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Recent Longevity News for the seven days ending
4/10/13. You should consult your doctor if you are taking any medications.
salt and increasing potassium will have major global health benefits -
Science Daily, 4/4/13 - "increased
potassium intake reduces
blood pressure in adults, with no adverse
effects on blood lipids, hormone levels or kidney function. Higher potassium
intake was linked with a 24% lower risk of stroke
in adults and may also have a beneficial effect on blood pressure in children,
but more data is needed" - See
potassium citrate at Amazon.com.
Assessing insulin resistance can inform about breast cancer risk - Science
Daily, 4/4/13 - "When tissues become resistant to the
action of insulin -- which occurs often in obese people -- a balancing mechanism
further increases insulin production leading to a chronic hyperinsulinemia. Such
high insulin levels can be detrimental to the body because insulin not only
regulates glucose metabolism but has more functions such as stimulating cell
proliferation and survival. Therefore the continuous activation of insulin
pathways can contribute to cancer development by fuelling cancer cell growth.
Consistently, by analyzing a cohort of 410 patients and 565 healthy women, the
researchers found that 49% of patients were insulin
resistant compared with 34% of controls indicating that insulin resistance
can indeed increase the risk of developing breast
Low Testosterone Linked to Later Arthritis in Study - WebMD, 4/3/13 -
"Swedish researchers analyzed blood samples collected
from 104 men who were later diagnosed with rheumatoid
arthritis and 174 men of the same age who did
not develop the disease. The average time between collection of the blood sample
and a diagnosis of rheumatoid arthritis was just less than 13 years ... men with
lower testosterone levels were more likely
to develop rheumatoid arthritis. They did not, however, prove a cause-and-effect
link between the two ... These men also had significantly higher levels of
follicle stimulating hormone -- a chemical involved in sexual maturity and
reproduction -- before they were diagnosed with rheumatoid arthritis"
Decreased melatonin secretion associated with higher risk of developing type 2
diabetes - Science Daily, 4/2/13 - "The analysis
consisted of a case-control study nested within the Nurses' Health Study cohort
... participants in the lowest category of urinary ratio of
6-sulfatoxymelatonin to creatinine had a 2.2
times higher odds of developing type 2 diabetes
compared to participants in the highest category" - [Abstract]
melatonin at Amazon.com.
Many Older Veterans
Suffer PTSD in Silence - Medscape, 4/2/13 - "Well
more than half (67%) of respondents reported having a lifetime emotional health
problem; such problems included depression, attention-deficit disorder, anger
issues, mania, anxiety, and substance abuse" - Note: A lot of
problems with that study though. It wasn't compared to non-vets plus only
72 of 400 responded and they may have been different plus it was at an Armed
Forces Retirement Home and they may also have been different.
illness linked to heavy cannabis use - Science Daily, 4/2/13 -
"People with mental illnesses are more than seven times
more likely to use cannabis weekly compared to
people without a mental illness ... researchers analyzed data from face-to-face
interviews with over 43,000 respondents over the age of 18 from the National
Epidemiologic Survey on Alcohol and Related Conditions"
Abstracts from this week's
Doctor's Guide Nutrition/Dietetics
plus abstracts from my RSS feeds (Click here
for the journals, the PubMed ones at the top):
high-protein diet predisposes female offspring to increased fat mass in
adulthood whereas a prebiotic fibre diet decreases fat mass in rats - Br J
Nutr. 2013 Apr 8:1-10 - "virgin Wistar dams were fed
either a control (C), high-protein (40 %, w/w; HP) or high-prebiotic fibre (21.6
%, w/w; HF) diet throughout pregnancy and
lactation. Pups consumed the C diet from 3 to 14.5 weeks of age, and then
switched to a high-fat/sucrose diet for 8 weeks ... The maternal HP and HF diets
had lasting effects on body fat and hepatic TAG accumulation in the offspring,
particularly in females. Whereas the HP diet predisposes to an obese phenotype,
the maternal HF diet appears to reduce the susceptibility to obesity following a
high-energy diet challenge in adulthood"
Meta-analyses of colorectal cancer risk factors - Cancer Causes Control.
2013 Apr 6 - "the published evidence and explored
associations between risk factors and CRC incidence ... Significant risk factors
include inflammatory bowel disease (RR = 2.93, 95 % CI 1.79-4.81); CRC history
in first-degree relative (RR = 1.80, 95 % CI 1.61-2.02); body mass index (BMI)
to overall population (RR = 1.10 per 8 kg/m2 increase, 95 % CI 1.08-1.12);
physical activity (RR = 0.88, 95 % CI 0.86-0.91 for 2 standard deviations
increased physical activity score); cigarette smoking (RR = 1.06, 95 % CI
1.03-1.08 for 5 pack-years); and consumption of red meat (RR = 1.13, 95 % CI
1.09-1.16 for 5 servings/week), fruit (RR = 0.85, 95 % CI 0.75-0.96 for 3
servings/day), and vegetables (RR = 0.86, 95 % CI 0.78-0.94 for 5 servings/day)"
Work and Levels of 6-Sulfatoxymelatonin and Cortisol in Men - Cancer
Epidemiol Biomarkers Prev. 2013 Apr 5 - "We investigated
whether male nightshift workers demonstrated changes in levels of
cortisol, potential biomarkers of cancer risk ... Nightshift workers had
significantly lower 6-sulfatoxymelatonin levels during daytime sleep, nighttime
work, and nighttime sleep on off-nights (57%, 62% and 40% lower, respectively),
relative to the dayshift workers during nighttime sleep (p<0.0001); urinary
cortisol in nightshift workers was 16% higher during daytime sleep and 13% lower
during nighttime sleep on off-nights (p<0.05). Morning serum cortisol post-work
and post-sleep in nightshift workers were 24% and 43% lower, respectively, than
post-sleep levels among dayshift workers (p<0.0001). Within-subject comparisons
among the nightshift workers revealed significantly lower melatonin levels and
significantly higher urinary cortisol levels during daytime sleep and nighttime
work, relative to nighttime sleep (p<0.01); morning serum cortisol levels
post-work were lower than those post-sleep ... Shiftwork could be an important
risk factor for many types of cancer"
high doses of vitamin D on arterial properties, adiponectin, leptin and glucose
homeostasis in type 2 diabetic patients - Clin Nutr. 2013 Feb 27 -
"The present study was designed to evaluate long term
impact of high doses of vitamin D on arterial
properties, glucose homeostasis, adiponectin and leptin in patients with type 2
diabetes mellitus ... Group 1 received oral
daily supplementation with vitamin D at a dose of 1000 U/day for 12 months.
Group 2 received matching placebo capsules ... Central aortic augmentation index
(AI) was evaluated using SphygmoCor ... After 12 months, AI decreased
significantly during the treatment period in patients received vitamin D (p <
0.0001) and did not change in placebo group. Glucose homeostasis parameters,
leptin as well as leptin adiponectin ratio did not change in both groups. 25 OH
Vit D level significantly increased (p = 0.022) and circulating adiponectin
marginally increased (p = 0.065) during 12 month treatment period in active
treatment and did not change in placebo group" - See
vitamin D at Amazon.com.
association between 25-hydroxyvitamin D and the incidence of Type 2 diabetes: a
community-based nested case-control study - Diabet Med. 2013 Mar 18 -
concentrations were measured for 761 participants (aged 20-83 years) in the
Tehran Lipid and Glucose Study ... Odds ratios for Type 2
diabetes were obtained from conditional
logistic regression models for tertiles of serum 25(OH)D concentrations
[tertile-1: 2.82-11.02 (reference), tertile-2: 11.03-21.80, and tertile-3: ≥
21.82 ng/ml] ... Unadjusted odds ratios (95% confidence intervals) of diabetes
were 0.73 (0.74-1.13), 0.54 (0.34-0.85) for the second and third tertiles,
respectively. Multivariate adjusted odds ratios were 0.47 (0.25-0.90) and 0.43
(0.23-0.82), respectively. Below the cutoff of ~ 10 ng/ml the risk of newly
diagnosed Type 2 diabetes increased dramatically" - See
vitamin D at Amazon.com.
Controlled Trial (RCT) of Vitamin D Supplementation in Pregnancy in a Population
with Endemic Vitamin D Deficiency - J Clin Endocrinol Metab. 2013 Apr 4 -
"Vitamin D (vD)
deficiency in pregnancy is a global health
problem and the amount of vD supplementation to prevent vD deficiency is
controversial. Objective: Determine effectiveness and safety of prenatal
2000 IU and 4000 IU/day compared with 400 IU/day vD3 supplementation in a RCT in
population where vD deficiency is endemic ... Arab women were randomized at
12-16 weeks of gestation to 400, 2000 and 4000 IU/day vD3 which were continued
to delivery ... Vitamin D supplementation of 2000 and 4000 IU/day appeared safe
in pregnancy and 4000 IU/day was most effective in optimizing serum 25(OH)D
concentrations in mothers and their infants" - See
vitamin D at Amazon.com.
patterns and risk of dementia in an elderly Japanese population: the Hisayama
Study - Am J Clin Nutr. 2013 Apr 3 - "dietary
pattern 1 was correlated with high intakes of soybeans and soybean products,
vegetables, algae, and milk and dairy products and a low intake of rice ...
vascular dementia (VaD) ... AD, and VaD were
reduced by 0.66 (95% CI: 0.46, 0.95), 0.65 (95% CI: 0.40, 1.06), and 0.45 (95%
CI: 0.22, 0.91), respectively, in subjects in the highest quartile of score for
dietary pattern 1 compared with subjects in the lowest quartile"
Fatty Acids, and Risk of Prostate Cancer in the NIH-AARP Diet and Health Study
- Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):697-707 -
"NIH-American Association of Retired Persons (AARP) Diet
and Health Study. Diet was assessed at baseline with self-administered
food-frequency questionnaires ... Total fat and mono- and polyunsaturated fat
intakes were not associated with incidence of
prostate cancer. Saturated fat intake
was related to increased risk of advanced prostate cancer (HRQuintile 5 vs.
Qunitile 1 (Q1 vs. Q5), 1.21; 95% CI, 1.00-1.46; Ptrend = 0.03) and fatal
prostate cancer (HRQ5 vs. Q1, 1.47; 95% CI, 1.01-2.15; Ptrend = 0.04).
α-Linolenic acid (ALA) intake was related to
increased risk of advanced prostate cancer (HRQ5 vs. Q1, 1.17; 95% CI,
1.04-1.31; Ptrend = 0.01). Eicosapentanoic acid (EPA)
intake was related to decreased risk of fatal prostate cancer (HRQ5 vs. Q1,
0.82; 95% CI, 0.64-1.04; Ptrend = 0.02)"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
Health Focus (Statins):
CoQ10 and L-carnitine
for Statin Myalgia? - Medscape, 1/4/13 - "In
summary, it has been proposed that CoQ10 can help to treat statin myalgia. While
this is not conclusive, there are two randomized controlled trials showing
significant improvements in the severity of muscle pain with the use of CoQ10 in
patients treated with statins. Thus, it is not unreasonable to supplement a
patient who is experiencing muscle pains on a statin with CoQ10. While there are
no clinical trials showing improvements in muscle pain with the use of
l-carnitine, patients who experience statin myalgia frequently have carnitine
abnormalities. It is too soon to recommend l-carnitine for statin myalgia, but
future trials should test this supplement to see if it has any place for this
adverse effect. Other common alternatives for treating statin myalgias are
supplementation with vitamin D or vitamin B12, especially in the setting of
suboptimal serum levels"
ubiquinol products at Amazon.com, GPLC at Amazon.com
acetyl l-carnitine products at Amazon.com.
Cholesterol medicine affects energy production in muscles - Science Daily,
1/3/13 - "A well-known side effect of statin therapy is
muscle pain. Up to 75 per cent of the physically active patients undergoing
treatment for high cholesterol experience pain. This may keep people away from
either taking their medicine or from taking exercise -- both of which are bad
choices ... Scientists also showed that the patients examined who were being
treated with statins had low levels of the key protein Q10. Q10 depletion and
ensuing lower energy production in the muscles could be the biological cause of
the muscle pain that is a problem for many patients" - See
ubiquinol products at Amazon.com.
n-3 fatty acids on major cardiovascular events in statin users and non-users
with a history of myocardial infarction - Eur Heart J. 2012 Feb 1 -
"In statin users, an additional amount of n-3 fatty
acids did not reduce cardiovascular events [HR(adj) 1.02; 95% confidence
interval (CI): 0.80, 1.31; P = 0.88]. In statin non-users, however, only 9% of
those who received EPA-DHA plus ALA experienced an event compared with 18% in
the placebo group ... In patients with a history of MI who are not treated with
statins, low-dose supplementation with n-3 fatty acids may reduce major
cardiovascular events. This study suggests that statin treatment modifies the
effects of n-3 fatty acids on the incidence of major cardiovascular events"
Mega Twin EPA at Amazon.com
Jarrow Max DHA at Amazon.com.
bacteria may affect whether a statin drug lowers cholesterol - Science
Daily, 10/13/11 - "Among the group who had a strong
response to the drug, three bile acids appeared to play a role. The bile acids
are produced by certain gut bacteria, which are increasingly understood as
factories for chemicals that can contribute to a state of health. Among the
people who responded poorly to the statin, five different bile acids were
commonly evident ... new strategies could be developed to manipulate the gut
microbiome using probiotics to spur different gut bacteria, which could then
give the drugs a boost" - See
probiotics at Amazon.com.
reduce deaths from infection and respiratory illness, data eight years on from
trial suggests - Science Daily, 8/28/11 - "In the
lipid-lowering arm of the trial, over 10,000 patients in the UK, Ireland and
Scandinavia with high blood pressure were randomly allocated either atorvastatin
or placebo between 1998 and 2000. In 2003, the trial was stopped early because
the statin proved to be highly beneficial in preventing heart attacks and
strokes. Since then, most participants from both groups have been taking statins
... The new analysis looked at the number and cause of deaths among the 4,605
participants in the ASCOT trial who are based in the UK. After 11 years'
follow-up, overall mortality is 14 per cent lower in the group originally
assigned atorvastatin, due largely to fewer deaths from infection and
effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of
intervention trials - Maturitas. 2010 Dec 14 -
"Lycopene, a carotenoid found in tomatoes ... Meta-analysis of the effect of
lycopene on systolic blood pressure of all trials suggested a significant blood
pressure reducing effect (mean systolic blood pressure change+/-SE:
-5.60+/-5.26mm Hg, p=0.04) ... Our meta-analysis suggests that lycopene taken in
doses ≥25mg daily is effective in reducing LDL cholesterol by about 10% which is
comparable to the effect of low doses of statins in patient with slightly
elevated cholesterol levels" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
Red Yeast Rice Comparable to Pravastatin for Statin-Intolerant Patients
- Medscape, 1/21/10 - "After 12 weeks of treatment,
red yeast rice reduced LDL-cholesterol levels 30% from baseline, from 181
mg/dL to 126 mg/dL, while pravastatin reduced LDL-cholesterol levels 27%, a
nonstatistical difference between treatments. Similarly, there were no
significant differences observed in changes in total cholesterol,
triglycerides, or HDL-cholesterol levels ... Regarding the primary end
point, the incidence of treatment discontinuation because of myalgia, both
red yeast rice and pravastatin were equivalent. In the red-yeast-rice arm,
one patient of 21 (5%) withdrew because of muscle pain, while two patients
of 22 (9%) withdrew in the pravastatin arm. Also, there were no reported
differences in the mean pain severity scores with the two treatments"
red yeast rice at Amazon.com.
B niacin offers no extra benefit to statin therapy in seniors already diagnosed
with coronary artery disease, study suggests - Science Daily, 11/18/09 -
"This does not mean that niacin therapy may not have
other cardiovascular benefits, but any such benefits are independent of reducing
the amount of plaque buildup and patients should be aware of that ... Lima
cautions that an ongoing national study of the long-term vascular benefits of
dual therapy and whether extended-release niacin,
also known as nicotinic acid, lowers death rates from heart disease should
provide more definitive data" - Note: The article implies that
prescription Niaspan works better than immediate release niacin. See
which implies the opposite. The prescription might have less flush but I
couldn't tell the difference. Like I've said in the past, the flush gets
less the longer you use it and is practically non-existent after you taken it
for several months if you take it with food. Also, the slow release may
produce liver damages. See:
Endothelial Dysfunction in Statin-Treated Type 2 Diabetics - Medscape,
5/29/09 - "Study subjects were randomized to receive
either 200 mg/day of oral CoQ10 or placebo for 12 weeks ... Our absolute
improvement in FMD of 1% with CoQ10 supplementation may potentially
translate to a 10-25% reduction in residual cardiovascular risk in these
patients" - See
ubiquinol products at Amazon.com.
Taking Statins? Five Ways
to Boost Your Energy - ABC News, 4/14/09 - "It's
a cruel irony that if statins make patients more lethargic, it could impair
their ability to exercise or make dietary changes that would help them
address their high cholesterol ... some studies have found that patients'
energy levels increased while using CoQ10 and statins together ... Try
pomegranate juice or a small chunk of dark chocolate, both of which have
beneficial antioxidants ... Skimping on sleep has been found to increase
calcium deposit build-up in your arteries" - See
ubiquinol products at Amazon.com.
Statins' Adverse Effects Documented - Science Daily, 1/29/09 -
"Coenzyme Q10 ("Q10") is a compound central to the
process of making energy within mitochondria and quenching free radicals.
However, statins lower Q10 levels because they work by blocking the pathway
involved in cholesterol production – the same pathway by which Q10 is
produced. Statins also reduce the blood cholesterol that transports Q10 and
other fat-soluble antioxidants ... "The loss of Q10 leads to loss of cell
energy and increased free radicals which, in turn, can further damage
mitochondrial DNA," said Golomb, who explained that loss of Q10 may lead to
a greater likelihood of symptoms arising from statins in patients with
existing mitochondrial damage – since these people especially rely on ample
Q10 to help bypass this damage" - My favorite is
QH-Absorb by Jarrow.
Fish Oil, Red Yeast Rice Cut Cholesterol - WebMD, 7/23/08 -
"We followed them for a three-month period ... The
LDL declined 42% in the supplement group and 39% in the Zocor group ... The
supplement group also lost an average of 10 pounds in 12 weeks, but there
was no significant weight loss in the medication group. Triglyceride levels,
while on average normal in both groups at the start, decreased by 29% in the
supplement group but just 9.3% in the medication group -- a significant
difference" - See
red yeast rice at Amazon.com
Mega Twin EPA at Amazon.com.
Lowering Blood Cholesterol With Fish Oil And Red Yeast Rice Instead Of
Statins - Science Daily, 7/8/08 - "The
alternative treatment group participants received daily fish oil and red
yeast rice supplements ... The statin group participants received 40
milligrams (mg) of Zocor (simvastatin) daily ... The researchers noted that
there was a reduction in LDL cholesterol levels in both groups. The
alternative treatment group experienced a 42.4 percent reduction, and the
statin group experienced a 39.6 percent reduction. Members of the
alternative therapy group also had a substantial reduction in triglycerides,
another form of fat found in the blood, and lost more weight" - See
red yeast rice at Amazon.com
Mega Twin EPA at Amazon.com.
Lycopene as effective as statins for artery health: rabbit study - Nutra
USA, 7/3/08 - "The results of our experiment in the
high-fat diet rabbit model showed that lycopene and fluvastatin lowered
serum levels of total cholesterol and LDL-cholesterol, improved lipid
metabolism, and reduced the amount of triacylglycerols ... Lycopene
intervention reduced the increase in ox-LDL levels in rabbits on the
high-fat diet, whereas fluvastatin did not show such an effect. The cause of
this difference is at present not known, although the result speaks in
favour of lycopene ... These findings provide a theoretical rationale for
the use of lycopene as a preventive in atherosclerosis" - [Abstract]
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
Comparison of lycopene and fluvastatin effects on atherosclerosis induced by
a high-fat diet in rabbits - Nutrition. 2008 Jun 26 -
"Compared with the control, levels of total
cholesterol, total triacylglycerol, low-density lipoprotein cholesterol,
malonaldehyde, oxidized low-density lipoprotein, and interleukin-1 were
increased and total antioxidant capacity and nitric oxide were decreased in
the animals with a high-fat diet (P < 0.05). Intragastric administration of
lycopene counteracted the change in these parameters (P < 0.05). In this
case, the data showed that lycopene in the used dose was better than the
fluvastatin intervention. Morphologic analysis revealed that lycopene and
fluvastatin markedly reduced the formation of atherosclerotic plaques in the
aorta compared with the situation in rabbits on a high-fat diet alone ...
Lycopene, like fluvastatin, significantly attenuated atherogenesis in
rabbits fed a high-fat diet" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and
liver and muscle enzyme levels in hypercholesterolemic patients treated with
atorvastatin: A randomized double-blind study - Atherosclerosis. 2007
Aug 4 - "All patients showed definite reductions of
plasma CoQ10 levels in the placebo group, by 42%. All patients supplemented
with CoQ10 showed striking increases in plasma CoQ10 by 127%. In conclusion
atorvastatin definitely decreased plasma CoQ10 levels and supplementation
with CoQ10 increased their levels"
Effect of coenzyme q10 on myopathic symptoms in patients treated with
statins - Am J Cardiol. 2007 May 15;99(10):1409-12 -
"coenzyme Q10 supplementation may decrease muscle
pain associated with statin treatment. Thus, coenzyme Q10 supplementation
may offer an alternative to stopping treatment with these vital drugs"
ubiquinol at Amazon.com.
Combining Agents Leads to Safe Treatment of Lipid Abnormalities -
Physician's Weekly, 5/7/07 -
"Combining the use of statins and niacin should be
encouraged because it appears to safely treat multiple lipid abnormalities
in appropriate high-risk patients"
Niacin Extended-Release Tablets Combined With Low/Moderate Dosed Statin
Achieves Better Total Lipid Control Versus Higher Dose Statin Monotherapy or
Simvastatin and Ezetimibe - Doctor's Guide, 6/22/06 -
"patients given Niaspan in combination with a low to
moderate dose of Lipitor or Crestor achieved equivalent reduction in LDL-C
(51-58%), 1.2 to 1.9-fold greater decreases in triglycerides and 2.5 to 3.5
fold greater increases in HDL-C, than patients who received high-dose
Crestor or Zocor/Zetia" - See
niacin at Amazon.com. My favorite is
Twinlab niacin 1000mg at Amazon.com.
Coenzyme Q10 Lessens Muscle-Related Side Effects in Patients on Statins
- Doctor's Guide, 3/7/05 - "Patients with
significant myopathy who are taking statin therapy have a significant
decrease in myopathic pain after 30 days of supplementation with coenzyme
Q10" - See
ubiquinol at Amazon.com.
- Diet Can Lower
Bad Cholesterol Like Statin Drug - WebMD, 2/8/05 -
"Load up on fiber and vegetables: They lower cholesterol almost as much as
cholesterol-lowering statin drugs ... Here's your shopping list:
Cholesterol-lowering margarines containing plant fats such as "Benecol" or
"Take Control", soy proteins and soluble fibers like oats, barley, psyllium,
plus all kinds of vegetables, including eggplant and okra"
Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at
Risk for Cardiovascular Disease and Stroke - Arch Neurol.
2004;61:889-892 - "Even brief exposure to
atorvastatin causes a marked decrease in blood CoQ10
concentration. Widespread inhibition of CoQ10 synthesis could explain the
most commonly reported adverse effects of statins, especially exercise
intolerance, myalgia, and myoglobinuria" - See
ubiquinol at Amazon.com.
Statins and Cancer
Mortality: Some Comfort - Medscape, 2/25/13 -
"They found that, overall, no matter what dose of statin patients were
taking, statins reduced cancer mortality by about 15%"
Statins and Colorectal
Cancer - Medscape, 2/18/13 - "In a retrospective
analysis conducted in more than 2500 veterans with a history of colonoscopic
polypectomy for adenomas, Siddiqui et al showed a 49% reduction in the
incidence of recurrent adenomas, and a 29% reduction in the incidence of
advanced adenomas, associated with continuous statin use over 3 to 5 years.
In a subsequent analysis of 231 individuals from the same population,
significantly fewer adenomas, of smaller size, were observed at follow-up
colonoscopy in individuals who had achieved 30% or more reduction in LDL
cholesterol level, compared with those who had not. This suggests that lipid
lowering, rather than statin use per se, may be partly responsible for the
effect of statins on adenoma development and progression. An independent
case-control study of 197 patients, also from a veterans population, found
no association between statin use and adenoma recurrence over a median of
3.4 years. Furthermore, a secondary analysis of data from 3 large
colorectal adenoma chemoprevention trials, with a combined total of 2915
subjects, failed to show any association between statin use and the
recurrence of any adenomas, multiple adenomas, or advanced adenomas. The
prevalence of self-reported statin use was, however, low (8.1%) across the 3
chemoprevention trials, limiting power for the post hoc analysis. Statin
users comprised a much larger proportion (37%) of participants in the
Adenoma Prevention With Celecoxib (APC) trial. However, in a secondary
analysis of APC trial data, Bertagnolli et al found no evidence to
support a chemopreventive effect of statin use over 5 years of follow-up. On
the contrary, statin use of more than 3 years was associated with a 39%
increased risk of adenoma recurrence. Although these data are derived from
an RCT, statin use was self-selected, and the patient population comprised
only high-risk patients with a history of multiple or large adenomas,
limiting the generalizability of the results. Nonetheless, this analysis
represents a large prospective study of statin use and incident adenomas.
Furthermore, assessment of the association between statin use and study end
points was a planned secondary analysis"
and colorectal cancer risk: a longitudinal study - Cancer Causes
Control. 2013 Jan 30 - "After multivariable
adjustment, initiators of statins had a lower incidence rate of CRC as
compared to initiators of glaucoma drugs [hazard ratio (HR) 0.79; 95 % CI
0.69-0.90]. In sex-stratified analyses we observed a protective effect in
men (HR 0.77; 95 % CI 0.67-0.88) but not in women (HR 0.96; 95 % CI
use and reduced cancer-related mortality - N Engl J Med. 2012 Nov 8 -
"Multivariable-adjusted hazard ratios for statin
users, as compared with patients who had never used statins, were 0.85 (95%
confidence interval [CI], 0.83 to 0.87) for death from any cause and 0.85
(95% CI, 0.82 to 0.87) for death from cancer"
Statins may reduce risk of esophageal cancer - Science Daily, 10/22/12 -
"Only 1 in 5 patients with this cancer will still be
alive five years after diagnosis ... The Mayo study combined data from 13
studies that included over 1.1 million patients, of which 9,285 had
esophageal cancer. The analysis found statins lowered cancer risk by nearly
one-third; the longer a patient was on statins, the greater the protective
effect ... When researchers looked specifically at Barrett's esophagus,
patients taking a statin and aspirin reduced their risk of esophageal cancer
by 72 percent"
Use As a Moderator of Metformin Effect on Risk for Prostate Cancer Among
Type 2 Diabetic Patients - Diabetes Care. 2012 Mar 28 -
"Mean follow-up was ~5 years, and 7.5% had a PCa
diagnosis. Statin use modified the effect of metformin on PCa incidence (P <
0.0001). Metformin was associated with a significantly reduced PCa incidence
among patients on statins (HR 0.69 [95% CI 0.50-0.92]; 17 cases/533
metformin users vs. 135 cases/2,404 sulfonylureas users) and an increased
PCa incidence among patients not on statins (HR 2.15 [1.83-2.52]; 22
cases/175 metformin users vs. 186 cases/1,930 sulfonylureas users). The HR
of PCa incidence for those taking metformin and statins versus those taking
neither medication was 0.32"
Low Levels of LDL
Cholesterol Predate Cancer Cases - Medscape, 3/25/12 -
"there is nothing here to suggest that statins would
Statin Risks Outweighed by Statin Benefits - USA Today, 3/1/12 -
"Clinical trials show that all of these
cholesterol-lowering drugs cut the risk of heart disease by 25% to 30% ...
analyses of controlled trials show that those who cross the threshold into
diabetes had exactly the same benefits of the statin ... As for the memory
loss and confusion, Nissen says it is "rare and completely reversible.""
New Warnings on Cholesterol-Lowering Statins - WebMD, 2/28/12 -
"Memory loss, confusion, high blood sugar, and type
2 diabetes are possible side effects of the popular cholesterol-lowering
drugs known as statins ... Brand name and generic versions of statin drugs
must carry these warnings on their labels"
Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's
Health Initiative - Arch Intern Med. 2012 Jan 9 -
"The WHI recruited 161 808 postmenopausal women aged
50 to 79 years at 40 clinical centers across the United States from 1993 to
1998 with ongoing follow-up ... Statin use at baseline was associated with
an increased risk of DM (hazard ratio [HR], 1.71; 95% CI, 1.61-1.83). This
association remained after adjusting for other potential confounders
(multivariate-adjusted HR, 1.48; 95% CI, 1.38-1.59) and was observed for all
types of statin medications"
Statins linked to higher diabetes risk - USATODAY.com, 1/9/12 -
"Study authors advise patients not to stop taking
their medications without talking to a doctor, because statins' proven power
to prevent heart attacks and strokes outweighs any potential increase in
type 2 diabetes risk. But the results - a nearly 50% increase in diabetes
among longtime statin users - should throw cold water on the idea of
prescribing these drugs to healthy people, which some have recommended as a
way to prevent disease ... In the study, 6.4% of women who didn't use
statins developed diabetes during the eight to nine years of follow-up ...
That rate rose to 9.9% among statin users"
Prescriptions and Breast Cancer Recurrence Risk - Medscape, 12/22/11 -
"It is possible that some past incidence studies did
not observe an association because a high proportion of statin users took
hydrophilic drugs. For instance, Cauley et al. observed a lower risk of
breast cancer among lipophilic statin users, 82% of whom took either
simvastatin or lovastatin (HR = 0.82, 95% CI = 0.70 to 0.97); and Boudreau
et al. observed an inverse association with overall statin use, when
approximately 48% of the study participants were simvastatin or lovastatin
users (odds ratio = 0.7, 95% CI = 0.4 to 1.0). However, Woditschka et
al. observed no association between statin use and breast cancer
incidence in which most users were exposed to the lipophilic drugs
simvastatin and lovastatin (odds ratio = 1.02, 95% CI = 0.97 to 1.08);
and Friis et al. studied statin use and breast cancer incidence in a
Danish population that overlaps with the population analyzed in our study
(so simvastatin is expected to have accounted for a large proportion of the
overall statin exposure) and also observed no association; (relative risk =
1.02, 95% CI = 0.76 to 1.36). Although the apparent discordance between
the statin associations with breast cancer incidence and recurrence may be
explained by inadequate exposure characterization with respect to
solubility, it is also important to realize that factors which prevent
recurrence are not necessarily expected to also prevent incidence"
Study: Statins reduce flu death risk by half - USA Today, 12/14/11 -
"Patients on statins were 41 percent less likely to
die, the study found, even after adjusting for age, the presence of heart,
lung and/or kidney disease, whether or not they had had a flu shot, or
whether or not they had received antiviral medications such as Tamiflu ...
There's no question that these observations are striking in terms of death
from influenza but they can't say why"
of early statin therapy in patients with acute myocardial infarction who
have extremely low low-density lipoprotein cholesterol - J Am Coll
Cardiol. 2011 Oct 11;58(16):1664-71 - "Intensive
lipid-lowering therapy with a target LDL-C value <70 mg/dl is recommended in
patients with very high cardiovascular risk. However, whether to use statin
therapy in patients with baseline LDL-C levels below 70 mg/dl is
controversial ... Statin therapy significantly reduced the risk of the
composite primary endpoint (adjusted hazard ratio [HR]: 0.56; 95% confidence
interval [CI]: 0.34 to 0.89; p = 0.015). Statin therapy reduced the risk of
cardiac death (HR: 0.47; 95% CI: 0.23 to 0.93; p = 0.031) and coronary
revascularization (HR: 0.45, 95% CI: 0.24 to 0.85; p = 0.013). However,
there were no differences in the risk of the composite of all-cause death,
recurrent MI, and repeated percutaneous coronary intervention rate"
More Evidence for Lowering LDL to Below 70 - Medscape, 10/4/11 -
"They compared outcomes among 1054 patients with LDL
levels below 70 mg/dL at the time of their MI as to whether they were
discharged on a statin or not ... Results showed that the rate of major
adverse cardiac events at one year was significantly lower in those patients
who were taking a statin, with the benefit mainly driven by the reduction of
cardiac death and coronary revascularization ... Dr Roger Blumenthal (Johns
Hopkins University, Baltimore, MD) suggested the study supported the
pleiotropic effects of statins and the idea that the ideal LDL-C is probably
closer to 50 than to 70 mg/dL ... levels of LDL below 70 are on a par with
those of nonhuman primates who don't develop atherosclerosis, adding that,
like these primates, humans were designed to be vegetarians ... Chimpanzees
don't eat meat; they eat very little fat. They have LDL levels in the range
of 40 to 70, and they don't get atherosclerosis. Maybe we wouldn't get
atherosclerosis either if we had levels this low"
mortality according to lipid-lowering drugs and lipoproteins in a general
population - Curr Med Res Opin. 2011 Sep 7 -
"The beneficial effect of lipid-lowering drugs (LLD) on cardiovascular risk
is established, but long term safety data remain scarce. Our aim was to
assess 10-year risk of cancer mortality according to blood lipoprotein
levels and LLD exposure, in a general population ... There were 3262
participants and 177 deaths were recorded over the 10-year period (78 due to
a cancer). The sample comprised 64% of normolipidaemic, 25% of untreated
dyslipidaemic and 11% of dyslipidaemic subjects treated with LLD (4%
statins, 6% fibrates and 1% other hypolipidaemic drugs). After adjustment
for centre, age, gender, smoking, gamma-glutamyl transpeptidase and mean
corpuscular volume, the hazard ratios (HR) for cancer mortality in subjects
with non-HDL cholesterol <3.5 mmol/L (135 mg/dL) and in those with HDL
cholesterol <0.90 mmol/L (35 mg/dL) were 2.74 (95% confidence interval:
1.66-4.52, p < 0.001) and 2.83 (1.62-4.96, p < 0.001), respectively. The
adjusted HR for cancer mortality was 0.31 (0.11-0.86, p = 0.025) in people
on LLD compared to untreated subjects. Conclusions: In the present study, we
confirm the significant association between low cholesterol and cancer
mortality without finding any harmful signal regarding cancer risk
associated with the use of LLD"
Intake of Cholesterol Is Positively and Use of Cholesterol-Lowering
Medication Is Negatively Associated with Prevalent Age-Related Hearing Loss
- J Nutr. 2011 May 25 - "After multivariable
adjustment, the likelihood of prevalent hearing loss increased from the
lowest (reference) to the highest quartile of dietary cholesterol intake
(P-trend = 0.04). Among persons self-reporting statin use (n = 274), a 48%
reduced odds of prevalent hearing loss was observed after multivariable
adjustment [OR = 0.52 (95% CI = 0.29-0.93)]. Participants in the second and
3rd quartiles of dietary monounsaturated fat intake compared with those in
the first quartile (reference) had a significantly reduced risk of hearing
loss progression 5 y later [multivariable-adjusted OR = 0.39 (95% CI =
0.21-0.71)] and [OR = 0.51 (95% CI = 0.29-0.91)], respectively. Our results
suggest that a diet high in cholesterol could have adverse influences on
hearing, whereas treatment with statins and consumption of monounsaturated
fats may have a beneficial influence"
and Prostate Cancer Diagnosis and Grade in a Veterans Population - J
Natl Cancer Inst. 2011 Apr 15 - "Compared with men
taking an antihypertensive medication, statin users were 31% less likely (HR
= 0.69, 95% CI = 0.52 to 0.90) to be diagnosed with prostate cancer.
Furthermore, statin users were 14% less likely (HR = 0.86, 95% CI = 0.62 to
1.20) to be diagnosed with low-grade prostate cancer and 60% less likely (HR
= 0.40, 95% CI = 0.24 to 0.65) to be diagnosed with high-grade prostate
cancer compared with antihypertensive medication users. Increased levels of
total cholesterol were also associated with both total (HR = 1.02, 95% CI =
1.00 to 1.05) and high-grade (HR = 1.06, 95% CI = 1.02 to 1.10) prostate
cancer incidence but not with low-grade prostate cancer incidence (HR =
1.01, 95% CI = 0.98 to 1.04)"
Statins make radiation more effective at curing prostate cancer, study
suggests - Science Daily, 3/23/11 - "the men
taking statins were less like to relapse than other patients. At five years,
11 percent of men taking statins saw their cancer return compared to 17
percent of patients not taking the medication. At eight years, 17 percent of
men on statins had a relapse compared to 26 percent not taking the drug"
Statins may prevent diabetic-related blindness, study suggests - Science
Daily, 2/17/11 - "oral treatment with the drug
atorvastatin blocked the formation of free radicals in the retina, which
restored proper levels of nerve growth factor and preserved neurons in the
retina. "It removed the break on the pro-form nerve growth factor to develop
into its mature form," she said. The drug was orally administered to rats in
doses proportional to levels given to human patients with cardiovascular
problems ... In a related study, also in the March edition of the journal
Diabetologia, El-Remessy and her colleagues found that epicathecin, a
component of green tea, also prevented the adverse actions of proNGF in the
retina. It does not affect the maturation of proNGF into NGF, explained
El-Remessy, but regulated a receptor downstream that proNGF uses to send a
signal to kill the neuron. Epicathechin prevents the death by inhibiting
that receptor. "We are still getting the same result, that we are preventing
neuronal death and restoring neuronal function, but just in a different
way,"" - See
green tea extract at Amazon.com.
Statins Lower Cardiovascular Risk Regardless of Baseline LDL : Abstract and
Introduction - Medscape, 1/21/11 - "In the
placebo-controlled trials, statin recipients had a 41-mg/dL greater decline
in LDL-C and a significant 22% reduction in first major vascular events
(2.8% vs. 3.6% annually). In the high-dose versus low-dose trials, high-dose
patients had a 20-mg/dL greater decline in LDL-C and a significant 15%
reduction in first major vascular events (4.5% vs. 5.3% annually). Relative
risk reductions of about 20% per 40-mg/dL decline in LDL-C were seen in both
placebo-controlled and high- versus low-dose trials for all prespecified
patient subgroups, and at all baseline LDL-C levels (including <80 mg/dL)"
Statin risks may outweigh benefits for patients with a history of brain
hemorrhage - Science Daily, 1/10/11
Statin use associated with statistically significant reduction in colorectal
cancer - Science Daily, 10/18/10 - "The relative
risk was 0.88 (95% CI 0.84-0.93; n=22) and represents a 12% reduction in the
odds of colorectal cancer among statin users ... the most common category of
statins, lipophilic (which includes atorvastatin or Lipitor®), showed the
greatest effect ... long-term use of statins is associated with reduced risk
of several cancers, including breast, prostate, lung, pancreas and liver"
Regular statin use is associated with a reduced risk of developing
rheumatoid arthritis - Science Daily, 9/7/10 -
"After adjusting for other possible confounders, patients who persistently
took statins had a lower risk (risk ratio of 0.58) of developing rheumatoid
arthritis compared with patients who did not persistently take statins.
There was only a small short term decrease in risk ratio in patients taking
statins and the development of osteoarthritis. (hazard ratio of 0.85)"
Statins associated with lower cancer recurrence following prostatectomy
- Science Daily, 6/28/10 - "the data showed that
overall, statin use reduced the risk of biochemical recurrence by 30 percent
... Among men taking statins equivalent to 20 mg of simvastatin a day, the
risk of recurrence was reduced 43 percent and among the men taking the
equivalent of more than 20 mg of simvastatin a day, the risk of recurrence
was reduced 50 percent. Men who took a statin dose the equivalent of less
than 20 mg of simvastatin daily saw no benefit"
Statins May Lower Testosterone, Libido - WebMD, 4/16/10 -
"When they compared men on statins to those not, the
men on statins were twice as likely to have low testosterone, regardless of
which of three commonly used thresholds for low testosterone they looked at"
Statins May Be Linked to Diabetes Risk - WebMD, 2/17/10 -
"use of statins increased the risk of type 2
diabetes by 9%. This risk was found primarily among older people; there was
no additional diabetes risk among statin users 60 and under"
Common cholesterol drugs, statins, fight cataracts, too - Science Daily,
and Breast Cancer in Postmenopausal Women without Hormone Therapy -
Anticancer Res. 2009 Dec;29(12):5143-5148 -
"Overall, there was no association between the use of statins and breast
cancer risk odds ratio (OR)=1.3 (95% confidence interval (CI) 0.7-2.5).
However, risk varied by hormone receptor status. Compared to non-users,
obese women who used hydrophobic statins had an elevated risk of
progesterone receptor-negative (PR(-)) breast cancer OR=4.0 (95% CI
1.2-13.8), but not of tumors with other hormone receptor profiles. The risk
for breast cancer was also significantly increased among overweight women
who used hydrophobic statins for less than or equal to 4 years OR=4.1 (95%
CI 1.2-14.4). CONCLUSION: This observational study found an increased risk
of breast cancer related to duration of statins use and PR(-) among
Statins May Soon Be Given to Those With Excess Inflammation - U.S. News,
12/17/09 - "The Food and Drug Administration is
considering expanding the use of cholesterol-lowering statin Crestor to
those who have increased levels of inflammation—but not high cholesterol ...
2.8 percent of folks in the Crestor group developed diabetes compared with
2.3 percent of those who took placebos ... Experts still can't explain why
Crestor would increase the likelihood of diabetes, but other research
suggests that the entire class of statin drugs appears to have this downside
... found a 13 percent increased risk in diabetes in the statin users ...
1.5 percent of the placebo takers had a heart attack or stroke compared with
0.72 percent of the statin takers"
Statins Lower Mortality, but Not Health Services Use - Medscape,
12/10/09 - "After adjustment for clinical and
demographic variables, receipt of statins was associated with a 59%
reduction in mortality"
Long-term Statin Use Associated With Decreased Risk Of Gallstones Requiring
Surgery - Science Daily, 11/10/09 - "Use of the
cholesterol-lowering drugs statins for more than a year is associated with a
reduced risk of having gallstones requiring surgery"
Widely Used Cholesterol-lowering Drug May Prevent Progression Of Parkinson's
Disease - Science Daily, 11/9/09 - "Simvastatin,
a commonly used, cholesterol-lowering drug, may prevent Parkinson's disease
from progressing further"
Cholesterol-lowering Medicines May Be Effective Against Cancer - Science
Daily, 11/2/09 - "Our results support the idea that
statins can be used in more ways than just to lower cholesterol," says
Pilon. "Not least that they can prevent the growth of cancer cells caused by
lipid-modified proteins, but also that they can be effective in the
treatment of diabetes and neurological disorders such as Parkinson's."
Statins Show Dramatic Drug And Cell Dependent Effects In The Brain -
Science Daily, 10/28/09 - "Besides their tremendous
value in treating high cholesterol and lowering the risk of heart disease,
statins have also been reported to potentially lower the risks of other
diseases, such as dementia ... statin drugs can have profoundly different
effects on brain cells -both beneficial and detrimental ... simvastatin
reduced the expression of the cholesterol transporter ABCA1 by approximately
80% in astrocytes, while pravastatin lowered expression by only around 50%.
Another interesting difference was that while both statins decreased
expression of the Tau protein -associated with Alzheimer's disease -- in
astrocytes, they increased Tau expression in neurons; pravastatin also
increased the expression of another Alzheimer's hallmark, amyloid precursor
Statin Drugs May Cut Dementia Risk - WebMD, 7/14/09 -
"people who took statin drugs were 58% less likely
to develop dementia than those who did not ... So what is going on? A risk
factor for dementia is high insulin; one theory is that statins may lower
the high insulin levels in the brain. Statins have also been shown to reduce
levels of C-reactive protein (CRP), a marker of inflammation that has been
linked to the pathology that can lead to dementia"
Muscle Damage From Statins May Evade Blood Test - WebMD, 7/6/09 -
"Studies suggest that between 10% and 15% of
patients who take cholesterol-lowering statin drugs like Crestor, Lipitor,
Lescol, Mevacor, Zocor, and Pravachol experience muscle pain as a side
effect of treatment ... Most do not end up with muscle damage, and a simple
blood test is routinely performed to identify patients who do ... But the
new study suggests the test for elevated levels of an enzyme associated with
muscle injury, known as creatine phosphokinase or CPK, may be less accurate
than widely believed ... Our findings call into question whether normal or
mildly elevated levels of serum (CPK) can be used to exclude underlying and
possibly ongoing muscle injury"
Muscle Damage May Be Present In Some Patients Taking Statins - Science
Daily, 7/6/09 - "Although in clinical practice, the
majority of patients with muscle symptoms improve rapidly after cessation of
therapy, our findings support that a subgroup of patients appears to be more
susceptible to statin-associated myotoxicity, suffering persistent
Cholesterol OK? Statins Still Help Heart - WebMD, 7/1/09 -
"Combined data from 10 trials that included more
than 70,000 patients without cardiovascular disease, but with cardiovascular
risk factors, showed a 12% reduction in deaths among patients who took
statins ... The statin group also had 30% fewer heart attacks and 20% fewer
strokes over four years of follow-up"
Statins Can Protect Against Alzheimer’s Disease, According To New Study
- Science Daily, 6/22/09 - "They clearly
demonstrated that treatment with a statin called Lovastatin could prevent
the death of nerve cells under these conditions. The statins not only
prevented cells from dying but also prevented the loss of memory capacity
that normally occurs after such cell death. In a previous study Dolga had
showed that these statins stimulate the protective capacity of tumor
necrosis factor, which is a key player in the brain’s immune response"
- [Abstract] -
is in red yeast rice. See
red yeast rice at Amazon.com.
Pretreatment with Lovastatin Prevents N-Methyl-D-Aspartate-Induced
Neurodegeneration in the Magnocellular Nucleus Basalis and Behavioral
Dysfunction - J Alzheimers Dis. 2009 Mar 6 -
"From these studies we conclude that treatment with lovastatin may provide
protection against neuronal injury in excitotoxic conditions associated with
neurodegenerative diseases including Alzheimer's disease" - Note:
the generic name and therefore shouldn't be capitalized) is in
red yeast rice. See
red yeast rice at Amazon.com.
Statin Drugs May Protect Against Cancer And Also Result in Fewer Gallbladder
Removals - Science Daily, 5/5/09 - "The research
team found a significant inverse association between having statin
prescriptions filled and the risk of developing HCC. There was a trend
toward stronger risk reduction with longer and more frequent statin
Statins Alter Prostate Cancer Patients' PSA Levels - Science Daily,
4/28/09 - "We found that PSA levels are actually
significantly lower in prostate cancer patients on statins versus prostate
cancer patients not on statins"
Major Statin Study Reveals Several Important Findings For Reducing Prostate
Cancer And Disease - Science Daily, 4/26/09 -
"non-statin users were three times more likely to develop prostate cancer,
suggesting statin use may prevent development of prostate cancer ...
Overall, statin use was not significantly associated with a decreased risk
of developing ED. However, statins were associated with a decreased risk of
ED among older men (>60 years). Men in this age category who used statins
were less likely to develop ED, compared to older men who did not use
statins. Additionally, men who took statins for a longer time were more
protected against developing ED. For example, men who took statins for
nearly nine years or more were 64 percent less likely to develop ED, while
men who took statins for less than three years had about the same risk of
developing ED. compared to men who did not take statins" - See
Statins May Exert Influence On Prostate Cancer Growth By Reducing
Inflammation - Science Daily, 4/26/09 - "men who
were on statins had a 72 percent reduction in risk for tumor inflammation,
and we believe this might play a role in the connection between prostate
cancer and statin use" - See atorvastatin at
Statins May Lower Stroke Risk - Science Daily, 4/15/09 -
"strokes were 18% less likely among patients taking
statins than among those who didn't get statins ... For every drop of 39
mg/dL in LDL "bad" cholesterol, stroke risk dropped by 21%"
Statin study: Lower cholesterol, diminished joy of sex linked - USA
Today, 3/5/09 - "In the study, sexual pleasure sank
along with LDL levels ... Some studies have found that statins improve
sexual function, probably because the pills can improve blood flow to the
genital area, Golomb says. But she says the drugs also may reduce Coenzyme
Q10, a nutrient that helps cells convert oxygen, blood and glucose into
energy. "Orgasm is a high-energy activity," so losing the nutrient could
weaken sexual pleasure, she says" - See
ubiquinol products at Amazon.com.
Aching Back? Cholesterol Medication Might Help - Science Daily, 3/3/09 -
"A new study finds that using statins may be useful
in treatment for degenerative discA new study finds that using statins may
be useful in treatment for degenerative disc ... Lovastatin increased the
synthesis of collagen II, a protein that makes up moveable joints, and
decreased the synthesis of collagen I, a protein that is related to fibrosis
(the formation or development of excess fibrous connective tissue)" -
Note: Lovastatin is the one that red yeast
rice is high in.
Statins Lower Stroke Severity, Improve Recovery - Science Daily, 2/27/09
- "patients who were taking statins before a stroke
experienced better outcomes and recovery than patients who weren't on the
drug — even when their cholesterol levels were ideal"
Statins Cut Deaths From Prostate Cancer - WebMD, 2/26/09 -
"men taking statins were 63% less likely to die from
the disease than men not taking statins ... The high-potency statins were
about 2.5 times more effective at preventing prostate cancer death than the
'Normal' levels of bad cholesterol may be too high - USA Today, 2/1/09 -
"Current guidelines recommend that doctors prescribe
a statin for anyone whose LDL is 100 milligrams per deciliter of blood or
higher ... half of all heart attacks are occurring below 100 (mg/dl) ... the
study supports the wisdom of a push to drive LDL even lower, in many cases
down to 70 mg/dl"
More May Benefit From Cholesterol Drugs - WebMD, 1/13/09 -
"Eight out of 10 middle-aged and older Americans may
benefit from treatment with cholesterol-lowering statin drugs ... All the
participants had elevated levels of high-sensitivity C-reactive protein
(hsCRP) ... Over an average of two years of treatment, participants who took
the statin Crestor had half as many heart attacks, strokes, and deaths from
cardiovascular causes as participants randomly assigned to receive a
Disorders Linked To Statin Drug Use In Some Patients - Science Daily,
JUPITER hits New Orleans: Landmark study shows statins benefit healthy
individuals with high CRP levels - theheart.org, 11/9/08 -
"In a study of individuals with low LDL cholesterol
but elevated C-reactive-protein (CRP) levels, investigators showed that
rosuvastatin (Crestor, AstraZeneca) 20 mg significantly reduced the primary
end point—a composite of nonfatal MI, nonfatal stroke, hospitalization for
unstable angina, revascularization, and confirmed death from cardiovascular
causes—by 44% compared with individuals treated with placebo" -
Note: They seem to be attributing this to the reduction in CRP. At 12
months, the CRP of the 20 mg Crestor group was 2.2. The baseline was 4.2.
That's a (4.2 - 2.2)/4.2 = 47.6% reduction in CRP. Another option to reduce
CRP might be Periostat (low dose doxycycline for periodontal disease). See
my CRP page for other ways to
reduce it. See:
Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart
Failure - Doctor's Guide, 11/20/02 -
"At six-month follow-up, sub-antimicrobial dose
doxycyline significantly reduced
levels by 45.8 percent compared to baseline values (p<0.05). The drug
was also associated with a 33.5 percent reduction in interleukin-6 and a
50 percent reduction in metalloproteinase ... The findings are exciting,
since research is now showing that CRP is both a key marker of
inflammation leading to future acute coronary events, but also that CRP
itself may contribute to the initiation and progression of
Study: Statins help people with normal cholesterol, too - USATODAY.com,
11/9/08 - "A study involving nearly 18,000 patients
has shown for the first time that giving a cholesterol-lowering statin drug
to seemingly healthy people with normal cholesterol can cut their risk of
heart attacks, stroke and death by nearly half"
Statins Lower Prostate Cancer Marker - WebMD, 10/28/08 -
"On average, PSA declined by 4.1% after starting a
statin ... a bigger decrease was seen in men who started out with the
highest PSA levels (2.5 ng/mL or more) -- but only among those who had the
greatest decrease in cholesterol. These men had a 17.4% drop in PSA"
Statins Reduce Dementia & Cognitive Impairment Risk - Physician's Weekly
Article, 10/13/08 - "Patients who had used statins
were about half as likely as those who did not use the drugs to develop
dementia or CIND"
Statins May Prevent Miscarriages, Study Suggests - Science Daily,
Top-selling Cholesterol Drug Does Little For Women, Study Suggests -
Science Daily, 9/17/08 - "Not one of the studies
that included women with a mixture of risk factors for heart attacks
provided statistically significant support for prescribing Lipitor or other
statins to protect against cardiovascular problems. Pfizer’s claims of
clinical proof that Lipitor reduces risk of heart attack in patients with
multiple risk factors for heart disease does not appear to be scientifically
supported for large segments of the female population ... Lipitor’s
advertising repeatedly fails to report that clinical trials were
statistically significant for men but not for women. Unqualified advertising
claims of protection against heart attacks may therefore be misleading"
Statins Lower Risk of Recurrent Stroke in Both Elderly, Younger Patients
- Doctor's Guide, 9/10/08 - "Within each group,
about half of the people received atorvastatin and about half received a
placebo. The participants were then followed for an average of 4.5 years ...
Low-density lipoprotein (LDL) cholesterol was lowered by an average of 61
points during the study for the elderly group, and by 59 points for the
younger group. Those in the younger group reduced their risk for another
stroke by 26% and the elderly group reduced their risk by 10%"
Cholesterol Drugs Lower Risk Of Stroke For Elderly, Too - Science Daily,
Lowering Cholesterol Early In Life Could Save Lives - Science Daily,
8/4/08 - "Our review of the literature convinces us
that more aggressive and earlier intervention will probably prevent
considerably more than 30% of coronary heart disease ... Studies show that
fatty streak lesions in the arteries that are a precursor to atherosclerosis
and heart disease begin in childhood, and advanced lesions are not uncommon
by age 30. Why not nip things in the bud?" Such early signs of heart disease
should be taken as seriously as early signs of cancer or diabetes"
Statins May Prevent Dementia in Older Adults - Doctor's Guide, 7/29/08 -
"People at high risk for dementia who took statins
were half as likely to develop dementia as those who do not take statins"
Can Statins Reduce Risk of Memory Loss? - WebMD, 7/28/08
Statins Have Unexpected Effect On Pool Of Powerful Brain Cells - Science
Statins Are "Remarkably Safe," Says New Review - Medscape, 6/10/08 -
"A new review of the safety of statins has concluded
that these drugs are well tolerated, with their main adverse effects —
myopathy and rhabdomyolysis — occurring very rarely at standard doses"
Cholesterol Leads To Lower PSA, Lower Prostate Cancer Risk, Study Suggests
- Science Daily, 5/15/08 - "PSA levels were reduced
after starting statin medications and that this decline was proportional to
the decline in LDL cholesterol"
Statins May Reduce Risk for Lung Cancer - Medscape, 5/8/08 -
"Statin use for more than 6 months was associated
with a reduced risk for lung cancer of 55%"
Reduction in Blood Pressure With Statins: Results From the UCSD Statin
Study, a Randomized Trial - Arch Intern Med. 2008 Apr 14;168(7):721-7 -
"Statins modestly but significantly reduced BP
relative to placebo,by 2.2 mm Hg for SBP (P = .02) and 2.4mm Hg for DBP"
Statins Cause Apoptosis
of Esophageal Cancer Cells - Medscape, 4/21/08
Statins Lower Blood Pressure - WebMD, 4/11/08 -
"We found that statins lower both systolic and diastolic blood pressure, and
that the effect extends to patients with pre-hypertension, with normal blood
pressure, and persons not on blood-pressure lowering medications"
Statins May Reduce Risk of Kidney Cancer - Medscape, 2/26/08 -
"Treatment with a statin was associated with a 48%
reduced risk of renal cell carcinoma"
Statins, NSAIDs vs. Prostate Cancer - WebMD, 2/18/08 -
"Men with prostate cancer who take
cholesterol-lowering statin drugs or anti-inflammatory drugs live longer
than those who don't take the drugs ... men who reported ever taking statins
were 41% to 65% less likely to die during the course of the study than men
who didn't. Men who took NSAIDs were 53% to 61% less likely to die than
those who didn't"
Why Patients Stop
Taking Statins and What Can Be Done About It - Medscape, 2/14/08 -
"Another reason why patients might stop taking
lipid-lowering therapy may be sleep disturbance, which has been associated
with statins" - That's something I didn't know. If you are taking
statins, you might want to take them in the morning instead of the evening.
Statins might reduce risk of renal cell carcinoma in humans: case-control
study of 500,000 veterans - Urology. 2008 Jan;71(1):118-22 -
"Statin use was significantly associated with a risk
reduction of renal cell carcinoma of 48% (adjusted odds ratio 0.52"
but Does It Prolong Life? - New York Times, 1/28/08 -
"High-risk groups have a lot to gain ... But
patients at low risk benefit very little if at all. We end up overtreating a
lot of patients ... This month, The Journal of the American College of
Cardiology published a report combining data from several studies of people
65 and older who had a prior heart attack or established heart disease. This
“meta-analysis” showed that 18.7 percent of the placebo users died during
the studies, compared with 15.6 percent of the statin users ... This
translates into a 22 percent lower mortality risk for high-risk patients
The Association Between Statins and Cancer Incidence in a Veterans
- J Natl Cancer Inst. 2008 Jan 8 - "After
multivariable adjustment, a statistically significantly decreased risk of
all cancers was also associated with increasing statin use"
Statins for All Adults with Diabetes? - WebMD, 1/10/08 -
"One-third fewer people with type 1 or type 2
diabetes would suffer heart attacks or strokes if they took
cholesterol-lowering statin drugs"
Statin Drugs May Cut Cancer Risk - WebMD, 1/8/08 -
"The veterans were followed for five years, on
average. During that time, 9% of those taking statins were diagnosed with
cancer, compared with 13% of those not taking statins, VA records show"
Elderly CHD Patients and Statins - Medscape, 1/3/08 -
"the use of statins for secondary prevention in
elderly patients with documented CHD reduced all-cause mortality 22% and
reduced CHD mortality 30%. Nonfatal myocardial infarction was reduced 26%,
the need for revascularization 30%, and stroke 25%"
Statin Use Tied to Fewer Relapses in Prostate Cancer - oncologystat.com,
11/26/07 - "Men who happened to be on statins when
given radiotherapy for prostate cancer were significantly more likely to be
disease free 10 years later"
CORONA: Little Clinical Benefit Seen in First Major Statin Trial in HF -
Medscape, 11/6/07 - "Over a median follow-up of 33
months, there were no significant differences in the primary end point or in
all-cause mortality, the rate of coronary events (which included sudden
death, fatal or nonfatal MI, percutaneous coronary intervention [PCI] or
coronary arterial bypass graft [CABG], resuscitated cardiac arrest, and
hospitalization for unstable angina), effects on NYHA class, or the rate of
newly diagnosed diabetes ... Despite the lack of difference in the primary
end point, there were significant reductions in levels of CRP; however, they
were not decreased to what would be considered a low level ... This does
bring into question whether higher doses of rosuvastatin could have
additional clinical benefit" - Note: Statins do little to increase
HDL which some studies imply may be more important. Also, statins have been
shown to decrease co-enzyme Q10. I would have liked to see the results if
they had added niacin to increase HDL and co-enzyme Q10.
Statins May Fight Prostate Cancer - WebMD, 10/29/07 -
"Overall, 76% of men who took statins were alive and
without cancer 10 years after treatment vs. 66% of those who didn’t"
Cholesterol-lowering Medicine Make Radiation More Effective At Curing
Prostate Cancer? - Science Daily, 10/29/07 -
"Patients with prostate cancer who receive high-dose radiation treatment and
also take statin drugs commonly used to lower cholesterol have a 10 percent
higher chance of being cured of their cancer at 10 years after diagnosis (76
percent), compared to those who don't take these medications (66 percent)"
Statin Use Linked to Better Blood Pressure Control - Medscape, 10/23/07
- "After adjustment for demographics, body mass
index, diabetes, smoking, exercise, low-salt diet, and antihypertensive
medications, the odds ratio for having blood pressure under control was 1.46
for statin users compared with nonusers"
Statins Cut Gallstones Risk - WebMD, 10/16/07 -
"The study suggested that overall, current statin use slashed the risk of
having gallbladder removal surgery by 18% -- no matter how long a woman had
been taking the drug ... Women with diabetes who had been taking statins for
two or more years reduced their risk of surgery by 75% ... Statins improve
insulin resistance in people with diabetes but not in nondiabetics"
QualityCounts.com Anti-aging Newsletter
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