids can lower cholesterol" - I believe that "Levels of "good"
cholesterol should be below 40" should be "above" not "below". - Ben
- Policosanol more
Effective than Lovastatin for Intermittent Claudication - New Hope
Natural Media, 5/29/03 -
policosanol had a 34% increase in pain-free walking distance, while no
change was observed in those taking
lovastatin. Quality of life was also
reported as being significantly better in the policosanol group compared
with the lovastatin group. Both treatment groups had significant reductions
in total cholesterol and LDL cholesterol. However, participants taking
policosanol had a significant 32% increase in HDL cholesterol and a 6%
decrease in fibrinogen, while these parameters remained unchanged in those
receiving lovastatin" - See
policosanol products. Claudication gets
my attention because my father has it and if there is a hereditary factor, I
want to prevent it. - Ben
Cranberry Juice Fights Heart Disease - WebMD, 3/24/03 -
is higher in phenol antioxidants than other fruit juices with the exception
of grape juice ... levels of high-density lipoprotein ("good" cholesterol)
appeared to increase significantly -- by as much as 121% -- after two or
three glasses of juice a day"
Differential effects of saturated and monounsaturated fats on postprandial
lipemia and glucagon-like peptide 1 responses in patients with type 2
diabetes - AJCN, 3/1/03 -
triacylglycerol concentrations and higher
HDL-cholesterol concentrations than did butter, without eliciting
significant changes in glucose, insulin, or fatty acids" - Olive oil
is 76% omega-9.
Policosanol Improves Lipid Profiles - Natural Foods Merchandiser, 1/03 -
"In one eight-week study with 68 older patients who
had both elevated LDL levels and various coronary heart disease risk
factors, researchers found 10 mg of Cuban
policosanol taken once daily reduced
(from baseline) LDL levels by 19 percent and
triglycerides by 14 percent, and
increased HDL levels by 18 percent, all statistically significant changes.26
The statin group (10 mg per day of pravastatin, the lowest dose recommended)
triggered a 16 percent reduction in LDL levels, no change in triglycerides,
and a 6 percent increase in HDL levels"
Ispaghula Husk [psyllium] Nearly As Effective As Simvastatin For
Hyperlipidemia - Doctor's Guide, 12/24/02 -
"One group received 3.5 grams of
twice a day and the second group received 20 milligrams of
simvastatin each day ... total
cholesterol decreased by 15.8 percent
and low-density lipoprotein (LDL) cholesterol decreased by 22.97 percent
among patients taking ispaghula husk ...
Triglycerides decreased by 20.89 percent and high-density lipoprotein
(HDL) cholesterol increased by 10.69 percent in these patients ... Among
patients taking simvastatin, total cholesterol decreased by 24.15 percent,
LDL cholesterol decreased by 36.08 percent, triglycerides decreased by 20.47
percent and HDL cholesterol increased by 11.4 percent" - I've got
that. See psyllium husk at Amazon.com.
3.5 grams is about one wafer (3.4 grams psyllium/wafer). Plus 24 wafers
for 30 of the 20 mg simvastatin.
- Eating Yogurt Daily
Increases “Good” Cholesterol in Women - New Hope Natural Media, 12/5/02
"In this study, 29 women ate 300 grams (about 10.6
ounces) of a full-fat (3.5% fat by weight) yogurt product daily for 21 weeks
... A larger, and statistically significant, 38% increase was observed in
HDL, or “good” cholesterol levels after eating the yogurt. No change was
observed in LDL, or “bad,” cholesterol levels ... each woman also ate the
probiotic- and prebiotic-containing product
for a 7-week stretch during the 21-week trial. During the period when the
women consumed the supplemented yogurt, there was a further increase in HDL
cholesterol beyond that seen from simply eating plain yogurt"
Genes Determine Effect of Diet, Good Cholesterol - WebMD, 10/21/02 -
"To increase HDLs, you shouldn't consume more
saturated fats. Instead, you should have more monounsaturated fats, which
are abundant in many vegetables, oils, and walnuts."
Alcohol Can Help Women's Hearts Too - WebMD, 9/16/02 -
"10 men aged 45-64 and nine women aged 49-62 drank
either regular beer or non-alcoholic beer for three weeks ... After 10 days
of drinking alcohol, HDL cholesterol levels
rose by an average of nearly 7% for both men and women ... Previous research
suggests that a 1% increase in HDL cholesterol is linked to a 2% reduction
in the risk of
Niacin May Be Effective Therapy For Broad Range Of Diabetes-Associated
Dyslipidaemias - Doctor's Guide, 7/25/02 -
niacin treatment, the patients' LDL peak particle diameter increased from
252 +/- 7 Å to 263 +/- 7, the researchers reported. Their small, dense LDLc
particle mass decreased from 27 +/- 11 mg/dL to 15 +/- 4 mg/dL. Total HDLc
increased from 39 +/- 7 mg/dL to 51 +/- 11 mg/dL. Their HDL2, as the
percentage of total HDLc mass, increased from 29 +/- 8 percent to 45 +/- 10
percent, and their Lp(a) decreased from 43 +/- 17 mg/dL to 25 +/- 10 mg/dL
... Twenty-one percent of the patients were unable to tolerate niacin
because of reversible adverse effects. Another 14 percent were unable to
adhere to the niacin dosing regimen of three times daily"
- HDL Too High? - Dr.
Weil, 6/6/02 -
"each increase of 4 mg/dl in the HDL level results
in a 10 percent decrease in risk of adverse coronary events"
- Policosanol Helps
Reduce High Cholesterol - New Hope Natural Media, 6/6/02 -
"In a six-month study, 10 mg per day of
policosanol reduced total cholesterol by
16% and LDL cholesterol by 24%, and
increased HDL cholesterol by 29%. Several other studies have compared
policosanol with some of the conventional medications used for lowering
cholesterol and the results have shown policosanol in the amount of 5 to 20
mg per day to be more effective than lovastatin (Mevacor®), pravastatin
(Pravachol®), and simvastatin (Zocor®), with fewer reported side effects.
While some prescription drugs used to lower cholesterol may cause liver and
muscle problems in rare instances, people taking policosanol have not
suffered any serious side effects" - See
- Health Benefits of Olive Oil
- California Olive Oil Council -
"Olive oil is 80% oleic acid, placing it at the top
of the list of monounsaturated fats ... Research has proved that using olive
oil significantly increases HDL levels"
Octacosanol Beats Statins - Dr. Janson, 4/02 -
"Taking a non-flush form of niacin, inositol hexaniacinate, provides the
same cholesterol effects without the liver changes, but it is more
expensive. Effective niacin doses are 1500 to 3000 mg daily"
Men's Fitness: Boost your good cholesterol sky-high: want to live longer?
Try raising this cholesterol with our 10 strategies - findarticles.com,
2/02 - "In a Canadian study, drinking a few glasses
of orange juice every day for four weeks increased participants' HDL by 21
percent, possibly due to a flavonoid called
hesperidin that appears extremely
Statins and Supplements - Natural Foods Merchandiser, 1/02
question regarding your new cholesterol-lowering supplement, Policosanol
- Life Extension Magazine, 11/01 -
"Studies show that niacin (B3) in doses of 1.5 grams
to 3 grams lower
triglycerides levels and raise HDL
concentrations. Those who tolerated higher doses of niacin (nicotinic acid)
showed even more improvement in lipid levels. Some people taking just 1000
flush-free niacin see an
elevation in beneficial HDL. Green tea also has been shown to elevate levels
of HDL while lowering serum triglyceride levels. In the Journal of Molecular
Cell Biochemistry, curcumin has been
demonstrated, in vivo, to decrease triglycerides and increase HDL. In a
study published in 1989 by the Journal of Associated Physicians-India, 125
showed a drop of 16.8% in triglycerides, and a 60% increase in HDL
cholesterol within three to four weeks. Make sure you are taking at least
Mega EPA fish oil capsules daily, as low
dose fish oil may not adequately suppress triglycerides. Finally, there are
some lifestyle changes you may wish to consider. If you are overweight,
weight loss would be recommended, as it would help to lower triglycerides
and raise HDL. Also, try reducing carbohydrates, which can raise
Product Review: Omega-3 Fatty Acids (EPA and DHA) from Fish/Marine Oils
- ConsumerLabs.com, 11/20/01 -
"It's been discovered that EPA and DHA may help
prevent heart disease and atherosclerosis by lowering
triglyceride levels, raising HDL
("good") cholesterol and, possibly "thinning" the blood ... By decreasing
inflammation, EPA and DHA can also reduce the pain of rheumatoid arthritis
Fish oils may also be useful in treating
a host of conditions including bipolar (manic-depressive) disorder,
Raynaud's phenomenon (abnormal sensitivity of hands and feet to cold),
lupus, IgA nephropathy, kidney stones, chronic fatigue syndrome, Crohn's
disease, cystic fibrosis, and ulcerative colitis ... EPA specifically may be
helpful for schizophrenia, while DHA may be more helpful in reducing high
blood pressure ... DHA may be helpful in the treatment of disorders such as
attention deficit disorders, dyslexia, and cognitive impairment and dementia
... experts now believe that the American diet contains too little omega-3
fatty acids and too much omega-6 fatty acids"
Cardiovascular Health - Nutrition Science News, 9/01 -
"HDL cholesterol was significantly increased in the
intervention [coenzyme Q10] group without affecting total cholesterol or LDL
An Antioxidant Cocktail May Prove to Be Heart Unhealthy - WebMD, 8/9/01
"Taken alone the drug combination simvastatin and
niacin increased HDL, the so-called good cholesterol by 25%, but when
antioxidants were added HDL increased by only 18%"
A Fish Story - Nutrition Science News, 4/01 -
"daily consumption of very low daily doses of
EPA/DHA (120 mg/180 mg, about one standard
fish oil capsule) in an enriched milk led
to a 19 percent decrease in blood
triglycerides and a 19 percent increase
in HDL cholesterol after six weeks ... It is unclear whether EPA is superior
to DHA, although EPA has proven more potent in relaxing cow coronary
arteries and producing the vasodilator gas,
nitric oxide, in vitro"
- Niacin Reduces
Triglycerides, Increases Good Cholesterol In Diabetics - Doctor's Guide,
Effects of policosanol in older patients with type II hypercholesterolemia
and high coronary risk - J Gerontol A Biol Sci Med Sci 2001
"while significantly (p é .01) increasing (p < .001)
high-density lipoprotein cholesterol (HDL-C) by 14.6% and 29.1%,
respectively ... No serious adverse experiences occurred in policosanol
patients (p < .01), compared with seven adverse experiences (7.9%) reported
by placebo patients"
- Niaspan (Niacin Extended
Release Tablets) Safe And Effective For Diabetics - Doctor's Guide,
- Statin Plus Niacin Reduces
Heart Attack Risk, Reverses Arterial Build-up - Doctor's Guide, 11/13/00
Spent Yeast Improves Cholesterol Count - Nutrition Science News, 5/00
- Rimostil May Increase Bone
Density While Raising Good Cholesterol - Doctor's Guide, 9/27/99 -
"The second effect was on HDL cholesterol levels.
Falling HDL levels after menopause is one of the main reasons that older
women suffer heart disease and stroke. P-081 caused an average 28% rise in
HDL levels, essentially restoring their HDL levels to pre-menopausal levels"
Rimostil at iHerb.
Prolonged treatment with slow release nicotinic acid in patients with type
II hyperlipidemia - Pol Arch Med Wewn. 1997 Nov;98(11):391-9
- Experts Urge Physicians and
Patients To Look Beyond LDL Cholesterol - Doctor's Guide, 9/10/97
Biological effects of hesperidin, a Citrus flavonoid. (note II):
hypolipidemic activity on experimental hypercholesterolemia in rat
- Farmaco. 1995 Sep;50(9):595-9 - "Hesperidin,
the most important flavanone of Citrus sp., significantly increases HDL"
A comparison of the efficacy and toxic effects of sustained- vs
immediate-release niacin in hypercholesterolemic patients - JAMA. 1994
Mar 2;271(9):672-7 -
"None of the patients taking IR niacin developed
hepatotoxic effects, while 12 (52%) of the 23 patients taking SR niacin did"
HDL cholesterol and estimates of HDL particle composition in future
development of type 2 diabetes in the general population: The PREVEND Study
- J Clin Endocrinol Metab. 2013 May 20 - "High
density lipoproteins (HDL) may directly stimulate β-cell function and
glucose metabolism ... Higher HDL cholesterol, as well as higher
HDL-cholesterol/apoA-I and HDL-cholesterol/apoA-II ratios are strongly and
independently related to lower risk of future type 2 diabetes"
HDL-C predicts risk and PCI outcomes in the Han Chinese population -
Atherosclerosis. 2012 Oct 3 - "Low HDL-C was the
most powerful lipid parameter for predicting the risk and the clinical
outcome of CHD in the Han Chinese population"
high-density lipoprotein cholesterol and progression to arterial stiffness
in middle-aged and elderly Chinese - Nutr Metab Cardiovasc Dis. 2012 Sep
22 - "participants in the highest quartile of HDL-c
had an odds ratio of 0.442 (95% CI 0.268-0.729) for developing high arterial
stiffness compared with participants in the lowest quartile" - See
niacin at Amazon.com.
Measuring HDL particles as opposed to HDL cholesterol is a a better
indicator of coronary heart disease, study suggests - Science Daily,
all 'good cholesterol' is 'good': Raising HDL not a sure route to countering
heart disease - Science Daily, 5/16/12
Raising HDL Levels May Not Lower Heart Attack Risk - WebMD, 5/16/12 -
"Many clinicians still prescribe the vitamin niacin
to help raise HDL levels, even though a government-funded trial proved
disappointing ... The trial was halted early a year ago when it was
determined that people with heart disease who had low HDL levels did not
benefit from the treatment ... The drug company Pfizer abandoned its
experimental HDL-boosting drug torcetrapib in 2006 when trials showed an
increase in heart attack and stroke risk among users ... the new research
casts even more doubt on the strategy of raising HDL to lower heart and
stroke risk ... HDL levels are related to risk, but that doesn't mean that
raising HDL is beneficial ... What we do know is that lowering LDL has a big
impact on risk, so the take-home message remains, 'Get those LDL numbers
- Erectile Dysfunction
/ Impotence - Prostate Health Guide - U. of Maryland Medicine -
"Direct risk factors for erectile dysfunction may
include the following: ... low levels of HDL (high-density lipoprotein)"
Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study
of HDL Cholesterol in 54,500 Individuals - J Clin Endocrinol Metab. 2011 Nov
16 - "Low plasma HDL cholesterol levels robustly
associated with increased risk of MI but genetically decreased HDL cholesterol
did not. This may suggest that low HDL cholesterol levels per se do not cause
HDL-cholesterol and prediction of coronary heart disease: Modified by physical
fitness?: A 28-year follow-up of apparently healthy men - Atherosclerosis.
2011 Oct 17 - "High-density lipoprotein cholesterol
(HDL) and physical fitness (PF) ... The highest HDL quartile was associated with
lower risk of CHD (HR: 0.57, 95% confidence interval [CI]: 0.43-0.74), fatal CHD
(HR: 0.56, CI: 0.36-0.86), fatal CVD (HR: 0.64, CI: 0.46-0.88) and all-cause
death (HR: 0.80, CI: 0.65-0.99) compared to the lowest quartile. Adjustments for
PF or changes in PF over 8.6 years did not change the results except for
all-cause death, which was not significantly different between HDL quartiles. We
found no interaction between HDL and PF"
high-density lipoprotein cholesterol and risk of subsequent hospitalization for
coronary artery disease or stroke among patients with type 2 diabetes mellitus
- Am J Cardiol. 2011 Oct 15;108(8):1124-8 - "During a
mean follow-up of 55.8 +/- 23.8 months, 3,023 patients (10.1%) experienced a CVD
hospitalization. After multivariate adjustment, each 5 mg/dl of baseline HDL
cholesterol was significantly associated with a 6% lower CVD hospitalization
risk (hazard ratio 0.94 per 5 mg/dl, 95% confidence interval 0.92 to 0.95, p
<0.0001) and each 5-mg/dl increase in HDL cholesterol was associated with a 4%
CVD risk reduction (hazard ratio 0.96, 95% confidence interval 0.94 to 0.99, p
<0.003). In the categorical analysis, a ≥6.5-mg/dl HDL cholesterol decrease was
associated with an 11% increased CVD risk (hazard ratio 1.11, 95% confidence
interval 1.00 to 1.24, p = 0.047) and a ≥6.5-mg/dl increase was associated with
an 8% CVD risk reduction (hazard ratio 0.92, 95% confidence interval 0.84 to
1.01, p = 0.077) relative to those with stable HDL cholesterol"
low high-density lipoprotein cholesterol on arterial stiffening and left
ventricular diastolic dysfunction in essential hypertension - J Clin
Hypertens (Greenwich). 2011 Oct;13(10):710-5 - "In
univariate regression analysis, HDL cholesterol was inversely associated with
arterial stiffness parameter and E/Em (r=-0.23 and r=-0.27, respectively,
P<.01). The association of HDL cholesterol with arterial stiffness and LV
diastolic function was observed in both men and women. Triglycerides were weakly
correlated with arterial stiffness parameter and E/Em, while low-density
lipoprotein and total cholesterol were not. In multiple regression analysis,
only low HDL cholesterol was found as an independent predictor for both arterial
stiffness and LV diastolic dysfunction. Enhanced arterial stiffness is
associated with LV diastolic dysfunction. Low HDL cholesterol may lead to the
deterioration of both arterial stiffness and LV diastolic function in patients
with essential hypertension"
and HDL cholesterol and risk of prostate cancer - Cancer Causes Control.
2011 Sep 14 - "After excluding the first 10 years of
follow-up, men with higher serum total cholesterol were at increased risk of
overall (≥240 vs. <200 mg/dl: HR = 1.22, 95% CI 1.03-1.44, p-trend = 0.01) and
advanced (≥240 vs. <200 mg/dl: HR = 1.85, 95% CI 1.13-3.03, p-trend = 0.05)
prostate cancer. Higher HDL cholesterol was suggestively associated with a
decreased risk of prostate cancer regardless of stage or grade ... In this
population of smokers, high serum total cholesterol was associated with higher
risk of advanced prostate cancer, and high HDL cholesterol suggestively reduced
the risk of prostate cancer overall. These results support previous studies and,
indirectly, support the hypothesis that statins may reduce the risk of advanced
prostate cancer by lowering cholesterol"
cholesterol function as important as its levels - Science Daily, 6/23/11
doesn't stop heart attacks, major study finds - Health - Heart health -
msnbc.com - MSNBC, 5/26/11 - "The newest study
tested Abbott Laboratories' Niaspan, an extended-release form of niacin that is
a far higher dose than is found in dietary supplements ... the Niaspan users saw
their HDL levels rise, and their levels of risky triglycerides drop, more than
people who took a statin alone. But the combination treatment didn't reduce
heart attacks, strokes or the need for artery-clearing procedures such as
angioplasty ... That finding "is unexpected and a striking contrast to the
results of previous trials," ... Also, there was a small increase in strokes in
the high-dose niacin users — 28 among those 1,718 people given Niaspan compared
with 12 among the 1,696 placebo users. The NIH said it was not clear if that
small difference was merely a coincidence, as previous studies have shown no
stroke risk from niacin. In fact, some of the strokes occurred after the Niaspan
users quit taking that drug" - See my niacin
and HDL pages for many more studies. For one thing,
there are waaaay more arguments for raising HDL than just heart disease. Things
such as centurions having unusually high HDL, prostate cancer, bowel cancer,
impotence, Alzheimer's, etc., not to mention that it conflicts with other
of apolipoprotein A-I and HDL are associated with risk of prostate cancer in the
Swedish AMORIS study - Cancer Causes Control. 2011 May 12 -
"ApoA-I and HDL were inversely associated with PCa risk
(e.g., HR for HDL: 0.93 (95% CI: 0.81-1.07), 0.88 (0.76-1.01), 0.81 (0.70-0.94),
for second, third, and fourth quartiles compared with the first quartile; with p
for trend: 0.004; HR for apoA-I: 1.00 (0.88-1.13), 0.93 (0.82-1.05), 0.88
(0.77-0.99),), for second, third, and fourth quartiles compared with the first
quartile; with p for trend: 0.022). ApoB, LDL, and non-HDL were not associated
with PCa risk"
Concepts of the Role of High-Density Lipoprotein in Protection from
Atherosclerosis - Curr Atheroscler Rep. 2011 Mar -
"HDL is able to interact with and remove cholesterol from the lipid-laden foam
cells in the peripheral vasculature with subsequent transportation to the liver
for excretion. However, HDL has multiple other physiologic effects that may play
a significant role in protection from atherosclerosis. HDL has been demonstrated
to exhibit multiple beneficial effects on the coagulation system. Platelet
function is improved by both direct and indirect mechanisms. HDL has a complex
interaction with the protein C and protein S system. Thrombolytic balance is
also improved by HDL. HDL has been demonstrated to have a significant natural
antioxidant effect that inhibits the oxidative step required for low-density
lipoprotein uptake by the macrophage. Additionally, HDL has also been
demonstrated to exert multiple beneficial effects on endothelial function,
including decreased apoptosis and endothelial repair" - See
niacin at Amazon.com
(niacin increases HDL).
levels of 'good' cholesterol may cut bowel cancer risk - Science Daily,
3/7/11 - "Each rise of 16.6 mg/dl in HDL and of 32 mg/dl
in apoA reduced the risk of bowel cancer by 22% and 18%, respectively, after
taking account of diet, lifestyle, and weight ... low HDL levels have been
linked to higher levels of proteins involved in inflammation, while higher
levels of proteins that dampen down the inflammatory response have also been
linked to high HDL levels ... The pro inflammatory proteins boost cell growth
and proliferation while curbing cell death, so HDL may alter the inflammatory
process in some way"
Between High-Density Lipoprotein Cholesterol and Survival to Age 85 Years in Men
(from the VA Normative Aging Study) - Am J Cardiol. 2011 Feb 4 - "We
categorized initial HDL cholesterol into <40 mg/dl (reference group), 40 to 49
mg/dl, or ≥50 mg/dl ... Treating HDL cholesterol as a continuous predictor, we
also determined the HR for each 10-mg/dl increment in HDL cholesterol. Fully
adjusted HR (95% confidence interval) for survival to 85 years of age for
participants with an initial HDL cholesterol level ≥50 mg/dl compared to the
reference was 0.72 (0.53 to 0.98). Each 10-mg/dl increment in HDL cholesterol
was associated with a 14% (HR 0.86, 0.78 to 0.96) decrease in risk of mortality
before 85 years of age. In conclusion, after adjusting for other factors
associated with longevity, higher HDL cholesterol levels were significantly
associated with survival to 85 years of age" - See
niacin at Amazon.com
(niacin increases HDL).
dusty punch cards, new insights into link between cholesterol and heart disease
- Science Daily, 1/5/11 - "He also found an old punch
card machine to extract their data. Then, with the help of students and research
assistants, he located and contacted 97 percent of the people in Gofman's study
over the next nine years ... Their 29-year follow-up uncovered 363 cases of
coronary heart disease. They found that both HDL2 and HDL3 lowered heart disease
risk, and that a one-milligram per milliliter increase in HDL2 produced a
significantly larger reduction in coronary heart disease risk than a
one-milligram per milliliter increase in HDL3" - I doubt if many people
besides me even remember what punch cards were.
HDL-C Levels May Curb Alzheimer's Disease Risk - Medscape, 12/16/10 -
"There was a definite threshold effect, the researchers
say, with a clear reduction in AD risk for people in the highest HDL-C level
quartile (>56 mg/dL) ... these analyses were limited by the small number of
cases of vascular dementia (n = 16) ... the current study linking higher HDL-C
to a lower risk for incident dementia contrast with a prior study by the same
researchers. This earlier study involved 1168 participants recruited from the
same community in 1992 – 1994 and showed no association between HDL-C and AD ...
Compared with the 1992 – 1994 cohort, the 1999 – 2001 cohort had a higher
proportion of subjects receiving lipid-lowering treatment (23.4% vs 14.5%),
higher mean HDL-C levels (48.3 vs 47.2 mg/dL), and fewer individuals who smoked
(9.4% vs 10.6%) and had heart disease (18.8% vs 34.1%)"
levels of 'good' cholesterol may be associated with lower risk of Alzheimer's
disease - Science Daily, 12/13/10 - "The researchers
defined higher levels of HDL cholesterol as 55 milligrams per deciliter or more
... higher levels of HDL cholesterol were associated with a decreased risk of
both probable and possible Alzheimer's disease"
lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is the
best surrogate marker for insulin resistance in non-obese Japanese adults -
Lipids Health Dis. 2010 Dec 7;9(1):138 - "In non-obese
subjects, the best marker of insulin resistance
was low-density lipoprotein cholesterol (LDL-C)/high-density
lipoprotein cholesterol (HDL-C) ratio of 0.74" - Note: I'm not sure
what I missed on that quote. See
http://www.americanheart.org/presenter.jhtml?identifier=183 . Ideally your
LDL should be below 100. In the average man, HDL cholesterol levels range from
40 to 50 mg/dL. So assuming an LDL of 100, for LDL/HDL to be equal to .74 your
HDL would have to be 135 which is nearly impossible. The full article is at
http://www.lipidworld.com/content/pdf/1476-511x-9-138.pdf and says
"The optimal cut-off point to identifying insulin
resistance for these markers yielded the following values: TG/HDL-C ratio of
≥1.50 and LDL-C/HDL-C ratio of ≥2.14 in non-obese subjects, and ≥2.20, ≥2.25 in
overweight subjects. In non-obese subjects, the positive likelihood ratio was
greatest for LDL-C/HDL-C ratio".
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